ライフサイエンスコーパス: principle

1 ion, and equality, which is a basic fairness principle.

2 nalized in the context of the Curtin-Hammett principle.

3 analyzed according to the intention-to-treat principle.

4 imum Entropy Generation; and the Variational Principle.

5 liver transient spectra in silico from first principles.

6 ict the electron mobility in GaAs from first principles.

7 mplex and suggest possible molecular disease principles.

8 low cost, and acquittance to green chemistry principles.

9 prokaryotic defence systems involves common principles.

10 core is calculated based on the SIGNIFICANCE principles.

11 s the linchpin for uncovering organizational principles.

12 etic design directed by fundamental chemical principles.

13 approach elucidates the underlying physical principles.

14 e our understanding of molecular recognition principles.

15 the determinants of structure from physical principles.

16 Rer progression of lung injury relies on two principles: 1) open the lung to minimize the presence of

17 aracteristic example of applying topological principles(4,5) to control optical fields and could lead

18 te that MAM by LC-MS peptide mapping can, in principle, adequately replace selected QC methods and wo

19 n the sum of the activities of either active principle alone.

20 This economic principle also applies to mate choice and, perhaps surpr

21 rized by its spatial receptive field, but in principle also depends on the responses of other RGCs an

22 nitoring devices based on innovative sensing principles, alternative body fluids, advanced flexible m

23 Our proof-of-principle analyses facilitated informative stratificatio

24 ssful implementation, including study design principles, analytical tools and future developments for

25 s) are derived using the extended Hamilton's principle and Galerkin decomposition is implemented to d

26 r, we are not convinced that the free energy principle and Thinking Through Other Minds will be usefu

27 Educating hepatology providers about PC principles and developing clear prognostic criteria for

28 In this review, the origin, basic principles and development of electrochemical aptasensor

29 However, the organizational principles and dynamic changes of the bacterial wine mic

30 We conclude by providing principles and guidelines for designing next-generation

31 fundamental understanding of key biophysical principles and sequence features important to phase sepa

32 us specifically on summarizing the synthetic principles and strategies developed to form random alloy

33 ldviews, and violent rejection of democratic principles and the rule of law).

34 With these principles and tools, we demonstrate the benefits and ve

35 n, we demonstrate how accumulated knowledge, principles, and recent advances, discussed in this revie

36 These principles appear to be borne out in both patient and an

37 Such an approach may be a general principle applicable to designing higher performance ele

38 Here, we revisit the Muller's ratchet principle applied to the aging of somatic cell populatio

39 This principle applies more broadly since genomic analysis in

40 Similar principles apply to other recombinase systems and other

41 ombined results-obtained from a purely first-principles approach with no empirical parameters-are str

42 Alloy design principles are described along with the structure and pr

43 bes the principles of Abi, details how these principles are implemented in a variety of natural defen

44 fic systems, the general underlying physical principles are not yet established.

45 SHE, we demonstrate that two of these design principles are weak crystal fields and the presence of s

46 Our PPP proposal is based on the same principles as were applied for the PCGW2 criteria but ad

47 directly relating complementary measurement principles based on (i) detuning of SPR as a result of t

48 A validated first principles-based approach is discussed to demonstrate th

49 This molecular recognition process could, in principle, be integrated into commercial gold-mining pro

50 nderstand the characteristics of UVR and the principles behind correct and appropriate UVR exposure i

51 ence with an understanding of the scientific principles behind the testing tools.

52 Despite its apparent importance, the principle by which plant stems respond to vertical loadi

53 These events can be probed, in principle, by monosaccharides with bioorthogonal tags th

54 First-principle calculations based on typical 2D N-doped carbo

55 Both first-principles calculations and linear dichroism measurement

56 emission spectroscopy measurements and first-principles calculations further demonstrate that MnBi(4)

57 In addition, the first-principles calculations indicate that the ETSs are relat

58 Both experiments and first-principles calculations reveal Ge pyramid-dominated netw

59 s-based criteria are incorporated into first-principles calculations to judge mode-by-mode between th

60 ption, magnetic circular dichroism and first-principles calculations to uncover the origin of high-te

61 ods using multiplexing by labeling, which in principle can also be used in combination with liquid AP

