ライフサイエンスコーパス: primary cilia

1 c machinery necessary for the degradation of primary cilia.

2 n between BAV and genetic variation in human primary cilia.

3 s required for the formation and function of primary cilia.

4 ys an important role in protein transport in primary cilia.

5 esponse because of enhanced dysregulation of primary cilia.

6 s with which we detected glycylation in many primary cilia.

7 c cell types and can be motile or non-motile primary cilia.

8 hog (Hh) signaling in vertebrates depends on primary cilia.

9 rane-bound SHH, only to receiving cells with primary cilia.

10 d enrichment of the somatostatin receptor in primary cilia.

11 lex required for assembly and maintenance of primary cilia.

12 iotropic ciliopathy caused by dysfunction of primary cilia.

13 retrograde intraflagellar transport (IFT) in primary cilia.

14 ty of which encode proteins that localize to primary cilia.

15 que structural features that are not seen in primary cilia.

16 ses Hh signaling and increases the length of primary cilia.

17 n using independent approaches to manipulate primary cilia.

18 localization of SDCCAG3 to the basal body of primary cilia.

19 in UNx-mice and prevented the elongation of primary cilia.

20 ciliogenesis and in localization of cargo to primary cilia.

21 Finally, we also applied the sensor to primary cilia.

22 athway through facilitating the formation of primary cilia.

23 w concentrations of H2O2 treatment elongated primary cilia.

24 genetically encoded calcium indicator in all primary cilia.

25 h factor (PDGF)-AA/alphaalpha, are linked to primary cilia.

26 ccurs in neurons with and without detectable primary cilia.

27 ansduction, and it shares many features with primary cilia.

28 was found to regulate Hedgehog signaling in primary cilia.

29 a heteromeric polycystin channel complex on primary cilia.

30 ermining their maturation and trafficking to primary cilia.

31 iously unknown association between KIF11 and primary cilia.

32 and adult mice was performed to evaluate for primary cilia.

33 , polycystin-1 and polycystin-2, localize to primary cilia.

34 d hedgehog signaling, which is transduced by primary cilia.

35 otic spindle and templating the formation of primary cilia.

36 afficking of signaling molecules to and from primary cilia.

37 enerated mice specifically lacking beta-cell primary cilia, a cellular organelle that has been implic

38 or our understanding of protein transport in primary cilia, a critically affected process in many gen

39 mbly, increased cilia disassembly, shortened primary cilia, a retrograde IFT defect for IFT and BBS p

40 Primary cilia act as communication hubs to transfer extr

41 t the chemosensory function of cholangiocyte primary cilia acts as a mechanism for tumor suppression.

42 s indicate that perturbations in exocyst and primary cilia affect EV number and protein content.

43 is associated with the aberrant formation of primary cilia, an organelle essential for canonical Hh s

44 Our findings demonstrate how primary cilia and autophagy are involved in the translat

45 re, we show that brown preadipocytes possess primary cilia and can respond to Hedgehog (Hh) signaling

46 in functional and structural maintenance of primary cilia and determined that the protein localized

47 nced accumulation of Smoothened (Smo) within primary cilia and elevated levels of full-length Gli3.

48 known link between KIF11 and the dynamics of primary cilia and further support non-mitotic functions

49 ghts into the effects of LiCl on chondrocyte primary cilia and Hedgehog signaling and shows for the f

50 load in ciliome genes, resulting in reduced primary cilia and HH pathway activation compared with na

51 In this review, we discuss the role of primary cilia and IFT proteins in the development of bon

52 lopment and highlight the current advance of primary cilia and IFT proteins in the pathogenesis of ca

53 Although signaling by primary cilia and interstitial inflammation both play a

54 Signaling occurs predominantly in primary cilia and is initiated by the entry of the G pro

55 tive PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces.

