ライフサイエンスコーパス: priming

1 o improvements in behavior (e.g., repetition priming).

2 o closed intermediate states before opening (priming).

3 R receptors via NEDD4/NEDD4L to regulate ISC priming.

4 e large diversity of MBC clones generated by priming.

5 y effects of RBP4 require NLRP3-inflammasome priming.

6 ct with enzyme having a stronger impact than priming.

7 property to pair with Ubc6 over Ubc7 during priming.

8 lyceollin content than R-elicitation without priming.

9 in naive adaptation, was also essential for priming.

10 iates hemocyte differentiation during immune priming.

11 evant tissues; and facilitated antigen cross-priming.

12 mbination with the effects of light and seed priming.

13 s critical for CD4(+) T cell development and priming.

14 r Prlr signaling contributes to hyperalgesic priming.

15 d with agents that reverse Type I or Type II priming.

16 uring disease and draining lymph node during priming.

17 s in cDC1 also prevented early CD4(+) T cell priming.

18 CD40 is sufficient to synergize with ICB for priming.

19 y the I-B system and Cas3 were necessary for priming.

20 ion, although it did promote systemic immune priming.

21 tro and has properties of Type I and Type II priming.

22 in APCs, resulting in more efficient T cell priming.

23 evidence of both clinical and immunological priming.

24 ays and genes related to DC-induced Tfh-cell priming.

25 ional profile, but had also initiated T cell priming.

26 direct evidence that Hrd1 uses Ubc7 also for priming.

27 soluble or IO-NP trimers after PADRE peptide priming.

28 and soma formation, and then undergo lineage priming.

29 DCs as a mechanism for pDCs to achieve cross-priming.

30 gen-presenting cells involved in CD4+ T cell priming.

31 c naive CD8+ T cells undergoing intrahepatic priming.

32 -mediated antigen transfer to cDCs for cross-priming.

33 Munc13 mediate synaptic vesicle docking and priming.

34 than 4-fold compared to elicitation without priming (1.9 +/- 0.4 umol/g DW).

35 (+) T cells 'license' cDC1 for CD8(+) T cell priming(12).

36 ay be an important source of TAAs for T cell priming(2), several recent studies suggest that infectio

37 ations of visible light by electrochemically priming a photocatalyst prior to excitation.

38 receptor (MOR) agonists produce hyperalgesic priming, a form of maladaptive nociceptor neuroplasticit

39 in aggressive behavior, known as aggression priming, activates neurons within the posterior ventral

40 DP4-DP12, which were tested for elicitor and priming activities in rice cells.

41 signficantly increased were assayed for PMN priming activity in vitro.

42 DP, but also observed apparent DA-dependent priming activity, with the ADDD+DADD fraction proving re

43 ases and observed significant differences in priming activity.

44 antigen presentation, and mediate CD8 T cell priming against foreign antigens.

45 This priming allowed for effective induction of caspase-1-dep

46 -pH-sensitive nanoparticle, PC7A, capable of priming an efficacious immune response without significa

47 he literature to provide a current update on priming and activating signals required for NLRP3 inflam

48 pite these studies, our understanding of the priming and activation events that lead to NLRP3 inflamm

49 from key cells involved in asthma can induce priming and activation of other asthma-associated cells.

50 fferentially regulate autophagy and both the priming and activation signals of the NLRP3 inflammasome

51 -1 and pro-IL-1beta, indicating inflammasome priming and activation.

52 nfectious inoculum, varying the time between priming and aerosol infection, and testing MAIT cell pri

53 molecular dynamics, demonstrate how specific priming and atypical sequence adaptations tune the motor

54 In an intramuscular protein priming and boosting regimen in mice, these proteins ind

55 ty by regulating granule localization and/or priming and calcium signaling in concert.

56 pDC-targeted vaccination led to strong cross-priming and durable CD8 T cell immunity.

57 1-mediated immunosuppression during both the priming and effector phases, provokes systemic T cell re

58 oth reactions in collaboration with specific priming and elongating E2 enzymes.

59 mportant role for B cells in indirect T cell priming and further emphasizes the advantage of combinat

60 factor that engages the DNA template for RNA priming and growth and disengages when needed to generat

61 ng of promoter DNA, but how they support RNA priming and growth was not understood.

