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1 o closed intermediate states before opening (priming).
2 nomenon that was greatest for the JE vaccine primed.
3 DCs as a mechanism for pDCs to achieve cross-priming.
4 gen-presenting cells involved in CD4+ T cell priming.
5 c naive CD8+ T cells undergoing intrahepatic priming.
6 -mediated antigen transfer to cDCs for cross-priming.
7 Munc13 mediate synaptic vesicle docking and priming.
8 R receptors via NEDD4/NEDD4L to regulate ISC priming.
9 e large diversity of MBC clones generated by priming.
10 y effects of RBP4 require NLRP3-inflammasome priming.
11 s in cDC1 also prevented early CD4(+) T cell priming.
12 y the I-B system and Cas3 were necessary for priming.
13 tro and has properties of Type I and Type II priming.
14 and soma formation, and then undergo lineage priming.
16 ay be an important source of TAAs for T cell priming(2), several recent studies suggest that infectio
17 hat interstitial macrophage-derived IL-1beta primes a subset of AT2 cells expressing Il1r1 for conver
19 DP, but also observed apparent DA-dependent priming activity, with the ADDD+DADD fraction proving re
20 dynamic metabolomics documented that 5-PAHSA primes adipocytes for glucose metabolism in a different
22 zation with pneumococcus and microaspiration prime AMs, leading to brisker responsiveness to both pne
24 to challenge and indicated the route of both prime and boost to be critical to the location of induce
28 fferentially regulate autophagy and both the priming and activation signals of the NLRP3 inflammasome
30 nfectious inoculum, varying the time between priming and aerosol infection, and testing MAIT cell pri
32 1-mediated immunosuppression during both the priming and effector phases, provokes systemic T cell re
34 mportant role for B cells in indirect T cell priming and further emphasizes the advantage of combinat
35 factor that engages the DNA template for RNA priming and growth and disengages when needed to generat
36 t role in suppressing MYC-mediated apoptosis priming and in protection from drug-induced apoptosis.
38 peralgesic priming with interleukin 6 (IL-6) priming and PGE(2) as a second stimulus as a model for p
40 stimulates the E3 APC/C to promote substrate priming and subsequent multiubiquitination by UBE2C.
41 el interactions that are essential for motor priming and the mode of recognition of its two light cha
44 ia-Hernandez et al. strengthens the case for prime-and-trap malaria vaccines and will greatly aid fur
46 has seen the emergence of immunotherapy as a prime approach to cancer treatment, revolutionizing the
48 terized by decreased mitochondrial apoptotic priming as measured by BH3 profiling, both in PDX models
51 icity data from the open-label 28-d interval prime-boost group (SD/SD D28; n = 10) are also presented
52 a non-randomised, unblinded ChAdOx1 nCoV-19 prime-boost group received a two-dose schedule, with the
56 ort further development of this heterologous prime-boost strategy.IMPORTANCE Immune responses to RSV
58 uggest that the choice of viral sequences in prime-boost vaccine regimens, and potentially adjuvants
60 vation of SNr GABA neurons attenuated heroin-primed, but not cue-induced, reinstatement of drug-seeki
62 efficiently prime gB-CD8s; however, gB-CD8s primed by a concurrent wild-type flank infection infiltr
64 similar in adults born before 1950, presumed primed by natural infection (51%; -8-77%) versus those b
65 hich panic symptoms (e.g., "dizziness") were primed by panic triggers (e.g., "elevator") compared wit
66 an intrinsic abnormality within CD8 T cells primed by rat RHV infection, an effect that is governed
67 on of activated ZIKV-specific CD8(+) T cells primed by recombinant L. monocytogenes is associated wit
68 of Mtf1 and TFB2M play a crucial role in RNA priming by aiding template strand alignment in the activ
71 generate this Tfh-dominant response, whereas priming by conventional dendritic cells was dispensable.
