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1 lete remissions in a large subset of heavily pretreated adult patients and the vast majority of child
6 icacy and limited toxicity for patients with pretreated AL amyloidosis who have limited therapeutic o
12 activity of ceritinib in both ALK inhibitor-pretreated and ALK inhibitor-naive patients with ALK-rea
14 ous saccharification and fermentation of the pretreated and enzyme-digested residues surprisingly res
15 splant recipients who were not pretreated or pretreated and failed to downstage compared with propens
18 ivariable analyses were performed for both T-pretreated and T-naive patients to determine predictors
21 s recommended that the raisins are thermally pretreated and the shipping conditions are controlled.
22 egative, nor were the MPMs different between pretreated and untreated organisms, suggesting that 10 d
23 6 out of 7 monkeys, while 6 out of 7 3BNC117-pretreated animals became infected, although with signif
24 endent on CD44 clustering in lipid rafts, we pretreated animals with methyl-beta-cyclodextrin (MbetaC
27 Our results showed that adipogenesis of ET1-pretreated ASCs and osteogenesis of ET1-pretreated BMSCs
28 al, we randomly assigned adults with heavily pretreated B-cell precursor ALL, in a 2:1 ratio, to rece
29 tween the pi* aromatic C horizontal lineC of pretreated barley straw adsorbent and pi* carbon atom in
30 om artificial contaminated water was done by pretreated barley straw adsorbent obtained from raw barl
31 In addition, site energy distribution of the pretreated barley straw for levofloxacin adsorption was
32 tivities of the ethanolic extracts from both pretreated beans and the control were 1.3-1.6 times high
33 red the effect of arginine on pH dynamics by pretreating biofilms with 75 mM arginine, followed by th
34 ET1-pretreated ASCs and osteogenesis of ET1-pretreated BMSCs were increased compared to those of con
35 ltiple pulse amperometry with a cathodically pretreated boron-doped diamond electrode, using 0.30molL
39 of (111)In-DOTA-IA in the area of VX2 tumors pretreated by pHIFU compared with the control VX2 tumors
40 ic delivery of (111)In-DOTA-IA in VX2 tumors pretreated by pHIFU compared with the control VX2 tumors
41 mpared with the control VX2 tumors not being pretreated by pHIFU, and statistical analysis revealed a
44 ofile and is active in patients with heavily pretreated ccRCC, validating direct HIF-2alpha antagonis
46 nd quantified by transfer experiments, where pretreated cells are mixed with untreated cells and byst
47 wever, ExoN(-) virus generated from IFN-beta-pretreated cells had reduced specific infectivity and de
51 (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrog
57 he second LPS treatment compared with saline-pretreated controls, which is consistent with the attenu
59 up to 86 gL(-1) Then, optimizing SSF of CELF-pretreated corn stover achieved unprecedented ethanol ti
60 ression of T cell proliferation by CDDO-DFPA pretreated DCs, which failed to passively induce EAE.
61 e DCD protocol, we investigate the impact of pretreating donors with phosphorothioate-linked cytosine
62 developing P. falciparum ring stages and DHA-pretreated dormant rings (DP-rings) using a panel of ant
63 y and a manageable safety profile in heavily pretreated, double-refractory iNHL, consistent with prev
67 e also found that lack of MGMT expression in pretreated GBM is linked to hypermutation, which in turn
68 peutic opportunity for patients with heavily pretreated, HER2-amplified metastatic colorectal cancer.
69 und model, we found the effects of succinate-pretreated hMSC enhanced wound closure, vascularization
70 tative cationic metabolite mixture in water, pretreated human plasma, and urine samples spiked with t
71 f enhanced micro-scale wrinkles based on oil-pretreated hyperelastic substrates (PDMS and Ecoflex) is
72 ltiple complex samples can be simultaneously pretreated in a multiple-well plate format, thus signifi
74 talyzed pro-EGF1020-1027 peptidolysis, while pretreating intact platelets with PAD4 suppressed ADAMDE
75 1-KO, HIF-1alpha-KO mice, and wild-type mice pretreated intracolonically with locked nucleic acid ant
76 parainfluenza virus 5 infection in IFN-alpha-pretreated, ISG15-deficient cells, confirming that resis
80 Using branched catechols likely found in pretreated lignin, we found that while MAR fully reduced
81 wall constituents during saccharification of pretreated lignocellulose, particularly in relation to r
85 Methods: Twenty-two patients with heavily pretreated lymphoproliferative or myeloid malignancies w
86 e of the tested TCRs consistently recognized pretreated MC2(+) cell lines from melanoma, head and nec
87 ingle-arm multicenter trial in patients with pretreated metastatic NSCLC who received either 8 or 10
88 olled adult patients (aged >/=18 years) with pretreated metastatic stage IV BRAF(V600E)-mutant NSCLC
89 objective responses in patients with heavily pretreated metastatic triple-negative breast cancer.
