ライフサイエンスコーパス: primary sequence

1 tive protein binds fibronectin with the same primary sequence.

2 an be predicted and manipulated based on the primary sequence.

3 orders of magnitude simply by optimizing the primary sequence.

4 spite a lower conservation of the nucleotide primary sequence.

5 from the Nab3 RNA recognition domain in the primary sequence.

6 densis that shares less than 30% identity in primary sequence.

7 typical of such enzymes, are apparent in its primary sequence.

8 he full time range and is independent of the primary sequence.

9 rylation of two residues widely separated in primary sequence.

10 buried upon folding (AABUF) derived from the primary sequence.

11 binding site residues of a protein from its primary sequence.

12 may be separated by significant intervening primary sequence.

13 n sites that would not be predicted from the primary sequence.

14 g dipeptide pools covering the entire 369 aa primary sequence.

15 and the ability to do so correlates with the primary sequence.

16 arily by amino acid composition, rather than primary sequence.

17 eraction of two noncontiguous regions in the primary sequence.

18 related to the protein conformation than the primary sequence.

19 motifs and a C-terminal J-domain within its primary sequence.

20 nd that this perturbation is mediated by the primary sequence.

21 ng of oppositely charged residues within the primary sequence.

22 via simple molecular-level tuning of peptide primary sequence.

23 served among the member RNAs compared to the primary sequence.

24 ure selection in lncRNAs have focused on the primary sequence.

25 ndary structure element rather than by local primary sequence.

26 can be tuned via precise organization of the primary sequence.

27 anscripts, all three RLuc mRNAs had the same primary sequence.

28 tive side chains are incorporated into their primary sequence.

29 minants and in a manner independent of local primary sequences.

30 50 nt) tertiary RNA structures starting from primary sequences.

31 R translocation, SPs have diverse but unique primary sequences.

32 th similar secondary structure but different primary sequences.

33 led high expression across a wide variety of primary sequences.

34 The linear build up of primary sequence (1 degrees ) also enabled a thermal Hui

35 bilization occurs despite large distances in primary sequence (10-15 amino acids) between the O-GlcNA

36 ng at least two defined regions of the PfRH5 primary sequence; 3) a brief exposure window of PfRH5 is

37 o the correspondence between RNA and protein primary sequences, a correlation exists between high lev

38 Primary sequence, activating chromatin marks, and DNA-bi

39 Primary sequence alignment of different Cxs shows the pr

40 A primary sequence alignment of PNT1 with clostripain and

41 Using the crystal structure, primary sequence alignment, pH-activity profiles, and si

42 Based on primary sequence alignment, three-dimensional topology,

43 zing mutations are readily identifiable from primary sequence alignments.

44 Interestingly, the primary sequence almost invariably avoids off-pathway ag

45 ence homology search and alignment work with primary sequence alone, neglecting higher-order correlat

46 Most alignment software considers the primary sequence alone; some specialized alignment softw

47 For the primary sequences alone, the web server can compute the

48 photodissociation (UVPD) to provide detailed primary sequence analysis and PTM site localization of t

49 Finally, we argue that primary sequence analysis and structural modelling do no

50 Primary sequence analysis revealed a unique tetraproline

51 A primary sequence analysis suggested that the SdeAgu115A

52 On the basis of primary sequence analysis, MppP and MppQ are pyridoxal 5

53 uired to understand the relationship between primary sequence and biological function in this class o

54 Despite their similarity in primary sequence and cofactor content, crystallographic,

55 entified, with the demonstration of the same primary sequence and disulfide linkages between the inno

56 volve as adaptive modules that may change in primary sequence and function while maintaining three-di

57 Comprehensive determination of primary sequence and identification of post-translationa

58 (70) or sigma(54), that differ both in their primary sequence and in the requirement of the latter fo

59 hat is highly conserved both in terms of its primary sequence and its three-dimensional structure.

