ライフサイエンスコーパス: prioritization

1 l (DNN-GFS) that is optimized for neoantigen prioritization.

2 ibution of biodiversity and for conservation prioritization.

3 iant a p-value to permit variant ranking and prioritization.

4 to ensure degradation fidelity and substrate prioritization.

5 ains unclear in the context of high waitlist prioritization.

6 study aims to evaluate the efficacy of this prioritization.

7 sample categorization and functional variant prioritization.

8 ized recipients might be poor under KAS high-prioritization.

9 effective tool for drug target discovery and prioritization.

10 ere characterized to help inform drug target prioritization.

11 ranking scores can improve epilepsy variant prioritization.

12 eir elective waiting list (WL) based on unit prioritization.

13 lication of the variants to achieve accurate prioritization.

14 neural substrates that support such dynamic prioritization.

15 ecific regulatory networks and for regulator prioritization.

16 eneral preparatory mechanism for value-based prioritization.

17 ols) to optimize the power of candidate-gene prioritization.

18 d to a cumulative threats index for possible prioritization.

19 to identify maximally diverse compounds for prioritization.

20 ant to therapeutic target identification and prioritization.

21 ated with spatial attention and multisensory prioritization.

22 or under Kidney Allocation System (KAS) high prioritization.

23 s, forecast trends, and inform public health prioritization.

24 ces by processes of functional inhibition or prioritization.

25 g to better inform clinical trial design and prioritization.

26 eed for strategies that advance disease gene prioritization(1,2).

27 Overall, our results are compatible with a prioritization account, but point to nuanced differences

28 Using a validated genetics-led target prioritization algorithm (Pi) of genome wide association

29 disease genes applying various network-based prioritization algorithms and proposes candidate drugs.

30 on systems and compared them to four variant prioritization algorithms and two single-measure control

31 Third, we developed signal prioritization algorithms to further differentiate micro

32 l and in silico studies, employing different prioritization algorithms.

33 suggest that visual salience contributes to prioritization among objects.

34 tions, haplogroup assignment, functional and prioritization analysis of mitochondrial variants) as we

35 Performing variant-prioritization analysis on germline DNA of 1,507 C-AYA p

36 products, and examples of successful strain prioritization and BGC activation strategies that have b

37 A) domains from DNA sequences, which enables prioritization and dereplication, and integration with o

38 This interface can inform target prioritization and drug design, and serves as a navigati

39 argue that Africans should take the lead in prioritization and evaluation of environmental hazards,

40 In summary, RepeatHMM-DB can facilitate prioritization and identification of disease-relevant ST

41 y provide pertinent clinical information for prioritization and optimal peritransplant management of

42 also provides an automated scheme for kernel prioritization and parameter tuning.

43 obabilistic causal models enabled detection, prioritization and replication of high-confidence master

44 outlined here can help to guide geographical prioritization and strategy design.

45 Through prioritization and stringent selection criteria, we sele

46 retrospective-cue WM paradigm to manipulate prioritization and suppression task demands designed to

47 We discuss the testing guidance for prioritization and their application in a hospital setti

48 Steps 1, 2 and 3 were discovery, prioritization and validation for tracking suicidality,

49 t methods for rapid sample characterization, prioritization and workflow optimization.

50 hylation profiling as a tool for causal gene prioritization and, potentially, therapeutic targeting i

51 very, differential expression analysis, eQTL prioritization, and pathway enrichment analysis.

52 in protein function prediction, disease gene prioritization, and patient stratification.

53 lts highlight implications of MOT allocation prioritization, and potential consequences to KAT candid

54 demonstrate how our genetics-led drug target prioritization approach (the priority index) successfull

55 Here, we present a restoration prioritization approach capable of revealing these syner

56 Our SIL-methylation prioritization approach effectively reduced the complexi

57 only be identified by means of an integrated prioritization approach that would not only preserve spe

58 Here, we demonstrate the use of a spatial prioritization approach to efficiently prioritize specie

59 in fine-mapping studies, we applied our MGW-prioritization approach to three non-coding regions asso

60 Through a tailored prioritization approach, we identify places containing f

61 This study is the first systematic review of prioritization approaches for selecting ECs that may pos

62 Online databases were searched for prioritization approaches relating to ECs in the aquatic

63 icochemical properties that allowed compound prioritization are presented.

64 exploratory time trend detection and feature prioritization are proposed.

65 In addition to our tool, we provide a gene prioritization atlas that includes mantis-ml's predictio

66 sis tools such as variant filtering and gene prioritization based on phenotype.