62 Using a first-principles carbon balance model with a prescribed live w

63 This proof of principle case can stimulate future mechanistic studies

64 ntial reactions, we describe its concept and principle, catalyst synthesis methodology, and applicati

65 human cells and provide insight into common principles causing ribosome stalling under physiological

66 The experimental, first-principles CCS values are compared to previously reporte

67 These results are compared with first principles chemical shielding calculations of Li-P-O/N c

68 In principle, CIT-MS can be easily adapted to track the flu

69 blue light-responsive photoreceptors are, in principle, considered inadequate for deep tissue stimula

70 We believe that this principle could find a broad interest in the medicinal c

71 This principle could unify cognitive science with the broader

72 on spectrophotometry and spectrofluorometry principles, customizing laboratory devices for automatio

73 ham-controlled trials have provided proof-of-principle data for its blood pressure-lowering efficacy.

74 We also provide proof-of-principle data that gene-targeting ASOs can be selected

75 asis for 'reactive' ML, we establish a first-principles database (Rad-6) containing closed and open-s

76 Our work serves as a proof-of-principle demonstration of the capability of our microfl

77 As a proof-of-principle demonstration, we show that this silk drive ca

78 e anchoring energy and obtain it using first-principles density functional theory calculations.

79 This abstraction allows us to apply principles derived from learning theory to understand th

80 Although such flow patterns can be, in principle, described by the Navier-Stokes equations, ext

81 The design principles dictating the spatio-temporal organisation of

82 e studies on four diseases show that network-principled drug combinations tend to have low toxicity.

83 nic action, and provide preclinical proof-of-principle evidence for targeting EZH2 in patients with M

84 bps) prototype are demonstrated as proof-of-principle exemplars for the enhanced method of demodulat

85 plemented using model-view-controller design principles, existing genome browsers, and existing molec

86 In a proof-of-principle experiment, we demonstrate high-fidelity opera

87 endent calling cards system and, in proof-of-principle experiments, show utility in defining cell typ

88 HPMs perform promisingly in these proof of principle experiments.

89 an empirical examination of how free-energy principles explain dynamic cultural behaviors and pragma

90 unlikely to have significantly affected the principle findings.

91 These results provide proof of principle for a novel strategy in developing highly sele

92 This study provides a proof of principle for a strategy to create protein-level cell ba

93 This work addresses a fundamental design principle for constructing molecular wires where protons

94 , these results provide therapeutic proof of principle for FEN1 blockade in tamoxifen-resistant breas

95 Our results provide important proof of principle for Gcn5 functions in formation and progressio

96 Their proof-of-principle for generating human tissue is demonstrated by

97 t random sparse connectivity as a key design principle for neuronal computation.

98 nscriptional switch may constitute a general principle for safeguarding neuronal identity throughout

99 The strategy provides a general design principle for synthesizing abiotic polymer inhibitors of

100 Here, we report a design principle for the creation of a selective yet robust cat

101 Taken together, this work offers a proof of principle for the design of a gene drive in viruses.

102 al 'phase diagram', which provides a guiding principle for the design of both phase-preserving and ph

103 comprehensive theory of five rational design principles for achieving giant intrinsic SHE in transiti

104 Design principles for anti diastereomer derivatives are also di

105 Here, we establish the chemical design principles for creating materials with this behavior.

106 there are currently no universally accepted principles for deciding which biological species should

107 Lastly, we identify key principles for designing binding assays that are optimal

108 n trying to derive the correction from first principles for each machine-learning algorithm, we obser

109 The design principles for engineering plasticity described can be a

110 s, we identify the general underlying design principles for generating stochastic transcriptional pul

111 based on autoencoding and optimal transport principles for lineage tracing in settings where existin

112 ay prompt the development of new therapeutic principles for Parkinson's disease.

113 bolic regulation, but also elucidated design principles for ratio-sensing signal processing that can

114 study around sanitation to identify guiding principles for sanitation that advance sustainable devel

115 g enormous chemical space and unclear design principles for small-molecule combinations, computationa

116 rochemical stability, and provide the design principles for the development of air-stable solid elect

117 Tit-for-tat is a familiar principle from animal behavior: individuals respond in k

118 different magnetization trajectories, using principles from control theory.

119 To validate and generalize principles from lac for practical applications, we previ

120 its neural correlates, and the optimization principles from which it originates.

