ライフサイエンスコーパス: previously unidentified

1 y complexities and interactions of the model previously unidentified.

2 o 72 h and increasing de novo synthesis of a previously unidentified 17-kDa protein beginning at 24 h

3 d transcripts, differential use of exons and previously unidentified 3' ends across development, new

4 Here, we developed a previously unidentified 3D migration and differentiation

5 /Ser/Thr repeats exemplified by a prominent, previously unidentified, 43 kDa protein in the solubiliz

6 Taken together, this study reveals a previously unidentified ability of pneumolysin to induce

7 Here we report the previously unidentified ability of the soil bacterium Ps

8 One of these was a previously unidentified Aboriginal Australian haplotype

9 rial mutations of tyrosine residues reveal a previously unidentified allosteric mechanism in which th

10 ome leakage from the capsid is achieved by a previously unidentified allosteric mechanism: gp16 bindi

11 h the protein establishes the existence of a previously unidentified allosteric regulatory site.

12 carried out an unbiased analysis to identify previously unidentified alterations in gastrointestinal

13 ent factors led to the identification of six previously unidentified and comparably low-abundance LD

14 ine 5'-phosphate (PAP) phosphatase SAL1 as a previously unidentified and conserved oxidative stress s

15 Hence, our study identifies a previously unidentified and conserved Sufu-binding motif

16 f this diatom-derived sulfonate represents a previously unidentified and likely sizeable link in both

17 The creation of a previously unidentified antibiotic binding site raises t

18 tment of diabetes and, thereby, represents a previously unidentified approach to efficient cell repla

19 Our data suggest that there are a number of previously unidentified ARE ABCFs in antibiotic producer

20 e lateral dorsal nucleus, submedial nucleus) previously unidentified as L5 targets.

21 ncer-related gene databases and reveals many previously unidentified aspects of transcriptional regul

22 Like other Plks, Plk4 possesses a previously unidentified autoinhibitory mechanism mediate

23 ly been described as allosteric, acting at a previously unidentified binding site.

24 Our findings suggest a previously unidentified biomimetic design strategy in wh

25 e hypothesized that BB0345 might represent a previously unidentified borrelial transcriptional regula

26 ogical investigation revealed widespread and previously unidentified burden ofT. evansiin local cattl

27 lines, and uncover the exocyst complex as a previously unidentified-but essential-component of this

28 cal role in this condition, and we provide a previously unidentified candidate for therapeutic interv

29 and genomic context identified this PC as a previously unidentified capsid protein from multiple unc

30 e results suggest that host VHA is part of a previously unidentified carbon concentrating mechanism f

31 These findings show a previously unidentified causal role for AVP in social ap

32 e of R. flavefaciens The data identified six previously unidentified CBM families that targeted beta-

33 A previously unidentified cell type in An. gambiae, which

34 Herein, we report a previously unidentified cell-autonomous Stat1 function,

35 nt intrinsic behaviors of tumors, offering a previously unidentified characteristic for studying canc

36 binds directly to H3K4 methylation through a previously unidentified chromatin-binding module related

37 s of protein stability and reveal Siah2 as a previously unidentified circadian clockwork regulator th

38 y parallel reporter assay (MPRA) uncovered a previously unidentified cis-regulatory element 12 kb ups

39 Overall, these molecules constitute a previously unidentified class of positive modulators and

40 nsitivity to agonist, thereby establishing a previously unidentified class of tools to study this rec

41 The findings describe a previously unidentified climatic factor that contributed

42 al dataset, we were able to rapidly annotate previously unidentified clusters from existing scRNA-Seq

43 The previously unidentified clusters were often widely geogr

44 from northern Australia, our study reveals a previously unidentified coherence between the austral an

45 TLs and enables the discovery of hundreds of previously unidentified colocalized loci that are masked

46 ole for autophagy and the autophagosome as a previously unidentified compartment that participates in

47 As part of this previously unidentified complex,SNORD27 regulates the al

48 monstrate BCCIP, especially BCCIPalpha, as a previously unidentified component of the mitotic spindle

49 lement of 13 TRAPPC subunits, including four previously unidentified components.