67 novel candidate variants for PD using a gene prioritization based on PPI information, and described w

68 r to 20 well-powered GWASs and compared gene prioritization based on strategies employing three diffe

69 Prioritizations based on terrestrial species yielded on

70 SNP prioritization-based fixation index (F(ST)) scores were

71 prioritization in the wider context of gene prioritization, burden testing and genotype-phenotype as

72 ience and reward expectations influence this prioritization but their relative contributions and unde

73 ther spatially is important for conservation prioritization, but the relationship remains poorly unde

74 opulation at two scales and aid conservation prioritization by identifying potential future habitat f

75 to improve the performance of TWASs in gene prioritization by integrating the expression regulatory

76 biomarker identification and in silico drug prioritization by the integration of multiomics data.

77 r, we also show that a reliance on ROI-based prioritization can sometimes exacerbate disagreements ov

78 r sizeable number and poorer annotation make prioritization challenging.

79 As might be expected from prioritization changes, post-KAS candidates were less li

80 include functional annotation, disease gene prioritization, comparative analysis of biological syste

81 s of inquiry should examine how geographical prioritization could affect HIV transmission.

82 sion prediction algorithms makes therapeutic prioritization difficult.

83 hese associations into future target or gene prioritization efforts.

84 w to support proteogenomics-based neoantigen prioritization, enabling more sensitive discovery of put

85 gaps in prostate cancer care, via a detailed prioritization exercise including all key stakeholders.

86 algorithm for reproducibility, sensitivity, prioritization, false positive rate and computational ti

87 rug synergy for individual tumors (treatment prioritization for a patient), drug repositioning and di

88 vered by nontarget analysis (NTA), but their prioritization for health concerns is challenging.

89 rocesses of related diseases and give a good prioritization for known disease genes.

90 There is currently no systematic or national prioritization for monitoring waters for chemicals with

91 Current prioritization for patients with ALF is highly effective

92 work recently approved liver transplant (LT) prioritization for patients with hepatocellular carcinom

93 roposed SNN model is able to perform disease prioritization for the metabolic profiles of IEM patient

94 The review concludes with a proposal for a prioritization framework for ECs in groundwater monitori

95 A gene prioritization framework, POCKET (prioritizing the candi

96 tion with conventional approaches to variant prioritization - genetic fine-mapping and regulatory ann

97 use cases such as biocuration support, gene prioritization, genetic disease analysis, and literature

98 Malaria vaccine design and prioritization has been hindered by the lack of a mechan

99 To date, empirical approaches to marine prioritization have not considered larval connectivity a

100 to scale-up treatment in prisons considering prioritization (HCV fibrosis stage vs. HCV prevalence of

101 EAR prioritization identified multiple sites, biological pat

102 pex detection algorithms in order to perform prioritization in data sets produced via LC-HR-MS.

103 perties could support scaffold selection and prioritization in small molecule development projects.

104 for the rank-ordering of drug libraries for prioritization in subsequent studies.

105 Pediatric prioritization in the allocation and development of impr

106 dy provided an analysis perspective for gene prioritization in the context of genetic heterogeneity a

107 We place variant prioritization in the wider context of gene prioritizati

108 Computational approaches for variant prioritization include machine learning methods utilizin

109 rain supervised learning models for compound prioritization, initial screening must provide the neces

110 However, an integrated approach whereby prioritization is based on all biodiversity components a

111 reservoir of biosynthetic gene clusters, but prioritization is required to predict which gene cluster

112 , but it is unknown whether this attentional prioritization is sustained throughout later time window

113 s for target validation, defining the target prioritization landscape for 30 immune traits at the gen

114 VAT prioritization may help explain several patterns of nutr

115 highlighted an exclusion (71%) rather than a prioritization mechanism (17%).

116 The developed prioritization method enables reducing raw data and incl

117 A prioritization method incorporating all genomic and MPRA

118 We have developed DeepPVP, a variant prioritization method that combined automated inference

119 proaches with Rosalind, a comprehensive gene prioritization method that combines heterogeneous knowle

120 Consequently, in this study, a prioritization method to handle time series in nontarget

121 e lack of a groundwater specific contaminant prioritization methodology in spite of widely recognized

122 DeepPVP further improves on existing variant prioritization methods both in terms of speed as well as

123 Although a few neoantigen prioritization methods have been proposed to address thi

124 exons; nevertheless, most noncoding variant prioritization methods only focus on transcriptional reg

125 -percentile CCRs complement existing variant prioritization methods when evaluating de novo mutations

126 ation, which cannot be found by most current prioritization methods, for example, variants affecting

127 ions, outperforming state-of-the-art variant prioritization methods.

