ライフサイエンスコーパス: principally

1 olar disorders and the general population is principally a result of excess deaths from cardiovascula

2 Although principally a strike-slip plate boundary, the faulted ma

3 Conservation outcomes are principally achieved through the protection of intact ha

4 depends on a common set of ancient proteins, principally actin filaments and myosin-II motors.

5 of hundreds of alternative splicing events, principally acting as a splicing repressor with only a s

6 ptake by liver and other peripheral tissues, principally adipose and muscle and with concurrently hig

7 We found that cannabinoids principally affect inhibitory inputs, potentially from t

8 neurons (MNs) are the neuronal class that is principally affected in amyotrophic lateral sclerosis (A

9 sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyc

10 nding of activation products derived from C3 principally, and also from C4, impaired immunoglobulin G

11 of diffusion analyses within clinical trials principally as an additional measure to improve understa

12 Seasonal cold is causal, but, we contend, principally as an ecologically relevant evolutionary pre

13 Industrially the avocado pulp is exploited principally as oil and paste, generating a huge quantity

14 Lesions occur principally as side-effects from phenytoin, nifedipine,

15 t as dissolved iron (<0.025 mum) at pH 4 but principally as small (<0.45 mum) iron oxyhydroxide parti

16 tion on discharge, with this rehealing being principally associated with the solid-solution reaction

17 ts and endophenotypes revealed that rs165940 principally associates within the psychosis (p = 0.025,

18 soforms were immunolocalized in ameloblasts, principally at maturation stage.

19 g that hybridization affects sRNA expression principally at specific loci rather than on a global sca

20 If selection for new antigenic variants acts principally at the point of initial virus inoculation, w

21 This remarkable change is principally attributable to the development of so-called

22 ompared to wheat flour bread, which could be principally attributed to retardation of amylopectin ret

23 to manage adult NMZL patients are presented, principally based on immunochemotherapy (when treatment

24 antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling.

25 e in vivo role of CD1a has remained unclear, principally because CD1a is lacking in mice.

26 ractable tumor despite therapeutic advances, principally because of its invasive properties.

27 als, were more sensitive to synaptic fatigue principally because of reduced vesicle recycling rates.

28 ne of the most intractable of human cancers, principally because of the highly infiltrative nature of

29 ered for DMD, or other muscular dystrophies, principally because skeletal-muscle-related symptoms are

30 ngly being used for biodiversity monitoring, principally because they are sensitive and can provide h

31 Principally, because of the far greater dependence of th

32 Previous examples have principally been tertiary amines, especially those with

33 MBD enrichment, however, appears principally biased towards the recovery of CpG-rich and

34 We hypothesized a principally biological cause for the hysteresis.

35 epted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-tar

36 Thus, channel dynamics are determined principally by activation kinetics.

37 The catalyst ligated by dtbpy decomposes principally by dissociation of the ligand and rapid bory

38 second, that adaptive radiations are driven principally by ecological opportunity rather than by the

39 iously described lncRNAs, NEAT1 is regulated principally by HIF-2 rather than by HIF-1.

40 within cancer susceptible epithelial tissues principally by influencing early events in malignant tra

41 tion studies confirm that this compound acts principally by inhibition of the chymotrypsin-like activ

42 1 reduced (alpha3beta4)2beta4-nAChR function principally by lowering cell-surface expression, whereas

43 ortunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage.

44 r prognosis, is essential for OC progression principally by promoting tumor-associated macrophage rec

45 ing via G-protein-coupled receptors (GPCRs), principally by receptors binding Galpha C termini.

46 he expression of over 100 genes and operons, principally by repressing during growth genes whose prod

47 erse cardiovascular events (MACE) after PCI, principally by resulting in a larger postprocedure lumen

48 che signal can promote stem cell maintenance principally by stimulating stem cell proliferation.