50 The three previously unidentified compounds, gerumycins A-C, have

51 nd 2015/2016 from each lake and screened for previously unidentified compounds.

52 rcuit in each mushroom body compartment with previously unidentified connections: reciprocal Kenyon c

53 Here we discover previously unidentified consequences of band-inversion o

54 Recent discoveries of previously unidentified CRISPR-Cas systems have uncovere

55 ionine sulfoxide reductase Mxr1 (MsrA) and a previously unidentified cytoplasmic pool of the reductas

56 recognition receptors, and thereby assign a previously unidentified danger-associated function to a

57 Patients who carry a previously unidentified, de novo, dominant variant in AC

58 These data identify a previously unidentified defect in lysosomal maturation t

59 ling of strain in soft materials and suggest previously unidentified designs of LC-based responsive a

60 The present work adds a previously unidentified dimension to the classical textb

61 Our work opens up a previously unidentified direction toward achieving high

62 rial DNA, perturbation of which represents a previously unidentified disease mechanism.

63 matin during SAR and identifies MLO3 and two previously unidentified DNA boxes as likely regulators o

64 t both Saci_0568 and Saci_0748 are part of a previously unidentified DNA importer.

65 a GPCR-Autoproteolysis-Inducing domain and a previously unidentified domain that we term Pentraxin/La

66 eins therefore indicates the presence of two previously unidentified domains which represent an emerg

67 pmentally downregulated 4-Like (NEDD4L) as a previously unidentified downstream gene regulated by DDB

68 tional validation highlighted both known and previously unidentified drug targets and resistance gene

69 ovo and cell-line mutations or reside within previously unidentified duplications and deletions.

70 These studies reveal previously unidentified dynamic changes in the conformat

71 ulation of E9.5-E10.0 hepatoblasts exhibit a previously unidentified early commitment to cholangiocyt

72 and activator of transcription 3 (STAT3), a previously unidentified EDNRB transcriptional activator.

73 trifugal tubular organization and identify a previously unidentified effector of Shh in axon guidance

74 This previously unidentified electron transfer was occluded d

75 s from previous theoretical proposals, and a previously unidentified enhancer competition step.

76 ggest that airborne pollen might represent a previously unidentified environmental risk factor for my

77 imited structural metamorphosis represents a previously unidentified environmentally responsive mecha

78 These results also provide previously unidentified evidence consistent with a uniqu

79 temperature to the circadian clock, and show previously unidentified evidence for coupling between th

80 model plant Gerbera hybrida We discovered a previously unidentified expression domain and functional

81 These findings imply a previously unidentified extrinsic function for TERRA and

82 Novel proxies using TracMouse revealed previously unidentified features of movement and may aid

83 human 26S holocomplex described here reveals previously unidentified features of the AAA-ATPase heter

84 se in dryland surface albedo may represent a previously unidentified feedback to future climate.

85 Six previously unidentified fish allergens, including TPI, w

86 ery similar overall structures, displaying a previously unidentified fold comprised of a compact 12-s

87 Here we document a previously unidentified form of deep-brain photoreceptio

88 +)-permeable AMPARs, which in turn induced a previously unidentified form of LTP as a compensatory re

89 andem duplicate overactivity appears to be a previously unidentified form of position effect.

90 ve status in combination with monitoring the previously unidentified fraction has the potential to ac

91 The previously unidentified fraction was highest among men (

92 We calculated the previously unidentified fraction, defined as the number

93 who were HIV-positive, representing an 8.1% previously unidentified fraction.

