ライフサイエンスコーパス: presynaptic inhibition

1 spond to weak mechanical stimuli and provoke presynaptic inhibition.

2 ry information is thought to be modulated by presynaptic inhibition.

3 ons and might represent a novel mechanism of presynaptic inhibition.

4 ex, may represent a target of Gbetagamma for presynaptic inhibition.

5 f the regulation of synapses and networks by presynaptic inhibition.

6 >12 hr) eventually desensitizes A1R-mediated presynaptic inhibition.

7 PCRs and their molecular effectors mediating presynaptic inhibition.

8 Rs and their molecular targets for mediating presynaptic inhibition.

9 nhibition and group B with reduced or absent presynaptic inhibition.

10 o bind RGS proteins (PTX/RGS-i) also rescued presynaptic inhibition.

11 ation, both in control conditions and during presynaptic inhibition.

12 (RGS proteins) are required for rapid, brief presynaptic inhibition.

13 by these two inhibitory neurotransmitters in presynaptic inhibition.

14 nts by G-proteins contributes importantly to presynaptic inhibition.

15 of the contralateral motor cortex decreased presynaptic inhibition.

16 r surfaces of the ipsilateral foot decreased presynaptic inhibition.

17 lso the contralateral sural nerve, decreased presynaptic inhibition.

18 tein-coupled signaling pathways that produce presynaptic inhibition.

19 rve at the head of the fibula, decreased the presynaptic inhibition.

20 level, load reduced movement signal gain by presynaptic inhibition.

21 was movement-parameter specific and required presynaptic inhibition.

22 neurons, unlike GABA(B) receptors that cause presynaptic inhibition.

23 g branch-point failures, rather than causing presynaptic inhibition.

24 and GAD67 in GABApre terminals and decreased presynaptic inhibition.

25 GABAergic axoaxonic synapses, which mediate presynaptic inhibition.

26 nduced spiking does not represent failure of presynaptic inhibition.

27 ies reluctant Ca(V)2.2 gating and subsequent presynaptic inhibition.

28 PAD-induced spiking is assumed to override presynaptic inhibition.

29 ransfer at sensory-motor connections through presynaptic inhibition.

30 ion of GABApre terminals and the efficacy of presynaptic inhibition.

31 s not yet experimentally observed or through presynaptic inhibition.

32 s suppressed at high temporal frequencies by presynaptic inhibition.

33 he defining physiological characteristics of presynaptic inhibition.

34 afferents must be efficiently controlled by presynaptic inhibition.

35 (eEPSCs), and decreased the GABABR-mediated presynaptic inhibition.

36 utamate carboxypeptidase II (GCPII) reducing presynaptic inhibition.

37 e amplitude of invading spikes and indicated presynaptic inhibition.

38 a high level of GABA(B)Rs and exhibit strong presynaptic inhibition.

39 xpress GABA(B)Rs and do not have significant presynaptic inhibition.

40 and determined the conditions necessary for presynaptic inhibition.

41 ibition determined the kinetics of GABAergic presynaptic inhibition across different BC classes.

42 Presynaptic inhibition acted differentially upon two maj

43 elated to a decrease in postsynaptic but not presynaptic inhibition after SCI.

44 ons presynaptically and postsynaptically via presynaptic inhibition and by reducing the currents carr

45 Rbeta in inhibitory neurons leads to reduced presynaptic inhibition and changes to sensory-evoked ref

46 strength of GABAB receptor (GABABR)-mediated presynaptic inhibition and could be different at the sam

47 ceptor (GABA(B)R) agonist baclofen to engage presynaptic inhibition and field EPSPs (fEPSPs) in hippo

48 to two groups, group A with normal levels of presynaptic inhibition and group B with reduced or absen

49 trimeric G protein, along with the nature of presynaptic inhibition and its physiological role.

50 polarizing conductance, cannabinoid-mediated presynaptic inhibition and long-term depression, are als

51 ibition of N-type (CaV2.2) channels supports presynaptic inhibition and represents a central paradigm

52 and P/Q-type Ca(2+) channels contributes to presynaptic inhibition and short-term synaptic plasticit

53 y reduction of gGABA poses a greater risk to presynaptic inhibition and the sensory processing that r

54 functional determinants of GABA(B)-mediated presynaptic inhibition and to test hypotheses on the rol

55 Attenuation of the afferent-driven presynaptic inhibition and/or disinhibition of the dorsa

56 r supraspinal control (via biasing activity, presynaptic inhibition, and fusimotor gain).

57 ceptors, GPCRs that mediate highly sensitive presynaptic inhibition, are instead dynamic in axons.