90 rogression-free survival among patients with pretreated metastatic triple-negative breast cancer.
91 ized and applied in an adsorption column, to pretreat methylene blue (MB) wastewater with high concen
92 t 6 and 24 hours after cyclophosphamide, KGF-pretreated mice also had apparent extracellular signal-r
95 8 days after cyclophosphamide treatment, KGF-pretreated mice had little proliferation and marked rest
98 ntreated conventional mice, but not from Abx-pretreated mice, enhanced the ability of APCs to prime a
101 e-escalation phase, 25 patients with heavily pretreated MM (22) or Waldenstrom macroglobulinemia (3)
102 tion with dexamethasone is active in heavily pretreated MM and propose a RP2D of 45 mg/m(2) (80 mg) p
105 marked single agent activity in extensively pretreated MM, and preliminary results from studies with
106 expression, (18)F-FDG negativity in (mainly pretreated) MM patients seems to be associated with addi
109 cacy as monotherapy in patients with heavily pretreated multiple myeloma in the GEN501 and SIRIUS stu
110 ermented model wine obtained from PEF and TV pretreated musts being the most different with an increa
111 1, or 2 mg/kg MEK1/2 inhibitor to TNF-alpha-pretreated nude mice before human SSRBC infusion inhibit
113 f the final chymosin induced gel network, by pretreating only a portion of the casein micelles, and m
114 x 10(7) CFU of NTHi R2866 Spec(r) Mice were pretreated or not with an intranasal inoculation of 5 x
115 een liver transplant recipients who were not pretreated or pretreated and failed to downstage compare
116 as either taxane chemotherapy pretreated (T-pretreated) or naive (T-naive) depending on whether they
117 ohort did not sterilize testing; however, no pretreated organisms identified resulted in a new diagno
120 tivity of niraparib among women with heavily pretreated ovarian cancer, especially in patients with H
121 with a manageable safety profile in heavily pretreated paediatric and adult patients with relapsed o
122 ent induced favorable responses in a heavily pretreated patient cohort, justifying further studies.
127 in 132 patients and seen in 25 of 62 (40%) T-pretreated patients and 40 of 70 (57%) T-naive patients.
128 c progression-free survival was 6.0 mo for T-pretreated patients and 8.8 mo for T-naive patients.
130 r venetoclax failure, we analyzed 67 heavily pretreated patients on 3 early phase clinical trials.
131 vity of this alternative schedule in heavily pretreated patients warrants further clinical evaluation
132 inferior OS in multivariable analysis for T-pretreated patients were poorer performance status, lowe
133 n both ALK inhibitor-naive and ALK inhibitor-pretreated patients who had progressed after chemotherap
135 e shows notable clinical activity in heavily pretreated patients with HER2-expressing metastatic canc
136 reliminary activity in trastuzumab emtansine-pretreated patients with HER2-positive breast cancer.