94 ly couples to G12/13 versus Gq and defines a previously unidentified function for N-linked glycosylat

95 thway to CcO and, surprisingly, link it to a previously unidentified function of CcO subunit Cox12 in

96 ntegrated sequencing experiments suggested a previously unidentified function of CENPA as a transcrip

97 Our data disclose a previously unidentified functional interaction between I

98 In addition to revealing previously unidentified functions of the retromer comple

99 We found a previously unidentified gene (flagrante delicto Y, FDY)

100 n this study, we characterized the role of a previously unidentified gene, PTPN (PTP-like Nucleotidas

101 This study reports previously unidentified genes highly responsive to P str

102 ate causal genes at 24 loci and a network of previously unidentified genes likely involved in control

103 lidated this system by identifying known and previously unidentified GIs between modifiers of ricin t

104 Our findings revealed a critical and previously unidentified group of catecholaminergic inter

105 The previously unidentified Gut-Liver-Bone Axis intriguingly

106 resulting landscape allows identification of previously unidentified HCV protease substrates, and gra

107 nd soluble secreted proteins, including many previously unidentified heparin-binding proteins.

108 Five subjects (12.5%) shared the identical, previously unidentified, heterozygous CACNA1H(M1549V) mu

109 mmobility, and does so in association with a previously unidentified hippocampus-wide network pattern

110 strategy results in the prediction of three previously unidentified homogeneously auxetic materials

111 Exome sequencing revealed a previously unidentified homozygous premature termination

112 ranscription throughout the genome, yielding previously unidentified human spermatogenic RNAs.

113 The hydrophobic linker binds to a previously unidentified hydrophobic crevice in mdm2.

114 We report a previously unidentified, hypervariable family of PDIs th

115 These findings define previously unidentified hypotheses on the genomic proces

116 analysis could lead to the identification of previously unidentified IBD-associated variants.

117 nalysis using the POE mQTL SNPs identifies a previously unidentified imprinted locus associated with

118 clinically relevant functional distinctions previously unidentified in DIPG.

119 e identified, adding a new list of compounds previously unidentified in lion urine.

120 cooperating genetic alterations and provide previously unidentified insights into functional analysi

121 Overall, the findings of this work provide previously unidentified insights into the complex biogen

122 These data provide a structural basis for previously unidentified insights into the molecular mech

123 ese results demonstrate the existence of two previously unidentified interactions: one between A33 an

124 Via two previously unidentified intermediate states, the RNA cha

125 mote inflammatory resolution and represent a previously unidentified internal regulatory system gover

126 lts reveal how animals compose behavior from previously unidentified internal states, which is a nece

127 F conformation is driven by protonation of a previously unidentified intracellular glutamate residue

128 emodeling of the sarcotubular system to form previously unidentified junctions between the sarcoplasm

129 We provide a previously unidentified kind of data identifying childre

130 Previously unidentified lagged climatic effects were det

131 We detected and located 48 previously unidentified large early aftershocks triggere

132 om all three assemblies, we characterized 36 previously unidentified large repetitive regions in the

133 Altogether these data describe a previously unidentified LEC > hippocampus > septal highe

134 amic changes in GR stoichiometry represent a previously unidentified level of regulation in steroid r

135 These previously unidentified ligand-receptor systems should b

136 phylogenetic analyses showed that MRE form a previously unidentified lineage sister to the hominis gr

137 a-p47 and p47-p97 interactions via a pair of previously unidentified linear motifs.

138 These studies reveal a previously unidentified link between insulin processing

139 These results unravel a previously unidentified link between O-GlcNAcylation, li

140 We identify four previously unidentified loci including two loci at 13q22

141 ther substituting at the Ca(2+) site or in a previously unidentified, low-symmetry site.

142 We propose that AIF and AMID are previously unidentified mammalian NDH-2 enzymes, whose b

143 Our survey highlights previously unidentified markers and programs, associates

144 tification of a novel 3MC patient carrying a previously unidentified MASP-3 G665S mutation prompted u

145 study reveals m(6)A-dependent RNA decay as a previously unidentified maternally driven mechanism that

146 Fission progeny size is fixed by previously unidentified mechanically vulnerable planes s

147 Thus, these results reveal the previously unidentified mechanism behind Moco biosynthes

148 These results suggest a previously unidentified mechanism by which a cell can us

149 egulate alternative splicing and establish a previously unidentified mechanism by which cells can ada