58 ectable suppression by iPNs, arguing against presynaptic inhibition as a primary mechanism.

59 I afferents in contralateral motoneurones to presynaptic inhibition as an indicator of the relative c

60 y, these mice exhibited reduced GBR-mediated presynaptic inhibition at excitatory and inhibitory syna

61 The mechanism of presynaptic inhibition at the mossy fiber synapse was in

62 nstrated that GABA(B)R activation results in presynaptic inhibition at the output synapses of both PT

63 We show that 5-HT receptor-mediated presynaptic inhibition, at this synapse, involves a redu

64 suggests that a receptor reserve exists for presynaptic inhibition, but that the magnitude of this r

65 of the ipsilateral plantar nerves increased presynaptic inhibition, but this action is attributed to

66 rs, and supraspinal structures can all evoke presynaptic inhibition, but we do not understand how the

67 All four PTx-ins Galpha subunits rescued presynaptic inhibition by adenosine A1 receptors.

68 NAP25Delta3 homozygote mice exhibited normal presynaptic inhibition by GABA(B) receptors, which inhib

69 substantia nigra reticulata (SNr) lose tonic presynaptic inhibition by GABAB receptors.

70 Conversely, presynaptic inhibition by KORs of inhibitory synapses on

71 eceptors, which inhibit VGCCs, but defective presynaptic inhibition by receptors that work directly o

72 Local presynaptic inhibition by TNTCFP did not change the syna

73 s of an invertebrate neural circuit show how presynaptic inhibition can play a key role in the genera

74 fast glutamatergic autaptic EPSC that showed presynaptic inhibition caused by concomitant dopamine re

75 inputs requires either the removal of tonic presynaptic inhibition caused by endocannabinoids or the

76 The presynaptic inhibition caused by the mu agonist DAMGO ha

77 Selective loss of GABA(A) receptor-mediated presynaptic inhibition causes an enhanced sensitivity an

78 tion of Ia afferent synapses and a change in presynaptic inhibition could contribute to maintain or e

79 ion in excitatory drive to that circuit, via presynaptic inhibition, coupled with a phase-specific ex

80 We conclude that GABABR-mediated presynaptic inhibition decreased with increasing frequen

81 t evidence from awake, behaving monkeys that presynaptic inhibition decreases the ability of afferent

82 d by vesicle-depletion, and partly caused by presynaptic-inhibition due to the activity of inhibitory

83 Second, presynaptic inhibition dynamically updates synaptic prop

84 two known Gbetagamma-mediated mechanisms for presynaptic inhibition: first, the action of Gbetagamma

85 it is not fully understood how light-evoked, presynaptic inhibition from amacrine cell inputs shapes

86 ar cells become tuned to orientation through presynaptic inhibition, generating lateral antagonism in

87 Previous research shows that GABA-mediated presynaptic inhibition has a critical role in cued fear

88 Our results further suggest that this presynaptic inhibition has appropriate functional conseq

89 The phenomenon of afferent presynaptic inhibition has been intensively studied in t

90 5-HT1B receptor-mediated presynaptic inhibition has been proposed as one mechanis

91 Galpha(o) subunits rescued adenosine-induced presynaptic inhibition in cultured hippocampal neurons.

92 ganglion cells thus highlighting the role of presynaptic inhibition in gain control and temporal filt

93 1,) Galpha(i2), and Galpha(i3)) in mediating presynaptic inhibition in hippocampal neurons by express

94 We demonstrate that Gbetagamma-mediated presynaptic inhibition in lamprey central synapses occur

95 , it has been difficult to study the role of presynaptic inhibition in most neural circuits due to la

96 a-containing GABABRs are believed to mediate presynaptic inhibition in principal neurons.

97 nct among mGluRs but closely matches that of presynaptic inhibition in some central nervous system pa

98 on, and seizures are consistent with reduced presynaptic inhibition in spinal cord and impaired inhib

99 is finding, Kiss1(ARH) neurons received less presynaptic inhibition in the absence of AgRP neurons (n

100 demonstrate a new paradigm of GPCR-mediated presynaptic inhibition in the CNS and add a new regulato

101 The classical GPCR-mediated presynaptic inhibition in the CNS is produced by direct

102 ization of a GABAergic circuit that mediates presynaptic inhibition in the mammalian CNS is therefore

103 s, greatly prolonged GABAB receptor-mediated presynaptic inhibition in tottering as compared to wild-

104 Blocking presynaptic inhibition in vivo increased the amplitude o

105 activity-dependent manner, a primary role of presynaptic inhibition in vivo may be to modulate the ma

106 Successful rescue of presynaptic inhibition indicates that the expressed muta

107 calcium-selective channels (Ca(V)2.2) during presynaptic inhibition is a decades-old question.