62 t role in suppressing MYC-mediated apoptosis priming and in protection from drug-induced apoptosis.

63 -deficient setting to mimic pathogen-induced priming and inhibition.

64 models, dMLH1 tumors potently induce T cell priming and lose resistance to checkpoint therapy indepe

65 n, suggesting key roles in both naive T cell priming and memory T cell responses.

66 peralgesic priming with interleukin 6 (IL-6) priming and PGE(2) as a second stimulus as a model for p

67 t rather occurs at gaps formed by PrimPol re-priming and resection by MRE11 and EXO1.

68 immune system activation, mesenchymal tissue priming and so-called 'remote' (non-immune and non-artic

69 stimulates the E3 APC/C to promote substrate priming and subsequent multiubiquitination by UBE2C.

70 el interactions that are essential for motor priming and the mode of recognition of its two light cha

71 a quantitative measure of chromatin lineage-priming and use it to predict cell fate outcomes.

72 , the ESR subset of hPSC displays no lineage priming, and that it can be clearly distinguished from g

73 san-lactate (CL) nanoparticles to facilitate priming anti- tumor T cells by tumor lysate-loaded DC va

74 y retained ICEp presenting a high density of priming antigens activated CAR T cells, driving local tu

75 Clec9a(-/-) mice deficient in DC cross-priming are protected from persistent immune-mediated my

76 terized by decreased mitochondrial apoptotic priming as measured by BH3 profiling, both in PDX models

77 Low concentrations of IL-12 during T-cell priming biases immune responses toward T(H)2.

78 se (MAPK) inhibitors, which reverses Type II priming, both partially attenuated OIHP.

79 oward the active, dimeric conformation, thus priming BRAF(D594G) as an effective allosteric activator

80 cDC1 was critical not only for CD8(+) T cell priming, but also for initial CD4(+) T cell activation.

81 ic cell subset (cDC1) for optimal CD8 T cell priming, but the underlying mechanism has remained uncle

82 of Mtf1 and TFB2M play a crucial role in RNA priming by aiding template strand alignment in the activ

83 We also found that CD4+ T cell priming by B cells was both necessary and sufficient to

84 that is also a preferred initiation site for priming by CCPol-MP.

85 generate this Tfh-dominant response, whereas priming by conventional dendritic cells was dispensable.

86 the crypt stem cell regions and regulate ISC priming by degrading LGR receptors.

87 icacy would require highly effective in vivo priming by peptide vaccination in the presence of proper

88 ction typically requires two signals: first, priming by recognition of pathogen-associated molecular

89 ccordingly, gcn2 displayed defects in immune priming by the fungal elicitor, chitin.

90 Once established, priming can also be maintained by the stroma-derived hom

91 in DC dampened type I IFN production and the priming capacity of DC.

92 feron I pathway, resulting in enhanced cross-priming capacity of DCs and tumor-specific CD8(+) T cell

93 ilencing of CTLA-4 can potentiate the T cell priming capacity of the DC vaccine, proposing a practica

94 rid myeloid features, capable of efficiently priming CD4(+) as well as CD8(+) T cells.

95 cells(2,3), whereas cDC2 are specialized for priming CD4(+) T cells(4,5).

96 d antigen-naive cDCs the capability of cross-priming CD8 T cells by transferring antigens to cDCs.

97 l synapses, both vesicle absence and vesicle priming contribute to the long recovery from paired-puls

98 ivation of cytotoxic CD8(+) T cells by cross-priming DC contributes to exacerbation of postischemic i

99 Cross-priming DC have the ability to activate both CD4(+) help

100 This study investigates a role for cross-priming DC in post-myocardial infarction immunopathology

101 A diverse DC population, including cross-priming DC, is present in the heart and activated after

102 y of complex immune responses, including the priming, differentiation, and modulation of specific eff

103 troma-derived homeostatic cytokine IL-7, and priming diminishes if Il7r is subsequently deleted in vi

104 r data provide rationale for adding an extra priming dose to those aged >=50 years.

105 x1 nCoV-19 is safe and better tolerated than priming doses.