49 ibody that neutralizes TNF-alpha and is used principally by systemic administration to treat many inf

50 In the heart, CXCL12 is expressed principally by the epicardium, and its receptor CXCR4 is

51 In this energy range, DNA damage arises principally by the formation of transient negative ions,

52 I-branched glycans catalyzed principally by the I-branching enzyme GCNT2 are now indi

53 hosphate (ppp) are detected in the cytoplasm principally by the innate immune receptor Retinoic Acid

54 al rapid tension fall in the model is caused principally by the reversal of the first tensing step, b

55 Epithelial barrier function is defined principally by tight junctions, which, in turn, depend o

56 itute, we show that batch effects are driven principally by two key experimental parameters: the reag

57 arcinoma, are common cancers that are caused principally by ultraviolet (UV) radiation.

58 durable protection from the virus, is driven principally by unconventional processing of antigen synt

59 is required for tumour growth and is induced principally by vascular endothelial growth factor A (VEG

60 ensive, abundant, and sustainable materials, principally, C and Fe, demonstrates remarkable current a

61 ogy, and secondary (functional) MR, which is principally caused by global or regional left ventricula

62 re diagnosed with cervical cancer, a disease principally caused by human papillomavirus (HPV).

63 Interventions in the teenage group were principally caused by trauma-related injuries (burns, 22

64 oup; interventions in the teenage group were principally caused by trauma-related injuries.

65 h TAp63 to modulate key biological pathways, principally cell-cycle regulation, extracellular matrix

66 The remaining two thirds of Zika cases, principally characterised by undifferentiated fever or a

67 Green and roasted coffee beans are principally characterized by a glassy structure that slo

68 d in red light developed relative hyperopia, principally characterized by flattening of corneal curva

69 syndrome is an autosomal recessive disorder principally characterized by postnatal growth failure an

70 gae (Chlorophyta) and single-celled diatoms (principally Cocconeis spp.), which were high light accli

71 ers that vary in both size and shape but are principally composed of dimeric building blocks.

72 It is principally composed of gamma-aminobutyric acid neurons.

73 , the fragment screening sets often used are principally comprised of sp(2) -rich aromatic compounds,

74 Experiments are principally conducted within confining systems that offe

75 pathways and their interacting network were principally confirmed by an independent transcriptome se

76 e nucleus is surrounded by active DCs, which principally control the degradation of beta-catenin and

77 Consequently, the rate of HOR is principally controlled by the rate of H-spillover at the

78 y midbrain structure for response selection, principally coordinate specific motor responses.

79 on is sensitive to in-cloud processes, which principally depend on atmospheric aerosols, including ic

80 suggests that their origin within breath is principally derived from the lungs and, by inference, fr

81 In those Review articles, Huisgen principally described the state of the art of 1,3-dipola

82 We propose instead that generics principally designate that categories are kinds.

83 t that the human brain and immune system are principally designed to keep the body biologically safe,

84 sis that the LTL-adult disease connection is principally determined before the second decade of life,

85 information conveyed by human speech, is not principally determined by basilar membrane mechanics.

86 n of adsorbed H/D on the catalyst surface is principally determined by the solvent isotopic compositi

87 known to be principally nocturnal and Aedes principally diurnal, details of mosquito activity are no

88 om COVID-19 in cancer patients appears to be principally driven by age, gender, and comorbidities.

89 ick sequences of organic sediments at a rate principally driven by the rate of RSLR, representing an

90 olic abnormality-iatrogenic hyperinsulinemia-principally drives insulin resistance and its consequenc

91 ess of lymphoma in specific PIDD populations principally drove this increased incidence, while no inc

92 Thus, AIF's effect on CI assembly is principally due to compromised intramitochondrial transp

93 owever, we conclude that for males, this was principally due to deterioration in barrier defences, wh

94 ders-of-magnitude after lateral compression, principally due to improved conductivity resulting from

95 iting increasing interest in honeydew honey, principally due to its functional properties.

96 Breast cancer mortality is principally due to recurrent tumors that arise from a re

97 f peptide drugs to the brain is challenging, principally due to the blood brain barrier and the low m

98 implying the different reaction outcomes are principally due to the formation of thioester versus est

99 Scores on the CMTPedS tended to worsen principally during childhood (ages, 3-10 years) for part

100 Rapidly cycling SCs function principally during normal tissue maintenance and are hig

101 of shallow discharging groundwater collected principally during summer through autumn.

