ライフサイエンスコーパス: primary amine

1 unctional groups (phenolic hydroxyl/carboxyl/primary amine).

2 he form of formamide (or urea in the case of primary amine).

3 including methyl ketimines, enamines, and a primary amine.

4 fer of the acetyl group from acetyl-CoA to a primary amine.

5 of alpha-ketoacetals, tosyl hydrazide, and a primary amine.

6 nd rapid construction of different ureas and primary amines.

7 formal alpha-allylation of (pseudo)benzylic primary amines.

8 othiophenium ylide followed by coupling with primary amines.

9 , affording a broad scope of enantioenriched primary amines.

10 n of unactivated aliphatic C-H bonds in free primary amines.

11 particularly for challenging alpha-tertiary primary amines.

12 ,4-b]indole-3-carboxylate, formaldehyde, and primary amines.

13 us Co-catalyzed hydrogenation of nitriles to primary amines.

14 ry hindered alpha,alpha,alpha-trisubstituted primary amines.

15 he presence of air for oxidative coupling of primary amines.

16 e of, respectively, 2, 4, 8, and 72 equiv of primary amines.

17 enable to a variety of D-A cyclopropanes and primary amines.

18 dary amines approximately tertiary amines >> primary amines.

19 ere comparable to absorber rates for several primary amines.

20 um borohydride to reduce the nitro-groups to primary amines.

21 mulation rates in washwaters were lowest for primary amines.

22 10(8) M(-1) s(-1)), yielding ketimines, with primary amines.

23 acid permits visualization of enantiomers of primary amines.

24 (carboxylated bPEI) via carboxylation of the primary amines.

25 d but polar, hydrophobic, and variably sized primary amines.

26 otodegradable monomer that can be coupled to primary amines.

27 n degree baseline separate all tested chiral primary amines.

28 l of this nucleophile for the preparation of primary amines.

29 be has been applied for chirality sensing of primary amines.

30 s(organylphosphino)butane, formaldehyde, and primary amines.

31 ndary amines, and moderate-to-low yield with primary amines.

32 ition of acetylated thermolysin, which lacks primary amines.

33 the conjugate to generate positively charged primary amines.

34 drogenation of nitriles to the corresponding primary amines.

35 se (SSAO) catalyses oxidative deamination of primary amines.

36 as observed with both aromatic and aliphatic primary amines.

37 id-phase synthesis starting from immobilized primary amines.

38 econdary aminopentene cyclizations require a primary amine (1-2 equiv vs catalyst).

39 secondary amine piperazine (PZ) than for the primary amines 2-amino-2-methyl-1-propanol (AMP) and mon

40 d reactions were performed between different primary amines, 2,5-hexanedione and dialkyl, diheteroary

41 lysis of 9 and subsequent HATU coupling with primary amines 4.

42 The primary amines 6b and 7 bearing a cyclohexyl and a pheny

43 ary alcohols, a separate CD assay for chiral primary amines, a UV-vis assay for de, and a fluorescenc

44 rbonyl group of the Nazarov reactant and the primary amine accepts a hydrogen bond from the hydroxyl

45 drogenation reactions in the N-alkylation of primary amines, achieving good to excellent yields under

46 and Mannich conjugate additions whereby the primary amine activates the aldehyde and the catalyst ac

47 of enaminioesters from beta-keto esters and primary amines, activation of their allylic sp(3) C-H, v

48 bstituted benzo[b][1,6]naphythyridines while primary amines afforded hydroamination products .

49 amines or via a three-component coupling of primary amines, aldehydes and trifluoroacetic acid.

50 yl vinyl ether (secondary or tertiary) and a primary amine (aliphatic or aromatic) in toluene or meth

51 ions involving multifunctional aldehydes and primary amines, allow the formation of complex and sophi

52 Accessing hindered amines, particularly primary amines alpha to a fully substituted carbon cente

53 Each CysMA residue comprises a primary amine and a carboxylic acid.

54 The combination of a primary amine and a secondary amine catalyst was found t

55 Specifically, it was hypothesized that primary amine and N-heteroaromatic substrates can displa

56 a multicomponent reaction of cyclohexanone, primary amine and N-tosyl-3-nitroindole followed by an o

57 We explore how two nonionic polar groups (primary amine and primary amide) influence hydrophobic i

58 gand, CdS MSC-360 develops in a mixture of a primary amine and water.