106 During each ADP, participants received a priming drink of alcohol followed by 3 1-hour, self-admi

107 Doa10 cooperates with the dedicated priming E2, Ubc6, while both E3s use Ubc7 for elongation

108 post-translational histone modifications on priming early mammalian development is just emerging(1-4

109 of labile carbon into sediment, we traced a priming effect and assessed the decomposition and export

110 This panic-priming effect in patients (compared with control subjec

111 q) of tomato demonstrated that biochar had a priming effect on gene expression and upregulated the pa

112 TLR9L also inhibited the priming efficacy of 2'3'-cGAMP.

113 e" HSV-1 genes either delayed or reduced the priming efficiency of gB-CD8s and their levels in the TG

114 e S1/S2 region, suggesting that KLK13 is the priming enzyme for this virus.

115 in human B cells is dependent on a metabolic priming event driven by cholesterol metabolism.

116 that memory encoding leads to an epigenetic priming event, marked by increased accessibility of enha

117 clonotypes reveal the presence of recurrent priming events manifesting in a dominant T-cell clonotyp

118 what extent such ligands can facilitate the priming events that generate antigen-specific effector a

119 timulation, and were necessary for the early priming events to occur.

120 Reduced priming explained the partial agonism of tryptamine; how

121 us adenosine triphosphate, PRL inhibited the priming (expression of Il1b and Nlrp3) and blocked the r

122 y associated 2 and 4 (DPPA2/4) as epigenetic priming factors that establish a permissive epigenetic l

123 mitment states characterized by multilineage priming followed by gradual T cell commitment.

124 teps: substrate modification with ubiquitin (priming) followed by repetitive ubiquitin-to-ubiquitin a

125 s platform capable of antigen processing and priming for both CD4(+) and CD8(+) T cells and of the di

126 ells, with increased baseline IFN production priming for inflammatory cell activation, immune respons

127 ed video and live performances of the mental priming force.

128 pe and Clec9a-depleted mice lacking DC cross-priming function.

129 es an instructive function to the offspring, priming future gene activation.

130 ctive and repressed TSS and is important for priming genes for rapid transcriptional activation.

131 For 16S rRNA, both enzyme and priming had a significant effect with enzyme having a st

132 This knowledge of apoptotic priming has paved the way for new therapies that trigger

133 This work shows that V1V2 scaffold DNA priming immunization provides a method to focus immune r

134 cal target in RV144 developed only after the priming immunization with V1V2 DNA.

135 d two SIV vaccine regimens combining mucosal priming immunizations and systemic protein boosting.

136 n clinical trial as a candidate bnAb vaccine priming immunogen.

137 better understand parental or developmental priming impacts on the processes of offspring recruitmen

138 IPK1 in these processes using a model of TLR priming in a TAK1-deficient setting to mimic pathogen-in

139 ancers are established de novo without prior priming in earlier stages.

140 fines safety and response rate of epigenetic priming in ER-positive breast cancer patients treated wi

141 ecessary for the development of hyperalgesic priming in female, but not male, mice.

142 .8(+) neurons was necessary for hyperalgesic priming in female, but not male, mice.

143 udy underlines the importance of DC-mediated priming in identifying novel regulators of T cell differ

144 We conclude that intranasal MAIT cell priming in mice induces early MAIT cell activation and e

145 and aerosol infection, and testing MAIT cell priming in nitric oxide synthase 2 (NOS2)-deficient mice

146 s are needed to clarify whether hyperalgesic priming in nonpeptidergic afferents or repeated acid inj

147 is independent of dendritic cells and T-cell priming in the draining lymph nodes.

148 red conventional DCs (cDCs) to achieve cross-priming in vivo by transferring antigens to cDCs.

149 nse to stiffness following two weeks of soft priming including decreased cell area, actin coherency,

150 played a critical role in pDC-mediated cross-priming independent of their function in antigen present

151 transcripts diversity were obtained with GS priming indicating this approach was better at recoverin

152 tor/glycoprotein Ibalpha-dependent platelet 'priming' induces integrin alpha(IIb)beta(3) activation t

153 L-P complexes, suggests differences between priming/initiation and elongation complexes.

154 Four stacked, priming injections (multi-dose priming) showed 40% VE ag

155 C CB1R in both sexes, sensitivity to cocaine priming injections is greater in females, CORT-potentiat

156 ry could be selectively induced by different priming input dynamics.