60 In particular, we assessed whether its primary sequence and length are critical for proper prot

61 ins in CpaA that were not predicted from its primary sequence and may explain CpaA's glycoprotein-tar

62 ich can be encoded by both polypeptide chain primary sequence and nucleic acid base sequence, control

63 globulin G (IgG) structure, both in terms of primary sequence and post-translational modifications (P

64 experiments to reveal information about both primary sequence and post-translational modifications.

65 The server takes primary sequence and raw crystal diffraction data as inp

66 that accommodates functional information in primary sequence and secondary and tertiary structure.

67 ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections

68 Accurate determination of the primary sequence and secondary structure of ncRNAs is im

69 al representation of the conservation of the primary sequence and secondary structure.

70 Computational analysis of the primary sequence and secondary structures of these trans

71 ntegrate rare experimental data and abundant primary sequence and sequence similarity.

72 The primary sequence and structure of the tubulin proteins a

73 bout the input data (i.e., it only uses gene primary sequence and the corresponding protein sequence)

74 ved although they have low similarity in the primary sequence and the secondary structure.

75 NAs (mRNAs) encode information in both their primary sequence and their higher order structure.

76 ytochrome P450 alpha-helical domain both the primary sequence and x-ray structure indicate the presen

77 Based on their primary sequences and functions sortases can be partitio

78 a protein that occurs spontaneously in prone primary sequences and leads typically to an equilibrium

79 was identified by computational analysis of primary sequences and secondary structures of hnRNP A18

80 there is little apparent correlation between primary sequences and three-dimensional folding unless s

81 f cis-regulatory elements bearing particular primary sequences and/or secondary-structures.

82 t predict secondary structure given only the primary sequence, and a model to evaluate the quality of

83 perturbation of interactions distant in the primary sequence, and atomic force microscopy.

84 s of proteolysis are dominated more by local primary sequence, and less by the tertiary protein fold.

85 etermination of DAR, characterization of the primary sequence, and localization of the drug conjugati

86 e in eukaryotes, yet their DNA structure and primary sequence are hypervariable.

87 atenin indicate that while variations in the primary sequence are well tolerated, an intrinsically di

88 The primary sequences around these modified residues do not

89 thways and tertiary structure using only the primary sequence as input.

90 in proteins result in virtually all of their primary sequence being exposed, at least at some time, t

91 vealing that the peptide, although of unique primary sequence, binds to alpha-Cbtx by mimicking struc

92 equences may have been selected not by their primary sequence but by their ability to form noncanonic

93 d droplet surface protein (LDSP) with unique primary sequence but structural similarities to other LD

94 c/MCAK), which are highly conserved in their primary sequences but display distinct localization and

95 select their substrates based on a protein's primary sequence, but a consensus sequence has been slow

96 urprisingly, these residues are separated in primary sequence, but cluster into a small 3D putative b

97 e clustered within the 101-110 region of the primary sequence, but they would have intermolecular spa

98 ntification of residue-residue contacts from primary sequence can be used to guide protein structure

99 Relatively modest modifications to AMPs primary sequence can induce substantial changes in poten

100 man PMTs, although similar in terms of their primary sequences, can act on the distinct sets of nonhi

101 recent advances in our understanding of how primary sequence, chromatin environment, and nuclear arc

102 Our results demonstrate the existence of a primary sequence code characteristic to hindbrain enhanc

103 Based on primary sequence comparisons and genomic context, Npun_F

104 Primary sequence comparisons and x-ray structural analys

105 how much a tertiary model of a given protein primary sequence conforms to the known protein structure

106 Despite low primary sequence conservation among the archaeal Nop56/5

107 As, mammalian-expressed lincRNAs show higher primary sequence conservation in their promoters and exo

108 Molecular dynamics simulations and primary sequence conservation suggest that the sorting s

109 s, including: short sequence length, lack of primary sequence conservation, and the importance of sec

