ライフサイエンスコーパス: primary sensory neuron

1 control of the temporal responsiveness of a primary sensory neuron.

2 messages are initiated - at the level of the primary sensory neuron.

3 to a subset of Rohon-Beard cells, a type of primary sensory neuron.

4 despite both forms occurring within the AWC primary sensory neuron.

5 ally expressed in small-diameter nociceptive primary sensory neurons.

6 iciency in coding that has not been found in primary sensory neurons.

7 nt receptor potential vanilloid I (TRPV1) in primary sensory neurons.

8 spinal synapses made by axotomized group IA primary sensory neurons.

9 us particles in axons following infection of primary sensory neurons.

10 uired for efficient transcription of TrkA in primary sensory neurons.

11 e inhibitory effect of capsaicin on VACCs in primary sensory neurons.

12 s a major determinant of the excitability of primary sensory neurons.

13 isoforms are found only in a small subset of primary sensory neurons.

14 NSRs) are expressed solely in small diameter primary sensory neurons.

15 itochondrial functions in cultured adult rat primary sensory neurons.

16 e-gated sodium channels present in motor and primary sensory neurons.

17 ion of nociceptor activity and plasticity of primary sensory neurons.

18 required simultaneously for survival of some primary sensory neurons.

19 expression, including frequent expression in primary sensory neurons.

20 a molecular integrator of painful stimuli on primary sensory neurons.

21 observed at the spinal level also applies to primary sensory neurons.

22 ch may be specific to a particular subset of primary sensory neurons.

23 t) mouse suffers from severe degeneration of primary sensory neurons.

24 important role in regulating excitability of primary sensory neurons.

25 m pepper family, which activates nociceptive primary sensory neurons.

26 ikely through the activation of NF-kappaB in primary sensory neurons.

27 ssibly by causing oxidative stress damage to primary sensory neurons.

28 ssion of Marina, a positively tuned GEVI, in primary sensory neurons.

29 Here, we show that AM404 is produced by primary sensory neurons.

30 histone marks and Cacna2d1 transcription in primary sensory neurons.

31 DJ-1 and its therapeutic potential in human primary sensory neurons.

32 aches toward selective targeting of GPCRs on primary sensory neurons.

33 of G-protein coupled receptors expressed in primary sensory neurons.

34 d increases in TRPA1 and TRPV1 expression in primary sensory neurons.

35 ic Mrgpr and its expression is restricted to primary sensory neurons.

36 en there are many more cortical neurons than primary sensory neurons.

37 actions of target tissues, immune cells, and primary sensory neurons.

38 irect synaptic input from both pain and itch primary sensory neurons.

39 ly well-suited for monitoring PKA and ERK in primary sensory neurons.

40 erve injury on the regenerative state of the primary sensory neurons.

41 to TRPV1 within a few hours, in nociceptive primary sensory neurons.

42 ervous system, including the spinal cord and primary sensory neurons.

43 s activates the D1-like dopamine receptor on primary sensory neurons.

44 riety of receptors and channels expressed by primary sensory neurons.

45 between neurotropic herpesviruses and murine primary sensory neurons.

46 el Nav1.8 is expressed almost exclusively in primary sensory neurons.

47 Kv7.2 activity increases the excitability of primary sensory neurons.

48 nduction and maintenance of sensitization of primary sensory neurons.

49 led receptor expressed by a subpopulation of primary sensory neurons.

50 pression and function of Cavbeta subunits in primary sensory neurons.

51 nd murine TRPM8 channels, including those on primary sensory neurons.

52 d its ligand ephrinB2 in the dorsal horn and primary sensory neurons.

53 voltage-gated calcium and sodium currents in primary sensory neurons.

54 Expression of Mtd promoted the death of primary sensory neurons, 293T cells and HeLa cells, indi

55 loss of eIF4E serine 209 phosphorylation in primary sensory neurons, a specific substrate of MNK, wi

56 odium channels underlie hyperexcitability of primary sensory neurons after injury?

