ライフサイエンスコーパス: primary progressive aphasia

1 diagnosis of FTD (behavioral variant FTD or primary progressive aphasia).

2 ate to syndrome-specific atrophy patterns in primary progressive aphasia.

3 e left language network in logopenic variant primary progressive aphasia.

4 semantic memory deficit in semantic variant primary progressive aphasia.

5 subjects and patients with semantic variant primary progressive aphasia.

6 temporoparietal regions in logopenic variant primary progressive aphasia.

7 (n = 45) and non-fluent (n = 39) variants of primary progressive aphasia.

8 tients represent a fourth variant of 'mixed' primary progressive aphasia.

9 atrophy, making this syndrome distinct from primary progressive aphasia.

10 language tests; hence, none met criteria for primary progressive aphasia.

11 matter changes that occur in the variants of primary progressive aphasia.

12 l in the multimodal diagnostic evaluation of primary progressive aphasia.

13 ed through detailed studies of patients with primary progressive aphasia.

14 nalysis to characterize the heterogeneity of primary progressive aphasia.

15 10 had the non-fluent agrammatic variant of primary progressive aphasia.

16 ical atrophy and eight for logopenic variant primary progressive aphasia.

17 18F-flortaucipir signal in semantic variant primary progressive aphasia.

18 s within language network in each variant of primary progressive aphasia.

19 tributed atrophy pattern in semantic variant primary progressive aphasia.

20 nges in the non-fluent/agrammatic variant of primary progressive aphasia.

21 cits are highly variable in individuals with primary progressive aphasia.

22 seen in most patients with semantic variant primary progressive aphasia.

23 in 43 of type C consistently led to semantic primary progressive aphasia.

24 ropsychological and neuroimaging features of primary progressive aphasia.

25 to verbal fluency and grammar impairment in primary progressive aphasia.

26 t the processing of non-verbal sounds in the primary progressive aphasias.

27 luent (n = 54) and semantic (n = 96) variant primary progressive aphasias.

28 in a consecutive series of 20 patients with primary progressive aphasia [12 with progressive non-flu

29 st common predominant clinical features were primary progressive aphasia (22 patients [25.0%]), behav

30 dementia, 14 patients with semantic variant primary progressive aphasia, 25 patients with Alzheimer'

31 hy, 4 subjects with the logopenic variant of primary progressive aphasia, 6 age-matched patients with

32 This study used patients with primary progressive aphasia, a clinical dementia syndrom

33 striking gains of function in a patient with primary progressive aphasia, a degenerative disease of t

34 work is affected in the nonfluent variant of primary progressive aphasia, a neurodegenerative disorde

35 Eight patients with the nonfluent variant of primary progressive aphasia (age, 67.0 +/- 7.4 y; 4 wome

36 ry progressive aphasia than semantic variant primary progressive aphasia (all P < 0.05).

37 (behavioral variant, semantic and non-fluent primary progressive aphasia) along with associated three

38 analysed speech samples for 50 patients with primary progressive aphasia, along with neurodegenerativ

39 Patients with logopenic variant primary progressive aphasia also showed significant hype

40 frontotemporal dementia and semantic variant primary progressive aphasia (also called semantic dement

41 Patients with the semantic variant of primary progressive aphasia, also known as semantic deme

42 (behavioral variant frontotemporal dementia, primary progressive aphasias, Alzheimer's disease, Parki

43 eed region derived from the semantic variant primary progressive aphasia analysis was strongly connec

44 ral dementia, 10 had the semantic variant of primary progressive aphasia and 10 had the non-fluent ag

45 tions on 28 TDP-C patients, 18 with semantic primary progressive aphasia and 10 with other syndromes.