110 two subclassifications of proteins, based on primary sequence conservation, protein size, and domain

111 Largely ignored and distinguished by lack of primary sequence conservation, the linker is presumed to

112 Our studies support that, besides the primary sequence context, the protein structure is a maj

113 The prediction of secondary RNA folds from primary sequences continues to be an important area of r

114 The most conserved contiguous region of the primary sequence corresponds to a crystallographically d

115 e the wealth of data available, ranging from primary sequence data to gene and genome structures, our

116 Using primary sequence data, we compared the genomes of these

117 ent siRNA design guidelines are based on RNA primary sequence data.

118 ructures, and alignment of nonredundant nsp5 primary sequences, demonstrated that ts and suppressor r

119 dy next-generation sequencing data work with primary sequence descriptors, leaving accompanying struc

120 These data highlight that primary sequence determinants and RNA structure are key

121 n the CENP-A targeting domain (CATD) are the primary sequence determinants for HJURP recognition, bur

122 These studies provide new insights into the primary sequence determinants of binding motifs, which i

123 Additionally primary sequence determinants within the intracellular d

124 cells, thereby confirming the importance of primary-sequence determinants for distinguishing pri-miR

125 ce of pairing in the stem and revealed three primary-sequence determinants, including an SRp20-bindin

126 These results highlight that small primary sequence differences between the two mammalian S

127 t into a wide range of parameters, including primary sequence, disulfide bonding, glycosylation patte

128 oup A rotavirus (RVA); however, the dramatic primary sequence divergence of NSP4s across serogroups r

129 um levels, demonstrating that despite strong primary sequence divergence, RV NSP4 has maintained viro

130 ubunit of the uniporter holocomplex, but its primary sequence does not resemble any calcium channel s

131 mosaic molecules, P and Q, incorporating the primary sequence elements of the four grass pollen aller

132 The primary sequence elements responsible for carbohydrate r

133 ROK glucokinases (Pfam 02685), revealing the primary sequence elements shared between these two prote

134 Primary sequences encoded into the suite of tricarb macr

135 Illuminating the primary sequence encryption of enhancers is central to u

136 inguished from nonfunctional motifs by local primary sequence features or by the larger genomic conte

137 rmine the role of weak motifs encoded in its primary sequence for the recruitment of its ubiquitin li

138 e further into the twilight zone by aligning primary sequences for a pair of proteins to a best-fit t

139 tistically significant prediction of protein primary sequence from mRNA using purely physiochemical i

140 e prediction of RNA secondary structure from primary sequence has had enormous impact on research fro

141 or in a predictable manner, while scrambling primary sequence has little effect on PrLD assembly and

142 , demonstrating that channels with identical primary sequence have different ligand recruitment thres

143 Based on its primary sequence, Hbp2 contains three NEAr transporter (

144 GDAP1 contains primary sequence homology to the GST superfamily; howeve

145 Despite showing no primary sequence homology to TNF family cytokines, UL141

146 Characterization of protein primary sequence, however, has thus far been limited.

147 ut Dothideomycetes, and despite their modest primary sequence identity, many are perceived by the cog

148 n superfamily despite a low level of overall primary sequence identity.

149 nosylation suggests a limited role for local primary sequence in dictating sites of attachment.

150 e are conflicting opinions as to the role of primary sequence in their conversion to the prion form:

151 in both viruses, despite differences in the primary sequence in this region.

152 n in Shaker-iVSD developed despite identical primary sequence, indicating an allosteric influence of

153 lusters of amino acid residues along the IDP primary sequence, individual residues can adopt a wide r

154 It is unclear to what extent S region primary sequence influences differential targeting of CS

155 f yielding the most comprehensive diagnostic primary sequence information about the proteins in the c

156 ) workflow results in acquisition of greater primary sequence information relative to conventional co

157 which the polypeptide chain can convert its primary sequence into functional structures, dysfunction

158 ated stem-loop in which the conserved exon 2 primary sequence is changed but secondary structure main

159 c loop critical in all species but for which primary sequence is not well conserved.

