ライフサイエンスコーパス: pro-apoptotic

1 as soluble receptor agonists are but weakly pro-apoptotic.

2 on of DUX4, which inhibits myogenesis and is pro-apoptotic.

3 FasL has been previously implicated in the pro-apoptotic actions of E(2).

4 at LyP-1-QU-NPs not only exhibited excellent pro-apoptotic activities but also presented strong inhib

5 Furthermore, CBD enhanced the pro-apoptotic activities of JNK1/2 and MAPK p38 signalin

6 d to activate immune response and to exhibit pro-apoptotic activity against some tumor cells.

7 elated apoptosis-inducing-ligand (TRAIL)-has pro-apoptotic activity in a range of cancers and synergi

8 ophobic aryl substitution were essential for pro-apoptotic activity in cancer cells.

9 ted that ATF3 activated p53 and promoted its pro-apoptotic activity in mouse thymi and small intestin

10 ht to investigate whether restoration of the pro-apoptotic activity of FOXO1 may be used as a new pro

11 nonresponsive cell types susceptible to the pro-apoptotic activity of IFN-lambda, revealing the comb

12 rotranslocation, is more significant for its pro-apoptotic activity than its ability to insert and to

13 affinity, which correlates with its stronger pro-apoptotic activity.

14 imilar affinity for both domains were potent pro-apoptotic agents in cancer cell lines and efficaciou

15 turated fatty acids as antiproliferative and pro-apoptotic agents in MDA-MB-231 breast cancer cells.

16 The clinical translation of effective pro-apoptotic agents involves drug discovery studies (ad

17 Pro-apoptotic analogues of vitamin E (VE) exert selectiv

18 Pro-apoptotic and anti-apoptotic Bcl-2 family proteins r

19 A study of pro-apoptotic and anti-apoptotic Bcl-2 family proteins s

20 OvCa patient-derived xenografts induces both pro-apoptotic and anti-apoptotic signaling responses tha

21 two analogs of the hit with high cytotoxic, pro-apoptotic and anti-mitotic activities.

22 otropic signal transducer that promotes both pro-apoptotic and anti-proliferative signaling, and they

23 ies revealed that SETD8 ablation rescued the pro-apoptotic and cell-cycle arrest functions of p53 by

24 as two opposing actions: antitumoral through pro-apoptotic and cytostatic activities, and pro-tumoral

25 -sulfur cluster biosynthesis, the release of pro-apoptotic and non-cell-autonomous signalling molecul

26 ng ERK1/2 kinase and inhibited expression of pro-apoptotic and pro-fibrotic JNK and TGFbeta1 proteins

27 Furthermore, we show that the pro-apoptotic and pro-tumorigenic functions of PKCdelta

28 miR-138 directly targets a suite of pro-apoptotic and tumour suppressive genes, including tu

29 hondria directly and exclusively through its pro-apoptotic and vacuolating cytotoxin VacA.

30 ike apoptotic response requires formation of pro-apoptotic Bak complexes with hundreds of subunits, s

31 In pro-apoptotic Bak, we demonstrate that the corresponding

32 ipts (N-Bak mRNA), leading to suppression of pro-apoptotic BAK1 proteins and allowing neurons to redu

33 -apoptotic Bcl-2 expression decreased, while pro-apoptotic Bax expression increased in vehicle-treate

34 three different types are increased when the pro-apoptotic Bax gene is knocked out.

35 Pro-apoptotic Bax induces mitochondrial outer membrane p

36 Pro-apoptotic BAX is a cell fate regulator playing an im

37 How the pro-apoptotic Bax protein permeabilizes the mitochondria

38 ak, Bok has long been considered part of the pro-apoptotic Bax-like subfamily, but no studies have ye

39 ibition of mitochondrial permeabilization by pro-apoptotic BAX.

40 where in turn, it inhibits up-regulation of pro-apoptotic Bbc3 and Dab2ip.