157 wing mucosal adenovirus (Ad)-SIV recombinant priming, intramuscular SIV envelope boosting and infecti

158 In essence, T cell priming involves a tug-of-war between the cytoskeletons

159 ring protein quality control by showing that priming is the rate-determining step in protein degradat

160 evidences the possibility that other virus-"priming" ligands may also be nonessential activating cof

161 The putative priming loop that is important for the initiation of RNA

162 Finally, drug-induced mitochondrial priming measured by dynamic BH3 profiling (DBP) identifi

163 ) (10 nm), another characteristic feature of priming, measured as reduction in action potential (AP)

164 Our findings uncover a novel epigenetic priming mechanism at developmental promoters, poising th

165 This priming mechanism is genetically separable from the mech

166 ture of the BLMP-1-dependent transcriptional priming mechanism is that chromatin decompaction is init

167 s neurotransmitter release, regulate vesicle priming, mediate augmentation, and regulate transmission

168 decrease in the duration of the hyperalgesic priming model of chronic pain.

169 smission in these circuits blocks aggression priming, naturally occurring aggression, and traumatic s

170 The mechanisms by which this heritable priming occurs are largely unknown.

171 us eruptions or liver injury consistent with priming of an immune response.

172 Unexpectedly, early priming of CD4(+) T cells against tumour-derived antigen

173 ed that CD11c(+) APCs are critical for early priming of CD8 T cells against the immunodominant TMEV p

174 l growth factor C (VEGF-C) promotes enhanced priming of CD8 T cells in the draining deep cervical lym

175 tation by dendritic cells in vitro and cross-priming of CD8 T cells in vivo.

176 ia with a direct-acting antiviral led to the priming of CD8 T cells with partial effector function, d

177 Priming of CD8(+) T cells by dendritic cells (DCs) is cr

178 Priming of CD8(+) T cells induces a TNIK-dependent nucle

179 However, the functional consequence of LEC priming of CD8(+) T cells is unknown.

180 Studies show, however, that DC vaccine priming of cytotoxic T lymphocytes (CTLs) requires the a

181 -2D(b)-deficient LysM(+) APCs retained early priming of D(b):VP2(121-130) epitope-specific CD8 T cell

182 imulates STING signaling and increases cross-priming of dendritic cells after anti-CD47 treatment.

183 ping showed similar skews in transcriptional priming of DNMT3A-mutated human clonal hematopoiesis bon

184 eracted by promoted decomposition due to the priming of downward-moving new SOC from upper layers on

185 extensive epigenetic but not transcriptional priming of HSCs/MPPs prior to their lineage commitment.

186 nance of interferon gamma (IFNgamma)-induced priming of human cells.

187 ited neutralization breadth involves vaccine priming of immune responses against a target site of vul

188 partyl tRNA synthetase IBI1, which activates priming of multiple immune responses, including callose-

189 We have examined the priming of naive CD4 T cells in vitro at fever temperatu

190 Priming of naive T cells from healthy donors with aberra

191 ptive network, which could contribute to the priming of pain pathways by early tissue damage.

192 e in NPR1 protein levels was associated with priming of Pip and SA biosynthesis genes to induction by

193 Mechanistically, amisyn interferes with the priming of secretory vesicles and the sizes of releasabl

194 induction of IL-12/23p40 in DCs may promote priming of T helper 1 (Th1) responses.

195 TLR priming of TAK1-deficient macrophages triggered inflamma

196 e-1, independent of inflammasome, in optimal priming of Th17 responses.

197 bility, which could in turn impinge upon the priming of the adaptive immune system.

198 These findings suggest a strong and early priming of the public fetal-derived Vgamma9Vdelta2 T cel

199 y and function of the APC(s) involved in the priming of this T cell response is (are) poorly defined.

200 tumor draining lymph node to initiate cross-priming of tumor-reactive cytotoxic CD8(+) T cells.

201 ction in the proximal gut involves bile acid priming of type III interferon.