102 four strains tested, cell division occurred principally during the night period under diel condition

103 e gQDs exhibit unusual single-QD properties, principally emitting from dim gray states but having hig

104 glial-specific rescue, whereas sulfatide is principally expressed and functional in glial membranes.

105 tified as a target of miR-199a-5p, which was principally expressed in quiescent mouse hepatic stellat

106 Clay minerals are principally Fe-Mg illite, mixed layers of illite/smectit

107 ultivars had high polyphenol concentrations (principally flavanols and phenolic acids) and high total

108 These discovery efforts have principally focused on culturing bacteria from natural e

109 While research studies have principally focused on determining the magnitude of prot

110 t affect plumage variation, but research has principally focused on major-effect genes (such as those

111 The field of immunology is principally focused on the molecular mechanisms by which

112 The transmissible prion agent is principally formed of PrP(Sc) itself and is associated w

113 ee text] band, while it has an extra band of principally [Formula: see text] orbital character, which

114 peculiarities of the larvae include features principally found in spider-associated insect groups, im

115 aded, whereas older reticulocytes (CD71(-)), principally found in the peripheral blood, were rarely i

116 ves for battery systems in California derive principally from a state-level subsidy program.

117 alue, and relatively flat band edges derived principally from Ag-d/I-p (valence band) and Bi-p/I-p (c

118 tary C(org) underneath seagrass meadows came principally from allochthonous (non-seagrass) sources (~

119 host-to-host spread of K. pneumoniae occurs principally from its intestinal reservoir, and that comm

120 vs. deciduous angiosperms, high LMA resulted principally from larger cell sizes, greater major vein a

121 mber and laminar position, which is produced principally from layers II-IV neurons.

122 While available evidence (stemming principally from mechanistic studies) has indicated that

123 function in old age-immunosenescence-derives principally from studies of modern human populations and

124 Developments over the last 5 to 10 years, principally from studies on comprehensively phenotyped p

125 reduced capacity to interact with solvents, principally from the 10% substitution level, with dimini

126 ly-varying signals of admixture with sources principally from the eastern and northern Mediterranean.

127 Principally, FT-IR provides a rapid, cost-effective plat

128 al transplant for a moderate-risk condition, principally Fuchs dystrophy or pseudophakic or aphakic c

129 undergoing PK for a moderate risk condition, principally Fuchs' dystrophy or pseudophakic or aphakic

130 ata reveal that (a) adipocyte respiration is principally fueled from nonglucose sources; (b) there is

131 Striatal neurons are principally GABAergic projection neurons and interneuron

132 oceramics and living cells is complex, it is principally governed by the implant's surface chemistry.

133 s associated with significant complications, principally graft-versus-host disease (GVHD) and opportu

134 n of ground-state prebiotic building blocks, principally HCN.

135 ratory studies on commercially bred species (principally honeybees and bumblebees) have identified su

136 many intriguing questions remain unanswered: Principally, how aggressively should the clinician scree

137 ial peptides essential for the host barrier, principally human alpha-defensin 5 (HD5) and HD6.

138 primary reason is that driver mutations are principally identified by their high frequency even thou

139 ds on different selection pressures that are principally immune and treatment mediated.

140 The expression of proteins differed principally in a region- and layer-specific pattern, wit

141 tently neutralizing TS mAbs recognized sites principally in E glycoprotein domains I and II, and patt

142 ng adaptive radiations, where species differ principally in ecology and behavior, these findings illu

143 IR muscle relaxation in the hypotropic eye, principally in its selectively innervated lateral compar

144 ying potassium 3.2 (Kir3.2) channel is found principally in neurons that regulate diverse brain funct

145 als with normal levels of white blood cells, principally in order to minimize risk of serious infecti

146 gray but not white matter volumes, observed principally in regions where structure generally did not

147 ine exhibited 30-65-fold lower amounts of SM principally in the amount of 16:0.