59 ensation/tautomerization of (pseudo)benzylic primary amines and 2,6-di-tert-butyl-1,4-benzoquinone, u

60 th a series of linear and methyl substituted primary amines and alkanolamines have been investigated

61 deprotonated Strecker products derived from primary amines and aromatic aldehydes with 2-halobenzyl

62 lladium-catalyzed C-N cross-coupling between primary amines and aryl halides has been developed.

63 ross-coupling reactions between a variety of primary amines and aryl halides; in many cases, these re

64 component reaction between o-nitrochalcones, primary amines and beta-dicarbonyl compounds in the pres

65 Treatment with primary amines and cesium carbonate in a two-step sequen

66 ne probe has reduced cross-reactivity toward primary amines and is highly reactive with the cysteine

67 on of alpha-chloroketones in the presence of primary amines and isocyanates.

68 e a novel IBX-promoted oxidative coupling of primary amines and its utilization to Ugi reaction.

69 ver, these dioxabicyclic lactones react with primary amines and lysine side chains of lysozyme to for

70 Here we describe an amide formation using primary amines and potassium acyltrifluoroborates promot

71 nt protocol furnished good results with both primary amines and secondary amines and sluggish aniline

72 mines by the treatment of nitroepoxides with primary amines and then a reducing agent.

73 al organocatalyst that contains tertiary and primary amines and thiourea moieties to activate substra

74 luding hydroformylation, condensation with a primary amine, and a rearrangement step giving water as

75 din-2-(3H)-ones from 3-arylglutaconic acids, primary amines, and aromatic aldehydes has been further

76 ponent reaction of ninhydrin, malononitrile, primary amines, and dialkyl acetylenedicarboxylates unde

77 dropyrimidines from azirine-2-carbaldehydes, primary amines, and diazo carbonyl compounds under Rh(II

78 ining one set of 1,2-diaza-1,3-dienes (DDs), primary amines, and isothiocyanates in a different seque

79 more readily nitrosatable than the pristine primary amines, and that can form stable N-nitrosamines.

80 are formed in the photochemical oxidation of primary amines, and their reaction with (*)NO is an impo

81 3))-H oxidations of tertiary, secondary, and primary amine- and pyridine-containing molecules with tu

82 Aliphatic primary amines are a class of chemical feedstock essenti

83 Primary amines are an important structural motif in acti

84 Thus, while primary amines are confirmed to be the most effective am

85 Primary amines are often cheap, naturally occurring, and

86 Aliphatic primary amines are prevalent in natural products, pharma

87 A wide variety of primary amines are selectively transformed to carboxylat

88 By exploitation of this behavior, primary amines are transformed into their corresponding

89 Using cinchona alkaloid-derived primary amines as catalysts and aqueous hydrogen peroxid

90 nzylamines and heterocycles have unprotected primary amines as efficient directing groups.

91 Secondary amines featuring these reactive primary amines as functional groups (e.g., secondary N-m

92 Primary amines as indicator for protein backbone breakag

93 The use of pyridinium-activated primary amines as photoactive functional groups for deam

94 ere used to determine the stereochemistry of primary amines, as well as cyclic and acyclic secondary

95 the photocatalytic reaction, addition of the primary amine at room temperature or the secondary amine

96 ikely to be involved in the incorporation of primary amines at selected peptide-bound glutamine resid

97 able entropic factors may be the main reason primary amine based adsorbents are more effective under

98 Using primary amine-based reagents that react with the aldehyd

99 (Me) displays reactivity toward a variety of primary amine-boranes, including those containing reacti

100 ,alpha,alpha-trisubstituted (alpha-tertiary) primary amines by C-H functionalisation has long been re

101 rein is the construction of C-N bonds, using primary amines, by direct C-H functionalization with an

102 Primary amines can be readily doubly protected as N-subs

103 carbazates, semicarbazides, amino acids, and primary amines can be used to synthesize a highly divers

104 the development of a highly enantioselective primary amine catalyst.