202 ion onto mature projection neurons, and the "priming" of nociceptive circuits in the developing spina

203 d autotrophic C inputs have led to positive 'priming' of soil organic matter, resulting in SOC loss,

204 lation mediating opioid-induced hyperalgesic priming (OIHP), a model of pain chronification, and eluc

205 n vitro model of opioid-induced hyperalgesic priming (OIHP), in male rats, to identify nociceptor pop

206 Seed hydro-priming or pre-soaking for 24 h also improved traits ass

207 Seed hydro-priming or pre-soaking increased emergence by 7-10% over

208 , together with seed pre-treatment via hydro-priming or presoaking can enhance germination and seedli

209 activity-dependent inhibition of vesicle un-priming or release site activation as novel facilitation

210 aggression and bystander behavior, including priming or winner/loser effects.

211 ntrathecal cordycepin, which reverses Type I priming, or the combination of Src and mitogen-activated

212 An automatic semantic priming paradigm specifically tailored for panic disorde

213 However, these free choice priming paradigms present participants with very few alt

214 ional profiles dictated by the nature of the priming pathogen.

215 presentations, the so-called partial-overlap priming pattern.

216 's trajectory during an initial first month "priming period" largely determines how the situation unf

217 we found that BTK bound to NLRP3 during the priming phase of inflammasome activation and, in doing s

218 lly related states-akin to a transcriptional priming phenomenon-the underlying transition dynamics be

219 LAM did not induce any of the classical PMN priming phenotypes, including enhancement of NADPH oxida

220 e receptor (SUCNR1) inhibition abrogated PMN priming, PMN sequestration, and ARDS.

221 Stimulated microbial co-metabolism (priming) potentially increases export of refractory orga

222 ROS-priming prior to elicitation provides opportunities for

223 Of those tested, only IFN-gamma priming prior to MEK inhibitor treatment resulted in gre

224 ROS-priming prior to R-elicitation (ROS + R) increased glyce

225 increased CR3 expression following TNF-alpha priming, production of reactive oxygen species (ROS), an

226 S217A enhanced the maximum rate of lever arm priming (recovery stroke) while slowing ATP hydrolysis,

227 luorimetry experiments demonstrated that the priming reduction of LPMO-Cu(II) to LPMO-Cu(I) is a fast

228 ared with the peak responses after the RV144 priming regimen at month 6; however, boosting at month 1

229 tenuated by inhibitors of Type I and Type II priming, remains to be elucidated.SIGNIFICANCE STATEMENT

230 ur rejection required cDC1 and CD8(+) T cell priming required the expression of major histocompatibil

231 Interestingly, Mtb LAM did not abrogate priming responses elicited by Pam(3)CSK(4) Notably, subf

232 n of cytokines but does not elicit early PMN priming responses, as seen with Pam(3)CSK(4) We speculat

233 It has been recently shown that Wnt plays a priming role for ISC self-renewal by inducing RSPO recep

234 This work revealed: (1) a priming role of platelet adhesion in thrombus contractio

235 2.7% (95% CI, -33.5 to 83.2) with a two-dose priming schedule for infants and 59.1% (95% CI, -31.1 to

236 l immunization program at a reduced two-dose priming schedule for infants, with a 12-month booster.

237 9.1% (95% CI, -31.1 to 87.2) with a two-dose priming schedule plus a booster at 1 year).

238 Four stacked, priming injections (multi-dose priming) showed 40% VE against heterologous CHMI, while

239 Ep were injected intratumorally to present a priming signal for systemically administered AND-gate CA

240 ion by blunting the MAPK (ERK, JNK)-mediated priming signal of the NLRP3 inflammasome and by regulati

241 Although MAIT cell priming significantly enhanced MAIT cell activation and

242 , these shifts trace back to transcriptional priming skews in uncommitted hematopoietic stem cells.

243 hrough a new mechanism called singlet oxygen priming (SOP), the singlet oxygen leads to hydroperoxide

244 commitment and show how pervasive epigenetic priming steers endocrine cell fates.

245 only mediated TLR2 signaling to initiate the priming step of NLRP3 activation but also modulated EV b

246 evidence points towards the need for a tumor priming step to improve intratumoral immune cell infiltr

247 In this study, we tested whether a MAIT cell priming strategy could protect against aerosol Mycobacte

248 Both enzyme and priming strategy greatly affected quantification of the

249 Inversely, for amoA only the change in priming strategy resulted in significant differences bet

250 We demonstrate that AAA4 controls the priming stroke of the motion-generating linker, which co

251 4) molecules are one of the main barriers in priming T cells by DCs.