57 (BDNF), we developed an in vitro model using primary sensory neurons and a modified ELISA, termed ELI

58 nti-neuroinflammatory effects of Curcumin on primary sensory neurons and activated macrophages in vit

59 They are expressed by primary sensory neurons and by glial cells in the centra

60 nish the resting membrane potential of mouse primary sensory neurons and cause cold-resistant hyperex

61 The lipid sensitizes TRPV1 ion channels in primary sensory neurons and causes increased frequency o

62 thesis of nonstructural proteins like KOR in primary sensory neurons and demonstrated a mechanism of

63 tion channel V1 (TRPV1) is also expressed in primary sensory neurons and detects painful stimuli such

64 olecular and functional heterogeneity of the primary sensory neurons and dorsal horn interneurons tra

65 unsaturated bonds, activate TRPA1 to excite primary sensory neurons and enteroendocrine cells.

66 ts high voltage-activated Ca(2+) channels in primary sensory neurons and excitatory synaptic transmis

67 alysis, metabolomics, and calcium imaging of primary sensory neurons and find no evidence of ligands

68 ted by hypochlorite and hydrogen peroxide in primary sensory neurons and heterologous cells.

69 and substance K, are produced in nociceptive primary sensory neurons and in many brain regions involv

70 Cbln2 expression tends to be more common in primary sensory neurons and in second-order sensory regi

71 that it is synthesized by subpopulations of primary sensory neurons and intrinsic spinal cord dorsal

72 eferentially expressed in the small-diameter primary sensory neurons and involved in the mediation of

73 (CePPEF) homolog is also highly expressed in primary sensory neurons and is not found outside the ner

74 ) are in close contact with the cell body of primary sensory neurons and might play physiological and

75 avbeta(3) subunit augments HVACC activity in primary sensory neurons and nociceptive input to dorsal

76 he vertebrate embryo that gives rise to most primary sensory neurons and pigment cells in the adult o

77 n reduced voltage-dependent Ca(2+) influx in primary sensory neurons and promoted their regeneration

78 s intracellular signaling molecules in these primary sensory neurons and provide a general mechanism

79 c proteins that are exclusively expressed in primary sensory neurons and provoke pain in humans.

80 tor) that decreases glucose-induced death of primary sensory neurons and reverses numerous clinical i

81 t the molecules that mediate chronic itch in primary sensory neurons and skin.

82 suggest that DOR-KOR heteromers exist in rat primary sensory neurons and that KOR antagonists can act

83 t least the Oprd1 and Cnr1 genes via REST in primary sensory neurons and that REST is a potential the

84 xtensive localization of the EP3 receptor in primary sensory neurons and the spinal cord.

85 el cues, which are thought to be detected by primary sensory neurons and then distinguished by downst

86 or leading to its functional inactivation in primary sensory neurons and to an efficacious attenuatio

87 e receptor 7 (TLR7) was expressed in C-fiber primary sensory neurons and was important for inducing i

88 Bone cancer upregulated CCR2 in primary sensory neurons, and CCR2 antagonism effectively

89 ce expression and action potential firing in primary sensory neurons, and dampens C-fiber responses.

90 as in mammalian cells, desensitize TRPV1 in primary sensory neurons, and has an acceptable PK profil

91 olfactory abilities likely originates in the primary sensory neurons, and suggest that hormonal modul

92 and LPC 16:0 can induce Ca(2+) transients in primary sensory neurons, and we identify LPC 18:1 as a p

93 In cultured primary sensory neurons, APDC blocked PGE2-induced poten

94 Dissociated primary sensory neurons are commonly used to study growt

95 Maladaptive changes of gene expression in primary sensory neurons are considered molecular basis o

96 injury-induced intrinsic immune responses in primary sensory neurons are critical for neuropathic pai

97 NMDARs in primary sensory neurons are essential for chemotherapy-i

98 Primary sensory neurons are generally considered the onl

99 Voltage-activated Na+ channels in the primary sensory neurons are important for generation of

100 isms mediating histamine-independent itch in primary sensory neurons are largely unknown.