148 Findings were principally in the frontal lobe, superior parietal lobes

149 a pancreatic hormone and neuropeptide, acts principally in the hindbrain to decrease food intake and

150 Glucosinolates, found principally in the plant order Brassicales, are modulate

151 nset T1D from the U.K. and that these differ principally in the proportion of infiltrating CD20(+) B

152 by evolutionary and economic theory, to act principally in their own interests.

153 In the parenchyma, DPP4 was found principally in type I and II cells and alveolar macropha

154 to improve the resistant starch content and principally in vitro cholesterol and bile acid/salts bin

155 rial phenotype than loss of Hh signaling and principally induced a different BMP ligand.

156 n cells and identify that replication stress principally induces mitotic death signalled through two

157 Harvest period principally influenced oleacein, oleocanthal, oleuropein

158 The product of this research is principally information published in scientific journals

159 ng-from-below for thorium, where 6p-orbitals principally interact with filled f-orbitals raising the

160 omponents of the viral capsid reported to be principally involved in cell entry with the correspondin

161 Club cells are principally involved in protection and maintenance of br

162 Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are

163 milabile chelate facilitates conversion of a principally ligand-based singly occupied molecular orbit

164 ality of the recipient's pretransplant PS is principally limited to the first 3 months after LT.

165 ivity of BET bromodomain inhibition has been principally linked to suppression of androgen receptor (

166 Pain was principally localized to the hands and the feet, neuropa

167 Glacial pollen and rare speleothem archives principally located in the Mediterranean domain.

168 Spectral domain OCT showed them to be principally located on or in the RPE/Bruch's membrane co

169 parasites that parasitize phagocytic cells, principally macrophages, of vertebrate hosts and the ali

170 Platelets circulate the bloodstream and principally maintain hemostasis.

171 when and how many times hominin hands became principally manipulative remains unresolved.

172 While neurons principally mediate brain function, astrocytes are emerg

173 potential-evoked neurotransmitter release is principally mediated by CaV2.1 calcium channels (CaV2.1)

174 Mitochondrial turnover is principally mediated by mitophagy, the trafficking of da

175 that the effect of education on lifespan is principally mediated through smoking while the effect of

176 AMPH principally mediates its pharmacological and behavioral

177 Oral hypoglycaemic agents, principally metformin and glibenclamide (glyburide), are

178 c normative values for RV measurements among principally middle-aged and older adults.

179 rove the vision of color-deficient observers principally modify the illuminant and are largely ineffe

180 trifugation showed that both IgG4 forms were principally monomeric with sedimentation coefficients s2

181 tested positive for neuronal autoantibodies (principally N-methyl-D-aspartate receptor antibodies) an

182 much narrower specificity for small lesions, principally N3-methyladenine (3mA).

183 Although Anopheles is known to be principally nocturnal and Aedes principally diurnal, det

184 Complex oligosaccharides consist principally of neutral oligosaccharides rich in arabinos

185 aled that the sheared archaella are composed principally of two of the four predicted archaellins, Fl

186 h, in other photosynthetic organisms, relies principally on a range of plastid-localized ATP generati

187 is generally assumed that nanocarriers rely principally on abnormal leaky vasculature for tumor acce

188 erature employing these techniques, focusing principally on applications of normative modelling to qu

189 Approaches to cooking practices have relied principally on artefactual evidence, macroscopic bone mo

190 To this end, in this review we focus principally on articulating areas of need in the prepara

191 atherosclerotic cardiovascular disease rely principally on estimated 10-year risk.

192 nagement of CKD in primary care should focus principally on identifying the minority of people at hig

193 evelopment of this promising field, focusing principally on lessons gleaned from immunological princi

194 The discussion focuses principally on methylammonium lead iodide (CH(3)NH(3)PbI

195 s about the nature of teaching have depended principally on naturalistic observation and some experim

196 r ongoing, current scientific evidence rests principally on observational case series with their pote

197 standard for clinical prognostication relies principally on pathological staging.