46 5 years), 12 patients with logopenic variant primary progressive aphasia and 13 patients with posteri

47 Thirty-five patients with primary progressive aphasia and 29 control subjects were

48 We asked 15 patients with semantic variant primary progressive aphasia and 57 patients with Alzheim

49 playing AD with severe language problems and primary progressive aphasia and a near splice-site mutat

50 frontotemporal dementia or semantic variant primary progressive aphasia and a structural MRI (n = 47

51 We conclude that both semantic variant primary progressive aphasia and Alzheimer's disease are

52 We found that both semantic variant primary progressive aphasia and Alzheimer's disease are

53 Both semantic variant primary progressive aphasia and Alzheimer's disease had

54 temporal regions, and both semantic variant primary progressive aphasia and behavioural variant fron

55 Logopenic variant primary progressive aphasia and developmental dyslexia b

56 t tract underlies verbal fluency deficits in primary progressive aphasia and further confirm the role

57 However, recent primary progressive aphasia and normal neurophysiologica

58 icits and meet criteria for semantic variant primary progressive aphasia and semantic dementia, patie

59 ntia, associative agnosia, semantic forms of primary progressive aphasia and semantic dementia.

60 l-variant FTD, non-fluent/agrammatic variant primary progressive aphasia and semantic variant PPA.

61 n-verbal sound perception and recognition in primary progressive aphasia and specific disorders at pe

62 ns of linguistic assessments in the study of primary progressive aphasia and the three most prevalent

63 rior cortical atrophy than logopenic variant primary progressive aphasia) and higher-order visual net

64 bvFTD), 89 patients with semantic variant of primary progressive aphasia, and 30 patients with Huntin

65 tia, semantic variant and non-fluent variant primary progressive aphasia, and 46 healthy controls) de

66 89 patients (27.0%) with semantic variant of primary progressive aphasia, and 6 of 30 patients (20%)

67 osterior cortical atrophy, logopenic variant primary progressive aphasia, and corticobasal syndrome).

68 cognitive difficulties in logopenic variant primary progressive aphasia, and predicts phenotypic div

69 fluent (n = 34) or semantic (n = 37) variant primary progressive aphasia-and 100 cognitively normal i

70 tegrity of these impacted neural networks in primary progressive aphasia are lacking.

71 gh some phenotypes such as logopenic variant primary progressive aphasia are more commonly associated

72 characteristics of early and mild disease in primary progressive aphasia are poorly understood.

73 Revisions of criteria for logopenic primary progressive aphasia are proposed to address thes

74 Fifty-eight autopsies of patients with primary progressive aphasia are reported.

75 The primary progressive aphasias are rare, language-led deme

76 re the evolution of the logopenic variant of primary progressive aphasia as a distinct clinical entit

77 istered to one patient with semantic variant primary progressive aphasia before repeating 18F-flortau

78 ening the understanding of logopenic variant primary progressive aphasia beyond the lens of an exclus

79 ed greater leftward asymmetry for tangles in primary progressive aphasia but not in the amnestic Alzh

80 : emotion recognition in semantic variant of primary progressive aphasia', by Bertoux et al. (doi:10.

81 nnected speech production in each variant of primary progressive aphasia, by quantifying speech outpu

82 Primary progressive aphasia cases demonstrated leftward

83 A review of published primary progressive aphasia cases with adequate clinical

84 nships are not universal and that individual primary progressive aphasia cases with Alzheimer patholo

85 rnia San Francisco Memory and Aging Center's primary progressive aphasia cohort (n = 198) for history

86 51 binding was increased in semantic variant primary progressive aphasia compared to controls in the

87 imary progressive aphasia; logopenic variant primary progressive aphasia), compared to 25 healthy age

88 ntactic comprehension in 51 individuals with primary progressive aphasia, composed of all clinical va

89 specific syndromes (Alzheimer's disease and primary progressive aphasia) converge over time into a d

90 diagnoses included frontotemporal dementia, primary progressive aphasia, corticobasal syndrome, and

91 tudy, leveraging machine learning on a large primary progressive aphasia dataset, delineated four dis