101 Changes in primary sensory neurons are likely to contribute to the

102 mber 1 (TRPV1) in pain-sensing (nociceptive) primary sensory neurons are pivotal for developing patho

103 Many primary sensory neurons are polymodal, responding to mul

104 This is what nociceptors do--these primary sensory neurons are specialized to detect intens

105 study, electrical stimulation of dissociated primary sensory neurons at 5 Hz, or treatment with eleva

106 At this longest survival, primary sensory neurons became infected.

107 s, and neuropathy of the cutaneous fibres of primary sensory neurons before any motor impairments wer

108 In cultured rodent primary sensory neurons, BoNT-A decreased the proportion

109 he finding that VR1 is expressed not only in primary sensory neurons but also in several brain nuclei

110 2I showed selective in vitro C2I delivery to primary sensory neurons but not motor neurons.

111 , wheat germ agglutinin (WGA), is induced in primary sensory neurons, but only after transection of t

112 her increasing the intrinsic growth state of primary sensory neurons by a conditioning peripheral ner

113 SDHN following the activation of nociceptive primary sensory neurons by burn injury, capsaicin applic

114 in HEK293 cells, Xenopus laevis oocytes, and primary sensory neurons by measuring Ca(2+) signals.

115 tes that reducing the heightened activity in primary sensory neurons by targeting G-protein-coupled r

116 Head movements are detected and signalled to primary sensory neurons by vestibular types I and II hai

117 In the present study, we aimed to monitor primary sensory neuron Ca(2+) activity in the intact dor

118 Using these methods, primary sensory neurons can be transfected with an effic

119 from the peripheral and central terminals of primary sensory neurons can critically contribute to noc

120 ems unlikely that Ca2+ channel inhibition on primary sensory neurons can fully explain the behavioral

121 ity and/or increased baseline sensitivity of primary sensory neurons can lead to abnormal burst activ

122 In the rat, expression of PV by primary sensory neurons coincides with the onset of feta

123 otection against glucose-induced toxicity of primary sensory neurons compared to 2.

124 lation in injured dorsal root ganglion (DRG) primary sensory neurons consistent with an early phase o

125 Our findings suggest that G9a in primary sensory neurons constitutively represses Trpa1 a

126 How primary sensory neurons contribute to persistent pain re

127 Primary sensory neurons convert external stimuli into el

128 Primary sensory neurons convey information from the exte

129 lation at the alpha2delta-1 gene promoter in primary sensory neurons could lead to long-lasting relie

130 In vitro primary sensory neuron culture systems were subjected to

131 The peripheral terminals of primary sensory neurons detect histamine and non-histami

132 ctoderm and neural folds in the region where primary sensory neurons develop.

133 MOR ablation in primary sensory neurons diminishes analgesic effects pro

134 tion of voltage-sensitive Ca(2+) channels in primary sensory neurons (dorsal root ganglion) was diffe

135 d with live-cell imaging revealed that adult primary sensory neurons downregulate molecular constitue

136 Nociceptive primary sensory neurons endogenously express VR1, and re

137 ing molecules responsible for this change in primary sensory neuron excitability are still not well d

138 sts that substance P (SP) is up-regulated in primary sensory neurons following axotomy and that this

139 rat trigeminal ganglion, the location of the primary sensory neurons for face sensation, specific sil

140 Primary sensory neurons form the interface between world

141 ns, heat and anandamide were investigated in primary sensory neurones from neonatal rat dorsal root g

142 plitude of CXCL12-induced Ca(2+) response in primary sensory neurons from CCD mice was significantly

143 ctrophysiological studies on mouse and human primary sensory neurons from dorsal root ganglia.