73 icacy would require highly effective in vivo priming by peptide vaccination in the presence of proper
74 ful tool to investigate how natural implicit primes can unconsciously influence decisions with multip
76 rd quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent b
77 ar physicochemical properties that make them prime candidates to explain much of the observed coaller
78 feron I pathway, resulting in enhanced cross-priming capacity of DCs and tumor-specific CD8(+) T cell
80 ed DCs stimulated with specific pathogens to prime CD4 T cells in vitro and found that these T cells
81 efficacy of adoptively transferred in vitro-primed CD8(+) T cells recognizing nonmutated tumor-assoc
83 results indicate the presence of activation-"primed" cell geometries that present higher activation l
85 orted-cell RNA-seq confirmed the presence of PRIME cells in 19 additional patients with rheumatoid ar
87 is manifested by an increased probability of primed cells to engage in target gene expression, correl
88 5-CD31-PDPN+ preinflammatory mesenchymal, or PRIME, cells in the blood from patients with rheumatoid
89 titutive heterochromatin marks and display a primed chromatin landscape, with bivalently marked prime
90 ody mass index: 31 +/- 1 kg m(-2) ) received primed continuous l-[ring-(2) H(5) ]phenylalanine before
91 l synapses, both vesicle absence and vesicle priming contribute to the long recovery from paired-puls
93 itors (VP) generated from normal and disease-primed conventional human induced pluripotent stem cells
94 ivation of cytotoxic CD8(+) T cells by cross-priming DC contributes to exacerbation of postischemic i
97 troma-derived homeostatic cytokine IL-7, and priming diminishes if Il7r is subsequently deleted in vi
100 During each ADP, participants received a priming drink of alcohol followed by 3 1-hour, self-admi
102 nate lymphoid cells, competent enhancers are primed during lineage acquisition, and formation of de n
103 al phenotypic partitioning of macrophages is primed during the resting state, dependent on cumulative
105 everse transcriptase fusions programmed with prime editing guide RNAs (pegRNAs), can edit bases in ma
108 of labile carbon into sediment, we traced a priming effect and assessed the decomposition and export
109 q) of tomato demonstrated that biochar had a priming effect on gene expression and upregulated the pa
111 et of de novo long-range interactions, where primed enhancers are brought in contact with their respe
114 ve immune score as a surrogate of interferon-primed exhausted CD8 + T-cells in the tumor microenviron
117 y associated 2 and 4 (DPPA2/4) as epigenetic priming factors that establish a permissive epigenetic l
119 ormation of glycosidic linkages has been the prime focus for contemporary carbohydrate chemistry.
121 teps: substrate modification with ubiquitin (priming) followed by repetitive ubiquitin-to-ubiquitin a
122 imed Th17 cells resembled that of Th17 cells primed following infection in vivo but was remarkably di
123 ivation of tetrazoles to form nitrile imines primed for 1,3-dipolar cycloaddition reactions is of wid
124 c instability, induced durable immunity, and primed for anamnestic antibody responses, making it an a
125 , respectively), indicating that the vaccine primed for anamnestic responses after natural RSV exposu
126 n being resistant to apoptosis, are actually primed for apoptosis owing to concomitant activation of
128 of a key membrane bound state of FAK that is primed for efficient autophosphorylation and activation,
130 echanism that maintains low HY5 in the dark, primed for rapid accumulation to reprogram growth upon l
135 s platform capable of antigen processing and priming for both CD4(+) and CD8(+) T cells and of the di
136 hypothesized, however, that these mice are "primed" for a corneal inflammatory response, which once
140 ated transcript promoter did not efficiently prime gB-CD8s; however, gB-CD8s primed by a concurrent w
142 Rapid Interface for Modelling and Economics (PRIME) has been used around the world to assess the heal
147 d two SIV vaccine regimens combining mucosal priming immunizations and systemic protein boosting.
148 as (89)Zr-Df-IAB22M2C for PET imaging is of prime importance to identify patients responding early t
150 urified neutrophils from healthy donors were primed in vitro with a papillary TC or ATC cell line con
151 IPK1 in these processes using a model of TLR priming in a TAK1-deficient setting to mimic pathogen-in
154 udy underlines the importance of DC-mediated priming in identifying novel regulators of T cell differ
155 and aerosol infection, and testing MAIT cell priming in nitric oxide synthase 2 (NOS2)-deficient mice
158 played a critical role in pDC-mediated cross-priming independent of their function in antigen present
159 tor/glycoprotein Ibalpha-dependent platelet 'priming' induces integrin alpha(IIb)beta(3) activation t
161 C CB1R in both sexes, sensitivity to cocaine priming injections is greater in females, CORT-potentiat
164 Pox Virus (FPV)-gag pol env-IL-4R antagonist prime, intramuscular (i.m.) recombinant Modified Vaccini
171 ) (10 nm), another characteristic feature of priming, measured as reduction in action potential (AP)
172 Our findings uncover a novel epigenetic priming mechanism at developmental promoters, poising th
173 Marchantia polymorpha has recently become a prime model for cellular, evo-devo, synthetic biological
176 pendent IL-1beta in lipopolysaccharide (LPS)-primed mouse bone marrow-derived dendritic cells (BMDC).
178 Innate and adaptive immune responses that prime myeloid cells, such as macrophages, protect agains
181 ial synchronization among the same subset of Primed Neurons was induced from random dynamics, which a
185 y areas of the interstitium, while NET-prone primed neutrophils were present in arteriolar microthrom
189 ed that CD11c(+) APCs are critical for early priming of CD8 T cells against the immunodominant TMEV p
190 ia with a direct-acting antiviral led to the priming of CD8 T cells with partial effector function, d
192 extensive epigenetic but not transcriptional priming of HSCs/MPPs prior to their lineage commitment.
193 partyl tRNA synthetase IBI1, which activates priming of multiple immune responses, including callose-
195 e in NPR1 protein levels was associated with priming of Pip and SA biosynthesis genes to induction by
197 y and function of the APC(s) involved in the priming of this T cell response is (are) poorly defined.
198 n vitro model of opioid-induced hyperalgesic priming (OIHP), in male rats, to identify nociceptor pop
199 ic animals (confrontation phase) after being primed on the content of the video (anticipation phase).