92 ortical atrophy and the logopenic variant of primary progressive aphasia, differ from amnestic AD in

93 0.001), while patients with semantic variant primary progressive aphasia discounted delayed rewards m

94 The Alzheimer's disease pathology in primary progressive aphasia displayed multiple atypical

95 in a consecutive series of 18 patients with primary progressive aphasia (eight with semantic variant

96 er neocortical-to-entorhinal tangle ratio in primary progressive aphasia establishes clinical concord

97 corticobasal syndrome, and nonfluent-variant primary progressive aphasia) exhibited higher globus pal

98 9 (7.0) years], nine with non-fluent variant primary progressive aphasia [five female; 67.4 (8.1) yea

99 sive aphasia (nonfluent PPA; n = 15), fluent primary progressive aphasia (fluent PPA; n = 7), and amy

100 a core central auditory impairment exists in primary progressive aphasia for non-linguistic stimuli.

101 64.8 (6.8) years], 12 with semantic variant primary progressive aphasia [four female; 66.9 (7.0) yea

102 different to that seen in the fluent form of primary progressive aphasia (fPPA), a neurodegenerative

103 ion deficits, helping to dissociate semantic primary progressive aphasia from semantic dementia.

104 s for distinguishing the semantic variant of primary progressive aphasia from the partially overlappi

105 Moreover, patients with semantic variant primary progressive aphasia had a significantly more pro

106 Patients with primary progressive aphasia had deficits of non-verbal s

107 follow-up, all participants with non-fluent primary progressive aphasia had evolved either corticoba

108 of neurodevelopmental learning disability in primary progressive aphasia has been reported.

109 The connected speech of patients with primary progressive aphasia has often been dichotomized

110 ment before making a definitive diagnosis of primary progressive aphasia has promoted diagnostic spec

111 Observations in semantic variant primary progressive aphasia have inspired an alternative

112 Patients with logopenic and nonfluent primary progressive aphasia have some deficits recognizi

113 s been associated with syntactic deficits in primary progressive aphasia in a number of structural an

114 co-pathological relationships in subtypes of primary progressive aphasia in hopes of utilizing langua

115 memory onset and to the logopenic variant of primary progressive aphasia in one family.

116 We examined 39 patients with primary progressive aphasia including logopenic variant

117 Patient presenting with logopenic variant primary progressive aphasia initially thought to be due

118 Primary progressive aphasia is a clinical syndrome defin

119 Primary progressive aphasia is a clinical syndrome that

120 Primary progressive aphasia is a neurodegenerative clini

121 Primary progressive aphasia is a neurodegenerative disea

122 Primary progressive aphasia is a neurodegenerative syndr

123 Primary progressive aphasia is a syndrome characterized

124 The logopenic variant of primary progressive aphasia is characterized by early de

125 icits may contribute to the phenomenology of primary progressive aphasia is not established.

126 irment for natural kinds in semantic variant primary progressive aphasia is related in part to diseas

127 discovered four neuroanatomical subtypes of primary progressive aphasia, labelled S1 (left temporal)

128 y and executive deficits), logopenic variant primary progressive aphasia (language deficits), and pos

129 Patients with logopenic variant primary progressive aphasia ('language variant of Alzhei

130 rimary progressive aphasia; semantic variant primary progressive aphasia; logopenic variant primary p

131 Most subjects with logopenic variant of primary progressive aphasia (lvPPA) have beta-amyloid (A

132 n participants with the logopenic variant of primary progressive aphasia (lvPPA) performed a recognit

133 sterior cortical atrophy (PCA), 12 logopenic primary progressive aphasia (lvPPA), 20 behavioural vari

134 al atrophy/PCA-AD; n = 103 logopenic variant primary progressive aphasia/lvPPA-AD; n = 35 behavioural

135 st that cortical atrophy in semantic variant primary progressive aphasia may follow connectional path

136 Cortical Atrophy (n = 16); logopenic variant Primary Progressive Aphasia (n = 15); and amnestic syndr

137 ic, n = 51) and individuals with unspecified primary progressive aphasia (n = 16).