252 ote tumor antigen-specific immune responses, priming T cells that can be used to control tumor growth

253 Patients also made more errors on the masked priming task than healthy control subjects and the types

254 In the masked priming task, positive and negative compatibility effect

255 d automatic motor inhibition with the masked priming task.

256 r commercial reverse transcriptases with two priming techniques to faithfully transcribe 16S rRNA and

257 dritic cells (DCs), which play a key role in priming Tfh responses, were unable to cluster to the int

258 provide a more complete description of CheY priming than proposed thus far.

259 m of hormetic conditioning, or environmental priming that elicits stimulatory effects.

260 ighting the importance of preconditioning or priming the capacity of biomaterials through cell-materi

261 thin the Golgi compartment are essential for priming the capsid to support efficient AAV genome trans

262 epressed, can be sensitized to compound 1 by priming the cells with the drugs EPZ-6438 (tazemetostat)

263 dent thrombin generation was increased after priming the endothelium with TNF-alpha, our data suggest

264 pment, and the possibility of lung clocks in priming the fetus for postnatal life.

265 retion to accelerate pulmonary metastasis by priming the premetastatic niche.

266 contacts and unshields the trimeric S2 core, priming the protein for fusion activation and dissociati

267 l immune activity within tumors after immune priming therapy, warrants further investigation into its

268 ived much attention for their role in T cell priming, there is emerging evidence for a role for monoc

269 Furthermore, immunological priming through the rectal mucosa with an attenuated ZIK

270 atorial approach based on epigenetic therapy priming to overcome resistance to immunotherapy in pancr

271 cancer cells, UBR5 suppressed MYC-dependent priming to therapy-induced apoptosis.

272 d stand establishments were enhanced by seed priming, total phenolics radical-scavenging activities,

273 We next examined whether astrocyte-priming underlies TGLI1-mediated brain tropism and found

274 e display enhanced liver injury and fibrosis priming upon MCDD challenge.

275 cDC1s but not cDC2s were required for cross-priming upon pDC-targeted vaccination, suggesting that c

276 Seed priming uses treatments to improve seed germination and

277 Priming vaccination with DNA expressing the HIV recombin

278 144 regimen at varying intervals between the priming vaccine series and the boost.

279 lpha pretreatments lead to opposite effects, priming versus desensitization, depending on input durat

280 Munc18-1 to initiate SNARE assembly, thereby priming vesicles for fast calcium-triggered vesicle fusi

281 reduction, including lymphodepletion, T cell priming via immunogenic cell death, and inflammation; al

282 s and activates synaptic vesicle docking and priming via Munc13-1.

283 revealed that the MeApv mediates aggression priming via synaptic connections with the ventromedial h

284 e dose escalation of PfSPZ using single dose priming was not significantly protective.

285 Furthermore, ROS-priming was superior to two physical primers which were

286 owever, equilibrium constants for gating and priming were similar for 5-HT and terpenoid activation.

287 ic depression protocol suppresses aggression priming, whereas high-frequency stimulation enhances agg

288 ally pre-conditioning on a soft matrix (soft priming) will delay adipose-derived stem cell (ASC) tran

289 Priming with 1 and 25Hz rTMS can augment the benefits of

290 We demonstrated that priming with a DNA vaccine expressing only the HIV Env V

291 of the present study demonstracted that seed priming with AgNPs can enhance seed germination, growth,

292 nducing tumor-associated antigen (TAA) cross-priming with antitumor CD8+ T cell elicitation and absco

293 Priming with appropriate vaccines may thus be beneficial

294 Mucosal priming with chitosan and DC programming may hold great

295 we developed a vaccine regimen that included priming with DNA expressing an HIV V1V2 trimeric scaffol

296 In conclusion, priming with DNA expressing the trimeric V1V2 scaffold a

297 on-independent manner, which was enhanced by priming with interferon gamma (IFNgamma).

298 We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE(2) as

299 Priming with reactive oxygen species (ROS) prior to elic

300 elicited in standard vaccine test animals by priming with the most prevalent N-terminal 8 residues of