121 eview evidence that the resource-rationality principle generalizes to human movement control.

122 rks to develop a better understanding of the principles governing behavior.

123 a similar approach could expose fundamental principles governing representation of information throu

124 However, this principle has recently been challenged by studies of nuc

125 , focusing on how physical organic chemistry principles have guided probe design.

126 If the same principles hold true in other world regions, then Bt cor

127 The mechanistic principles, however, are unclear, mainly because structu

128 We demonstrate that this molecular design principle, i.e., incorporation of sterically demanding s

129 atched patches is a prominent organizational principle in M1.

130 We have demonstrated this principle in one of our newly reported material, (TMPEA)

131 this Perspectives article, we introduce six principles in behavioural economics (loss aversion, fram

132 pensatory mechanism, together with Bateman's principles in sequential hermaphrodites, should be forma

133 In principle, information can be represented in DNA by simp

134 y through incorporation of the self-assembly principle into drug design.

135 gration operates by a common set of physical principles, irrespective of the input.

136 The principle is based on a mathematical model of the sporoz

137 The detection principle is based on Forster resonance energy transfer

138 oyment of the direct electron transfer (DET) principle is expected.

139 particular form of reciprocation, where the principle is that of strong retaliation, or 'tits-for-ta

140 The underlying principle is that the acid transport rate is associated

141 The underlying principle is to convert a fluctuating, unbiased force in

142 ble potentiometric and triboelectric sensing principles is reported.

143 hypothesis, as formalized by the free-energy principle, is ascendant in cognitive science.

144 edicted for a correlated Hund metal by first-principles many-body theory.

145 The demonstrated principle may be used for energy harvesting in various n

146 scribe an optimized high-throughput proof-of-principle method for the expanded generation, enrichment

147 brid modeling approach that combines a first-principle model and an artificial neural network (ANN) m

148 Our proof of principle model successfully predicted the daily evoluti

149 us theoretical problems with the free-energy principle model, which are shown in the current article.

150 line surfaces in ultrahigh vacuum, and first-principles modeling using density functional theory calc

151 icity and comparable forecast skill to first-principles models at short lead times.

152 interface is studied via classical and first-principles molecular dynamics simulations combined with

153 Here, we explore a biophysical cost-benefit principle, namely that the cell should keep its proteome

154 knowledge, practical considerations and key principles need to support exposure assessment for engin

155 w the convergence of combinatorial inputs to principle neurons of associative brain regions is establ

156 determine the optimal number of states in a principled, objective way.

157 -oxidants has been utilized as the detection principle of an analytical procedure applied for the fir

158 inireview, we first illustrate the molecular principle of CRISPR functioning process from sensing to

159 stematically identify many violations of the principle of detailed balancing in a model proposed for

160 Capacitive deionization (CDI), based on the principle of electrosorption, has been intensively resea

161 e entire blood flow architectures follow the principle of equipartition of imperfections.

162 Our results point to a general principle of interplay between phasic arousal and decisi

163 e Riemannian manifold, was obtained from the principle of least action.

164 For example, physics has the Principle of Least Action; the Principle of Minimum Powe

165 ure-function relationships are a fundamental principle of many naturally occurring systems.

166 priate number of expression groups using the principle of maximum entropy.

167 ysics has the Principle of Least Action; the Principle of Minimum Power Dissipation, also called Mini

168 The detection principle of nanopore sensors relies on measuring change

169 Our results uncover a simple design principle of organ growth where progenitors and differen

170 r deflection driven by sample expansion, the principle of our approach is to maintain a zero amplitud

171 sation of water droplets help understand the principle of phase separation.

172 hus, the results suggest an important design principle of separable contributions from ECM prestrain

173 strate a much more elaborate interconnection principle of the anuran dopaminergic system than previou

174 The basic principle of the described methodologies is also applica

175 The principle of the E-DNA sensor is the target induced conf

176 abdane diterpene andrographolide, the bitter principle of the herb Andrographis paniculata (known as

177 synthesis of nanomaterial; (3) The detection principle of the proposed aptasensor.

178 We previously identified and modeled a principle of visual map alignment in the midbrain involv

179 as a framework for understanding the design principles of a number of types of molecular motors and

180 It describes the principles of Abi, details how these principles are impl

181 Although the basic principles of axon guidance are well established, it rem

182 These types of guidance outline principles of best practice and provide a framework for

183 meworks to help identify the neurobiological principles of brain disorders.