138 nestic variants, including logopenic-variant primary progressive aphasia (n = 25), posterior cortical

139 's disease, semantic dementia and non-fluent primary progressive aphasia (n = 9 each) were contrasted

140 Disease Research Center (semantic variant of primary progressive aphasia, n = 7; behavioural variant

141 ndrome, n = 13; behavioural variant, n = 14; primary progressive aphasias, n = 21) and 27 control sub

142 The non-fluent/agrammatic variant of primary progressive aphasia (naPPA) is a young-onset neu

143 ture of the non-fluent/agrammatic variant of primary progressive aphasia (naPPA), but well-controlled

144 al dementia (bvFTD n=64), non-fluent variant primary progressive aphasia (nfvPPA n=36), semantic vari

145 ssive aphasia (svPPA), 14 non-fluent variant primary progressive aphasia (nfvPPA) and 12 semantic beh

146 the biomarker cascades in non-fluent variant primary progressive aphasia (nfvPPA) and behavioural var

147 hology in patients with nonfluent/agrammatic primary progressive aphasia (nfvPPA) and progressive sup

148 The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) is a neurodegenerat

149 sive aphasia (svPPA), (4) non-fluent variant primary progressive aphasia (nfvPPA) or (5) early onset

150 phasia (svPPA), five with non-fluent variant primary progressive aphasia (nfvPPA)) and 17 healthy con

151 ionally termed non-fluent/agrammatic variant primary progressive aphasia (nfvPPA), or exist as two co

152 temporal dementia (bvFTD), nonfluent variant primary progressive aphasia (nfvPPA), posterior cortical

153 y Richardson syndrome (PSP-RS) and nonfluent primary progressive aphasia (nfvPPA), where underlying f

154 epresenting the three canonical syndromes of primary progressive aphasia (non-fluent/agrammatic varia

155 ed in difficulty, in patients with nonfluent primary progressive aphasia (nonfluent PPA; n = 15), flu

156 sed on larger groups of patients with either primary progressive aphasia or a typical amnestic dement

157 only associated with the semantic variant of primary progressive aphasia or behavioural variant front

158 Cases with predominant primary progressive aphasia or extra-pyramidal syndromes

159 pe, posterior cortical atrophy, or logopenic primary progressive aphasia), or MCI with uncommon AD or

160 ary progressive aphasia, or semantic variant primary progressive aphasia), or mild cognitive impairme

161 heimer's disease dementia, logopenic variant primary progressive aphasia, or posterior cortical atrop

162 frontotemporal dementia, non-fluent variant primary progressive aphasia, or semantic variant primary

163 frontotemporal dementia and semantic variant primary progressive aphasia patients alone confirmed thi

164 corticobasal syndrome, and nonfluent-variant primary progressive aphasia patients had a pallidal SUVr

165 se, non-fluent variant and logopenic variant primary progressive aphasia patients very well from heal

166 odulated to a lesser extent or not at all in primary progressive aphasia patients whose syntax was re

167 f frontotemporal lobar degeneration; and 103 primary progressive aphasia patients).

168 tly limbic and symmetric pathology cause the primary progressive aphasia phenotype, characterized by

169 ral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA) and corticobasal syndr

170 ral language productions of individuals with primary progressive aphasia (PPA) and healthy individual

171 usions) have been described in patients with primary progressive aphasia (PPA) but their diagnostic v