144 rent in prephenotype dorsal root ganglia and primary sensory neurons from dt mice, suggesting they ar

145 -Cre recombinase transfection of adult mouse primary sensory neurons from floxed Pcdhgamma mice was a

146 calcium ion channel highly expressed in the primary sensory neurons, functioning as a polymodal sens

147 sitive fluorescent protein G-CaMP to map the primary sensory neurons governing avoidance to CO2.

148 In mice with conditional Grin1 KO in primary sensory neurons (Grin1-cKO), gabazine and strych

149 onditional Grin1 (gene encoding GluN1) KO in primary sensory neurons (Grin1-cKO), paclitaxel treatmen

150 Adult Wistar rat primary sensory neurons grown at physiological pH 7.4, t

151 However, the function of ERK2 in primary sensory neurons has not been directly tested.

152 Viral tracing of the circuits engaged by primary sensory neurons has, however, been hampered by t

153 tic studies of postoperative surgery pain in primary sensory neurons have been limited to in vitro mo

154 t ganglia (DRG), which contain the somata of primary sensory neurons, have increasingly been consider

155 cranial nerves (gV, gVII, gIV and gX) and in primary sensory neurons (i.e., Rohon-Beard neurons) in t

156 In cultured primary sensory neurons IL-31 triggered Ca(2+) release a

157 ognise the importance of ectopic activity in primary sensory neurones impinging on a sensitised centr

158 athways are segregated immediately after the primary sensory neuron in the chemotaxis circuit, and se

159 at induction of eIF2alpha phosphorylation in primary sensory neurons in a chronic inflammation pain m

160 DiI-labeling and immunostaining of primary sensory neurons in coculture revealed that these

161 e that transcriptional changes that occur in primary sensory neurons in dermatitis-susceptible animal

162 restricted mainly to those subpopulations of primary sensory neurons in developing and adult DRGs tha

163 Motor neurons and primary sensory neurons in dorsal root ganglia had stron

164 TLR3 is expressed mainly by small-sized primary sensory neurons in dorsal root ganglions (DRGs)

165 e trigeminal ganglion cells are unique among primary sensory neurons in having two branches entering

166 ar effector, underlying the formation of any primary sensory neurons in higher vertebrates.

167 lly to transcriptional repression of MORs in primary sensory neurons in neuropathic pain.

168 nstrate a critical role of MORs expressed in primary sensory neurons in opioid analgesia and suggest

169 roid hormones, targeted TRPA1 in peptidergic primary sensory neurons in rodent and human cells expres

170 mined the specific role of MORs expressed in primary sensory neurons in the analgesic and hyperalgesi

171 Our understanding of coding properties of primary sensory neurons in the auditory and visual syste

172 m-CPP also decreased activity in primary sensory neurons in the crayfish.

173 ministered cisplatin (2 mg/kg i.p. for 5 d), primary sensory neurons in the dorsal root ganglion die

174 Primary sensory neurons in the DRG play an essential rol

175 imulus-evoked excitability in small diameter primary sensory neurons in the perinatal period and the

176 ceptors (NMDARs) at the central terminals of primary sensory neurons in the spinal cord.

177 al mechanical origin of tactile information, primary sensory neurons in the trigeminal ganglion (Vg)

178 the response magnitude of whisker-sensitive primary sensory neurons in the trigeminal ganglion.

179 neurotoxin that destroys small unmyelinated primary sensory neurons in the vagus, as well as in othe

180 OX2 activity to control pain, in nociceptive primary sensory neurons in tissue injuries.

181 have demonstrated that anandamide can excite primary sensory neurons in vitro via transient receptor

182 We describe a model of gp120 toxicity to primary sensory neurons, in which gp120 induces neuritic

183 y eliminated on ablation of TRPV1-expressing primary sensory neurons, indicating a crossover inhibiti

184 T, Ramsey, and T47D cells as well as that of primary sensory neurons, indicating that Diva is a proap

185 ct connections between the motor neurons and primary sensory neurons, indicating that further study w