160 Its primary sequence is similar to the reactive loop of plan

161 e secondary structure is more conserved than primary sequence, it can be leveraged to improve the ali

162 T domain in Hbp2 binds hemin even though its primary sequence lacks a highly conserved YXXXY motif th

163 Homologs segregate into two classes based on primary sequence length and the presence/absence of a un

164 ) domain that is not highly conserved at the primary sequence level but folds into a three-helix bund

165 SPA proteins are not homologous at the primary sequence level but share overall physical proper

166 e TFIIEbeta homologue in archaea that on the primary sequence level is related to the RNAPIII subunit

167 Although highly divergent at the primary sequence level, an atomic resolution (1.1 A) cry

168 detectable homology of the promoters on the primary sequence level, histone modification patterns we

169 gh these domains are highly divergent at the primary sequence level, the structures of dozens of PAS

170 eraction specificity is often encoded at the primary sequence level.

171 s, they appear to be rapidly evolving at the primary sequence level.

172 Though not evident from inspection of their primary sequences, many serine-threonine kinases display

173 s sequence-independent, and does not require primary sequence modification (e.g. the addition or remo

174 lterations in either LRP2 expression or LRP2 primary sequence modulate the uptake of LRP2 ligands.

175 imetic compound, c(HS4-4), containing the SE primary sequence motif QKRAA, which was synthesized usin

176 lational modification of selected targets by primary sequence motif recognition.

177 We further show that the CNNC primary sequence motif selectively enhances the processi

178 tive mass spectrometry and characterized the primary sequence motif specificity of mTOR using positio

179 Primary sequence motifs, with millimolar affinities for

180 viously identified features, including three primary-sequence motifs, yielded a unifying model defini

181 hanism where a loop distantly located in the primary sequence occupies the IP(3)-binding site and com

182 The primary sequence of a protein defines its free-energy la

183 How the primary sequence of a protein encodes conformational pre

184 for rapid and accurate determination of the primary sequence of a protein therapeutic drug product.

185 Novel modules in the primary sequence of alpha-synuclein optimized for calciu

186 It is further shown that the primary sequence of an ELP can be tuned to exhibit eithe

187 The primary sequence of cartilage-associated protein is homo

188 Although the primary sequence of COPT6 contains the family conserved

189 The primary sequence of CRABP-II contains three putative SUM

190 so seen in S-crystallins suggesting that the primary sequence of crystallins may be specifically enri

191 ed questions in genome biophysics is how the primary sequence of DNA bases influences the global prop

192 of the tunnel and is directed by the unique primary sequence of each nascent peptide.

193 ly, through its constituent subunits, to the primary sequence of each protein.

194 njugated oligomers critically depends on the primary sequence of monomers.

195 ngly suggest that maquettes derived from the primary sequence of NiSOD are mechanistically distinct f

196 Two major domains are predicted from the primary sequence of P3H1: an amino-terminal domain and a

197 e gamma-carboxyl group of a glutamate in the primary sequence of proteins and additional glutamates a

198 symmetry in the CC structure, encoded in the primary sequence of rod 1B, provides a striking example

199 pped the polymorphisms spread throughout the primary sequence of ROP5 to two major surfaces, includin

200 Although the primary sequence of Rv2179c has no detectable similarity

201 The primary sequence of Son contains a concentrated region o

202 Because the primary sequence of sororin does not contain any previou

203 We found that approximately 90% of the primary sequence of the ADC conjugated with either monom

204 d whether the PIP2 sensor resides within the primary sequence of the channel itself, or, as recently

205 phate, double-stranded RNA structure, or the primary sequence of the foreign circRNA.

