ライフサイエンスコーパス: primary

1 who were being treated non-operatively for a primary Achilles tendon rupture at the participating cen

2 aseline and either no neuritic plaques (i.e. primary age-related tauopathy) or moderate to frequent n

3 a-ROI SUVRs were not elevated in Braak IV or primary age-related tauopathy.

4 The primary aim was a descriptive analysis of the prevalence

5 Using PhFCl/AgNO(3), a primary alcohol can be protected in good yield in the pr

6 ity, even when the two substituents are both primary alkyl groups.

7 ere used to determine the stereochemistry of primary amines, as well as cyclic and acyclic secondary

8 nd rapid construction of different ureas and primary amines.

9 protected in good yield in the presence of a primary ammonium salt or a carboxylic acid.

10 The primary analyses detected no convergence across studies.

11 In the primary analysis and subsequent reports, progression-fre

12 ricular assist device implantation (stage D; primary analysis) and ARNI therapy initiation (stage C;

13 date was set as the clinical cutoff for the primary analysis.

14 Based on primary and beta-secondary isotope effects, it is establ

15 ge analysis of motile cell populations, both primary and cultured, typically reveals an intercellular

16 ency ablation (SRFA) for very large (>=8 cm) primary and metastatic liver tumors with curative treatm

17 these modifiable risks may be effective for primary and secondary AF prevention.

18 tion scope with different alcohols, allowing primary and secondary alcohols to be employed as nonhaza

19 chemically driven photochemical oxidation of primary and secondary aliphatic alcohols using a pair of

20 A broad range of primary and secondary amines may be inserted by this met

21 ma triggers a series of reactions leading to primary and secondary brain injuries and permanent neuro

22 for decades, patients with RA receive poorer primary and secondary CVD preventive care than other hig

23 CS and the PACS eye in asymmetrical disease (primary angle closure in fellow eye) were analyzed.

24 used to identify adults in England receiving primary antireflux surgery for GERD in 2000 to 2012 with

25 Among 22,377 patients who underwent primary antireflux surgery in the Hospital Episode Stati

26 o support a hierarchical process, present in primary auditory cortex and refined in secondary auditor

27 are usually under negative selection during primary B cell development.

28 mutant and FLT3-resistant AML cell lines and primary blasts from AML patients, while showing no cytot

29 rine fibroblasts and prevented activation of primary bone marrow-derived dendritic cells ex vivo.

30 of glioblastomas, the most malignant of all primary brain tumors in adults, is responsive to TOP2 po

31 Glioblastomas are aggressive primary brain tumors known for their inter- and intratum

32 itive metastases in women with HER2-negative primary breast cancer.

33 rficial part of the canal forms from an open primary canal that closes and then reopens.

34 aled that cell fitness in cancer cell lines, primary cancer cells, and fibroblasts under unhindered g

35 sed at age younger than 15 years (matched on primary cancer diagnosis, including leukaemia, lymphoma,

36 igneous oceanic crust, not sediment, is the primary carbon-bearing reservoir in slabs subducted to d

37 es were predominantly involved in night-time primary carboxylation reactions and malate movement acro

38 tal n-3 FAs did not significantly reduce the primary cardiovascular end point of major CVD events (co

39 of participants commencing treatment in the primary care arm (75%, 43/57) was significantly higher t

40 s with SVR12 was significantly higher in the primary care arm, compared to in the SOC arm (49% [28/57

41 Primary care patients with influenza-like illness treate

42 Participants, whose primary care physician considered them appropriate for m

43 after adjustment for characteristics of the primary care physicians (PCPs), patients, and types of v

44 ere provided by surgeons in 52% of cases and primary care physicians in 16% of cases.

45 of performance, we evaluate the accuracy of primary care physicians to categorize skin lesion morpho

46 previous blood tests were recruited from 32 primary care practices across Derbyshire, United Kingdom

47 om low-income families and support nondental primary care providers delivering preventive oral health

48 es electronic health record data to describe primary care services offered by US community health cen

49 25 years old were recruited from 119 public primary care units, including all 26 state capitals and

50 location, 26.8% hospital-based, and 24.6% in primary care).

51 er presenting with influenza-like illness in primary care.

52 im-3 blockade increased HIV-1 replication in primary CD4(+) T cells, thereby suggesting that Tim-3 ex

53 ese LTR12C elements drive gene expression in primary CD4+ T cells.

54 geneous populations of mature differentiated primary cell types can display variable responsiveness t

55 Primary cell wall cellulose is synthesized by the cellul

56 ortheastern United States, and represent the primary challenges to marten conservation at the souther

57 was performed in an independent cohort with primary chemotherapy from Heidelberg, Germany.

