ライフサイエンスコーパス: primitive

1 molecules in host cells and tissues remains primitive.

2 g to demonstrate that number is a conceptual primitive.

3 t our hypothesis that the OCP2 is relatively primitive.

4 ally depleted by melt extraction rather than primitive.

5 adult animals, comprising motor synergies or primitives.

6 melt is provided by X-ray microtomography of primitive achondrite Northwest Africa (NWA) 2993.

7 ative core formation in the parent bodies of primitive achondrites.

8 Primitive AML cells exhibited dysregulated transcription

9 n shown to promote short-term maintenance of primitive AML cells in culture, no work to date has exam

10 is membrane network is conserved in maturing primitive and definitive erythroblasts despite their res

11 oietic ontogeny is characterized by distinct primitive and definitive erythroid lineages.

12 le cranium that shares with DNH 7 a suite of primitive and derived features unlike those seen in adul

13 We conclude that Erf is required for both primitive and erythromyeloid progenitor waves of hematop

14 xpansions associated with the segregation of primitive and fat-tailed phenotypes.

15 The mechanical behavior of primitive and gyroid schwartzite structures across diffe

16 in PBG apoptosis and differentiation from a primitive and pluripotent (homeobox protein Nanog+/ sex-

17 aintaining the normal encoding of behavioral primitives and forming a sparse link between the LFP spi

18 nd densely functional neuromorphic computing primitives, and energy-efficient validation of neuroscie

19 rmined by growing evidence for sleep in very primitive animals, and thus a very early origin in evolu

20 uc family fluoride channels are assembled as primitive antiparallel homodimers.

21 Here, we show that, globally, primitive arc magmas have Li contents and Li/Y ratios si

22 ti-dimensional tasks in which a set of fixed primitives are each able to compensate for errors in a s

23 ck of such methods is that the decomposition primitives are usually presumed from the onset, which ma

24 xt of nanotechnology, our demonstration that primitive assemblers may arise from simple phase separat

25 re then sometimes inferred to be products of primitive biosynthesis, which can stretch the limits of

26 he epiblast, but the mechanisms that specify primitive blood cells are still largely unknown.

27 mo erectus, or whether H. erectus had a more primitive body shape that was distinct from both the mor

28 at the near-Earth asteroid (101955) Bennu, a primitive body that represents the objects that may have

29 compatible with the relatively stocky, more primitive, body shape of H. erectus.

30 Expressing those primitive bona fide CHIs in the Arabidopsis chi mutant r

31 resent an interesting group for the study of primitive brain features, most likely present in the anc

32 on effects on offspring LTL in Soay sheep, a primitive breed experiencing strong sperm competition.

33 Such edible cryptographic primitives can play an important role in pharmaceutical

34 somatic equivalents of blastomeres, the most primitive cancer stem cells reported to date.

35 Examination of E13.5 limb skin showed a primitive capillary network with increased branching com

36 monolayer and organization of the cells into primitive capillary-like assemblies in 3D sea sponge sca

37 h asteroid (162173) Ryugu is thought to be a primitive carbonaceous object that contains hydrated min

38 a2 sample-return mission, is thought to be a primitive carbonaceous object.

39 eved substantial expansion of phenotypically primitive CD34(+) cord blood and bone-marrow-derived HSP

40 ses were also obtained efficiently from both primitive (CD34+CD38-) and late granulocyte-macrophage p

41 could have driven the growth and division of primitive cell membranes.

42 CuO(4+delta), with only one CuO(2) layer per primitive cell, is an ideal system to tackle this puzzle

43 cell signature suggesting a therapy-induced primitive cell-state transition, whereas those present a

44 (3), despite its highly symmetric and simple primitive cell.

45 oblastoma, a tumor arising in childhood from primitive cells of the sympathetic nervous system.

46 stem cell (iPSC) lines and found these more primitive cells to be susceptible to infection but not p

47 d existence of an autocrine loop promote CML-primitive cells' TKI resistance.

48 biotic pathways that led to the emergence of primitive cells.

49 etwork topologies within their corresponding primitive cells.

50 onic stem cells, thereby phenocopying a more primitive cellular state.