198 ection pressures from host immune responses, principally on the hemagglutinin (HA) viral surface prot

199 ical developments, and centre our discussion principally on the increasing trend to exploit the large

200 Most studies focused principally on the overstory trees with little attention

201 In this review, we focus principally on the regulation of differentiation and fun

202 rasites are affected by oogenetic processes, principally orchestrated by the steroid hormone 20-hydro

203 s will experience MSVI or blindness by 2050, principally owing to our growing and ageing global popul

204 ifficulties associated with their synthesis, principally owing to the unfavorable entropy and transan

205 s of each that showed burst characteristics (principally period and spike frequency) similar to the a

206 This occurs principally perpendicular to the net orientation of cell

207 Emerging contaminants are principally personal care products not readily removed b

208 Yet, abiotic factors, principally precipitation regimes, shape biogeographical

209 latives) are a moderately diverse lineage of principally predatory animals, at least in their immatur

210 tlearning generalization across effectors is principally predicted by the level of an implicit mechan

211 While hollow core waveguides principally provide such conditions, currently used appr

212 etalliferous release occurring when sulfide (principally pyrite)-containing rock from mining activiti

213 While the demonstration is principally qualitative at this point, it is believed th

214 m neutralizing antibody responses, but these principally recognize only the infecting serotype.

215 he major producers of type I interferon, are principally recognized as key mediators of antiviral imm

216 f cross-presentation of phagocytosed OVA may principally reflect a requirement for recycling MHC-I mo

217 Furthermore, these findings principally reflected alterations in the schizophrenia s

218 This principally reflected profoundly defective IFN-gamma pro

219 Translation is principally regulated at the initiation stage.

220 Fibrogenic pathways in the liver are principally regulated by activation of hepatic stellate

221 cluding intermediate signaling molecules are principally regulated by proteasomal degradation pathway

222 a Inducible transcription Factors (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II)

223 tibiotics and that the reaction mechanism is principally related to attack by hydroxyl radicals and o

224 cal Wnt/beta-catenin signaling appears to be principally reliant on ligand-induced Fzd/LRP6 heterodim

225 l formation and that, respectively, they are principally responsible for diencephalic and temporal lo

226 of high-molecular-weight hyaluronan (HA) is principally responsible for generating pressures that ca

227 ests that the C-terminal domain of hISG15 is principally responsible for interactions.

228 Mesothelium-produced FGF9 is principally responsible for mesenchymal growth, whereas

229 oid beta protein (oAbeta) are believed to be principally responsible for neurotoxicity in Alzheimer d

230 The two NTD-bound resveratrol molecules are principally responsible for promoting tighter binding be

231 s suggested that mutation at position 89 was principally responsible for the changes in inhibitory po

232 luorescence-lifetime imaging microscopy, are principally responsible for the decrease in catalytic pe

233 at we have identified the kinetic parameters principally responsible for the differences in the flash

234 ts the properties of the PDK isozyme that is principally responsible for the regulation of PDC activi

235 However, such analysis has hitherto been principally restricted to scent-marking territorial anim

236 e remain controversial as available data are principally retrospective, and there is therefore little

237 d by increased pacing, phosphorylated ser302 principally, ser282 to a lesser degree, and ser273 not a

238 Our current knowledge of allostery is principally shaped by a structure-centric view, which ma

239 Principally, structural-functional decoupling observed f

240 ble the visual cortex, an area that has been principally studied for its sensory processing function,

241 pes, and provides evidence that connectivity principally supports host metapopulations afflicted by f

242 Phenolic compounds can principally suppress the off-flavor development in ultra

243 at are associated with immune control of HIV principally target conserved epitopes within the capsid

244 e first minute of the session when intake is principally taste-driven.

245 Crosslinking traps principally tetrameric alphaS in intact normal neurons,

246 Principally, TgAMA4 lacks both a deep surface groove and

247 nefits of an asexual reproductive existence: principally, that it is rapid and convenient.