41 ing pathway (i.e., OTUD7B and TNIP2) and the pro-apoptotic Bcl-2 associated death promoter (BAD) prot

42 echanistic insights into the function of the pro-apoptotic BCL-2 family member BOK have remained elus

43 Three WM cell lines expressed pro-apoptotic Bcl-2 family members Bim or Bax and Bak at

44 PUMA is a pro-apoptotic Bcl-2 family protein that can act as a tum

45 pendent functions of IRF3 and also on Bax, a pro-apoptotic Bcl-2 family protein, through a direct int

46 The multidomain pro-apoptotic Bcl-2 family proteins BAK and BAX are beli

47 Pro-apoptotic Bcl-2 homology 3 (BH3)-only proteins antag

48 rest are endogenous factors that can inhibit pro-apoptotic BCL-2 mitochondrial outer membrane translo

49 damage checkpoint eliminates oocytes via the pro-apoptotic BCL-2 pathway members Puma, Noxa and Bax.

50 ed by radiotherapy increases the activity of pro-apoptotic BCL-2 pathway proteins, and lymphomas are

51 The pro-apoptotic Bcl-2 protein Bax can permeabilize the out

52 port a general mechanism of sequestration of pro-apoptotic BCL-2 proteins into fibers by HN to inhibi

53 Pro-apoptotic BCL-2 proteins oligomerize at the mitochon

54 to the binding specificity of BH3 domains of pro-apoptotic BCL-2 proteins towards apoptotic suppresso

55 ha7 that resembles the BH3 binding domain of pro-apoptotic Bcl-2 proteins, and can be blocked by BH3

56 ting apoptosis through interactions with the pro-apoptotic BCL-2 proteins.

57 Pro-apoptotic Bcl-2-associated X protein (BAX) is an exe

58 election within exon 2 to produce either the pro-apoptotic Bcl-x(s) or the anti-apoptotic Bcl-x(L).

59 optosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim).

60 effects primarily through interactions with pro-apoptotic BH3 containing proteins that achieve high

61 hosphorylation of a distal serine inhibits a pro-apoptotic BH3 domain and promotes cell survival.

62 the in vitro sensitivity of ALPS DNTC to the pro-apoptotic BH3 mimetic, ABT-737.

63 o TWIST1 suppression of transcription of the pro-apoptotic BH3-only gene, BCL2L11 (BIM), by directly

64 duction of SOX2, which in turn represses the pro-apoptotic BH3-only genes BIM and BMF.

65 ment caused increased accumulation of NOXA a pro-apoptotic BH3-only member of the BCL2 family.

66 correlated with increased expression of the pro-apoptotic BH3-only protein BIM, cleaved caspase 3 an

67 In response to pro-apoptotic BH3-only protein signaling and pharmacolog

68 this by upregulating a cluster of redundant pro-apoptotic BH3-only proteins and suppressing pro-surv

69 Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2 pathway inhibition is

70 n expression of MCL-1 but importantly induce pro-apoptotic BIM expression.

71 t does so primarily by reducing the level of pro-apoptotic BIM.

72 ranscription factor SLUG to directly repress pro-apoptotic BMF, limiting drug-induced apoptosis.

73 GD3 is pro-apoptotic but GD3(A) can protect cells from apoptosi

74 rolled by c-FLIP isoforms, which function as pro-apoptotic (c-FLIPL only) or anti-apoptotic (c-FLIPL/

75 kine and ER stress-induced activation of the pro-apoptotic calcium-dependent enzyme, calpain, and par

76 nt with activation of anti-proliferative and pro-apoptotic canonical target genes.

77 ntermediate compartment, where DR5 assembles pro-apoptotic caspase 8-activating complexes.

78 luciferase biosensors detect granzyme B and pro-apoptotic caspase activation within minutes of targe

79 r findings demonstrate how Shigella inhibits pro-apoptotic caspase activity, effectively delays coord

80 y programmed cell death when the predominant pro-apoptotic caspase CED-3 is compromised.

81 aB-driven gene transcription pathway and the pro-apoptotic caspase pathway.

82 Consequently, the activity of pro-apoptotic caspases and neuronal death were enhanced

83 e insensitive to TRAIL, robust activation of pro-apoptotic caspases by NK cell-derived TRAIL was dete

84 d BIR3 domain inhibitors that displace bound pro-apoptotic caspases.

85 amide biosynthesis, which contributes to the pro-apoptotic cellular response.

86 gents, including paclitaxel (Taxol), involve pro-apoptotic ceramide in their anticancer effects.