150 These results provide evidence for a previously unidentified mechanism by which organic aeros

151 tudy has not only identified mTOR/IL-10 as a previously unidentified mechanism for beta-catenin-depen

152 Together, our results suggest a previously unidentified mechanism for regulating microtu

153 ified by CD44v3 overexpression, represents a previously unidentified mechanism governing malignant pr

154 The previously unidentified mechanism is demonstrated in a h

155 Our results highlight a previously unidentified mechanism of bacterial pathogene

156 Thus, MC-derived serotonin is a previously unidentified mechanism of DENV-induced thromb

157 We demonstrate a previously unidentified mechanism of IL-33 activity that

158 Here, we define a previously unidentified mechanism of mTOR-independent 4E

159 Together, our findings have uncovered a previously unidentified mechanism that BCL11A may use to

160 indicated that polar flagella rotation is a previously unidentified mechanism that confers bacteriop

161 These results define a previously unidentified mechanism that controls iNKT cel

162 teractions between particles and points to a previously unidentified mechanism that may play a role i

163 Overall, these results define a previously unidentified mechanism that modulates iNKT ce

164 his study reveals ribosome inactivation as a previously unidentified mechanism through which the stri

165 Here, we unravel a previously unidentified mechanism underlying this parado

166 Thus, we have uncovered a previously unidentified mechanism used by intracellular

167 P promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcripti

168 This interaction is a previously unidentified mechanism, in which mutations in

169 This is a previously unidentified mechanism, suggested by the stru

170 es lining the RNA binding groove, and offers previously unidentified mechanistic and evolutionary ins

171 Our data elucidate a previously unidentified mechanistic cycle of BiP functio

172 ne whether our proteomic screen could reveal previously unidentified mediators of heart development.

173 of new bacteria and viruses which represent previously unidentified members of the human microbiome.

174 Previously unidentified membrane vesicles lying immediat

175 phase, additionally this material exhibits a previously unidentified mesophase.

176 Our results identify a previously unidentified metabolic pathway from NaAD usin

177 gluconeogenesis in Mtb virulence and reveals previously unidentified metabolic redundancy at the FBPa

178 reconstruction identified a large number of previously unidentified metabolite classes, including th

179 (18)F-FDG PET/CT detected previously unidentified metastases in 8 (38%) of 21 pati

180 Furthermore, we propose a previously unidentified method based on strontium and ca

181 atterning and neuronal function, revealing a previously unidentified mode of posttranslational microt

182 Here, we report a previously unidentified model of resistance to Fas recep

183 Two previously unidentified modifying enzymes are proposed t

184 ene-activation screen in vivo and discovered previously unidentified modulators of tumor growth and t

185 This previously unidentified molecular cascade could be a the

186 e and dynamic portions of cMyBP-C, providing previously unidentified molecular insight into the modul

187 Here, we uncover a previously unidentified molecular mechanism in which dir

188 hus, fluctuations in KYNA levels emerge as a previously unidentified molecular mechanism linking long

189 ur results implicate S6K1 dysregulation as a previously unidentified molecular mechanism underlying s

190 two forms of cyclin B1 is brought about by a previously unidentified motif that is accessible in free

191 This promoter directs transcription of a previously unidentified MTMR2 transcript that is enriche

192 one participant's HSV-2 isolate, we found a previously unidentified mutation close to the putative r

193 Surprisingly, a previously unidentified mutation in the double-stranded

194 A previously unidentified mutation in the dsRNA-binding do

195 We discovered previously unidentified mutations in the ligand-interact

196 ynthesis, enabling the targeted isolation of previously unidentified natural products directly from c

197 resolves known binding partners, as well as previously unidentified network components.

198 HD phenotype associated with a prominent and previously unidentified neurobiological impairment.

199 -1) and calamari (cali), were expressed in a previously unidentified non-neural CNS cell type.