56 enal disease have elongated and disorganized primary cilia and that this ciliary phenotype is specifi

57 rotein complexes direct both the assembly of primary cilia and the trafficking of signaling molecules

58 participate in the formation and function of primary cilia and usually result from disruption of retr

59 -traffic with Smoothened into the developing primary cilia and we identify EHD1 as a direct binding p

60 target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability

61 al transduction they dynamically localize in primary cilia, antenna-like solitary organelles present

62 Primary cilia are antenna-like sensory microtubule struc

63 Defective primary cilia are causative to a wide spectrum of human

64 In the brain, the primary cilia are crucial for early patterning, neurogen

65 Together, these results suggest that primary cilia are dispensable for TonEBP-dependent osmoa

66 Non-motile primary cilia are dynamic cellular sensory structures an

67 Primary cilia are essential for CNS development.

68 Primary cilia are essential sensory and signaling organe

69 Primary cilia are hair-like cellular extensions that sen

70 Primary cilia are hair-like organelles that play crucial

71 Primary cilia are hairlike extensions of the plasma memb

72 Primary cilia are highly specialized small antenna-like

73 Our study suggests that primary cilia are important for neuronal maturation and

74 in vitro and in vivo systems, we showed that primary cilia are important mediators of fluid flow to s

75 Primary cilia are important organizing centers that cont

76 We have previously shown that primary cilia are involved in chemically-induced osteoge

77 Primary cilia are key coordinators of various signaling

78 Primary cilia are located in the dental epithelium and m

79 Primary cilia are lost during cancer development, but th

80 Primary cilia are microtubule-based organelles that play

81 Primary cilia are microtubule-based organelles that play

82 Primary cilia are organelles necessary for proper implem

83 Primary cilia are organelles that have recently been imp

84 Here, we show that primary cilia are predominantly present on basal cells o

85 hh signaling is impaired in null embryos and primary cilia are reduced in multiple tissues.

86 esults indicate that structurally integrated primary cilia are required for detection of electrical f

87 Primary cilia are restricted subcellular compartments, a

88 Primary cilia are sensors of electrical field stimulatio

89 Primary cilia are sensory organelles crucial for cell si

90 Primary cilia are sensory organelles indispensable for o

91 Primary cilia are sensory organelles located at the cell

92 Primary cilia are sensory organelles that are essential

93 Primary cilia are solitary, generally non-motile, hair-l

94 The diverse morphologies of primary cilia are tightly regulated as a function of cel

95 Primary cilia are ubiquitous mammalian cellular substruc

96 Primary cilia are ubiquitous sensory organelles that med

97 Primary cilia are ubiquitous, microtubule-based organell

98 Primary cilia are vital signaling organelles that extend

99 ilia generate fluid flow, whereas nonmotile (primary) cilia are required for sensory physiology and m

100 ubert syndrome, particularly the function of primary cilia, are still incompletely understood.

101 egulates CNS axon regeneration and implicate primary cilia as a regenerative signaling hub.

102 ed with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived

103 s, PI3K/mTOR hyperactivation interfered with primary cilia assembly (scenario also observed in other

104 interacting partners play a crucial role in primary cilia assembly in mammalian cells.

105 the G2-to-M transition and in regulation of primary cilia at the G1-to-S transition.

106 te 3D structural model of typical epithelial primary cilia based on structural maps of full-length pr

107 ng is known about the role of glycylation in primary cilia because of limitations in detecting this m

108 showed that the use of the centriole to form primary cilia blocks centrosome formation and mitotic sp

109 Rhodopsin was depleted from primary cilia but gained access, without being enriched,

110 s not at the level of upstream regulators or primary cilia, but rather at the level of Gli transcript

111 ing of IFT proteins at the base of mammalian primary cilia by optimizing single-particle tracking pho