87 tive GSH and SOD activity;si-TTP upregulated pro-apoptotic cleaved-caspase-3 expression, and downregu

88 nstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced per

89 ivation was prevented, assembly of the TNFR1 pro-apoptotic complex II was reduced, and TNF-induced ap

90 Under pro-apoptotic conditions, however, cyt c gains cardiolip

91 a BDNF-independent manner in NB cells under pro-apoptotic conditions, such as serum deprivation and

92 hat distinguish them functionally from their pro-apoptotic counterparts.

93 itochondria-derived signalling downstream of pro-apoptotic cues may also have non-lethal functions.

94 nalized with linTT1 peptide in tandem with a pro-apoptotic [D(KLAKLAK)2] peptide showed p32-dependent

95 tion, BOK is stabilized to initiate a unique pro-apoptotic death program.

96 he gene expression of both proliferative and pro-apoptotic E2F1 target genes.

97 sed by cancer cells, once activated, exert a pro-apoptotic effect in different tumors.

98 ); and (v) complete abrogation of the normal pro-apoptotic effect of dexamethasone and fluticasone fu

99 is, and importantly, antagonizing the normal pro-apoptotic effect of GCS.

100 hondrial biogenesis may account for the poor pro-apoptotic effect of metformin in cancer cells.

101 easome, and that binding to IP3Rs limits the pro-apoptotic effect of overexpressed Bok.

102 BB-Cl-amidine had a pro-apoptotic effect on all Th subsets in vitro with Th1

103 icipate in this process by either activating pro-apoptotic effectors or inhibiting anti-apoptotic com

104 Thus, anti-nucleolar and pro-apoptotic effects of protein C are flavivirus-specie

105 n of MLK3 in the HER2+ cell line blunted the pro-apoptotic effects of trastuzumab and lapatinib.

106 independent GISTs had anti-proliferative and pro-apoptotic effects, associated with Rb activation and

107 Associated with these cell cycle and pro-apoptotic effects, we observed increased CCNA2 and B

108 enario, this can have either pro-survival or pro-apoptotic effects.

109 kinases 1 and 2, enhanced activation of the pro-apoptotic enzymes caspase-3 and -7 and increased apo

110 cysteine proteases, which also includes the pro-apoptotic enzymes known as caspases.

111 ed to the mitochondria, wherein they trigger pro-apoptotic events leading to shrinkage of basal KCs u

112 These pro-apoptotic events were absent in KI mice and were att

113 subsequently promotes the expression of the pro-apoptotic factor BAX (Bcl-2-associated X protein), a

114 s, and is rescued by genetic blockade of the pro-apoptotic factor BAX.

115 d as a mediator of cell cycle arrest or as a pro-apoptotic factor in stressful conditions, the MAP3K

116 BRAF or EGFR inhibitors, rapidly deplete the pro-apoptotic factor NOXA, thus creating a dependence on

117 es apoptosis by increasing the expression of pro-apoptotic factor p53-upregulated modulator of apopto

118 that modulate the expression of PDCD4, a key pro-apoptotic factor, and also reveals new insights into

119 stress-induced cleavage of caspase-2 and the pro-apoptotic factor, Bid, leading to subsequent release

120 reduction of spz, Toll, or the rpr/hid/grim pro-apoptotic factors each suppresses invasion, suggesti

121 In addition, the pro-apoptotic factors FoxO1/3 are overly degraded by ace

122 optosis through ATF4-dependent expression of pro-apoptotic factors including Bid and Trb3.

123 Pro-apoptotic family members contain a weakly conserved

124 or development by its anti-proliferative and pro-apoptotic features.

125 We evidence that pro-apoptotic fragment generated by caspase cleavage of

126 We demonstrate that the pro-apoptotic fragment of the bone marrow kinase on chro

127 eaved in the intestinal mucosa to generate a pro-apoptotic fragment that is spatially restricted to t

128 so highlights the potential role of villin's pro-apoptotic function in the pathogenesis of inflammato

129 endant phosphorylation of FOXO1 restored the pro-apoptotic function of FOXO1 in PCa.

130 Consistent with the pro-apoptotic function of MLK3, stable knockdown of MLK3

131 gs suggest that HER2 activation inhibits the pro-apoptotic function of MLK3, which plays a mechanisti

132 ylation sites regulating the pro-oxidant and pro-apoptotic function of p66.