51 ents a combination of derived and apparently primitive character states that are not seen in other th

52 therto unobserved combination of derived and primitive character states.

53 ulted in taxa with unusually high numbers of primitive characters.

54 dies are chemically fractionated compared to primitive, chondritic meteorites and, by inference, the

55 are also present in Nematodes, Cnidaria and primitive chordates, this method could also have high po

56 er abundance of heteroatoms than in IOM from primitive (CI,CM,CR) carbonaceous chondrites, and thus i

57 with functional assays, we demonstrate that primitive CML cells rely on upregulated oxidative metabo

58 Chondritic meteorites are composed of primitive components formed during the evolution of the

59 with amphibians and helps to understand the primitive condition that would have characterized the co

60 s several characters that exhibit putatively primitive conditions not encountered in the family Chann

61 Another circuit primitive-content addressable memory (CAM)-shows great p

62 on of the developing cortex, also termed the primitive cortical zone.

63 y of ~60%, about 3 times higher than that of primitive Cu nanowires, and even surpasses the most effi

64 charged phase changes the structure from the primitive cubic ([Formula: see text]) to the double diam

65 report water vapor sorption studies on four primitive cubic, pcu, pillared square grid materials: SI

66 liferative Hopx(+) neural progenitors in the primitive dentate region, and they, in turn, generate gr

67 Echinoderms are among the most primitive deuterostomes and have been used as model orga

68 sensor could be considered suitable for the primitive diagnosis of several chronic diseases, manifes

69 velopment has been considered to reflect the primitive dinosaurian condition.

70 g dynamical models utilizing dynamical motor primitives (DMPs) of human multiagent coordination that

71 These primitive EC clones further give rise to cells of endoth

72 dge, the first report that clonally enriched primitive ECs promote occlusive pulmonary arteriopathy a

73 The same primitive ECs showed a limited ability for mesenchymal l

74 function creates widespread dysregulation of primitive elements of the GRN.

75 ation of immature smooth muscle cells in the primitive embryonic dorsal aorta establishes the long-li

76 hanism to ensure the progressive assembly of primitive embryonic tissues.

77 pecification of the inner cell mass (ICM) to primitive endoderm (PE) and epiblast (EPI).

78 ll mass (ICM), followed by epiblast (EPI) or primitive endoderm (PE) specification within the ICM.

79 evealed hPFCs share hallmark properties with primitive endoderm (PrE) and can be regulated by non-can

80 by-stage analysis of EPI and extra-embryonic primitive endoderm (PrE) formation during preimplantatio

81 ) is the key signal driving specification of primitive endoderm (PrE) versus pluripotent epiblast (EP

82 ophectoderm (TE), the epiblast (Epi) and the primitive endoderm (PrE).

83 bryo, and surrounding it the extra-embryonic primitive endoderm and the trophectoderm tissues.

84 transcriptional signatures of the epiblast, primitive endoderm and trophectoderm, and identify deepl

85 Primitive endoderm cells displayed higher overall levels

86 show distinct embryonic-abembryonic axes and primitive endoderm differentiation and can initiate the

87 eversibly progress from pluripotency towards primitive endoderm while retaining their capacity to re-

88 cells) and pre-implantation embryos towards primitive endoderm, and inhibiting ERK supports ES cell

89 nalysis revealed development trajectories of primitive endoderm, trophectoderm, epiblast lineages, an

90 ng of the second extra-embryonic tissue, the primitive endoderm.

91 nucleic acids, could have originated in the primitive environment, though most contemporary biomonom

92 his ES cell line, we observed that the first primitive erythroblasts are detected in vitro around day

93 Primitive erythroblasts are the first blood cells genera

94 We found that primary primitive erythroblasts express the major membrane skele

95 .1 R isoform switching and protein 4.1R-null primitive erythroblasts fail to establish normal membran

96 We conclude that maturing primitive erythroblasts initially navigate the embryonic

97 Membrane deformability and stability of primitive erythroblasts, assayed by microfluidic studies

98 and composition of the membrane skeleton in primitive erythroblasts, which progressively mature whil

99 s demonstrate that both in vivo and in vitro primitive erythrocytes are generated from hemogenic endo

100 d the presence of avascular blood islands of primitive erythroid cells expressing hemangioblast marke

101 H1 hemoglobin gene expressed specifically in primitive erythroid cells.

102 ddition, avascular isolated cells expressing primitive erythroid, hemangioblast and endothelial maker

103 To selectively investigate primitive erythropoiesis, we have engineered a new trans

104 feature not only of definitive, but also of primitive, erythropoiesis in mammals.