112 Such an architecture explains why primary cilia can elastically withstand liquid flow for

113 Primary cilia carry out numerous signaling and sensory f

114 Loss of primary cilia causes a group of human pleiotropic syndro

115 H) binds to its receptor Patched1 (PTCH1) in primary cilia, causing its inactivation and delocalizati

116 such as cellular junctions, focal adhesions, primary cilia, caveolae, clathrin-coated pits, and plaqu

117 The Hh pathway relies on primary cilia, cellular organelles that receive and tran

118 ransition (EMT) traits and by the absence of primary cilia compared to bile ducts and PBG cells in co

119 at the cell center, near the Golgi, forming primary cilia confined or submerged in a deep narrow pit

120 ew, we highlight central mechanisms by which primary cilia coordinate HH, G protein-coupled receptor,

121 nescent cell plasma membrane, which leads to primary cilia defects and a resultant failure to inhibit

122 Primary cilia defects result in a group of related pleio

123 d ventricle floor, apical profiles with only primary cilia define an additional uniciliated (E3) epit

124 peractivation promotes tumor progression via primary cilia degeneration and aberrant Hh signaling.

125 Overall, our analyses reveal how primary cilia determine neuronal subtype composition of

126 mber 3 A (Kif3a) to inhibit the formation of primary cilia did not affect hyperosmotic upregulation o

127 Our data demonstrate the architecture of primary cilia differs extensively from the commonly ackn

128 Our findings indicate that, although primary cilia directly modulate STAT3 activation in vitr

129 We have previously shown that primary cilia directly regulate insulin secretion.

130 mily, but also contribute to the assembly of primary cilia during embryogenesis.

131 implications for human disorders related to primary cilia dysfunctions, such as ciliopathies and cer

132 vel GPR161 rare variants mislocalized to the primary cilia, dysregulated Shh and Wnt signaling and in

133 ced by a reduction of renal mass, results in primary cilia elongation, and this elongation is associa

134 enesis of the skin in which Hh signaling and primary cilia exert important functions.

135 This study demonstrates that hASC primary cilia exhibit mechanosensitivity to cyclic tensi

136 We review these advances in our knowledge of primary cilia, focusing on brain development, and discus

137 e importance of the chemosensory function of primary cilia for the control of migration and invasion

138 l carcinoma (BCC), coinciding with increased primary cilia formation and activated hedgehog (Hh) sign

139 a pharmacological inhibitor of AURKA, causes primary cilia formation and cellular senescence by irrev

140 show that MaSC and MaTIC EMT programs induce primary cilia formation and Hedgehog (Hh) signaling, whi

141 ted the formation of BCC through suppressing primary cilia formation and Hh signaling, suggesting tha

142 Induction of primary cilia formation by serum starvation led to a two

143 nt upregulation is likely a prerequisite for primary cilia formation during Hh-dependent tumorigenesi

144 defects, inducing a significant increase in primary cilia formation in VHL-deficient cells.

145 also found that AURKA is down-regulated and primary cilia formation is enhanced when cellular senesc

146 Suppression of primary cilia formation limits cellular senescence induc

147 NRF2 also suppresses primary cilia formation through p62-dependent inclusion

148 depletion of caveolin-1 expression promotes primary cilia formation through the proteasomal-dependen

149 nin and elevated AURKA expression, decreased primary cilia formation, and caused significant shorteni

150 ber 3A (Kif3a), a gene that is essential for primary cilia formation, at will in transplanted cells a

151 ed to the Golgi and its knockdown suppresses primary cilia formation, similar to pathogenic LRRK2.

152 cell migration, focal adhesion dynamics, and primary cilia formation.

153 the levels of MyosinVa at the centrosome and primary cilia formation.

154 itosis, cell polarization and migration, and primary cilia formation.

155 Primary cilia function as cellular signaling hubs, integ

156 Here, we demonstrate that disruption of primary cilia function following the selective loss of c

157 The emerging evidence implicates primary cilia function in tooth development.

158 p of ciliopathies in which mutations disrupt primary cilia function, are characterized by axonal trac

159 ich play roles in cell cycle progression and primary cilia function.