108 Presynaptic inhibition is a form of neuromodulation that

109 G-protein-coupled receptor (GPCR)-mediated presynaptic inhibition is a fundamental mechanism regula

110 We further revealed that presynaptic inhibition is a simple mechanism for divisiv

111 Presynaptic inhibition is a widespread mechanism modulat

112 During the retraction phase, presynaptic inhibition is absent and MCN1 elicits a fast

113 he modulatory transmission that it receives, presynaptic inhibition is also used effectively to rhyth

114 ation of GABAergic interneurons that mediate presynaptic inhibition is directed by their sensory targ

115 This presynaptic inhibition is driven by graded potentials wi

116 Additional presynaptic inhibition is generated by spiking amacrine

117 We conclude that GABA(B)R-mediated presynaptic inhibition is more accurately described as a

118 manipulation enabled us to demonstrate that presynaptic inhibition is most likely the source of divi

119 These data suggest that GABA-mediated presynaptic inhibition is not critical for retrieval of

120 bouts of activity, 5-HT/Gbetagamma-mediated presynaptic inhibition is relieved, leading to a frequen

121 erminals, membrane-delimited G(i/o)-mediated presynaptic inhibition is ubiquitous and acts via Gbetag

122 erminals, membrane-delimited G(i/o)-mediated presynaptic inhibition is ubiquitous and acts via GBy to

123 A major mechanism producing afferent presynaptic inhibition is via a channel-mediated depolar

124 namic response ranges were different because presynaptic inhibition limited glutamate release from ON

125 our understanding of G protein signaling and presynaptic inhibition, many of which were published in

126 the trigeminal and cervical afferent-driven presynaptic inhibition may contribute to development of

127 rotein modulation and the consequent reduced presynaptic inhibition may contribute to migraine attack

128 ion in the afferent terminals indicates that presynaptic inhibition may shape the synaptic transmissi

129 a dendrotoxin-sensitive potassium current in presynaptic inhibition mediated by a G protein-coupled r

130 In addition, presynaptic inhibition mediated by A(1) adenosine recept

131 Presynaptic inhibition mediated by G protein-coupled rec

132 Presynaptic inhibition mediated by G protein-coupled rec

133 Presynaptic inhibition mediated by GABA(B)Rs on GABA ter

134 We summarize the classic studies of presynaptic inhibition mediated by GABA-gated Cl channel

135 as did pertussis toxin, an agent that blocks presynaptic inhibition mediated by metabotropic glutamat

136 In contrast, the onset of presynaptic inhibition mediated by PTX/RGS-i Galpha(i1)

137 The onset of presynaptic inhibition mediated by PTX/RGS-i Galpha(o) w

138 Presynaptic inhibition mediated by PTX/RGS-i subunits de

139 hat in the turtle, GABA and dopamine mediate presynaptic inhibition not by affecting action potential

140 f pyloric-timed AB input likely results from presynaptic inhibition of AB in each CoG because, when a

141 -selective alpha-adrenoceptor antagonism and presynaptic inhibition of adrenergic neurotransmission d

142 Presynaptic inhibition of afferent terminals by descendi

143 Presynaptic inhibition of Akt also selectively prevented

144 of local GABAergic transmission by KYNA via presynaptic inhibition of alpha7-nicotinic acetylcholine

145 uditory neurons in the singing cricket, that presynaptic inhibition of auditory afferents and postsyn

146 cyclic voltammetry recordings confirmed that presynaptic inhibition of dopamine release by the KOR ag

147 echanism of AgRP inhibition was dependent on presynaptic inhibition of EPSCs mediated by G(i)/G(o)-pr

148 BA-independent mechanisms of inhibition: the presynaptic inhibition of excitatory neurotransmission a

149 nal excitability within the DRN through both presynaptic inhibition of excitatory synaptic transmissi

150 ure rates were not attributable to excessive presynaptic inhibition of GABA release by activation of

151 at GABAB receptor activation exerts a strong presynaptic inhibition of GABA release in SCN neurons, p

152 ue is two orders of magnitude lower than for presynaptic inhibition of GABA release on to VTA neurons

153 Presynaptic inhibition of GABA release was studied at te

154 amine cells in the ventral tegmental area by presynaptic inhibition of GABA release.