58 Our study suggests that primary cilia are important for neuronal maturation and

59 man RPE1 cells, a classic model for studying primary cilia in vitro, with a genetic dissection of the

60 Kif3a, a gene essential for the formation of primary cilia, in a mouse model of SCLC induced by condi

61 c machinery necessary for the degradation of primary cilia.

62 way is that signal transduction requires the primary cilium (PC) where major pathway components are d

63 ystic cholangiocytes UDCA-HDAC6i #1 restored primary cilium length and exhibited potent antiprolifera

64 reported that they are able to provide their primary clinical responsibilities for ophthalmic care in

65 curve for prevalent diabetes of 0.766 in the primary cohort (95% confidence interval: 0.750-0.782; se

66 available, to consider how size affects the primary components of viral fitness.

67 The primary composite end point occurred in 24.7% of placebo

68 In both groups, primary contributing ASSR sources were identified in the

69 molecular biology to confocal microscopy in primary cortical cultures, and from acute hippocampal an

70 bution of the AMPARGluA1 in HEK293 cells and primary cortical neurons, and decreases AMPAR-mediated c

71 omise for improving healing by balancing the primary defensive functions and excessive tissue damage

72 ditional dendritic branches, formed a second primary dendrite, acquired more mushroom spines, and had

73 with bilateral infiltrates more often had a primary diagnosis of pneumonia (41% vs 28%; p = 0.02) an

74 Only the primary domestic cat host and related small cat species

75 r, the biological functions of these ancient primary DR sequences remain largely unknown.

76 a liquidity crisis, itself propelled by the primary effects of lockdowns, government regulations and

77 At the time of the primary efficacy analysis (ie, when all participants had

78 ed similar benefit (2.3% versus 1.4% for the primary efficacy end point at 3 years, Gail-Simon qualit

79 re measured by the clinical composite score (primary efficacy end point), quality of life, LV structu

80 The primary efficacy end point, percentage change in total p

81 assess non-inferiority of the groups for the primary efficacy endpoint.

82 The primary end point for this analysis was the composite of

83 %) completed the trial with ascertainment of primary end point status.

84 The primary end point was 3-year BPFS.

85 The primary end point was met, with an sCR rate of 60% after

86 The primary end point was percentage improvement in Eczema A

87 The primary end point was the percentage of patients with an

88 4.3) follow-up, 160 patients experienced the primary end point, and 88 experienced the arrhythmic end

89 d inclusion and exclusion criteria, selected primary end points, and comparator populations to emulat

90 A primary end-point event occurred in 187 patients (6.8%)

91 ames beginning 30 days post-second dose, the primary endpoint (overall vaccine efficacy) was assessed

92 h higher reporting included having PROs as a primary endpoint (p=0.008) and the presence of a subsequ

93 The primary endpoint was American College of Rheumatology 20

94 The primary endpoint was assessed in the intention-to-treat

95 The primary endpoint was biopsy-confirmed acute rejection (B

96 The primary endpoint was first manifestation of CAV diagnose

97 The primary endpoint was progression-free survival assessed

98 The primary endpoint was reached in 101 (8.7%) patients in t

99 The primary endpoint was resolution of NASH.

100 The primary endpoint was safety and we observed 6 of 28 pati

101 Primary endpoint was the difference in maximum walking d

102 The primary endpoint was the proportion of patients achievin

103 The primary endpoint was the remission of MS at 12 months.

104 The primary endpoint was time to recovery, defined as return

105 The primary endpoint was total HIV DNA isolated from periphe

106 The primary endpoints were event-free survival, overall resp

107 medulloepithelioma is commonly treated with primary enucleation.

108 Human intestinal enteroids (HIEs) are primary epithelial cell cultures that can provide insigh

109 theoretical focus on ecological change as a primary factor affecting the trade-off between male mati

110 Finally, we provide evidence that primary FCRL4-bearing human memory B cells are constitut

111 of-function alleles, we show using patients' primary fibroblasts and biochemical assays, that these m

112 Here, we report that primary fibroblasts from DC patients and late generation

113 ND superfamily of efflux transporters with a primary focus on the assembly and function of the inner

114 iggered at the transition from primordial to primary follicle and is accompanied by dynamic changes i

115 ential for the transition from primordial to primary follicle.

116 As LSTs are a primary functional component of homologous recombination

117 his interaction is especially complex in the primary gateway to the body: the oral cavity.

118 11 (12.9%) had primary glaucoma and 74 (87.1%) had secondary glaucoma.