248 to this disproportionally high productivity, principally the extensive shallow-water banks covered in

249 s often achieved by structural modification, principally the introduction of D-amino acid residues in

250 requires more conventional model organisms; principally the mouse, because of similarities in crania

251 -induced gingival overgrowth lesions exhibit principally the presence of inflammation and little fibr

252 RTN neurons are glutamatergic and innervate principally the respiratory pattern generator; they regu

253 We suggest that sampling errors are principally the result of inaccuracies in measuring the

254 ndosome trafficking during the assembly, but principally the secretion, of infectious virus.

255 Biological oceanic processes, principally the surface production, sinking and interior

256 nderlying the thrombolytic effects of NAC is principally the VWF that cross-link platelets in arteria

257 Principally, the finding that NRG3 classes II and III ar

258 umented for a variety of marine animals, but principally those that feed at the sea surface or use th

259 ction with the HIV-1 PR, which appears to be principally, though not exclusively, driven by electrost

260 ow that Scc2 binds dynamically to chromatin, principally through an association with cohesin.

261 seen major advances in the genetics of T2D, principally through ever-increasing large-scale genome-w

262 d approximately 160 m widening over 6 years) principally through fluvial plucking and block topple.

263 r tuning the surface properties of polymers, principally through free-radical chemistry.

264 ary consumers within several lake food webs, principally through lake-specific impacts on zooplankton

265 increased progressively starting at 4 weeks, principally through nonproliferative growth.

266 nteracts with the N-terminal half of TRN-SR2 principally through the HEAT repeats 4, 10, and 11.

267 both situations these effects were mediated principally through the Hif2a isoform.

268 This owes principally to a lack of tools to study this scarce lipi

269 Tonic BCR signaling acts principally to activate AKT, and forced activation of AK

270 ula were in many cases compound-specific due principally to conditions affecting signal intensity suc

271 Moreover, SAP bound principally to hepatosplenic amyloid, whereas p5+14 was

272 , such as Saccharomyces cerevisiae, responds principally to nutrients, e.g., nitrogen and phosphate s

273 Gas-phase reaction with OH is expected principally to result in formation of the acid anhydride

274 sis, and that the stasis is likely to be due principally to selective pressure acting on pollen morph

275 e for protein modification has been ascribed principally to stabilization of a fluoride leaving group

276 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), p

277 In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol est

278 This bimodality is principally underscored by the antagonistic actions of t

279 ns: political, economic, and social factors, principally unplanned urbanisation, illiteracy, poverty,

280 am of caspase-1 and caspase-8 activation and principally up-regulates NF-kappaB and IL-1beta signalin

281 Pathway analysis showed principally up-regulation of pattern recognition and inn

282 n widely reported, with mRNA detection based principally upon RT-PCR assays.

283 tive RhoA revealed that LM11A-31 likely acts principally upstream of tau phosphorylation, and has eff

284 Povidone-iodine (PVI) is principally used as an antimicrobial agent.

285 s cells against diverse types of DNA damage, principally UV irradiation.

286 Principally, valence-dependent effects were observed onl

287 : for instance, typhus group rickettsiae are principally vectored by insects (i.e., lice and fleas),

288 to influence bone quality and osteoporosis, principally via calcium-dependent alteration of bone str

289 ude helminths switch from UQ to RQ synthesis principally via changes in the alternative splicing of c

290 to determine essential circadian parameters, principally via increased PERIOD protein synthesis.

291 older multiply mated males become infertile principally via reduced sperm transfer and viability.

292 spontaneously under physiological conditions principally when a glycyl residue is at the carboxyl sid

293 the broader implications of these findings, principally whether deviations from Haldane's rule might

294 of deaths within 24 hours halved (33%-16%), principally with a fall in mortality between 3 and 24 ho

295 ery S cone in the parafoveal retina synapses principally with a single OFF midget bipolar cell, which

296 chievement that had been previously observed principally with DNA structures.

297 s and taxonomic compositions were correlated principally with latitude, carbon and carbonates content

298 el substrate preprolactin (pPL) was isolated principally with Sec61alphabetagamma upon membrane targe

299 Our reasons extend beyond those concerned principally with the environment, to also include impact

300 Thus, IRF3 acts principally within the stromal compartment to exacerbate