128 ur study than those provided by related gene prioritization methods.

129 ource, sequence-dependent DNA topology, as a prioritization metric for fine-mapping.

130 sage of sequence-dependent DNA topology as a prioritization metric in genomic association studies.

131 Here, we developed GenieScore, a prioritization metric that integrates a consensus-based

132 ed and applied Minor Groove Width (MGW) as a prioritization metric.

133 rity trial design, choice of end points, and prioritization of a patient's perspectives, are presente

134 l; this function may be useful for automated prioritization of abnormal chest radiographs.

135 aking, provided that the uncertainty affects prioritization of actions.

136 tation-level interpretation, including joint prioritization of all nonsilent mutation consequence typ

137 uctural annotation of metabolites and guides prioritization of analysis by using Mass2Motif prevalenc

138 genes was transferred to the prediction and prioritization of ASD-associated lncRNAs.

139 oteins and ligands, which can be used in the prioritization of assays to be performed in both discove

140 deficient when IDA is diagnosed owing to the prioritization of available iron to red blood cells over

141 rm is designed to support identification and prioritization of biological targets for follow-up.

142 g clones between conditions, and enables the prioritization of biomarkers for follow-up experiments b

143 icult decisions are being made regarding the prioritization of both active treatments and palliative

144 generate testable hypotheses on disease gene prioritization of brain disorders.

145 ta sets might improve the identification and prioritization of cancer vulnerabilities as well as pati

146 s useful results in cases where an efficient prioritization of cancer-associated genes is needed.

147 Here, we present a framework for the 'Prioritization of candidate causal Genes at Molecular QT

148 This facilitates prioritization of candidate genes for functional follow-

149 a major bottleneck is the identification and prioritization of candidate genes for manipulation.

150 most existing multi-tissue methods focus on prioritization of candidate genes, and cannot directly i

151 el network based approach for the systematic prioritization of candidate inhibitors for arbitrary tar

152 resources and forced rationing, triage, and prioritization of care in general, specifically of surgi

153 xtremely useful to guide decision-making and prioritization of care.

154 th single-cell gene expression permitted the prioritization of causal genes, functional variants and

155 The identification and prioritization of chemically tractable therapeutic targe

156 ions for in vitro-in vivo extrapolation, and prioritization of chemicals in nontarget screenings.

157 Our results suggest that impaired prioritization of cognitive resource allocation may cont

158 loped and can serve as "roadmaps" to support prioritization of compounds for clinical testing.

159 We interpret the results as supporting a prioritization of cortical resources for walking, leadin

160 ures relevant to Mendelian disorders and the prioritization of de novo mutations associated with comp

161 consent process for each involved party, the prioritization of deceased donor kidneys, the allocation

162 lepsies will aid in targeting resources, the prioritization of diagnostic testing and development of

163 isk individuals and for genetically-informed prioritization of drug targets for prevention trials.

164 The selection and prioritization of drug targets is a central problem in d

165 The model combines the prioritization of environmental outcomes in terms of car

166 gulatory complexes, thereby facilitating the prioritization of epigenetic targets for DUX4 silencing.

167 signals mediated by dopamine help guide the prioritization of events for long-term memory consolidat

168 Prioritization of evidence-based medical education is ne

169 Further prioritization of features in wastewater before and afte

170 Prioritization of future areas for protection is hampere

171 ons in asexual parasites and enable rational prioritization of future functional characterization and

172 ood leukocyte 'regulome' that can facilitate prioritization of future functional studies.

173 ine activity in drinking water and to inform prioritization of future monitoring, chemical testing an

174 trations of biofouled microplastics, and (V) prioritization of gaining a mechanistic and functional u

175 ecular mechanisms underlying ADHD and allows prioritization of genes for functional validation in val

176 Our results suggest that knowledge-guided prioritization of genes using ProGENI gives new insight

177 arity-based method that provides genome-wide prioritization of genes, variants, or gene sets and can

178 g pipelines, allowing the categorization and prioritization of genetic variants for follow up analysi

179 This study provides a framework for prioritization of GWAS variants and highlights a role of

180 ying tumor biology which can be utilized for prioritization of HCC LT candidates.

181 local policy makers in their assessment and prioritization of health care infrastructure.