133 and this phosphorylation is crucial for its pro-apoptotic function.

134 nhibiting p53 aggregation can reactivate p53 pro-apoptotic function.

135 otes podocyte survival by inhibiting dendrin pro-apoptotic function.

136 KDM3A suppressed pro-apoptotic functions of p53 by erasing p53-K372me1, a

137 ng the normal transcriptional activation and pro-apoptotic functions of p53.

138 -fold, and adenoviral vectors expressing the pro-apoptotic gene Bax by >150,000-fold.

139 neurogenesis by conditional deletion of the pro-apoptotic gene Bax in stem cells reduced excitatory

140 nducible transgenic mouse model in which the pro-apoptotic gene Bax is deleted from neural stem cells

141 Finally, the pro-apoptotic gene Baxwas necessary to generate the dimo

142 translocated to the nucleus, and induced the pro-apoptotic gene BCL2-like 11 (Bim).

143 cell death but did cause upregulation of the pro-apoptotic gene BIM.

144 a novel association of a polymorphism in the pro-apoptotic gene FASTKD2 (fas-activated serine/threoni

145 show that Nos-Pum-mediated repression of the pro-apoptotic gene head involution defective (hid) is re

146 chemotherapy, associated with increased P53 pro-apoptotic gene promoter occupancy and target gene ex

147 stream activities as genetic ablation of the pro-apoptotic gene Puma reverts the reproductive abnorma

148 Delivery of the pro-apoptotic gene PUMA to FLS via human adenovirus type

149 rus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a r

150 ediated by transcriptional repression of the pro-apoptotic gene reaper.

151 genes BCL2 and BCL2L1 was downregulated and pro-apoptotic gene TNFSF10 was upregulated in MSB1 cells

152 d to strong, selective overexpression of the pro-apoptotic gene XAF1 (X-linked inhibitor of apoptosis

153 FSP1) and which was initially described as a pro-apoptotic gene(11), confers protection against ferro

154 ulates the transcription of the neighbouring pro-apoptotic gene, Bcl2l11 (also known as Bim), by prom

155 pecies (ROS) and induction of transcripts of pro-apoptotic genes and TNF-alpha in vitro at a concentr

156 Here we show that deletion of the pro-apoptotic genes Bak and Bax in osterix (Osx, also kn

157 By making double mutants with the pro-apoptotic genes Bax and Trp53 (p53), we find that p5

158 ne expression of pro-inflammatory cytokines, pro-apoptotic genes BIM and TRAIL and expression of a su

159 ting mutated p53 to induce the expression of pro-apoptotic genes in breast cancer with mutant p53.

160 rmore, PEITC treatment induced expression of pro-apoptotic genes in tumor cells, which was partially

161 er, the expression of E2F1 proliferative and pro-apoptotic genes is correlated with the levels of UCH

162 er developmental stages by up-regulating the pro-apoptotic genes reaper and hid The apoptosis induced

163 These include pro-apoptotic genes that are transcriptionally down-regu

164 clin-dependent kinase, osteocyte marker, and pro-apoptotic genes were increased in isolated Men1 knoc

165 ene targets (including tumor suppressors and pro-apoptotic genes) and resistance to cytotoxic chemoth

166 G9a augmented p53-dependent transcription of pro-apoptotic genes, including Bax and Puma, resulting i

167 ed apoptosis by augmenting the expression of pro-apoptotic genes, PUMA and Bax.

168 target membranes to form pores that deliver pro-apoptotic granzymes into the target cell.

169 These large pores facilitate the entry of pro-apoptotic granzymes, thereby rapidly killing the tar

170 ional downregulation and upregulation of the pro-apoptotic histone H2AX but clinically problematic du

171 Genetic codepletion of Hdac1 with Hdac2 was pro-apoptotic in Emicro-Myc lymphoma in vitro and in viv

172 masomes directly utilize caspase-8 as both a pro-apoptotic initiator and major IL-1beta-converting pr

173 antial increase in the abundance of the most pro-apoptotic isoforms of Bim.

174 Mechanistically, PARP14 inhibits the pro-apoptotic kinase JNK1, which results in the activati

175 tastasis with stem-cell mediated delivery of pro-apoptotic ligands and have important clinical implic

176 ultimately led to induction of the important pro-apoptotic marker gene chop.