105 While MCU alone can transport Ca(2+) in primitive eukaryotes, metazoans require an essential sin

106 trinsic disorder, supported through a short, primitive exit tunnel.

107 e that shedding involved tooth resorption, a primitive feature in bony fishes, but absent in sharks a

108 red neural mechanisms to extract motion as a primitive feature of the visual world [1].

109 HSC and may provide new tools to manipulate primitive features in HSC for clinical applications.

110 eratodontiformes, which retained most of the primitive features of ancient lobe finned-fishes.

111 o and presents a mixture of modern human and primitive features.

112 amming long-lived somatic cells in vivo to a primitive, fetal-like, and proliferative state.

113 pose a new paradigm based on mature parallel primitives for generating GLRLMs and extracting multiple

114 ss of analog and probabilistic computational primitives for hardware implementation of statistical ne

115 At the protein level, starting with a primitive form in cyanobacteria, RCA of chlorophytes evo

116 Here we report a primitive form of artificial phagocytosis in a binary co

117 -dependent microbial behaviour, represents a primitive form of microbial memory.

118 cycles; and produce surfactants relevant to primitive forms of biological compartmentalization.

119 However, more primitive forms of photosynthesis that fix CO(2) into bi

120 ut they do not represent ancestral groups or primitive forms.

121 The study of primitive fossil insect nymphs has revealed that wings d

122 of chondritic meteorites, which in turn are primitive fragments of planetary bodies.

123 aluations and cost-benefit decisions made by primitive generalist foragers.

124 isode and to what extent they have preserved primitive genetic characters, we analysed retroviral ins

125 cleavage and hydrolysis, which would degrade primitive genetic information and lead to an accumulatio

126 At the start of life, the origin of a primitive genome required individual replicators, or gen

127 ing a beating cardiac tissue near a putative primitive gut-like tube, from which it is separated by a

128 haemogenic endothelium, which only produced primitive haematopoietic progenitors.

129 line, where they meet and fuse to create the primitive heart tube.

130 ckdown does not affect erythropoiesis during primitive hematopoiesis (no effect on gata1 or h-bae1) o

131 Our results show that Nanog regulates primitive hematopoiesis by directly repressing critical

132 erived macrophages, microglia originate from primitive hematopoiesis in the embryonic yolk sac and se

133 lantation stages, we found that Nanog blocks primitive hematopoiesis in the gastrulating embryo, resu

134 These cells are generated through primitive hematopoiesis in the yolk sac and migrate into

135 blast markers, etsrp, fli1a, and scl; blocks primitive hematopoiesis, as shown by decreased expressio

136 It was shown critical for primitive hematopoiesis.

137 These events result in the accumulation of primitive hematopoietic blast cells in the blood and bon

138 is linked to SP and NK-A to protect the most primitive hematopoietic cell and also to maintain immune

139 ng-term culture-initiating cell assay cells (primitive hematopoietic cells).

140 ive DNA damage, is compromised in Foxo3(-/-) primitive hematopoietic cells.

141 mesoderm and WNT-independent KDR(+)CD235a(+) primitive hematopoietic mesoderm revealed strong CDX gen

142 ecification resulted in a >90% repression in primitive hematopoietic potential, but conferred fivefol

143 In contrast, CDX4 knockout hPSCs had intact primitive hematopoietic potential, but exhibited a fivef

144 11A), which functions as a growth factor for primitive hematopoietic progenitor cells.

145 odel to transfer genes specifically into the primitive hematopoietic stem cell compartment through th

146 e results demonstrate that a morphologically primitive hominin, Homo naledi, survived into the later

147 otential after four divisions, but show that primitive HSCs of adult mice continue to cycle rarely.