105 Direct comparison of the designed enzymes to primary amine catalysts in solution revealed a rate acce

106 A cinchona-alkaloid-derived chiral primary-amine-catalyzed enantioselective method for the

107 and is selective for the dehydrogenation of primary amines (-CH2NH2) in the presence of amines witho

108 ist et al. using a cinchona alkaloid-derived primary amine (cinchona amine) organocatalyst, have been

109 ivities and yields in the arylation of small primary amines compared to previously reported YPhos lig

110 tRAL) is directly cytotoxic and that certain primary amine compounds that transiently sequester atRAL

111 The primary amine compounds were initially obtained as their

112 ort here the detection and quantification of primary amine-containing compounds in the original sampl

113 veloped a high-throughput method to quantify primary amine-containing metabolites in the yeast Saccha

114 by its immersion in an aqueous solution of a primary amine-containing polymer (polyallylamine (PAAm))

115 gation in these compounds matches the single primary amine coordination of the putative active site o

116 onal groups capable of anchoring probes with primary amines covalently.

117 d and >100:1 rotaxane:axle selectivity, from primary amines, crown ethers and a range of C=O, C=S, S(

118 he site-selective alpha-functionalization of primary amine derivatives through the generation of alph

119 A primary amine-derivatized 4-dibenzocyclooctynol (DIBO) w

120 ect addressed in this article is a series of primary amines deriving from aniline having been engaged

121 The primary amines described here represent new chemotypes f

122 catalyzed, nitromethane-mediated reaction of primary amine/diamine, furfural, and 1,3-diketone.

123 The endo primary amines displayed the lowest K(i) values on both

124 Due to the lipophilic cationicity and primary amine docking group, CTNF126 outperforms the oth

125 gate proteases and preferentially react with primary amines (e.g. on lysine side chains), whereas tho

126 terocycle-containing, and (3) alpha-tertiary primary amines, each of which previously required a diff

127 ons of protonated ammonia and the protonated primary amines either in the interior or at the surface

128 thod for discriminating between alpha-chiral primary amine enantiomers is reported.

129 to NPs, owing to its capability to label the primary amines exposed on protein surface, but also coul

130 We argue that the primary amine facilitates room-temperature decomposition

131 vinylketones catalyzed by a vicinal thiourea-primary amine first reported by Tius have been explored

132 san (GC) polymer, which contains pH-titrable primary amines, followed by gadolinium complexation (GC-

133 lation to afford a wide range of homoallylic primary amines following hydrolytic workup.

134 of carboxylic acids as a direct surrogate of primary amines, for the synthesis of primary ureas, seco

135 e synthesis of aryl-, heteroaryl-, and alkyl primary amines from the corresponding boronic acids has

136 tic backbones can be achieved in which a new primary amine function represents a possible center for

137 abling feature of this chemistry is that the primary amine functionality (-CH2NHBoc) of the original

138 In contrast to other primary amine-functionalized solid adsorbents that uptak

139 ation of 4-bromophthalazin-1(2H)-ones 4 with primary amines generates aminophthalazin-1(2H)-ones in g

140 minosulfur oxydifluorides (R-N=SOF(2) ) with primary amines give sulfamides (8 examples, up to 98 %),

141 h an aldehyde group and a peptide ion with a primary amine gives rise to water loss in conjunction wi

142 icarbonyls glyoxal and methylglyoxal and the primary amines glycine and methylamine have been determi

143 The N-terminus primary amine group does not make a significant contribu

144 rine PL in the presence or in the absence of primary amine group from aminophospholipids and amino ac

145 bond is formed between a free, unprotonated, primary amine group of a lysine side chain in the peptid

146 acT, is an acetyltransferase that blocks the primary amine group of amino acids on charged tRNA molec

147 r reagents was developed that react with the primary amine group of glycerophosphoethanolamine (PE) l

148 on going from a tertiary to a secondary to a primary amine group, but that solvent insertion dominate

149 s of all-trans-retinal by drugs containing a primary amine group.

150 ion between the carboxyl group of 5caC and a primary amine group.

151 PS NP coated with primary amine groups (NH2) possessed positively charged

152 DOTA-tetraamide complexes with four appended primary amine groups are measured as a function of pH.

153 g reduction, there was sufficient amounts of primary amine groups for covalent attachment of a polyet

154 Covalent modification of primary amine groups in multiply protonated or deprotona

155 The ability to covalently modify primary amine groups in the gas phase with N-hydroxysucc

156 Different primary amine groups were found to be (potential) labeli

157 OSCs with primary amine groups were reacted with isotopic formalde

158 e to the exclusive accessibility of nsPCR to primary amine groups, as demonstrated by its general app

159 tacetate, through reactions with its pendant primary amine groups.