155 s in the shell of nucleus accumbens, and the presynaptic inhibition of GABA-A IPSCs by opioids was ex

156 This report describes an acute presynaptic inhibition of GABAB-mediated IPSPs by mu- an

157 neurons activate downstream neurons: through presynaptic inhibition of GABAergic afferents.

158 tion of Schaffer-specific NMDA receptors and presynaptic inhibition of GABAergic terminals.

159 ]) facilitated synaptic transmission through presynaptic inhibition of GABAergic transmission (disinh

160 In addition, we found that the presynaptic inhibition of GABAergic transmission at both

161 ese results are consistent with the reported presynaptic inhibition of GABAergic transmission by grou

162 SST suppresses discharges in RT neurons, via presynaptic inhibition of glutamate release and postsyna

163 The presynaptic inhibition of glutamate release by glucocort

164 neurones in vivo, and that this could be via presynaptic inhibition of glutamate release from either

165 These in vitro results suggest that presynaptic inhibition of glutamate release from primary

166 These data indicate that SST mediates presynaptic inhibition of glutamate release onto RT neur

167 cillations may therefore be a consequence of presynaptic inhibition of glutamate release.

168 We show here that cannabinoid-induced presynaptic inhibition of glutamatergic neurotransmissio

169 interneurones that inhibit the machinery of presynaptic inhibition of group Ia afferents.

170 d over time in parallel with the decrease in presynaptic inhibition of Ia afferents and postsynaptic

171 tion through loss of GABAA receptor-mediated presynaptic inhibition of inputs to the CNS.

172 e-activated calcium channels and a defective presynaptic inhibition of lamina IIi interneurons.

173 This includes presynaptic inhibition of local glutamatergic release fr

174 loric rhythms, the gastric mill rhythm-timed presynaptic inhibition of MCN1 causes a rhythmic interru

175 olongs the gastric mill retractor phase, via presynaptic inhibition of MCN1.

176 , whereas I(MI-MCN1) is also regulated by LG presynaptic inhibition of MCN1.

177 stive phase of feeding inhibits behaviors by presynaptic inhibition of mechanosensory neurons.

178 iation of inhibitory ion channels as well as presynaptic inhibition of neuroexocytosis.

179 (2) slow excitation of enteric neurons, (3) presynaptic inhibition of neurotransmitter release at sy

180 ition of postsynaptic glutamate receptors or presynaptic inhibition of neurotransmitter release signi

181 ly rectifying potassium channels (GIRKs) and presynaptic inhibition of neurotransmitter release throu

182 g IL-1beta in late pregnancy is explained by presynaptic inhibition of noradrenaline release in the p

183 K-14,304 eliminated the alpha1-A(R)-EPSC via presynaptic inhibition of noradrenaline release, likely

184 d, as well as their potential involvement in presynaptic inhibition of orofacial nociception.

185 nt tactile behaviors, as altered feedback or presynaptic inhibition of peripheral mechanosensory neur

186 In contrast, presynaptic inhibition of pIC-BLA connections decreases

187 Presynaptic inhibition of proprioceptive afferent neuron

188 Presynaptic inhibition of protein kinase C abolished the

189 with bath-applied GDNF (100 nM) confirm the presynaptic inhibition of SDH neurons after stimulation

190 Cortical regulation of presynaptic inhibition of sensory afferents may focus th

191 Presynaptic inhibition of soleus muscle Ia afferent fibr

192 ly coordinated enkephalin- and GABA-mediated presynaptic inhibition of somatosensory neurons.

193 cellular mechanism for PPI--a combination of presynaptic inhibition of startle afferent neurons toget

194 eous neuronal spike firing and CB1R-mediated presynaptic inhibition of synaptic transmission at IN-PC

195 dependent mechanisms: one, an analog, graded presynaptic inhibition of terminal glutamate release and

196 hdrawal from chronic morphine is an enhanced presynaptic inhibition of the excitatory inputs to the d

197 ts an acute delivery of bumetanide decreased presynaptic inhibition of the H-reflex, but not postsyna

198 I, an acute delivery of bumetanide decreases presynaptic inhibition of the H-reflex, but not postsyna

199 We investigated two signatures of presynaptic inhibition of the macaque corticospinal path

200 ent increased postynaptic inhibition but not presynaptic inhibition of the plantar H-reflex evoked by

201 This study demonstrates that leptin causes a presynaptic inhibition of the probability of glutamate r

202 LTD was sensitive to presynaptic inhibition of the proteasome and was associa

203 Suppression of the IPSP resulted from presynaptic inhibition of the release of norepinephrine

204 fact that both GABA and enkephalin can exert presynaptic inhibition of the sensory afferents.