148 A recent study proposed that primitive HSCs symmetrically divide only four times to t

149 halassemia had a unique capsid that targeted primitive HSPCs through human CD46, a relatively safe SB

150 omplexes results in suppression of growth of primitive human AML progenitors in vitro and elicits str

151 vents that 5 GFs elicit directly in the most primitive human hematopoietic cell types to promote thei

152 bility to selectively support the culture of primitive human uSPG.

153 oviding in situ measurements confirming that primitive ice has a very low compressive strength (less

154 e decompose selection into six computational primitives, identify demands that their execution places

155 Although perhaps more primitive in some respects, quantitative analysis sugges

156 tion factor network that is usually found in primitive intestinal cells during embryonic development,

157 Coincident with KRT9 loss is a gain of the primitive keratin 7 and a signature of dsRNA sensing, in

158 potent stem cells for the development toward primitive kidney structures.

159 il Genomosperma is considered among the most primitive known seeds, with highly lobed integument and

160 escales, spiking activity in an evolutionary primitive (koniocellular) LGN pathway is specifically li

161 to the combination of the time-reversal and primitive-lattice translation symmetries, giving rise to

162 d develop a mechanistic model to examine the primitive life cycles that emerge from a unicellular anc

163 southern China and, hence, the retention of primitive-like traits.

164 e that nearly all early catarrhines shared a primitive locomotor repertoire resembling that of the we

165 receptor as a potential target to eradicate primitive LSCs in AML.

166 lunar carbon and S isotopic compositions of primitive lunar materials.

167 We used these cultures, called primitive lung-in-a-dish (PLiD), to recreate metastatic

168 se brain model by transplanting hPSC-derived primitive macrophage progenitors into neonatal mouse bra

169 shows that kimberlites do not derive from a primitive mantle source but sample the same geochemicall

170 yet reported, and it shows a combination of primitive marine chelicerate and derived arachnid charac

171 eration ability and increased maintenance of primitive markers in vitro in both liquid and OP9-DeltaL

172 f the early Solar System that have preserved primitive materials since their formation approximately

173 in water deer (Hydropotes inermis, the most primitive member of the family Cervidae), reindeer (Rang

174 at Lats1/2 kinases suppress expansion of the primitive mesenchymal progenitors, where YAP activation

175 roviding a source of chemiosmotic energy for primitive metabolic reactions.

176 These tube-dwellers are presumed to be primitive metazoans, but resolving their phylogenetic id

177 Among the primitive meteorite classes, Enstatite Chondrites (EC) a

178 However, studies of primitive meteorites have revealed they contain extrater

179 depletion of bulk silicate Earth relative to primitive meteorites is consistent with the depletion of

180 ompare these two methods, while also using a primitive method without BSSVS, and highlight the differ

181 FIRE/DeltaFIRE) embryos, the arrival of both primitive microglia and intracerebroventricular macropha

182 icles with aqueous microcompartments to form primitive microreactors.

183 sed on the pore-space partition of the cubic primitive minimal-surface net (MOF-14-type) has been rea

184 barotactic response is conserved in the more primitive model organism Dictyostelium discoideum using

185 herapeutic molecules and span the range from primitive model organisms such as Sacchaomyces cerevisia

186 ze under certain conditions than the GLMs or primitive models, and believe that the connection betwee

187 The rigidity and relatively primitive modes of operation of catheters equipped with

188 We found a pauperization of the most primitive MSC pool caused by increased ROS production in

189 assessed and correlated with the presence of primitive MSCs in vitro and in vivo.

190 We confirmed a reduced frequency of primitive MSCs in vivo in BT patients.

191 a different approach to modeling behavior in primitive multicellular organisms.

192 otential mechanism by which adtrp1 regulates primitive myelopoiesis and definitive hematopoiesis.

193 fpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.

194 ffecting children that is characterized by a primitive myxoid stroma with cystically dilated bile duc

195 invertebrate-like channels, which we termed primitive myxoid vascularization.

196 eminiscent of the architecture of ancestral, primitive nervous systems.