200 te-directed mutagenesis then revealed that a previously unidentified NRPS-PKS gene cluster from Flavo

201 We therefore suspect that this previously unidentified nutrient sensing paradigm may be

202 rprisingly small, ~10(7) s(-1), presenting a previously unidentified obstacle to the design of effici

203 lized and propagating surface plasmons and a previously unidentified optical mode type called absorpt

204 under cyclohexamide stress and also detects previously unidentified oxidative stress sensitivity acr

205 Representing a previously unidentified paradigm in OM transport, CymA m

206 This study identifies a previously unidentified pathway in decidual senescence,

207 Here, we describe a previously unidentified pathway in the KO hippocampus th

208 tured programmable liquid wires that present previously unidentified pathways for the design of new h

209 wn to change with cell-material interaction, previously unidentified pathways, such as apoptosis and

210 These data provide a previously unidentified perspective on the role of ORs i

211 This study opens previously unidentified perspectives for an effective ph

212 sively validate Seeker's ability to identify previously unidentified phages, and employ this method t

213 We have identified a previously unidentified phosphoprotein encoded by MDV OR

214 e to define interactions between ligands and previously unidentified plasma-membrane receptors.

215 In conclusion, we identify miR-3151 as a previously unidentified player in MM and PTC pathogenesi

216 ot required for centriole duplication, but a previously unidentified Plk4-binding domain in the C ter

217 combined results provide strong evidence for previously unidentified POE-influenced CpGs at 171 indep

218 We have identified a previously unidentified pore-scale event during capillar

219 SISTANCE LOCUS O3 (MLO3) was identified as a previously unidentified positive regulator of SAR.

220 arum erythrocyte invasion and offers it as a previously unidentified potent target for antimalarial s

221 Agd3 homologues are encoded in previously unidentified putative bacterial exopolysaccha

222 To identify previously unidentified putative targets in pathogenic T

223 rug targets for lipid lowering, and identify previously unidentified rare alleles associated with lip

224 t, we interrogated the potential of CFH as a previously unidentified regulator of Bruch's membrane li

225 catalytic subunit of PP2A holoenzymes, as a previously unidentified regulator of formative cell divi

226 Together, these data uncover a spectrum of previously unidentified regulators of EGFR TKI sensitivi

227 ssion through its 3'UTR, and we identified a previously unidentified regulatory element in the UTR.

228 CERES readily identified known and previously unidentified regulatory elements, some of whi

229 Here, we present a previously unidentified regulatory mechanism of Paneth c

230 This previously unidentified regulatory mechanism was observe

231 This study demonstrates a previously unidentified regulatory pathway in fibrogenes

232 mTFs function at a previously unidentified regulatory tier downstream of fa

233 osomes, complete rRNA of the LSU, as well as previously unidentified ribosomal proteins.

234 y the composition of the gut microbiota as a previously unidentified risk factor for severe malaria a

235 ties, specifically obesity and diabetes, are previously unidentified risk factors for severe malaria

236 In essence, PKM2 serves a previously unidentified role as a molecular integrator o

237 Here, we report a previously unidentified role for AFPs in effectively inh

238 Taken together, our findings highlight a previously unidentified role for AhR in regulating coron

239 -extrinsic apoptosis pathway, highlighting a previously unidentified role for CD27 in augmenting auto

240 These results suggest a previously unidentified role for CeuE within the Fe(III)

241 ture and lower BW in BAT-Kiss1r KOs reveal a previously unidentified role for endogenous kisspeptin s

242 Taken together, our studies uncover a previously unidentified role for Hh as an inhibitor of B

243 These results uncover a previously unidentified role for MBs besides memory stor

244 Here we show a previously unidentified role for microvessels and their

245 cific Panx1 knockout mouse line, we report a previously unidentified role for Panx1 channels in promo

246 Our data revealed a previously unidentified role for perivascular cells in p

247 In conclusion, our findings identify a previously unidentified role for peroxisomes in macropha

248 These results reveal a previously unidentified role of an FSI-embedded circuit

249 We report a previously unidentified role of ECM confinement in EMT i

250 In all, our results uncover a previously unidentified role of IKKbeta in regulating gl

251 Our findings reveal a previously unidentified role of NRF2 in controlling a ce

252 Our study reveals a previously unidentified role of NS3/4A in regulation of

253 lly regulated by InsP6 binding, suggesting a previously unidentified role of the eukaryote-specific c