119 This primary H/D KIE leads to the inference that hole-driven

120 tegration of newborn screening into existing primary health-care immunisation programmes is feasible

121 Expanding delivery of primary healthcare to urban poor populations is a priori

122 Primary hemophagocytic lymphohistiocytosis is a rare syn

123 gest that ABO expresser phenotype influences primary hemostasis though several different pathways.

124 plug formation at sites of vascular injury (primary hemostasis).

125 tation followed by sequencing (eCLIP-seq) in primary hepatocytes induced with glucagon.

126 Silencing Klf10 also sensitized primary hepatocytes to apoptosis along with increased ca

127 plication in human lung epithelial cells and primary human airway tissues by increasing the infectivi

128 rom the human HUDEP2 erythroid cell line and primary human erythroid cultures.

129 proteins belonging to 1-2 mum structures in primary human foreskin fibroblasts or mouse bone marrow-

130 re, we demonstrate that DCLK1-overexpressing primary human hepatocytes formed spheroids in suspension

131 Using primary human retinal vascular endothelial cells and an

132 ases that will add value through curation of primary image data.

133 The primary imaging modalities used to select patients for e

134 ogenic disorders of the blood system such as primary immunodeficiencies and beta-thalassaemia.

135 n large cohorts of patients transplanted for primary immunodeficiency are lacking.

136 models assumed CMV vaccination would prevent primary infection and 2 models also assumed prevention o

137 extracellular traps in helminth damage after primary infections.

138 The primary input for the server consists of a set of peptid

139 We stimulated primary intestinal intraepithelial CD8(+) T-cell lines,

140 A primary limitation in the use of pluripotent stem cell-d

141 biochemically relapsed prostate cancer after primary local therapy.

142 of epicuticular waxes was mainly observed in primary long chain alcohols and, to a minor extent, in l

143 ion and established a new infection model of primary lymphatic endothelial cells (LECs) infected with

144 ell as small interfering RNA studies in mice primary macrophages, showed that the transcriptional res

145 Acoustics is the primary means of sensing and communication in the ocean

146 Primary mechanosensory neurons play an important role in

147 d by coat protein complex II (COPII) are the primary mediators of vesicular traffic from the endoplas

148 is necessary to better characterize both the primary metabolism and metabolic regulation of C. acetob

149 orial study of multiple transgenes targeting primary metabolism thus offers opportunities to probe th

150 dified with a variety of groups derived from primary metabolism.

151 severe bunch thinning on the accumulation of primary metabolites and on four families of glycosylated

152 r of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts with the TR

153 d their possible differential effects on the primary motor and sensory cortices by using transcranial

154 suggested that antidromic activation of the primary motor cortex (M1) plays a significant role in me

155 In the primary motor cortex (M1), residual subperceptual hand t

156 imulation over the arm representation of the primary motor cortex, maximal voluntary contractions, th

157 Here we show that primary mouse and human T cells engage in macropinocytos

158 Primary mouse lung endothelial cells (MLEC) and human um

159 mic break clusters, termed RDCs, in cultured primary mouse neural stem and progenitor cells (NSPCs).

160 Primary mouse neurons transfected with CYLDM719V exhibit

161 and neurotoxicity in Drosophila and cultured primary mouse neurons.

162 in a variety of cellular systems, including primary neurons.

163 stimuli are detected by terminal endings of primary nociceptive neurons, which are organized into mo

164 causal link between Ca(2+) dysregulation and primary, nonapoptotic degeneration of photoreceptors and

165 ential soils collected in the AHHS, with the primary objective of gaining a better understanding of d

166 One primary objective of synthetic biology is to improve the

167 fied serotonin levels in brain synapses is a primary objective when treating major depressive disorde

168 rop improvement and crop protection, but the primary obstacle for the development of this technology

169 Different levels (comprehensive and primary) of stroke centre and telemedicine networks have

170 (3)-pathway to induce phagocytic uptake into primary or immortalized murine cells.

171 All patients with histologically verified primary or secondary lymphoma of the lacrimal gland were

172 10, frequently administered to patients with primary or secondary mitochondrial dysfunction, might be

173 retrospective analysis of MSM diagnosed with primary or secondary syphilis at Melbourne Sexual Health

174 The rate of the primary outcome (per 100 person-years) increased with HF

175 ersonalized Approach was established for the primary outcome 3-month cumulative SSTI: 23 of 212 (10.8

176 [55%] women), 320 (97%) were included in the primary outcome analysis.