137 e and showed preliminary activity in heavily pretreated patients with HER2-positive gastric or gastro
139 e the first-in-human experience in 3 heavily pretreated patients with intramedullary and extensive ex
140 tion of metastatic sites at baseline in 1864 pretreated patients with locally advanced/MBC from studi
141 ng preliminary antitumor activity in heavily pretreated patients with mesothelin-expressing solid tum
142 profile and therapeutic activity in heavily pretreated patients with metastatic colorectal cancer, a
145 exhibited antitumor activity in extensively pretreated patients with relapsed or refractory B- and T
147 and was generally well tolerated in heavily pretreated patients with relapsed or refractory follicul
149 le, is an active salvage regimen for heavily pretreated patients with relapsed or refractory Hodgkin'
150 tuximab vedotin plus bendamustine in heavily pretreated patients with relapsed or refractory Hodgkin'
153 ositive patients, including seven crizotinib-pretreated patients, an objective response was achieved
161 t clinical activity in patients with heavily pretreated, platinum-refractory metastatic urothelial ca
163 /L CORM-401 (or inactive compound iCORM-401)-pretreated PMN for 5 minutes in the presence of 1.0 dyn/
167 nd-line treatment for patients with platinum-pretreated recurrent or metastatic squamous cell carcino
168 nd has high single agent activity in heavily pretreated relapsed and refractory multiple myeloma (MM)
170 t-generation anti-CD20 antibodies in heavily pretreated relapsed or refractory non-Hodgkin lymphoma w
171 has demonstrated clinical benefit in heavily pretreated relapsed/refractory AML patients, responses a
172 uch substrates and to ferment hydrothermally pretreated rice straw under simultaneous saccharificatio
173 reatment choice for patients who had heavily pretreated, rituximab-refractory Waldenstrom's macroglob
174 able safety profile in patients with heavily pretreated RRMM, including those with triple-class-refra
176 and total antioxidant activity of OD or UOD pretreated samples compared to pectin or pectin + CA coa
179 online characterization of electrochemically pretreated samples showed that not only mass spectrometr
180 eld with 3-5 cm flooding depths, control and pretreated seeds of Ciherang-Sub1 introgression lines an
181 ty deterioration were effectively reduced by pretreating shrimps in GLE-S before refrigerated storage
182 ubation arm AK clearance for the microneedle pretreated side was 43% compared with 38% on the sham si
183 skin reactions were most intensified in AFXL-pretreated skin and correlated with PPIX fluorescence an
184 e was 2.5 times higher than with dilute acid-pretreated solid and 13.8 times higher than with untreat
186 mpared to 24-h storage ( P < 0.05), with EDC pretreated specimens exhibiting significantly lower acti
188 egradation mechanism of CelA on a variety of pretreated substrates to better understand how the diffe
189 ere classified as either taxane chemotherapy pretreated (T-pretreated) or naive (T-naive) depending o
193 een renewable fuels and high-value chemicals pretreats the biomass with organic solvents in aqueous s
194 poly(lactic acid) filament electrode that is pretreated to introduce quinone functional groups to the
196 ity when treated with gemcitabine versus the pretreated tumor; the Raman G-band intensity reversed to
198 dHc with AAV-Cre, and in NBQX- and rapamycin-pretreated wild-type mice, these compounds blocking alph
199 reas slow hydrolysis occurred when they were pretreated with 1 g L(-1) urea (14-35% hydrolysis after
200 with primary human T cells, epithelial cells pretreated with 1,25D suppressed activation of CD4(+) an
201 synthetic human urine when the bacteria were pretreated with 10 g L(-1) urea, whereas slow hydrolysis
202 human bronchial epithelial cells (NHBE) were pretreated with 17beta-estradiol (E2), propyl-pyrazole-t
205 on of sensitive and resistant CCA cell lines pretreated with a gamma-secretase inhibitor (GSi) cockta
206 with stage IIB to IV MF/SS) and were heavily pretreated with a median of four prior systemic therapie
210 rescence reached highest intensities in skin pretreated with AFXL (median, 8661 arbitrary units [AU])
212 of a mouse heart with control RBCs (beta93C) pretreated with an arginase inhibitor to facilitate expo
214 nents or releasable products, platelets were pretreated with an inhibitor of actin polymerization (cy
215 y peripheral blood mononuclear cells (PBMCs) pretreated with anti-HLA antibody positive (HS) or negat
219 ed phase shifts are blocked when animals are pretreated with atropine injections to the SCN, demonstr
222 or C5aR antagonist or administration of MSCs pretreated with C3aR and C5aR antagonists, prevented int
224 uperior persistence in immune-deficient mice pretreated with DARA, and enhanced ADCC activity against
225 ymphoma cells with distinct surface antigens pretreated with different bispecific streptavidin-scFv f
226 ectively, by liver microsomes from male rats pretreated with different inducers; untreated male monke
227 ence signal was detected when specimens were pretreated with EDC compared to controls ( P < 0.05).