182 y in epidemiologic research; and 4) increase prioritization of health disparities research and method

183 ist management of emerging pandemics through prioritization of high-resolution testing or isolation m

184 Prioritization of highly sensitized (HS) candidates unde

185 gical activity, but challenges remain in the prioritization of hit series.

186 o date and developed consensus guidelines on prioritization of immunoassays, specimens, and collectio

187 To guide the prioritization of implementation, we evaluate ten land m

188 ing resources, making the identification and prioritization of individuals most at-risk a critical ch

189 egSNPs-intron and ASSET-seq enable effective prioritization of iSNVs for disease pathogenesis.

190 lignancies to conflicting degrees, hindering prioritization of key therapeutic targets within the net

191 Rapid evaluation and prioritization of large numbers of chemicals used in mat

192 ologically based PK models can assist in the prioritization of leading preclinical drug candidates fo

193 harmonization and informs knowledge gaps and prioritization of limited resources.

194 ut the effect of dopamine replacement on the prioritization of memories by reward and the time-depend

195 tical regions, and reflect enhanced cortical prioritization of memory representations that serve as a

196 Our results accelerate the evaluation and prioritization of new drug development programmes and re

197 The outcome of this study is the prioritization of NNS to inform decision-making for the

198 encoding of information by allowing for the prioritization of novel stimuli over familiar ones.

199 ntry's political stability, the government's prioritization of nutrition and execution of nutrition e

200 o improve maternal and child health; and the prioritization of nutrition-sensitive initiatives by bot

201 ectly repress defence, consistent with plant prioritization of nutritional stress over defence.

202 composition of habitat-building species and prioritization of particular configurations for protecti

203 introduce MutPred2, a tool that improves the prioritization of pathogenic amino acid substitutions ov

204 Earlier prioritization of patients at risk of experiencing a sus

205 ividuals at high risk of COVID-19 and enable prioritization of PCR testing and containment efforts.

206 cohort may facilitate the identification and prioritization of potential drug targets and selection o

207 thways that target tumor vulnerabilities and prioritization of potential pharmacogenomics biomarkers

208 Limited objective data exist to guide the prioritization of prevention efforts within pediatric su

209 ures, patient preparation and communication, prioritization of procedures, and development of outpati

210 This study was conducted to aid prioritization of quality improvement initiatives.

211 for downstream experimental examination and prioritization of reef sites for conservation/restoratio

212 Working memory (WM) relies on the prioritization of relevant information and suppression o

213 e compromised, resulting in a failure in the prioritization of relevant information.

214 This review contributes to a strategic prioritization of research efforts across multiple disci

215 research; transparency in all reporting; and prioritization of research questions.

216 ss taxa, ecosystems and processes, strategic prioritization of research that addresses stakeholder-re

217 They argue that, although prioritization of resources is critical, fairness requir

218 ant defenses function in ecosystems, and the prioritization of responses to emerging challenges such

219 ification of species and basins at risk, and prioritization of restoration measures, such as dam remo

220 -biobank study offers a new value of PRSs in prioritization of risk factors that could be potential t

221 vant biological PM metabolites permitted the prioritization of screening in different salmon tissues

222 al cortex (LPFC) plays a central role in the prioritization of sensory input based on task relevance.

223 heritability between populations, suggesting prioritization of shared functional variants.

224 f a plant's life cycle depends on successful prioritization of signaling favoring either growth or de

225 graphic variations in care seeking may guide prioritization of some regions for intensified engagemen

226 ietary counselling, food-policy planning and prioritization of species for aquaculture to fight hunge

227 To guide the effective prioritization of specific biosynthetic gene clusters (B

228 ildhood deaths that could be informative for prioritization of strategies aimed at reducing under-5 m

229 pulations are not well known, preventing the prioritization of STRs that may be associated with human

230 d vector control and provide a basis for the prioritization of surveillance.

231 ata from distinct experimental platforms for prioritization of targets and treatments.

232 Ultimately, prioritization of testing will depend on institutional-s

233 QSAR modeling can be used to aid testing prioritization of the thousands of chemical substances f

234 enetic vulnerabilities of OSCC, enabling the prioritization of therapeutic targets for further explor

235 This supports the prioritization of therapies and lifestyle interventions

236 Translational studies should guide adequate prioritization of those therapeutic agents and combinati

237 This led to prioritization of transmembrane protein Tmem63c as a nov

238 ay improve the selection process for and the prioritization of transplant candidates.