211 esent a pluripotency state between naive and primed pluripotency and harbor molecular, cellular, and
213 n, the epiblast (Epi) transits from naive to primed pluripotency, before giving rise to the three ger
218 only TXNIP(hi)KAP1(lo) cells, that is, in a primed/prolytic state, turn expression of the replicatio
219 n paradoxically exert antitumor activity and prime protective immunity, the pathways driving this phe
221 S217A enhanced the maximum rate of lever arm priming (recovery stroke) while slowing ATP hydrolysis,
222 luorimetry experiments demonstrated that the priming reduction of LPMO-Cu(II) to LPMO-Cu(I) is a fast
223 T cells in the lung revealed that the airway prime regimen induced more antigen-specific multifunctio
224 ct of higher PfSPZ doses, a novel multi-dose prime regimen, and a delayed vaccine boost upon vaccine
225 ared with the peak responses after the RV144 priming regimen at month 6; however, boosting at month 1
231 ur rejection required cDC1 and CD8(+) T cell priming required the expression of major histocompatibil
233 It has been recently shown that Wnt plays a priming role for ISC self-renewal by inducing RSPO recep
234 2.7% (95% CI, -33.5 to 83.2) with a two-dose priming schedule for infants and 59.1% (95% CI, -31.1 to
236 ion by blunting the MAPK (ERK, JNK)-mediated priming signal of the NLRP3 inflammasome and by regulati
238 The vaccine regimens, especially the mucosal primes, significantly altered the rectal microbiome.
241 t embolism formation during stress, they may prime stems for recovery during rehydration by modifying
242 evidence points towards the need for a tumor priming step to improve intratumoral immune cell infiltr
245 s) in these tails, followed by microhomology-primed synthesis sufficient to resolve broken ends.
246 nts with cancer and thereby enabling them to prime T cells, we develop a general approach for rapid p
247 and adapts to the external environment, is a prime target for exploration of exposomal influences on
248 s with mutated BRCA1 or BRCA2, making APE2 a prime target for homologous recombination-defective canc
249 pression in ocular cells, making LOXL1-AS1 a prime target for investigation in PEX syndrome and glauc
251 smodium parasites and human erythrocytes are prime targets of blood stage malaria vaccine development
254 dritic cells (DCs), which play a key role in priming Tfh responses, were unable to cluster to the int
255 , the transcriptome of in vitro C. rodentium-primed Th17 cells resembled that of Th17 cells primed fo
256 M4-work in concert to remove constraints and prime the channel for rapid opening, facilitating fast s
257 rm survival in 87.5% of GBM-bearing mice and prime the immune system to develop anti-GBM immunologica
259 larmins bind to the Toll-like receptor 4 and prime the nod-like receptor family pyrin domain-containi
262 onstrate that Lef1 expression in fibroblasts primes the adult skin macroenvironment to enhance skin r
263 luding a major structural rearrangement that primes the Cys-122-Cys-66 disulfide for thioredoxin redu
265 tion of sEV secretion and PTX3 protein cargo primes the premetastatic niche and suggests that inhibit
266 trate that the cyclin-dependent kinase CDK-1 primes the recruitment of PLK-2 to the synaptonemal comp
267 ighting the importance of preconditioning or priming the capacity of biomaterials through cell-materi
268 thin the Golgi compartment are essential for priming the capsid to support efficient AAV genome trans
270 contacts and unshields the trimeric S2 core, priming the protein for fusion activation and dissociati
271 ived much attention for their role in T cell priming, there is emerging evidence for a role for monoc
273 e also destabilizing sentinel mRNAs that are primed to activate rescue pathways when m6A levels drop.
274 onstructs is that the MSCs are appropriately primed to differentiate along osteogenic or chondrogenic
275 ted in vivo, suggesting that these cells are primed to grow in the bone, and were enriched in skeleta
277 s subtle nonverbal and verbal conversational primes to influence spectators to choose the three of di
279 sion is structured according to the acronym 'PRIME' to organize the various treatment strategies curr
281 d stand establishments were enhanced by seed priming, total phenolics radical-scavenging activities,
282 neration of mesenchyme-free HIOs that can be primed towards more colonic or proximal intestinal linea
283 have a common epigenetic configuration that primes transcriptional program for embryonic development
284 a comprehensive miRNA profiling of naive-to-primed transition in hPSC, a process recapitulating aspe
286 cDC1s but not cDC2s were required for cross-priming upon pDC-targeted vaccination, suggesting that c
288 standard doses of ChAdOx1 nCoV-19, after the prime vaccination local reactions were reported in 43 (8
289 d that, although ribbon synapses deliver and prime vesicles faster than most conventional synapses, b
291 reduction, including lymphodepletion, T cell priming via immunogenic cell death, and inflammation; al
293 revealed that the MeApv mediates aggression priming via synaptic connections with the ventromedial h
295 ally pre-conditioning on a soft matrix (soft priming) will delay adipose-derived stem cell (ASC) tran
296 ot ganglion (DRG) neurons cultured from rats primed with fentanyl, robust nociceptor population-speci
300 elicited in standard vaccine test animals by priming with the most prevalent N-terminal 8 residues of