184 zed through effective dissemination of these principles of care, with more primary palliative care de

185 apeutic techniques that exploit the physical principles of cavitation.

186 elf-management (PePS) intervention, based on principles of CBT, to determine feasibility and prelimin

187 we explore the common themes and core design principles of cellular clocks, giving special considerat

188 expression, as well as cell-type-independent principles of chromatin organization.

189 y data while remaining dedicated to the FAIR principles of data management (findability, accessibilit

190 cally handle parameter settings based on the principles of database management systems.

191 pairs, co-coding themes based on established principles of effective coaching: (i) self-identified go

192 s this hypothesis in relation to established principles of electrophysiological theory.

193 sent unique platforms for efforts to harness principles of enzyme function for catalyst design.

194 omathematical framework based on fundamental principles of evolution and radiobiology for in silico c

195 ions for anxious youths are largely based on principles of extinction learning studied in adulthood.

196 improve our understanding of the ecological principles of FMT and have a positive translational impa

197 vity of nucleic acid sequences have revealed principles of gene regulation and guided genetic variati

198 Ultimately, this in-depth study unravels the principles of hydrocarbon activation with different Pt s

199 The principles of image-based approaches to detecting oral c

200 hat constrains using MEG/EEG to reveal novel principles of information processing or to translate fin

201 ereas major insight has been gained into the principles of intraspecies interaction, much less is kno

202 ntric outlook underscores the spatiotemporal principles of membrane and signaling lipids, which helps

203 Furthermore, we summarized the regulatory principles of miRNAs in NSDs, including miRNA synergisti

204 Here, the fundamental principles of MRI contrast agents are discussed, and the

205 muscle stretch velocity - emerge from first principles of muscle contractile mechanics.

206 we describe a sampling approach derived from principles of neural coding as a framework to understand

207 Understanding the principles of neuronal connectivity requires tools for e

208 In this review, we reveal the basic principles of oral bacterial delivery, from internal gen

209 resses, it is becoming possible to apply the principles of population health science to help us bette

210 rs is key to revealing emergent organization principles of Rho signalling.

211 Sound principles of statistical inference dictate that uncerta

212 Building and expanding on principles of statistics, machine learning, and scientif

213 eview focuses on the fundamental operational principles of the main single-molecule nanomechanical te

214 The complexity and principles of these regulatory networks are only beginni

215 Uncovering the principles of this dynamism, including new ways to obser

216 Understanding the principles of VILI energetics may provide valuable insig

217 ruses have expanded our understanding of the principles of virology.

218 analogies and differences in the organizing principles of visuo-social processing across two phyloge

219 nding the behavior of chalcogenides (and, in principle, other lone-pair materials) by studying protot

220 First-principles path-integral computations are carried out, p

221 CMP is rooted in the principled physics of driving forces and reveals granula

222 d has prepared this updated statement of our principles, placed in the context of the advances in cov

223 This new design principle provides an effective and versatile platform f

224 The experiment-free approach based on first principles provides an analytical framework for estimati

225 The principle QTL determining SET (SET1: dormancy cycling) i

226 atterns they reveal to establish informative principles rather than fastidious rules.

227 potentially reversible, thus representing a principled read-out for the neurophysiological assessmen

228 ses, malignant B cell expansion, and generic principles relating to receptor interactions and crossta

229 We propose a set of five key principles relevant to the European Medicines Agency, Eu

230 ed polymers in industry, of which the design principle remains unknown [M.

231 ave been valuable tools in accelerated first-principles screening for the discovery of the next gener

232 in situ and operando characterization, first-principles simulation, high throughput computation, mach

233 Using first-principles simulations combined with thermodynamic model

234 Using high-level first-principles simulations of all critical experimental step

235 We report data from first-principles simulations showing that the lifetime of the

236 ing neutron scattering techniques with first-principles simulations.

237 This proof-of principle study provides valuable probes for NTMT1/2 and

238 In this proof-of-principle study, we have utilized label-free spontaneous

239 We focus on the general principles, such as breaches in immune tolerance and bar

240 e the broader use of these compounds, design principles supported by density functional theory calcul

241 Ala tailing thus follows mechanistic principles surprisingly similar to canonical translation

242 ease that is prone to drug resistance, is in principle susceptible to such traps.