197 nd those without a bone sarcoma (ie, neither primitive neuroectodermal tumor nor osteosarcoma) (HR fo

198 Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressi

199 Cs were transformed with N-Myc, we generated primitive neuroectodermal tumors with divergent differen

200 the origin of life began with the onset of a primitive nonenzymatic version of metabolism, initially

201 Furthermore, neither primitive nor evolved hydrated Martian crust show notice

202 ntified that the Kihnu sheep have preserved 'primitive', 'Nordic', and other 'ancient' retrotypes tha

203 turbed orbits beyond Neptune, is composed of primitive objects preserving information about Solar Sys

204 remyella diplosiphon and the presumably more primitive OCP2 paralog from the same organism, we show t

205 tanglement distillation on a quantum network primitive of distant electron-nuclear two-qubit nodes.

206 Here we describe a primitive Old World monkey from Nakwai, Kenya, dated at

207 We show that primitive olivine crystal cargoes and their melt inclusi

208 a given eruption, melt inclusions trapped in primitive olivine crystals exhibit compositional diversi

209 Entrainment of hot primitive olivines into cooler, evolved carrier melts dr

210 a expression, mesoderm harboring exclusively primitive or definitive hematopoietic potential to under

211 that accompanies the emergence of the first (primitive or extra-embryonic) endodermal population and

212 which may consist of internal models, motor primitives or motor synergies.

213 ces in carbonaceous, enstatite, Rumuruti and primitive ordinary chondrites are about 6 times, 9 times

214 Many bacteria contain primitive organelles composed entirely of protein.

215 ple set of sensorimotor rules performed by a primitive organism.

216 lear receptors are encoded in the genomes of primitive organisms that lack endocrine signaling, sugge

217 ditory cortex (A1) represents the structural primitives out of which sounds are composed, we employ a

218 f differentiating and demonstrates that some primitive outer Solar System objects related to icy aste

219 d (SHF) give rise to the right ventricle and primitive outflow tract (OFT).

220 They may represent: (i) an anatomically primitive outgroup of vertebrates (the morphology-based

221 e temporally restricted glimpses of the most primitive parts of the mantle(3,4), but key questions re

222 ting an ancestral EPR-1 was a component of a primitive Polycomb repression pathway.

223 The first episode included predominantly 'primitive populations', while the second and most recent

224 prolonged charge storage is also observed in primitive power cells constructed from the purple bacter

225 emia stem cells are a rare population with a primitive progenitor phenotype that can initiate, sustai

226 rs exhibited a developmental trajectory from primitive progenitor-like to more mature neuronal-like c

227 order of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differen

228 mpartmentalization of inorganic catalysts in primitive protocells.

229 Furthermore, we demonstrate that the most primitive quiescent HSPCs are more resistant to spontane

230 loss of miR-146a depleted a subpopulation of primitive, quiescent HSCs.

231 are now describing infants with exaggerated primitive reflexes, epilepsy, acquired hydrocephalus and

232 reditary information, requiring some form of primitive replication without enzymes.

233 bstract temporal concepts are not built from primitive representations of time.

234 been a gradual decrease in the frequency of primitive retrotypes.

235 igns are presented where, quadratic residue, primitive root and ternary sequence diffusers are mimick

236 ositionally evolved samples compared to more primitive samples subjected to equivalent currents.

237 The primitive signaling scheme used in access networks enabl

238 mesoderm through to the organization of the primitive sinusoid at single-cell resolution.

239 interactions during the organization of the primitive sinusoid.

240 ing normal development, highlight the likely primitive skeletogenic potential of this cell population

241 by a crust containing an outermost layer of primitive solar nebula materials.

242 miRNA, but quantification pipelines are in a primitive stage and still evolving; there are many facto

243 ged block copolymers, however, is still at a primitive stage.

244 pithelium is transiently reprogrammed into a primitive state.

245 ctinellid spicule homology, and supports the primitive, stem-silicean interpretation of simpler-struc

246 The left wall of the primitive stomach expands more than the right wall, as t

247 Although the earliest production of primitive stone tools, predating the genus Homo and emph

248 ion in the anterior visceral endoderm (AVE), primitive streak (PS) and definitive endoderm (DE) have

249 icropattern system to model formation of the primitive streak (PS) by WNT.

250 ogether a rudimentary fate map for the human primitive streak (PS).