206 and occurs without any known changes in the primary sequence of the genome; thus the switch is epige

207 T-causing mutations dispersed throughout the primary sequence of the human glycyl-tRNA synthetase (GA

208 of approximately 30 years since the complete primary sequence of the intermediate filament (IF) prote

209 gh disordered in solution, inspection of the primary sequence of the linker reveals that positively c

210 holine) vesicles that was dependent upon the primary sequence of the peptide.

211 n of two specific recognition sites into the primary sequence of the polyprotein allows for the selec

212 ositioning of the competing sites within the primary sequence of the pre-mRNA is a predictor of 5' sp

213 ts indicate that HDAg does not recognize the primary sequence of the RNA; rather, the principle contr

214 that binding to AP-1 or AP-3 depends on the primary sequence of the signal and not its position with

215 Further analysis of the primary sequence of the TNT1 region revealed a unique pa

216 ab, F4ac, and F4ad) exist that differ in the primary sequence of their major adhesive subunit FaeG, a

217 the activity of SNAREs should depend on the primary sequence of their TMDs.

218 ong their contour to study the effect of the primary sequence of these polymers on their organization

219 This suggests that subtle changes in the primary sequence of transporter drug binding domains cou

220 Comparative analysis of the primary sequence of TS from a number of mammalian specie

221 nction may be achieved through variations in primary sequence of tubulin isotypes.

222 sed this genome to determine the H. hammondi primary sequence of two major T. gondii mouse virulence

223 se data provide functional evidence that the primary sequences of alpha-actinin-2 and alpha-actinin-3

224 with significant net charge, the very basic primary sequences of ARMs are expected to adopt coil-lik

225 hree decades, molecular data, most obviously primary sequences of DNA and proteins, have provided an

226 pact of nonconservative substitutions in the primary sequences of drug binding domains of sea urchin

227 Without such enzymes, the highly ordered primary sequences of genes would rapidly deteriorate.

228 irectly from the instructions encoded in the primary sequences of natural product BGCs.

229 Although otherwise conserved, the primary sequences of Nrp1 and Nrp2 differ significantly

230 opose a novel numerical vector based on only primary sequences of organism to build their phylogeny.

231 erned substitution of d-amino acids into the primary sequences of self-assembling peptides influences

232 by performing systematic mutagenesis of the primary sequences of the 12 transmembrane segments (TMSs

233 redicting small molecule structures from the primary sequences of the biosynthetic gene clusters.

234 inding to human CPEB3 in vitro, although the primary sequences of the human and C. elegans PUF protei

235 l amino acids and ribonucleotides within the primary sequences of the interacting protein and RNA cha

236 The primary sequences of the Yaps reveal little similarity t

237 Thus, the primary sequences of these elements, but not their secon

238 fy novel tumor-homing ACPPs with no bias for primary sequence or target protease.

239 hich map the distribution of PQs in terms of primary sequence or which categorize PQs.

240 Thus, a specific primary sequence or zippering beyond the SNARE domains i

241 a from heterogeneous data sources, including primary sequence, pathways, domains and interactions.

242 However, primary sequence per se is a poor predictor of function,

243 P isoforms reveals a less complex pattern of primary sequence polymorphism in the rat than the mouse.

244 , caspase-7, which shares the same substrate primary sequence preference as caspase-3, is better at c

245 that T4 RNA ligases do not show significant primary sequence preference in RNA substrates, but are b

246 tribute to the evidence that, in addition to primary sequence, prion species barriers are controlled

247 Three chemical and physical properties of primary sequences: purine, pyrimidine and keto are also

248 sion is determined by small stretches of the primary sequence rather than the secondary structure of

249 ences in the RefSeq collection is the set of primary sequence records submitted to the International

250 myosin interface despite preservation of the primary sequence regions composing it, suggesting an evo

251 47-kDa protein containing three consecutive primary sequence regions that comprise its alpha, beta,

252 oupled to the high level of control over the primary sequence results in a system with significant po

253 and RcnR are quite similar, small changes in primary sequence reveal that the specific mechanisms inv