160 rol patients, respectively, which identified primary cilia genes as associated with the BAV phenotype

161 e constituents, development, and function of primary cilia has advanced considerably in recent years,

162 (2+)-responsive mechanosensor hypothesis for primary cilia has been invoked to explain a large range

163 Primary cilia have been considered central to PKD pathog

164 Primary cilia have been linked to signaling pathways inv

165 Primary cilia have pivotal roles as organizers of many d

166 erstanding of the crosstalk between NRF2 and primary cilia/Hh signaling could not only open new avenu

167 protein complex that plays a central role in primary cilia homeostasis.

168 Primary cilia host numerous signaling pathways affected

169 How primary cilia impact epidermal growth and differentiatio

170 l transduction proteins can also localize to primary cilia in a cell type-dependent manner; available

171 Glycylation accumulates in primary cilia in a length-dependent manner, and depletio

172 en described in developing heart, a role for primary cilia in adult heart has not been reported.

173 quired for the normal assembly of motile and primary cilia in Chlamydomonas, planaria and mice.

174 Here, we investigate the role of primary cilia in controlling the decision between formin

175 glycylating enzymes modulates the length of primary cilia in cultured cells.

176 the current evidence for the localization of primary cilia in dental tissues and the impact of disrup

177 ing of adult adiposity, which is mediated by primary cilia in developing hypothalamic neurons.

178 Primary cilia in different organs serve diverse roles in

179 Here, we investigate the role of primary cilia in EFS-enhanced osteogenic response of hum

180 However, the role of renal primary cilia in EV production and content is unclear.

181 n human forebrain malformations, the role of primary cilia in forebrain morphogenesis has been little

182 We uncover complex functions of primary cilia in forebrain morphogenesis through region-

183 ther, these results suggest a novel role for primary cilia in HBC activation, proliferation, and diff

184 y functions, confirming the central role for primary cilia in Hh signaling.

185 kappa B pathway, autophagy, and the loss of primary cilia in human BTSCs.

186 A similar approach was used to assess for primary cilia in infarcted human myocardial tissue.

187 Loss of primary cilia in injured conditional Ift88 mice results

188 We demonstrate significant elongation of primary cilia in IS patient bone cells.

189 In addition, we show that primary cilia in KIF14-depleted cells are defective in r

190 Primary cilia in many cell types contain a periaxonemal

191 We identified primary cilia in mouse, rat, and human heart, specifical

192 that KIF11 localized to the basal bodies of primary cilia in multiple cell types, including neoplast

193 eracts with host proteins at the base of the primary cilia in neural progenitor cells, causing an aty

194 Consistent with important roles for primary cilia in signalling, mutations that lead to thei

195 l dysplasias, implying the important role of primary cilia in skeletal development and homeostasis.

196 by Lang et al. (2020b) demonstrates loss of primary cilia in Spitzoid melanoma compared with Spitz n

197 d tongue agenesis, following the loss of the primary cilia in the CNC-derived palatal mesenchyme.

198 t ADAMTS9 localized near the basal bodies of primary cilia in the cytoplasm.

199 Our findings suggest a role of primary cilia in the memory function of mature dentate g

200 catenin in regulating AURKA and formation of primary cilia in the setting of VHL deficiency, opening

201 We also include the role of primary cilia in tooth development and highlight the cur

202 mulates on the cell surface in Drosophila or primary cilia in vertebrates, which is thought to be ess

203 man RPE1 cells, a classic model for studying primary cilia in vitro, with a genetic dissection of the

204 , functioning as an AKAP, recruits PKA RI to primary cilia in zebrafish embryos.