186 Primary sensory neurons innervating hindpaw glabrous ski

187 uce robust axonal plasticity of normal adult primary sensory neurons into areas of transgene expressi

188 that sodium channel immunoreactivity within primary sensory neurons is dramatically increased within

189 Presynaptic inhibition (PSI) of primary sensory neurons is implicated in controlling gai

190 st ~ 30% of TRPV1-expressing cultured murine primary sensory neurons, is mediated through upregulatio

191 a genetically tractable Drosophila model and primary sensory neurons isolated from adult mouse to exa

192 r 1 TGR5 (encoded by GPBAR1) is expressed by primary sensory neurons; its activation induces neuronal

193 that the satellite glial cells that surround primary sensory neurons located in sensory ganglia of th

194 nels, K(V) 4 (i.e. K(V) 4.1 and K(V) 4.3) in primary sensory neurons mainly participate in physiologi

195 n (TTX)-resistant sodium channels present in primary sensory neurons may be responsible for the excit

196 Primary sensory neurons may constitute a final common pa

197 Sodium channels within primary sensory neurons may play an important role in th

198 ral side of the segmental ganglia, including primary sensory neurones, motoneurones and interneurones

199 Furthermore, calcium imaging in isolated primary sensory neurons of both sexes revealed HFD induc

200 essional changes of pain-associated genes in primary sensory neurons of DRG are critical for neuropat

201 eceptor VR1 is a cation channel expressed by primary sensory neurons of the "pain" pathway.

202 POU-domain transcription factor expressed in primary sensory neurons of the cranial and dorsal root g

203 dominant background potassium current in the primary sensory neurons of the dorsal root and trigemina

204 report highly effective gene transfer to the primary sensory neurons of the dorsal root ganglia (DRGs

205 g with Cav3.2 being the prominent isoform in primary sensory neurons of the dorsal root ganglion (DRG

206 Since primary sensory neurons of the dorsal root ganglion show

207 , target spiral ganglion neurons (SGNs), the primary sensory neurons of the ear.

208 Interestingly, a subset of primary sensory neurons of the ipsilateral trigeminal ga

209 ature olfactory sensory neurons (mOSNs), the primary sensory neurons of the olfactory epithelium.

210 expressed on olfactory sensory neurons, the primary sensory neurons of the olfactory epithelium.

211 The olfactory placodes generate the primary sensory neurons of the olfactory sensory system.

212 terminals of olfactory sensory neurons (the primary sensory neurons of the olfactory system, which p

213 tivating TRPA1, an excitatory ion channel on primary sensory neurons of the pain pathway.

214 chemical and thermal stimuli by nociceptors, primary sensory neurons of the pain pathway.

215 l molecular detector of cold temperatures in primary sensory neurons of the somatosensory system.

216 ne how tactile information is represented in primary sensory neurons of the trigeminal ganglion (Vg).

217 s of these results under the assumption that primary sensory neurons of the trigeminal ganglion are s

218 Eliminating NMDARs in primary sensory neurons or alpha2delta-1 KO also attenua

219 edge of the neural plate become Rohon-Beard primary sensory neurons or neural crest.

220 axonal injury, concentrations of BH4 rose in primary sensory neurons, owing to upregulation of GCH1.

221 MORs in primary sensory neurons, particularly those expressed pr

222 sfer is a feature shared by other classes of primary sensory neurons, permitting the identification a

223 This indicates widespread DRG primary sensory neuron plasticity.

224 Our findings suggest that MyD88 in primary sensory neurons plays an active role in regulati

225 These data indicate that the primary sensory neuron population and its projections ma

226 in controlling the intrinsic excitability of primary sensory neurons possibly via Ca(2+)-activated SK

227 When the axons of primary sensory neurons project into the embryonic mamma

228 nctional interactions in a sub-population of primary sensory neurons (PSN).