254 o comprehensively probe the contributions of primary sequence, secondary RNA structure and linear spl

255 The features may come from the primary sequences, secondary or three dimensional struct

256 gical functions despite differences in their primary sequences, secondary structures, or chromosomal

257 However, their primary sequence showed no relationship to any known DNA

258 ssion between species is governed in part by primary sequence similarity between the infectious prion

259 codes an open reading frame with significant primary sequence similarity to intermedilysin (ILY; 69.2

260 a targeted enzyme at a location predicted by primary sequence similarity to only the selected C-extei

261 lack of tertiary structural information and primary sequence similarity to other proteins.

262 no simple relationship between function and primary sequence, so that assigning function is challeng

263 model membranes will inform understanding of primary-sequence-specific antimicrobial mechanisms.

264 However, despite similar primary sequences, structural folds, and affinities for

265 Analysis of the PARP-1 primary sequence suggested that phosphorylation of PARP-

266 played some similarity at the level of their primary sequence, suggesting an ancient coevolution betw

267 C is uniformly distributed along the protein primary sequence, suggesting that intermolecular coevolu

268 n coordinates two zinc ions, analysis of the primary sequence suggests an alternative classification

269 Its primary sequence suggests that the HpxO catalytic activi

270 While we expect there to be elements of primary sequence that affect the process, our experiment

271 evolution of a thermodynamically compromised primary sequence that balances folding, stability, and o

272 nthetic prokaryotes and that is based on the primary sequence that had been assigned as an NADPH-depe

273 structure of the amyloid core residues and a primary sequence that is almost entirely arranged in a r

274 ochemical and biochemical alterations in the primary sequence that trigger the formation of macromole

275 ability of thousands of transit peptide (TP) primary sequences, the structural and/or physicochemical

276 cally to peptidyl fragments of the wild-type primary sequence, themselves obtained by solid-phase pep

277 rate that even with this limited identity in primary sequence, these two proteins share remarkable si

278 methods to predict disorder from a protein's primary sequence, they all were developed using informat

279 ts a new class of substrates that use unique primary sequence to induce allosteric binding, processiv

280 encodes information for the progression from primary sequence to secondary, tertiary, and ultimately

281 t, and length of protein sequences, from the primary sequences to predict crystallizabillity by using

282 information on how subtle changes in protein primary sequence trigger cross-beta fibril formation, wi

283 The entries are linked, when appropriate, to primary sequence (UniProt) and structural (PDB) database

284 nomes and nuclear ribosomal DNA (nR) are the primary sequences used to understand plant diversity and

285 erent levels of heterogeneities ranging from primary sequence variants to post-translational modifica

286 introduce intrinsic heterogeneity including primary sequence variants, varied drug-to-antibody ratio

287 tate to peptides and proteins with unrelated primary sequences, various chain lengths, and widely dif

288 Its primary sequence was determined by combining Edman degra

289 Using evolutionary information encoded in primary sequences, we trained a machine learning classif

290 Interestingly, ribosomal primary sequences were more accurately predicted than no

291 ), a nuclear receptor most similar to CAR in primary sequence, were negligible in human fetal liver t

292 ta-CoVs have diverged significantly in their primary sequences while maintaining the same essential b

293 The inputs of the web server require RNA primary sequences, while corresponding secondary structu

294 This procedure produced an intriguing primary sequence whose structure-function analysis is de

295 of capturing both contiguity information and primary sequence with a single technology.

296 on two primary goals: (i) assimilating known primary sequences with predicted feature data and (ii) p

297 es generally lack the ability to control the primary sequence, with sequence control referred to as t

298 ic analysis detected >60% of the ancient p62 primary sequence, with Western blotting indicating p62 a

299 designed synthetic ribozymes with different primary sequences without altering the secondary structu

300 proteome contain unique insertions in their primary sequences, yet it is largely unclear what effect