160 ely modifying other analytes containing free primary amine groups.

161 mplete reduction of a nitrile (CN) bond to a primary amine (H(2)C-NH(2)).

162 les from carboxymethyl cyclohexadienones and primary amines has been developed.

163 with a covalent modification of unprotonated primary amines (i.e., N-terminus and epsilon-NH(2) of ly

164 c and fluorescent discrimination of aromatic primary amines, i.e., anilines.

165 nitrobenzene sulfonic acid (TNBS) binding to primary amines, (ii) electrophoretic migration in polyac

166 nitriles were reduced to their corresponding primary amine in 70-99% isolated yields.

167 e formation generated via reaction between a primary amine in the peptide cation and the aldehyde moi

168 to be positioned to interact with the distal primary amine in the putrescine substrate as well as the

169 d nitrogen sources that can be prepared from primary amines in a single step.

170 imine acts as an ammonia surrogate to afford primary amines in a two-step/one-pot process.

171 s undergo hydrogenation to the corresponding primary amines in good to excellent yields under the rea

172 rivatives can detect and identify protonated primary amines in methanol and in water, and even discri

173 r to substituted pyrroles in the presence of primary amines in protic solvent at ambient temperatures

174 tom bond formation strategy to functionalize primary amines in tandem to produce a series of valuable

175 associated with the oxidative degradation of primary amines in the absorber unit, a process known to

176 at a conjugated thiophene vinylene dyad with primary amines in the alpha,alpha'-positions could be pr

177 talyst allow for chemoselective amidation of primary amines in the presence of secondary amines.

178 he side chain of arginine (Arg), and several primary amines including methylamine, ethylamine, n-prop

179 st can be replaced by commercially available primary amines, including alpha-methylbenzylamine, with

180 A wide variety of primary amines, including amino acids and more complex a

181 formaldehyde by in situ condensation with a primary amine into the corresponding imine in very mild

182 hylamine dehydrogenase (MADH) which converts primary amines into the corresponding aldehydes and ammo

183 Zincke reaction allows the transformation of primary amines into their respective N-alkylated or N-ar

184 74-III can be covalently functionalized with primary amine (IRMOF-74-III-CH2NH2) and used for the sel

185 ronsted acid catalyzed kinetic resolution of primary amines is described that is based on the condens

186 amination employing ammonia and hydrogen to primary amines is described.

187 tones catalyzed by cinchona alkaloid-derived primary amines is determined with density functional cal

188 (II)-catalyzed gamma-C(sp(3))-H arylation of primary amines is realized by using 2-hydroxynicotinalde

189 ctive N-alkylation of various heteroaromatic primary amines is reported.

190 f alkylpyridinium salts, readily formed from primary amines, is the first example of a metal-catalyze

191 ause this assay relies on the formation of a primary amine, it could be adapted to measure the activi

192 ly, in the presence of an excess amount of a primary amine, it is demonstrated that this catalytic sy

193 tic ring with Pd(II) occurs, directed by the primary amine, leading to the formation of a palladacycl

194 aining aldehyde functionalities and selected primary amines leads to several XF-imine derivatives.

195 uble nucleophilic substitution reaction with primary amines led to the synthesis of amino-substituted

196 Reactivity studies presented here show primary amine ligated cores are competent oxidants, capa

197 ivity provide hints to the potential role of primary amine ligation in pMMO: increased substrate acce

198 Primary amine ligation in these compounds matches the si

199 This accumulation was reduced by primary amine modification of the nanoparticles.

200 ess, the pK(a) values of the carboxylate and primary amine moieties of 11 heparin disaccharide standa

201 metal oxide nanotubes with covalently bonded primary amine moieties on their inner wall, synthesized

202 y of STG, leading to nitro-STG (TP 437) (the primary amine moiety is transformed into a nitro group).

203 Ozone attacks the primary amine moiety of STG, leading to nitro-STG (TP 43

204 L1)Pd(p-tolyl)](+) fragment occurred via the primary amine moiety, affording the crystallographically

205 te binding of even very large alpha-tertiary primary amine nucleophiles.