177 Prespecified secondary outcomes included primary outcome components, biological and pharmacokinet

178 th missing data were counted as having had a primary outcome event in the LMA group and as not having

179 The primary outcome measure was a comparison of the DISCERN

180 The primary outcome measure was correction of head tilt.

181 The primary outcome measure was freedom from distant metasta

182 The primary outcome measure was HR.

183 Primary outcome measure was patient utilization of outpa

184 n the ocular surface severity scores was the primary outcome measure, while change in CDVA was the se

185 The primary outcome measures included the size of the epithe

186 Primary outcome measures were changes in perimetric mean

187 The primary outcome measures were confounding factors affect

188 The primary outcome of the study was insulin sensitivity, us

189 The primary outcome of the study was safety, and secondary o

190 The primary outcome of the study was the effect of primary t

191 The primary outcome of this study was to determine the frequ

192 The primary outcome was all-cause mortality, and the seconda

193 Primary outcome was COPD defined by postbronchodilator r

194 The primary outcome was death or colectomy within 90 days af

195 The primary outcome was disability, measured with the Expand

196 The primary outcome was failure to spontaneously pass the ge

197 The primary outcome was long-term survival.

198 Primary outcome was overall response rate.

199 The primary outcome was reperfusion of greater than 50% of t

200 The primary outcome was the proportion of adolescents who ha

201 The primary outcome was the proportion of patients with at l

202 The primary outcome was the rate of decline in the total sco

203 owing percutaneous coronary intervention.The primary outcome was the rate of prasugrel or ticagrelor

204 The primary outcome was the severity of lung disease on admi

205 The primary outcome was time to death or symptomatic stroke

206 Primary outcome was time to functional recovery and leng

207 The primary outcome was time-weighted average of hypotension

208 The primary outcome was treatment failure during the 3-day c

209 The primary outcome was ventilator-free days, determined at

210 se (MTD) and recommended phase 2 dose (RP2D, primary outcome) is the FDA/EMEA approved dose of gemcit

211 The primary outcome, assessed by an independent adjudication

212 tcomes included individual components of the primary outcome, Clostridioides difficile infection, and

213 The primary outcome, in-hospital mortality, was analyzed usi

214 12 months were in the same direction as the primary outcome.

215 t designed or powered to assess atrophy as a primary outcome.

216 y and clinically important difference in the primary outcome.

217 e at 12 weeks post-treatment (SVR12) was the primary outcome.

218 98%) of 711 women had available data for the primary outcome.

219 lly analyzes the distribution of P values of primary outcomes for phase II and phase III drug trials

220 The primary outcomes included pathogenic variant detection p

221 The primary outcomes were in-hospital vascular complications

222 The primary outcomes were the proportion of participants wit

223 cality, pre-intervention achievement against primary outcomes, total quality scores, and levels of pa

224 The sinus node (SAN) is the primary pacemaker of the human heart, and abnormalities

225 f pediatric palliative oncology-encompassing primary palliative care provided by the multidisciplinar

226 Treatment in P2 was a predictor of worse primary patency and F-MALE and therefore close and long

227 for systems designed to perform expeditious primary percutaneous coronary intervention for patients

228 ction requiring inter-hospital transfers for primary percutaneous coronary intervention that reflects

229 transcription initiation and elongation are primary points of control in the regulation of gene expr

230 /American Heart Association guideline on the primary prevention of CVD introduced the concept of risk

231 ity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

232 Among 61 (37.0%) patients in primary prevention, the annual rate of appropriate ICD t

233 iate therapies, including those implanted in primary prevention.

234 of production passed up trophic levels) and primary production can account for the observed increase

235 y sulfur oxidising bacteria, suggesting that primary production in the sediment was driven by chemoli

236 which in turn might have impacted the marine primary productivity and organic carbon burial.

237 However, data supporting the use of ISA for primary prophylaxis in these patients are lacking.

238 se of proton pump inhibitors, and the use of primary prophylaxis were not significant predictors of H

239 sed rate of bIFI, notably IPA, using ISA for primary prophylaxis.