254 These findings unravel the previously unidentified role that transcriptional repres

255 For instance, recent studies have discovered previously unidentified roles of PXR in inflammatory res

256 Our work opens a previously unidentified route for developing compliant s

257 This network contains both reported and previously unidentified routes to biotic targets, as wel

258 This new resistant genotype also carries a previously unidentified rpoB mutation conferring resista

259 These fragment inhibitors represent previously unidentified scaffolds for development of nov

260 oss movements, drive conservation predicts a previously unidentified scaling law between the overall

261 Here, we identify a previously unidentified signal transduction cascade that

262 mployed in the geosciences, we identify new, previously unidentified, signal types.

263 actor (PDGF)-DD, opened the possibility of a previously unidentified signaling pathway involved in tu

264 on of PIP2 and the calcified CaM N lobe to a previously unidentified site in Kv7.1 helix B, also know

265 Mobile phone data therefore offer a valuable previously unidentified source of data for measuring key

266 ncovers key human CSF components produced by previously unidentified specialized epithelial subtypes.

267 d regulated IFN-beta via direct binding to a previously unidentified specific regulatory site distal

268 quent retention of RNAP on DNA constitutes a previously unidentified stage, termed here as recycling.

269 se-directed STAT3 inhibition may represent a previously unidentified strategy for antifibrotic drug d

270 Our results reveal a previously unidentified strategy for HIV-1 to antagonize

271 This previously unidentified structure type has an intermedia

272 (II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric

273 visual processing impairments characterize a previously unidentified subgroup of dyslexia and suggest

274 This study reveals the first member of a previously unidentified superfamily of TIM-barrel-fold e

275 nalysis method, we discover and characterize previously unidentified surface restructuring mechanisms

276 This surface might represent a previously unidentified switch region that engages with

277 we identified nine individuals affected by a previously unidentified syndrome characterized by growth

278 kappaB, and miR-155 function as members of a previously unidentified system that has the potential to

279 Here, we found a novel, previously unidentified TA system in Escherichia coli na

280 his study reveals the glucagon receptor as a previously unidentified target for GLP-1 receptor agonis

281 ved in AMPA receptor trafficking, suggesting previously unidentified targets for therapeutic interven

282 Our studies uncover previously unidentified targets of HSF-1 and show that H

283 econdary bacterial infection and may provide previously unidentified targets to combat bacterial biof

284 s cancer cell state changes and also provide previously unidentified therapeutic implications for PKC

285 of BCR-ABL1(+) B-ALL cells, and suggesting a previously unidentified therapeutic strategy for this di

286 ight that FXR agonists represent a potential previously unidentified therapy for MS.

287 The high sensitivity of the method reveals previously unidentified tight binding states for Taq and

288 Our results reveal a previously unidentified tolerance defense strategy invol

289 Our findings reveal a previously unidentified transitional zone in the epithel

290 We found hundreds of previously unidentified TSS and PAS which revealed two i

291 ximal tubule and fibroblast cell states, and previously unidentified tubulointerstitial signaling pat

292 Here we show that MEKK1 contains a previously unidentified tumor overexpressed gene (TOG) d

293 ays interspersing the euchromatin provides a previously unidentified type of centromeric chromatin or

294 aerobic conditions effectively, indicating a previously unidentified type of regulatory mechanism.

295 heterozygous missense variants in IL10RA and previously unidentified variants in MSH5 and CD19.

296 ,500 human proteins, we find and validate 51 previously unidentified virus-host interactions.

297 hogen emergence" encompasses everything from previously unidentified viruses entering the human popul

298 These previously unidentified VZ characteristics suggest alter

299 More broadly, our work provides a previously unidentified way of envisioning highly concen

300 Of these, three were previously unidentified while a major QTL on chromosome