206 tions identified the salt-bridge between the primary amine of 5-HT and the lipid phosphate group as t

207 atalyzes the hydroxylation of the side chain primary amine of ornithine in the initial step of the bi

208 The transient Schiff base conjugate that the primary amine of taurine forms with retinaldehyde would

209 of the transistor by electrooxidation of the primary amine of the glycine moiety.

210 e, a cleavable chromogen, were conjugated to primary amines of a hydrated poly(HEMA)-based hydrogel.

211 '-phosphosulfate (PAPS) to the hydroxyls and primary amines of acceptors.

212 -phosphosulfate (PAPS)] to the hydroxyls and primary amines of numerous metabolites, drugs, and xenob

213 osine 5'-phosphosulfate to the hydroxyls and primary amines of these acceptors.

214 sine 5'-phosphosulfate) to the hydroxyls and primary amines of xeno- and endobiotics.

215 ophilic primary amines (typically, aliphatic primary amines) often lead to quantitative reactions and

216 2-(S,S)-d(3), was prepared and used to assay primary amines on a micromolar scale.

217 red ring systems, by addition of a lithiated primary amine or hydrazine 5 to a dinitrile 7, 8, or 9 w

218 -3-(methylthio)acrylonitrile precursors with primary amines or amides via two key C-N bond-forming pr

219 ting from linear or alpha-branched aliphatic primary amines or secondary amines.

220 amines, tertiary amines, sterically hindered primary amines, or amines without oxygenated groups.

221 Employing a cyclohexanediamine-derived primary amine organocatalyst, a range of prochiral cyclo

222 nced enthalpic contributions associated with primary amines over secondary amines, but may be due to

223 es are shown to selectively recognize linear primary amines--over branched, secondary, and tertiary a

224 Vascular adhesion protein-1 (VAP-1) is a primary amine oxidase and a drug target for inflammatory

225 -HT shows the opposite orientation, with the primary amine pointing toward the membrane core.

226 A random copolymer rich in primary amines, poly(2-aminoethyl methacrylate hydrochlo

227 Primary amine products have been prepared using zirconiu

228 lic addition reaction of aromatic aldehydes, primary amines, propiolic acid, isocyanides, and hydrazi

229 er(III) bis(mu-oxo) complexes ligated by the primary amines, propylenediamine, and N,N,-dimethyl prop

230 The primary amines (R,R)-18-20 with an axially oriented phen

231 When using a chiral primary amine, racemic nitroepoxides are transformed int

232 A primary amine racemizes the aldehyde substrate via enami

233 1.0 nM to 2.6 nM, and we identified several primary amines ranging in length from C2 to C16 in Titan

234 Primary amines react faster than secondary amines due to

235 on substitution reactions with virtually any primary amine, regional control of the substitution with

236 amino radicals is well established, however, primary amines remain challenging because of competitive

237 The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environm

238 ategy to generate a sugar-1-phosphate, and a primary amine-requiring nucleotidylyltransferase that ge

239 vivo, likely due to the presence of multiple primary amines responsible for their polyP binding abili

240 effective N-acylating agents, reacting with primary amines, secondary amines, and sulfonamides to fo

241 lical conformation that displays a catalytic primary amine-secondary amine diad in a specific three-d

242 Ozonation followed by chlorination of the primary amine side chain of lysine demonstrated low yiel

243 typically initiated by hydroxylation of the primary amine side chains of l-ornithine or l-lysine.

244 more important than in the absorber, but for primary amines, significant formation of total N-nitrosa

245 The assay employs fluorescamine, a primary-amine specific fluorogenic dye, to label protein

246 ollowing advantages: it uses a wide range of primary amines, starting materials are easily available,

247 eeds via Schiff base chemistry, in which the primary amine substrate first attacks the C5 carbonyl of

248 ctions: a reductive half-reaction in which a primary amine substrate is oxidized to its corresponding

249 nd the absolute initial concentration of the primary amine substrate show that the latter parameter s

250 analogous to that observed with unprotonated primary amines such as the N-terminus or epsilon-amino g

251 Proton transfer occurs only with linear primary amines, that is, when the best size and shape fi

252 Conveniently synthesized from protected primary amines, the hydrazone DGs are shown to site-sele

253 method for installation of the t2M motif on primary amines, the method described herein streamlines

254 promotes high selectivity for reactions with primary amines, thereby constraining the scope of potent

255 with formation of the pyridinium salts from primary amines, this method enables the noncanonical tra

256 f the dimethyl ester derivative with various primary amines, this methodology was used to design a ra

257 ivates sterically encumbered alpha-3 degrees primary amines through visible light photoredox catalysi

258 harges that develop during the addition of a primary amine to a cyclic sulfate.