172 The dementia syndrome of primary progressive aphasia (PPA) can be caused by 1 of

173 Primary progressive aphasia (PPA) defines a group of neu

174 Primary Progressive Aphasia (PPA) is a behaviorally foca

175 Primary progressive aphasia (PPA) is a clinical dementia

176 Primary progressive aphasia (PPA) is a clinical syndrome

177 Primary progressive aphasia (PPA) is a focal dementia ch

178 Primary progressive aphasia (PPA) is a neurodegenerative

179 Primary progressive aphasia (PPA) is a neurodegenerative

180 Primary progressive aphasia (PPA) is a neurodegenerative

181 Primary progressive aphasia (PPA) is a neurodegenerative

182 Primary progressive aphasia (PPA) is a progressive langu

183 Noninvasive brain stimulation in primary progressive aphasia (PPA) is a promising approac

184 Primary progressive aphasia (PPA) is an uncommon degener

185 Primary progressive aphasia (PPA) is characterized by an

186 The semantic variant of primary progressive aphasia (PPA) is characterized by th

187 Primary progressive aphasia (PPA) refers to a disorder o

188 diagnosis in a large cohort of patients with primary progressive aphasia (PPA) variants defined by cu

189 sia when predominantly right-sided, semantic Primary Progressive Aphasia (PPA) when left-sided, and s

190 aging, and genetic study of 31 patients with primary progressive aphasia (PPA), a decline in language

191 Primary progressive aphasia (PPA), a selective neurodege

192 autopsy in up to one third of patients with primary progressive aphasia (PPA), but clinical features

193 In the nonfluent variant of primary progressive aphasia (PPA), degeneration of the p

194 essionals in the management and treatment of primary progressive aphasia (PPA), however, there are ga

195 D), amyotrophic lateral sclerosis (ALS), and primary progressive aphasia (PPA), including 281 AD, 256

196 mentia, non-fluent, and semantic variants of primary progressive aphasia (PPA), progressive supranucl

197 In primary progressive aphasia (PPA), speech and language d

198 the nonfluent variant or semantic variant of primary progressive aphasia (PPA), unspecified PPA, prog

199 Impaired word retrieval is a main symptom of primary progressive aphasia (PPA).

200 ific language functions and often damaged in primary progressive aphasia (PPA).

201 e diseases like Alzheimer's disease (AD) and primary progressive aphasia (PPA).

202 hemisphere-dominant pattern of deposition in primary progressive aphasia (PPA).

203 eurodegenerative dementia syndromes, such as primary progressive aphasias (PPA), have traditionally b

204 -stroke aphasia, PSA) and neurodegeneration (primary progressive aphasia, PPA) have overlapping sympt

205 n 118 consecutive autopsies on patients with primary progressive aphasia, primary diagnosis was Alzhe

206 eration and resultant language impairment in primary progressive aphasia reflect complex interactions

207 est that syntactic comprehension deficits in primary progressive aphasia reflect not only structural

208 t language network for the logopenic variant primary progressive aphasia region of interest, and the

209 sion in the non-fluent/agrammatic variant of primary progressive aphasia relates to the strength of c

210 entia, also known as the semantic variant of primary progressive aphasia, remains unclear.

211 individual patients in both semantic variant primary progressive aphasia samples.

212 Our study included 270 participants with primary progressive aphasia seen for research in the UCL

213 ssive aphasia (non-fluent/agrammatic variant primary progressive aphasia; semantic variant primary pr

214 the pathological process in semantic variant primary progressive aphasia, should be further studied a

215 uroanatomical phenotypes do exist within the primary progressive aphasia spectrum, but that these are

216 of atrophy in non-fluent/agrammatic variant primary progressive aphasia spreads over time from a syn

217 p that was matched in age and gender to each primary progressive aphasia subgroup (n = 20, age = 65 +

218 ty had a predilection for one or more of the primary progressive aphasia subtypes.

219 rity of white matter tracts in the different primary progressive aphasia subtypes.

220 and semantic dementia (SD)/semantic-variant primary progressive aphasia subtypes.