240 Primary prostate cancers are often multifocal, having to

241 demonstrate that elevated MYC in a subset of primary prostate cancers functions in a negative role in

242 This paper aims to define the concepts of primary pseudotumor cerebri, in which the cause cannot b

243 Individuals with a primary PTSD diagnosis (N = 66) participated in a random

244 The NIH remains the primary public funding source for surgical research in t

245 .005), and a greater proportion demonstrated primary PVR (11/82 patients [13.4%] in 2020 vs. 5/111 pa

246 ulted in six studies meeting the criteria of primary qualitative research published since 2010 and fo

247 While procedures for primary radiomic analyses have been established in recen

248 Sialic acids (Sia) are the primary receptors for influenza viruses and are widely d

249 The primary regulatory role of Hot216, and specifically the

250 The results demonstrate a primary renal proximal tubule cell AT(2)R natriuretic de

251 The primary reported risk factors for herpes zoster (HZ) inc

252 dpoints consisted of (i) technical efficacy; primary - requiring one treatment, and secondary - requi

253 osition database for raw images derived from primary research that will supply data for future knowle

254 Using live time-lapse imaging of primary resected tumors, we discover that tumor-derived

255 rns and non-human animals has challenged the primary role assigned to culture, in determining this sp

256 his study compares moderately complex phakic primary RRD treated with SB, PPV, or PPV/SB to review an

257 A total of 1158 of 2620 eyes (44%) with primary RRD were pseudophakic.

258 Most tumors were primary sarcomas (88.5%), the majority of which were hem

259 However, treatment of flies and primary Schwann cells with an antioxidant suppressed the

260 Although the liver is the primary site for clinical islet transplantation, it pose

261 ites within each subunit: a highly conserved primary site in transmembrane domain (TMD) housing the Z

262 regulating tumor cell dissemination from the primary site to the skeleton remain largely unknown.

263 p-disordered breathing (SDB), which includes primary snoring through to obstructive sleep apnea syndr

264 estigated how OFC dynamically interacts with primary somatosensory cortex (S1).

265 caused an increase in neuronal activation in primary somatosensory cortex of young mice and behaviora

266 , adults (aged 16-55 years) with symptomatic primary spontaneous pneumothorax were recruited from 24

267 luded, of whom 129 patients were scanned for primary staging, 67 for biochemical recurrence, and 23 f

268 the solution-to-gel transition of mucin, the primary structural component of mucus.

269 women) who underwent surgery with in-network primary surgeons and facilities, 20.5% of episodes (95%

270 omitant Collis gastroplasty in 4 (3.1%), and primary suture repair in 20 (15.6%).

271 e analysis identified tumor-characteristics (primary T4, right colon), biological features (K/N-RAS s

272 The brain's endocannabinoid system, the primary target of cannabis, has been implicated in psych

273 makes it suitable for large-scale studies in primary tissue samples.

274 abitats due to convergent adaptations in the primary toxicity target and a major detoxification enzym

275 Primary tracheal intubation group included children with

276 In primary transcripts of eukaryotic nuclear genes, coding

277 CER: $4,500/QALY) compared to SQ and reduced primary transmissions through age 30 by 40%.

278 ng (gross and microscopic examination of the primary tumor and draining lymph nodes) require the infr

279 ons with the loss of VHL through analysis of primary tumor genomic and transcriptomic data.

280 tudy aimed to clarify the prognostic role of primary tumor location in NSCLC.

281 maintains the pro-metastatic cluster within primary tumors but ablates pro-metastatic neutrophils.

282 ebral gliomas (9 low-grade, 34 high-grade; 9 primary tumors, 34 recurrent tumors) who had preoperativ

283 e is mounting evidence that resection of the primary tumour and/or localised radiotherapy (locoregion

284 er seems to arise from a single clone in the primary tumour but can exhibit subclonal heterogeneity a

285 imary outcome of the study was the effect of primary tumour subtype, age, and sex and on severe acute

286 demonstrate that, even after removal of the primary tumour, MDSCs contribute to the development of p

287 constitute 18% of patients operated on for a primary ventral hernia, but consensus is lacking on the

288 included, of whom 2113 underwent repair of a primary ventral hernia.

289 ing in autism: responses are attenuated in a primary visual area but amplified in a subsequent higher

290 expression in the entorhinal cortex (EC) and primary visual cortex (PVC) of aged APOE mice.

291 atial frequency (SF) vary greatly across the primary visual cortex (V1), increasing in a scale invari

292 ces ocular dominance plasticity in the adult primary visual cortex (V1).

293 mage projection occurring between retina and primary visual cortex can be mathematically described by

294 We additionally applied a model predicting primary visual cortex responses to the set of stimuli.

295 nctional impact of L6CT projections from the primary visual cortex to the dorsolateral geniculate nuc

296 A lesion of primary visual cortex, V1, can result in the perceived s

297 sumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tu

298 integration and dynamic stability within the primary visual network.

299 e review, consecutive patients who underwent primary vitrectomy for TRD from proliferative diabetic r

300 associations between the stage of syphilis (primary vs secondary) and behavioral data collected by c