205 Kif3a, a gene essential for the formation of primary cilia, in a mouse model of SCLC induced by condi

206 of mechanically induced calcium increases in primary cilia, in tissues upon which this hypothesis has

207 The length of primary cilia is associated with normal cell and organ f

208 lization of Hedgehog effectors to the tip of primary cilia is critical for proper signal transduction

209 Moreover, ablation of these primary cilia is sufficient to repress Hh signaling, the

210 nsport of membrane and cytosolic proteins in primary cilia is thought to depend on intraflagellar tra

211 e that mechanosensation, if it originates in primary cilia, is not via calcium signalling.

212 y activating LKB1 and bypassing the need for primary cilia, it is possible to emulate this chemosenso

213 Dysfunction of renal primary cilia leads to polycystic kidney disease.

214 stigate whether renal mass reduction affects primary cilia length and function.

215 Akap12 expression while also ensuring normal primary cilia length and renal epithelial morphogenesis,

216 ibition is associated with a 97% increase in primary cilia length from 2.09 +/- 0.7 mum in untreated

217 We observed a significant increase in primary cilia length in vitro in the context of either o

218 his flow-induced process is dependent on the primary cilia located on the apical side of epithelial c

219 pha-tubulin and SOX9 proteins, the number of primary cilia(+) LPCs, and increased active gamma-glutam

220 cating intraflagellar transport processes in primary cilia may be more complicated than that reported

221 re polycystin-2 channel dysregulation in the primary cilia may contribute to cystogenesis.

222 s during EFS, our findings also suggest that primary cilia may potentially function as a crucial calc

223 sults thus define a specific requirement for primary cilia-mediated GPCR signaling in interneuronal c

224 al signals promote osteogenic fate through a primary cilia-mediated mechanism.

225 s called ciliopathies is caused by defective primary cilia morphology or signal transduction.

226 Together, these findings demonstrate that primary cilia not only orchestrate beta-cell-intrinsic a

227 ilia based on structural maps of full-length primary cilia obtained by serial section electron tomogr

228 the endoplasmic reticulum (ER) membrane and primary cilia of all cell and tissue types.

229 We then measured responses to flow in primary cilia of cultured kidney epithelial cells, kidne

230 d balance in the nonperiodic fluctuations of primary cilia of epithelial cells.

231 A direct link between the primary cilia of mature dentate granule cells and behavi

232 rgeting of Ift88 with Wnt1-Cre, we show that primary cilia of neural crest cells (NCC), precursors of

233 eta2AR) and co-localizes with beta2AR on the primary cilia of neurons in the brain.

234 8 has a highly conserved function within the primary cilia of the CNC-derived mesenchyme in the lip a

235 Primary cilia on crown cells are required to interpret t

236 We identified primary cilia on endothelial cells as the underlying cau

237 The loss of primary cilia on melanocytes is a useful biomarker for t

238 The architecture of primary cilia on neuroepithelial cells in Pam(-/-) mouse

239 subtype 3 (Sstr3) is selectively targeted to primary cilia on neurons in the mammalian brain and is i

240 idence has shown that loss or malfunction of primary cilia or ciliary proteins in bone and cartilage

241 s may occur in other small compartments like primary cilia or dendritic spines.

242 ial polydactyly, as seen with dysfunction of primary cilia or Gli3-repressor.

243 ns in proteins of the transition zone of the primary cilia or the closely associated distal end of ce

244 Primary cilia, organelles protruding from the surface of

245 Primary cilia perceive the extracellular environment thr

246 ital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both

247 ng a primary cilium and to determine whether primary cilia play a role in disease-related remodeling.