243 We present an automatic probability-principled synapse detection algorithm and integrate it

244 lth equity remains the guiding institutional principle that applies to all its activities across the

245 inhibition ELISA (g-iELISA) is based on the principle that binding of monoclonal antibodies to speci

246 Thus, our results provide proof of principle that D/N Vif variants could have therapeutic p

247 fests tapering symmetry, a felicitous design principle that may have evolved not only to aid the anal

248 to share some of the unconventional guiding principles that brought me to where I am in this rich sc

249 ave converged on a consistent set of general principles that characterize visual processing of motion

250 ur data have implications for the organizing principles that govern assembly of these large loci as w

251 After an analysis of the general principles that govern controlled and directed movement

252 While general principles that govern the shape of SDSL ESR spectra are

253 sing on reaching and grasping and the neural principles that guide them.

254 We identify principles that guide whether physical distancing, masks

255 ts and processes that are designed following principles that make them conducive to life.

256 Surprisingly, many basic physiological principles that underlie neuronal signaling in the AOB r

257 ndings extend our understanding of the basic principles that underpin pHLA selectivity and exemplify

258 In principle, that difference can support more and larger g

259 cal and cultural evolution may be similar in principle the underlying mechanisms and time scales are

260 llations, that have so far escaped a common, principled theoretical account.

261 Here, we carried a principled theoretical analysis to answer this question.

262 First-principles theoretical explorations of the electronic st

263 cryogenic vibrational spectroscopy and first principles theory.

264 To establish proof-of-principle therapeutic effects, we tested PEAMOtecan as m

265 based sensing modalities are suitable, as in principle they can detect and quantify electroactive dru

266 In accordance with the force-from-filament principle, they may provide a connection to the ECM that

267 As a proof of principle, this manuscript investigates the comparative

268 Since optimality is accepted as a physical principle, this provides a theoretical explanation for w

269 In principle, this scenario would be compared to the emergi

270 This work establishes a general design principle to control over ultra-large optical asymmetry

271 protease, suggesting that it is possible in principle to fully biochemically reconstitute the sequen

272 In conclusion, we provide proof-of-principle to propose AD is a PCBDopathy, a disease of pr

273 n Nature, using biologically inspired design principles to recapitulate native crypt-villi topography

274 in motion (conservation of mass and momentum principles) to predict the flow characteristics.

275 s that have been utilized and suggest design principles toward high-mobility indacenodithiophene-base

276 ing visual processing and what computational principles underlie these history dependencies.

277 these specific questions will reveal general principles underlying brain function.

278 e provide key insights into the minimalistic principles underlying centromere maintenance.

279 To understand the principles underlying such belief updates, we need tools

280 ess this problem, we discuss the biophysical principles underlying the droplet state of proteins by a

281 Our study reveals a central principle underpinning intra-tumoral heterogeneity and m

282 s body of work in light of key computational principles underpinning discovery of circulating microRN

283 perimentally and investigated the underlying principles using computer simulations.

284 In principle, variability in levels of cervical OS has the

285 In particular, we provide a principled way to transfer knowledge from these two doma

286 Central to the adaptation-enhancing principle we identify is the ability of noise to mitigat

287 As a proof of principle, we applied this approach to the malaria-causi

288 As a proof-of-principle, we apply MutSpace to 560 breast cancer patien

289 As a proof of principle, we apply torsional forces to a coarse-grained

290 As an initial proof-of-principle, we chose an anchoring molecule composed of ag

291 As a proof of principle, we demonstrated that SimCells can be used as

292 As proof of principle, we have quantified an endogenous peptide of h

293 As proof-of-principle, we used site-specific mutagenesis to examine

294 only establish a set of general engineering principles which can be used to convert natural and desi

295 Reusability is part of the FAIR data principle, which aims to make data Findable, Accessible,

296 Using the free energy principle, which bridges information theory and Bayesian

297 n is inhibited by the Heisenberg uncertainty principle, which imposes a limit to the precision with w

298 We created A-IDP puncta using these simple principles, which are capable of sequestering an enzyme

299 emerged as another important organizational principle within cells.

300 er minds creatively situates the free-energy principle within real-life cultural processes, thereby e