259 adducts produced from covalently attaching a primary amine to the spiroiminodihydantoin lesion, were

260 enzymes with quinone cofactors that oxidize primary amines to aldehydes.

261 rs govern the selectivity in the addition of primary amines to alpha,beta-unsaturated aldehydes and k

262 r the click reaction family: the addition of primary amines to alpha-tertiary isocyanates (alpha-(t)N

263 dynamic kinetic resolution (DKR) to convert primary amines to amides in high yields and excellent ee

264 Here, through chemical modification of the primary amines to aromatic domains we achieved nucleic a

265 r reactions, most particularly conversion of primary amines to azides.

266 h several chiral secondary alcohols and some primary amines to evaluate their potential as chiral der

267 ered the reaction of aromatic aldehydes with primary amines to give imine derivatives.

268 en modified via carbamylation to convert all primary amines to less basic carbamates.

269 responsible for the oxidative deamination of primary amines to their corresponding aldehydes.

270 mine exchange followed by a cyclization with primary amines to yield fluorescent products with emissi

271 ost nonfluorescent in water, but addition of primary amines turns the fluorescence on; formation of i

272 While nucleophilic primary amines (typically, aliphatic primary amines) oft

273 ncluding industrially relevant dinitriles to primary amines under mild conditions.

274 Nitriles underwent reduction to primary amines under optimized conditions at 25 degrees

275 in situ from readily available enynones and primary amines undergo thermal cyclization in diphenyl e

276 ative disconnection to access alpha-arylated primary amines upon aqueous workup.

277 The selective hydrogenation of nitriles to primary amines using a bench-stable cobalt precatalyst u

278 es, triflates, or nonaflates with aryl/alkyl primary amines using QUINAP as the ligand provides the c

279 he direct and stereoretentive deuteration of primary amines using Ru-bMepi (bMepi = 1,3-(6'-methyl-2'

280 rly with a phenol or intermolecularly with a primary amine via addition-elimination reaction(s).

281 c cycle to achieve the synthesis of hindered primary amines via heterocoupling of radicals from readi

282 The derived primary amine was acylated with alpha-phenylselenylacryl

283 The absolute configuration of the primary amines was unambiguously assigned by comparison

284 The absolute configurations of primary amines were assigned using a kinetic resolution

285 asured for the insertion of the DAC into the primary amines were consistent with an electrophilic act

286 ith optimal surface inorganic stoichiometry, primary amines were identified as "ideal" organic ligand

287 Finally, the primary amines were isolated through column chromatograp

288 Similarly high yields from other primary amines were limited to those with functional gro

289 permanently blocked by iodoacetamide and the primary amines were temporarily masked with citraconic a

290 g processes, especially for the syntheses of primary amines, which often are non-selective and suffer

291 we reduced the nitrile groups in TFN-CDP to primary amines, which reverses its affinity towards char

292 ies on the specific interactions between (i) primary amine with TNT and (ii) TNT and anti-TNT aptamer

293 amine synthesis, but the direct synthesis of primary amines with a fully substituted alpha carbon cen

294 the heterogeneous photo-oxidation of various primary amines with conversion efficiency above 99% unde

295 By condensing alpha-3 degrees primary amines with electron-rich aryl aldehyde, we enab

296 enzoyl oximes with cyanoarenes to synthesize primary amines with fully substituted alpha-carbons.

297 hat Cu promotes N-nitrosamine formation from primary amines with hydroxyl or carboxyl groups (amino a

298 Oxidation of the primary amines with Pb(OAc)(4) in CH(2)Cl(2), CHCl(3) or

299 senheimer complexes produced by reactions of primary amines with pendant dinitroaromatics attached to

300 d (15)N- isotopologues of amino acids with a primary amine without separating them in the m/z domain.