248 Primary cilia play a vital role in cellular sensing and

249 Our data suggest that primary cilia play an integral role in maintaining the f

250 Primary cilia play central roles in signaling during met

251 Primary cilia play critical roles in development and dis

252 is confirmed an inverse relationship between primary cilia presence and Ras/MAPK activation, and prim

253 Primary cilia, present on most mammalian cells, function

254 Thus, the requirement for primary cilia presents a conundrum: how are proliferativ

255 Primary cilia project in a single copy from the surface

256 We conclude that endothelial cell primary cilia regulate islet vascularization and vascula

257 The sensory capacity of primary cilia relies on the coordinated trafficking and

258 cilia presence and Ras/MAPK activation, and primary cilia removal in BCCs potentiated Ras/MAPK pathw

259 We hypothesize that primary cilia respond to cyclic tensile strain in a line

260 ons that affect the structure or function of primary cilia result in ciliopathies, a group of develop

261 ic disorder characterized by malfunctions in primary cilia resulting from mutations that disrupt the

262 Detailed analysis of primary cilia revealed region-specific changes in ciliar

263 f miR-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link bet

264 In addition, primary cilia seem to functionally modulate effects of E

265 cues that diminish Siah2-activity leading to primary cilia shortening and attenuation of the mitogeni

266 evidence indicates the important role of the primary cilia signaling pathway in bone elongation.

267 dulate axonal connectivity and that impaired primary cilia signaling underlies axonal tract defects i

268 n renal epithelia results in abnormally long primary cilia similar to that observed in Notch-signalin

269 erived stem cells (hASCs) by knocking down 2 primary cilia structural proteins, polycystin-1 and intr

270 These FAPs dynamically produced primary cilia, structures that transduce intercellular c

271 n in centrosome number, spindle formation or primary cilia, suggesting that the major effect of BubR1

272 Rsg1 mutant embryos have fewer primary cilia than wild-type embryos, but the cilia that

273 ation of basal stem cells uniquely possesses primary cilia that are aligned in an apical orientation

274 ining the biliary tree in the liver, express primary cilia that can detect several kinds of environme

275 ntage of cultured primary NP cells possessed primary cilia that changed length in response to osmotic

276 es with the C terminus of Ptch1 (Ptch1-C) in primary cilia to inhibit Ptch1-mediated cell death.

277 CDK10 in transducing signals received at the primary cilia to sustain embryonic and postnatal develop

278 ing Gli transcription factors, accumulate at primary cilia to transduce the Hh signal, but the mechan

279 ccurs through an indirect mechanism in which primary cilia trigger macrophage recruitment to the kidn

280 ins involved in the structure or function of primary cilia, ubiquitous antenna-like organelles essent

281 Defects in primary cilia underlie a class of human diseases collect

282 izes with the SHH receptor Smoothened in the primary cilia upon ligand stimulation.

283 This H2O2-induced elongation of primary cilia was also prevented by MnTMPyP treatment.

284 lacking both Tgifs, the number of cells with primary cilia was significantly decreased, and we observ

285 tic MT mechanisms and indeed, centrosome and primary cilia were altered and spindles were found to be

286 Primary cilia were elongated in proximal tubule cells, c

287 In addition, vesicles releasing from kidney primary cilia were observed in the structural maps, supp

288 Remarkably, T-box3 is present in primary cilia where it colocalizes with Gli3.

289 The regulatory GTPase Arl13b localizes to primary cilia, where it regulates Sonic hedgehog (Shh) s

290 PC-1 and PC-2 enrich on primary cilia, where they are thought to form a heterome

291 Primary cilia, which are essential for normal developmen

292 Here we show that this depends on primary cilia, which are nonmotile, cell-surface structu

293 Because Shh reception occurs at primary cilia, which are positioned within the apical me

294 otherwise-forbidden actin polymerization in primary cilia, which excises cilia tips in a process we

295 cylation is essential for the homeostasis of primary cilia, which has important implications for huma

296 nipulations localized IGF1 receptor to their primary cilia, which maintained their signaling competen

297 equired for the assembly and function of the primary cilia, which mediate the activity of key develop

298 with Cby1 at the centrioles/basal bodies of primary cilia, while FAM92B is undetectable.

299 ic proteins in the 250-nm-wide shaft of live primary cilia with a spatiotemporal resolution of 2 ms a

300 within 2 min and leads to a complete loss of primary cilia within 8 h.