228 atients with advanced breast cancer who were pretreated with endocrine therapy and mTOR inhibitors.
229 +) subpopulations of ASCs and those of BMSCs pretreated with ET1 were prone to turning into adipocyte
232 ure 17 is significantly enriched in patients pretreated with fluorouracil, taxanes, platinum and/or e
235 ndard chart after 5 to 12 weeks for children pretreated with glasses (2 RCTs, 240 participants); more
236 olate (FA)-labeled human serum albumin (HSA) pretreated with glutathione (GSH) based on the low pH- a
237 ntial neuroprotective property, neurons were pretreated with GM1 for 24 h prior to glutamate exposure
238 Huh7 and PLC5) and an ectopic xenograft were pretreated with HDAC inhibitor or short hairpin RNA to k
239 r, resistance could be induced if cells were pretreated with IFN-alpha for longer times, presumably b
241 in allergen-challenged mice, which had been pretreated with IL-2/alphaIL-2 complexes in the presence
242 developed after the infusion; Patient 2 was pretreated with immunosuppressive drugs and did not have
245 and survival in vitro Furthermore, mouse SCs pretreated with Inh X migrate extensively in the demyeli
251 alveolar bone crest destruction, but animals pretreated with Losartan (G4) did not show these feature
255 ere observed in neurons of adult female mice pretreated with LPS, nor in adolescent mice of either se
257 n was consistently observed in J774.A1 cells pretreated with MAbs specific to CD9 and CD81 and with C
258 eated with LCA, CM derived from HCT116 cells pretreated with metformin and then treated with LCA lost
262 re the SERS substrate, SMP sheets were first pretreated with n-octylamine for effective decoration wi
264 We observed no immunosuppression in mice pretreated with natural EVs, whereas MSCs and CIMVs-MSCs
265 uorescence levels were demonstrated for skin pretreated with non-AFXL (median, 2898 AU), methyl amino
270 nt potentiation was also observed in neurons pretreated with pertussis toxin, an uncoupler of G prote
271 est this hypothesis, depressed patients were pretreated with rapamycin, an mTORC1 inhibitor, prior to
272 ty occurred in 100% of participants who were pretreated with rifampicin or efavirenz followed by RTV-
274 ted in rodent aortas in the presence of RBCs pretreated with S-nitrosocysteine or with hemolysates or
278 tage-clamped, intact Casq2-/- cardiomyocytes pretreated with tetrodotoxin to inhibit sodium channels
280 vehicle-treated whereas the other half were pretreated with the A2A receptor-selective antagonist KW
281 Groups of Abcc1 ((-/-)) rats, wild-type rats pretreated with the ABCC1 inhibitor MK571, and wild-type
282 human coronary artery endothelial cells were pretreated with the antiretrovirals abacavir sulphate (A
283 s were introduced into protoplasts that were pretreated with the glycopeptide antibiotic phleomycin,
285 ow-mediated dilation was measured in vessels pretreated with the telomerase inhibitor BIBR-1532 or ve
287 on of murine and human HSPCs, which had been pretreated with treprostinil and forskolin, enhanced sur
290 Beating heart controls and DCD rats were pretreated with vehicle or stimulatory CpG ODN (beating
292 posure in different groups of rats that were pretreated with vehicle solution, a PAC1 receptor antago
293 n peripheral blood mononuclear cells (PBMCs) pretreated with Whole Smoke-Conditioned Medium (WS-CM) o
295 s in neurons, effects that can be reduced by pretreating with a microtubule stabilizer, an antioxidan
296 hannel activation by trans-anethole, whereas pretreating with glutathione, a nucleophile, did not.
297 tivity by introducing the mutation K1250A or pretreating with the CFTR potentiator VX-770 (Ivacaftor)
298 led patients with mUC (n = 155) were heavily pretreated, with 96% having prior platinum-based chemoth
300 ndent osteogenesis on rigid substrates, with pretreated xenografts calcifying in vivo to a similar ex