239 available options, an informed selection or prioritization of treatments is becoming harder for clin

240 approaches for the systematic and efficient prioritization of tumor-context specific protein activit

241 is and patient-derived cell assays), enables prioritization of under-explored targets and allows for

242 tions provide initial guidance to inform the prioritization of urban climate adaptation measures and

243 This evidence supports the prioritization of vaccines within the global strategy to

244 lligence (AI) in enhancing understanding and prioritization of variance in the clinical setting and p

245 gh-throughput genomic data make analysis and prioritization of variants difficult for researchers wit

246 done through annotation, filtering, and then prioritization of variants for manual curation.

247 Prioritization of variants in personal genomic data is a

248 However, prioritization of variants in rare disease patients rema

249 n in complex disorders, and the curation and prioritization of variants in recall-by-genotype studies

250 Visual temporal attention, the prioritization of visual information at specific points

251 ata is highly needed as it could enhance the prioritization of weak loci.

252 r the lower-frequency category, suggesting a prioritization of weakly learned information early in a

253 novel valid alternative for the quantitative prioritization, optimization and development of novel dr

254 Whilst its prioritization performance is state-of-the-art, a distin

255 The prioritization performances demonstrate the feasibility

256 DNN-GFS demonstrated increased neoantigen prioritization power comparing to existing sequence-base

257 % and >=35%) to reflect differing allocation prioritization pre-KAS and post-KAS.

258 The analyst is therefore required to perform prioritization prior to nontarget structural elucidation

259 stic isotope patterns, we established a data prioritization process to identify the amino compounds i

260 gy and evidence-based reviews to inform this prioritization process.

261 the amygdala can initiate endogenous memory prioritization processes in the absence of emotional inp

262 15 loci, we concluded that evidence for gene prioritization remains inconsistent, insufficient, or ab

263 henotypic observation has contributed to the prioritization result.

264 clinical guidelines for review and return of prioritization results.

265 or popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, an

266 Prioritization schemes that limit unnecessary in vivo te

267 hit prioritization that we call Hit to Lead Prioritization Score (H2LPS).

268 and prioritized, and 3 received the maximum prioritization score by the LAC: first, to establish mor

269 methods and pointing to the capture of true prioritization signals for disease-associated genes.

270 ile and active role in adaptive sensorimotor prioritization.SIGNIFICANCE STATEMENT In many situations

271 The combined text classification and signal prioritization significantly enriched true positives amo

272 hat compares performance of similarity-based prioritization strategies to each other (and to random c

273 ecular network and score-based approaches as prioritization strategies, the Northeastern Atlantic mar

274 s (in eight probands) survived our filtering/prioritization strategy.

275 We treated the classifiers as variant prioritization systems and compared them to four variant

276 eneous sources to improve the reliability of prioritization systems.

277 using an algorithm that we designed for hit prioritization that we call Hit to Lead Prioritization S

278 ptome-wide association studies for risk gene prioritization through integration of genome-wide associ

279 y, new biomarkers, and in silico drug target prioritization through interrogation of drug target data

280 We showcase the application of this prioritization to somatic burdening, cancer differential

281 ts also completed a validated health outcome prioritization tool and an instrument determining the ac

282 ncing data (GeMSTONE), a cloud-based variant prioritization tool with high-level customization and a

283 lculate exposure-activity ratios (EARs) as a prioritization tool.

284 Many prioritization tools and online interpretation resources

285 export the extracted HPO concepts into gene prioritization tools.

286 Variant prioritization using IMPACT resulted in increased trans-

287 iological basis, using a stepwise discovery, prioritization, validation, and testing in independent c

288 Then, using a stepwise discovery, prioritization, validation, and testing in independent c

289 the top biomarkers that survived discovery, prioritization, validation, and testing was FKBP5, a wel

290 Furthermore, this dynamic prioritization was associated with the temporally specif

291 Final prioritization was generated hierarchically on the basis

292 The system's performance in radiograph prioritization was tested in a simulation by using an in

293 To enhance biological precision and gene prioritization, we integrated three complementary famili

294 Third, we show that this prioritization weight feature is significantly less vari

295 l in the classification of samples, and thus prioritization, when compared to the other evaluated app

296 TWAS is especially prone to spurious prioritization with expression data from non-trait-relat

297 nfold cross-validations as well as candidate prioritization with hypothetical loci.

298 We suggest best practices for causal-gene prioritization with TWAS and discuss future opportunitie

299 nto the neural implementation of attentional prioritization within working memory.

300 er of key areas in which additional research prioritization would facilitate both research fields sim