221 stic cognitive deficits in logopenic variant primary progressive aphasia, suggesting that degeneratio

222 sive aphasia (nfvPPA n=36), semantic variant primary progressive aphasia (svPPA n=25), progressive su

223 The semantic variant of primary progressive aphasia (svPPA) is a clinical syndro

224 The semantic variant of primary progressive aphasia (svPPA) is typically associa

225 al dementia (rtFTD), (3) semantic variant of primary progressive aphasia (svPPA), (4) non-fluent vari

226 ral variant FTD (bvFTD), 13 semantic variant primary progressive aphasia (svPPA), 14 non-fluent varia

227 l lobe (ATL): patients with semantic variant primary progressive aphasia (svPPA), a clinical syndrome

228 ementia (bvFTD), eight with semantic variant primary progressive aphasia (svPPA), five with non-fluen

229 dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associa

230 offered by patients with semantic variant of primary progressive aphasia (svPPA).

231 mporal dementia (bvFTD) and semantic variant primary progressive aphasia (svPPA).

232 ed a right-sided variant of semantic variant primary progressive aphasia (svPPA).

233 f resting state neuronal synchronizations in primary progressive aphasia syndromes.

234 patients with bvFTD and semantic variant of primary progressive aphasia than in those with AD and is

235 in Alzheimer's disease and logopenic variant primary progressive aphasia than semantic variant primar

236 nition of this area and presenting data from primary progressive aphasia that challenged this classic

237 Within semantic variant primary progressive aphasia the right-handed and non-rig

238 operculum and caudate nucleus in non-fluent primary progressive aphasia (the corticobasal degenerati

239 ltiple clinical subtypes, and one subtype of primary progressive aphasia to be caused by multiple neu

240 These findings expand the differential of primary progressive aphasia to include prion disease.

241 yses related performance in semantic variant primary progressive aphasia to ventral and medial portio

242 h semantic dementia (SD) or semantic variant primary progressive aphasia typically present with marke

243 -PET-negative patients with semantic variant primary progressive aphasia underwent 11C-PBR28 and 18F-

244 istent region of atrophy in semantic variant primary progressive aphasia using cortical thickness ana

245 pography of inflammation in semantic variant primary progressive aphasia using high-resolution PET an

246 mage and syntactic deficits in patients with primary progressive aphasia, using multimodal neuroimagi

247 The primary progressive aphasia variant pooled crude inciden

248 s of regional spectral power changes in each primary progressive aphasia variant, compared to age-mat

249 Each of the primary progressive aphasia variants showed different pa

250 trols showed significant differences between primary progressive aphasia variants themselves.

251 of network-specific neuronal dysfunction in primary progressive aphasia variants.

252 ntre of the non-fluent/agrammatic variant of primary progressive aphasia was derived in a group of 10

253 No subject with a diagnosis of primary progressive aphasia was identified with this mut

254 feature for all pathologies associated with primary progressive aphasia was the asymmetric prominenc

255 kinson's disease and the posterior insula in primary progressive aphasias was also observed.

256 ical diagnosis of frontotemporal dementia or primary progressive aphasia, we included 70 subjects wit

257 -linguistic dysfunction in logopenic variant primary progressive aphasia, we propose that a significa

258 frontotemporal dementia and semantic variant primary progressive aphasia were most likely to exhibit

259 sis of patients with the semantic subtype of primary progressive aphasia, which is associated with ma

260 ntroversy were addressed in 72 patients with primary progressive aphasia who collectively displayed a

261 fied clinically into behavioral variant FTD; primary progressive aphasia with 3 subtypes, semantic, n

262 The association of logopenic primary progressive aphasia with Alzheimer's disease pat

263 ing research has associated semantic variant primary progressive aphasia with distributed cortical at

264 Behaviourally, patients with primary progressive aphasia with non-semantic subtypes w

265 ing in healthy controls and in patients with primary progressive aphasia with relatively spared synta

266 et Alzheimer's disease and logopenic variant primary progressive aphasia), with a trend towards lower

267 thology displays an atypical distribution in primary progressive aphasia yielded inconclusive results