205 reviously that the gastric mill rhythm-timed presynaptic inhibition of the STG terminals of MCN1 is p

206 l neurons expressing hSNSR4, BAM8-22 induced presynaptic inhibition of transmission that was abolishe

207 from a single neuron has been shown to cause presynaptic inhibition of transmitter release at many di

208 entify the first cellular mechanism for PPI--presynaptic inhibition of transmitter release from the a

209 s autoreceptors and heteroreceptors to exert presynaptic inhibition of transmitter release in the cen

210 cal activation, we find that mGluR2-mediated presynaptic inhibition of ventromedial prefrontal cortex

211 In contrast, presynaptic inhibition of VTA GABA(A) IPSCs by the mu-op

212 nduced depolarization is not solely due to a presynaptic inhibition of wake-active neurons as previou

213 Here we examine further the effect of presynaptic inhibition on action potentials in the CBCO

214 We examined the effects of presynaptic inhibition on excitatory synaptic transmissi

215 onventional, layer-specific way, by exerting presynaptic inhibition on synapses in layer 1 while leav

216 Presynaptic inhibition onto axons regulates neuronal out

217 and GABA(C) receptor clustering and disrupts presynaptic inhibition onto RBC terminals.

218 s of, respectively, Ia afferent synapses and presynaptic inhibition (P-boutons) on retrogradely label

219 To investigate whether presynaptic inhibition played a role in this phenomenon,

220 As presynaptic inhibition (PSI) is centrally modulated to a

221 As presynaptic inhibition (PSI) is centrally modulated to a

222 Presynaptic inhibition (PSI) of primary sensory neurons

223 ation after agonist removal, but recovery of presynaptic inhibition requires more time.

224 e in postsynaptic currents and a decrease of presynaptic inhibition, respectively.

225 The afferent-driven presynaptic inhibition shapes the trigeminocervical Adel

226 This means that afferent-driven presynaptic inhibition shapes the way trigeminal and cer

227 rotraction phase of the gastric mill rhythm, presynaptic inhibition suppresses MCN1 excitation of the

228 is more weakly and more briefly depressed by presynaptic inhibition than is the monosynaptic activati

229 ly released 5-HT and exogenous 5-HT caused a presynaptic inhibition that outlasted the postsynaptic h

230 neurons exhibited exclusively D(2)R-mediated presynaptic inhibition that was similar to the regulatio

231 and traffics with synaptic vesicles to drive presynaptic inhibition through an activity-dependent ani

232 nism has left unresolved the contribution of presynaptic inhibition to motor behaviour.

233 class of interneurons that provide GABAergic presynaptic inhibition to the axons of movement-encoding

234 lative contribution of vesicle-depletion and presynaptic-inhibition to ORN-->AL synaptic-depression.

235 account to accurately assess the effects of presynaptic inhibition under physiologically relevant co

236 To determine whether differences in presynaptic inhibition uniquely modulate BC synaptic out

237 al regions of SNr neurones is susceptible to presynaptic inhibition via a D1-like receptor.

238 1) metabotropic glutamate receptor-mediated presynaptic inhibition was also enhanced in morphine-wit

239 -NPY, but not by [Pro34]-NPY, suggesting the presynaptic inhibition was mediated by a Y2/Y5 receptor.

240 GABA(B)R-mediated presynaptic inhibition was unaffected by agonist (baclof

241 fferent depolarization (PAD), an estimate of presynaptic inhibition, was recorded in individual affer

242 nsgenic mice lacking GABAc receptor-mediated presynaptic inhibition, we found that this inhibition re

243 rvical and trigeminal afferents interact via presynaptic inhibition, where inputs to Lamina I neurons

244 rvical and trigeminal afferents interact via presynaptic inhibition, where monosynaptic inputs to Lam

245 ibited strong and exclusively D(2)R-mediated presynaptic inhibition, whereas large-amplitude connecti

246 High-fat feeding blunts AMPK-dependent presynaptic inhibition, whereas PLC-mediated GABAergic f

247 he globus pallidus showed solely D2-mediated presynaptic inhibition, whereas projections to the subst

248 for 2 hr has no effect on adenosine-induced presynaptic inhibition, whereas such treatment nearly ab

249 ons may be responsible for the modulation of presynaptic inhibition which has been observed to preced

250 he earliest suppression could be produced by presynaptic inhibition, which effectively reduces synapt

251 t of synaptic-depression caused primarily by presynaptic-inhibition will give rise to a less reliable

252 r SCI, but it also decreases the recovery of presynaptic inhibition with step-training.