229 NaViPA1 expression in primary sensory neurons (PSNs) of dorsal root ganglia (D

230 The peripheral axonal branch of primary sensory neurons readily regenerates after periph

231 Full-length Rest conditional knockout in primary sensory neurons reduced SNI-induced pain hyperse

232 The peripheral branch of primary sensory neurons regenerates after injury, but th

233 Mechanistically, DJ-1 in primary sensory neurons regulated this hypersensitivity

234 ular basis of mechanosensory transduction by primary sensory neurones remains poorly understood.

235 Thus, the primary sensory neurons responsive to beta-alanine are l

236 Activation of most primary sensory neurons results in transduction currents

237 A recent study in primary sensory neurons shows that electrical activity--

238 ikely through the activation of NF-kappaB in primary sensory neurons.SIGNIFICANCE STATEMENT In the pr

239 f TRPM8 channels in these injured trigeminal primary sensory neurons.SIGNIFICANCE STATEMENT We unveil

240 Combining primary sensory neuron-specific GCaMP3 imaging with a tr

241 ficantly blunted phosphorylation of c-Jun in primary sensory neurons subjected to trophic deprivation

242 causative factor may be that only 50-60% of primary sensory neurons succeed in regenerating axons af

243 ) are present on the peripheral terminals of primary sensory neurons, suggesting that they might be i

244 t mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsa

245 We characterized the populations of primary sensory neurons that become latently infected wi

246 associated with inflammation and trauma, but primary sensory neurons that convey the sensation of acu

247 role for activity in the development of the primary sensory neurons that detect touch.

248 Thus, PKD1, PKD2, and PKD3 are expressed in primary sensory neurons that mediate neurogenic inflamma

249 rotrophic factor (BDNF) is expressed by many primary sensory neurons that no longer require neurotrop

250 dorants by olfactory sensory neurons (OSNs), primary sensory neurons that physically contact odor mol

251 Although primary sensory neurons that transmit pruritic signals a

252 f WNT/frizzled/beta-catenin signaling in the primary sensory neurons, the spinal dorsal horn neurons,

253 espite prominent expression of NMDARs in DRG primary sensory neurons, the unique role of peripheral N

254 Brn3a and Islet, which together characterize primary sensory neurons throughout the developing embryo

255 e have compared the membrane response of rat primary sensory neurons to capsaicin and noxious heat, u

256 ve protease-activated receptor 2 (PAR(2)) on primary sensory neurons to induce neurogenic inflammatio

257 t acts as a coincidence detector that allows primary sensory neurons to integrate information from ne

258 We used primary sensory neurons to interrogate the role of Stmn2

259 d treatment promotes mGluR5 trafficking from primary sensory neurons to the spinal dorsal horn.

260 in sodium channel subunit Nav1.8-expressing primary sensory neurons, to examine the unique role of n

261 The principle by which unmyelinated primary sensory neurons transducing thermal, itch and pa

262 vents might also impact central processes of primary sensory neurons, triggering in nociceptors a hyp

263 ransient receptor potential melastatin 8) in primary sensory neurons using both pharmacological inhib

264 eral nerve injury promotes CB2 expression in primary sensory neurons via epigenetic bivalent histone

265 effects were mediated by the transduction of primary sensory neurons via transport of FIV vectors fro

266 In trigeminal primary sensory neurons, we detected single-channel acti

267 e and the frequency of transport in axons of primary sensory neurons were both reduced.

268 ive ligand-gated channel highly expressed in primary sensory neurons where it mediates nociception.

269 C(50) = 0.1 nm) and TRPA1 (IC(50) = 2 nm) in primary sensory neurons, whereas RvE1 and RvD1 selective

270 r noxious (harmful) environmental cues using primary sensory neurons, which serve as the first node i

271 s defined by the existence of a diversity of primary sensory neurons with unique biological features

272 e spindles, taste buds, enteric neurons, and primary sensory neurons within the cranial and dorsal ro

273 nnections between cochlear sensory cells and primary sensory neurons, without loss of the sensory cel