251 s axial symmetry, and induces markers of the primitive streak and epithelial-to-mesenchymal transitio

252 E-cadherin needs to be downregulated in the primitive streak and in the epiblast, concomitant with t

253 nitor population transcriptomes in the mouse primitive streak and tail bud throughout axial elongatio

254 Zeb2 repress P-cadherin transcription in the primitive streak and the neural plate, respectively.

255 he anterior-most somites ingress through the primitive streak before E7 and migrate anteriorly by E7.

256 d specification of primordial germ cells and primitive streak cells.

257 initiates a process that resembles posterior primitive streak development in a SNAI1-dependent manner

258 al programs similar to those observed during primitive streak formation and subsequent gastrulation i

259 last of chick embryos in the early stages of primitive streak formation.

260 n and avian embryos is the appearance of the primitive streak in the future posterior region of a rad

261 The primitive streak marks the midline of the future embryo.

262 ing the basement membrane of the prospective primitive streak more prone to breaching.

263 ed primary body) through the activity of the primitive streak on axial progenitors within the epiblas

264 e mechanisms responsible for positioning the primitive streak remain largely unknown.

265 n is weakly expressed in the epiblast at pre-primitive streak stages where it is substituted for by P

266 strulation, epiblast cells delaminate at the primitive streak to form mesoderm and definitive endoder

267 nally different from that coordinated by the primitive streak, as it does not lead to mesodermal diff

268 coding genes, associated with pluripotency, primitive streak, limb development and extracellular mat

269 all are associated with abnormalities in the primitive streak, the site of the EMT.

270 involved in the convergence of visceral and primitive streak-derived endoderm.

271 rcation event early in the trajectory when a primitive streak-like cell population segregated into th

272 s described here, hPSCs are first induced to primitive streak-like cells by activating canonical Wnt

273 elop beyond 14 days or the appearance of the primitive streak.

274 ectively, inhibit or induce formation of the primitive streak.

275 lecules BMP4 and Vg1/GDF1 in positioning the primitive streak.

276 orcine PGCs originate from the posterior pre-primitive-streak competent epiblast by sequential upregu

277 ions on the posterior side are essential for primitive-streak extension during gastrulation by render

278 FOXH1 is a primitive-streak specifier and ACTIVIN co-effector that

279 In situ, Tcf15 expression labels the most primitive subset of true multipotent HSCs.

280 Remarkably, we find that spatial primitives/synergies of adult injured and neonatal injur

281 ol, but this need not have been the case for primitive systems.

282 echanism by which cancers arising from these primitive tissues exploit PRC2 activity to enable immune

283 daptation is implemented by cosine tuning of primitives to the current direction of the error, which

284 The contribution of the primitives to the motor output is determined by both top

285 hominins is evidently best interpreted as a primitive trait inherited from an arboreal ancestral spe

286 opean breeds, several of which have retained primitive traits (e.g., a small body size and short or t

287 actors, SOX2 and SOX9, and recapitulate more primitive transcriptional programs spanning stem-like to

288 s of human gene regulatory networks activate primitive transcriptional programs, driving common hallm

289 s periosteal stem/progenitor cells in a more primitive, tripotent state, while suppression of Hox gen

290 t covering that was a characteristic of more primitive trochozoans.

291 Additionally, MR766 is highly trophic toward primitive trophoblast, which may put the early conceptus

292 , PLPPR3, that allowed purification of human primitive undifferentiated spermatogonia (uSPG) highly e

293 microbeads that can be pre-cultured to form primitive vascular networks within the modular structure

294 C during developmental angiogenesis in which primitive vascular plexuses are remodeled into hierarchi

295 nuity with modern metabolism would require a primitive version of metabolism to build and break down

296 In this way, they act as primitive versions of today's protein catalysts, elongat

297 It exposed primitive water ice-that is, water ice from the time of

298 Additionally, we sequenced 100 accessions of primitive, wild and cultivated citrus.

299 etamorphosed H ordinary chondrite contains a primitive xenolithic clast that was accreted to the pare

300 he, and lateral hypothalamus, which regulate primitive, yet fundamental functions, such as circadian