177 In fact, multiple pro-apoptotic markers were increased, whereas anti-apopt

178 Deltapsi(m)) substantiated the intracellular pro-apoptotic mechanism activated by the binding of this

179 through VDR-dependent anti-proliferative and pro-apoptotic mechanisms.

180 nts of the unfolded protein response and the pro-apoptotic mediators CamkII and Stat1 was impaired in

181 The first direct activator of BAX, a pro-apoptotic member of the BCL-2 family, has been recen

182 t was abrogated in cells lacking Bak/Bax-two pro-apoptotic members of the Bcl-2 family of proteins re

183 sequences are found on both pro-survival and pro-apoptotic members, although their primary function i

184 e to capture the critical BH3 alpha-helix of pro-apoptotic members.

185 Also, Bax activation and pro-apoptotic mitochondrial intermembrane space protein

186 ofound reduction in the kinase activity of a pro-apoptotic mixed lineage kinase 3 (MLK3) in HER2-posi

187 ctor FoxO3a, and decreased expression of the pro-apoptotic molecule Bim.

188 The pro-apoptotic molecule, Bim, was significantly elevated

189 IL-33 also increased the expression of pro-apoptotic molecules, including Bcl-2-associated X pr

190 blocked by pharmacological inhibition of the pro-apoptotic molecules, JNK, glycogen synthase kinase 3

191 election by suppressing expression levels of pro-apoptotic molecules.

192 Interestingly, Bim, a highly pro-apoptotic negative regulator of Bcl-2, was upregulat

193 h low anti-apoptotic BCL-xL expression, high pro-apoptotic NOXA expression, and paradoxical, MYCN-dri

194 tic cytoplasmic CLU was decreased, while the pro-apoptotic nuclear CLU was largely maintained, after

195 mor selectivity and antitumor efficacy of IP pro-apoptotic NWs.

196 s and requires the nuclear and mitochondrial pro-apoptotic p53 program to induce and execute apoptosi

197 kine-induced activation of the IRE1alpha/JNK pro-apoptotic pathway in cytokine-exposed beta cells.

198 A novel pro-apoptotic pathway initiated by the interaction betwe

199 This cofilin-p53 pro-apoptotic pathway is subject to negative regulation

200 nd thereby inhibit the p-eIF2alpha/ATF4/CHOP pro-apoptotic pathway, identifying miR-30b-5p and miR-30

201 initiates retrograde activation of a somatic pro-apoptotic pathway, which, in turn, is required for d

202 stress, suppresses the p-eIF2alpha/ATF4/CHOP pro-apoptotic pathway.

203 and initiate cell death through induction of pro-apoptotic pathways.

204 asculature-homing peptide (CGKRK) fused to a pro-apoptotic peptide [D(KLAKLAK)2] coated on iron oxide

205 synthetic approach to enzyme-responsive and pro-apoptotic peptide brush polymers.

206 A fusion peptide of M2pep with pro-apoptotic peptide KLA (M2pepKLA) was further used to

207 or example, intracellular delivery of KLA, a pro-apoptotic peptide, results in toxicity against a var

208 ins, as well as cell entry and function of a pro-apoptotic peptide.

209 Critically, increased grafting density of pro-apoptotic peptides on brush polymers correlates with

210 Moreover, pro-apoptotic polypeptide brushes show enhanced cell upt

211 signalling and explained the differences in pro-apoptotic potential between soluble and membrane-bou

212 ncer cell populations even in the absence of pro-apoptotic pressure.

213 fy new combinations of stimuli that maximize pro-apoptotic processes.

214 cause this pathway is normally halted by the pro-apoptotic protease caspase-8 and the IAP ubiquitin l

215 llele occurrence and increased levels of the pro-apoptotic protein appoptosin in PSP patients.

216 uzumab treatment, but rather inactivated the pro-apoptotic protein BAD, the BCl-2-associated death pr

217 mitochondria, MCL-1 interacts with the major pro-apoptotic protein BAK and prevents BAK-BAK homo-olig

218 ential of a pharmacological activator of the pro-apoptotic protein BAX to suppress acute myeloid leuk

219 , and functions to activate the Bcl-2 family pro-apoptotic protein Bax.

220 s significantly reduced the induction of the pro-apoptotic protein Bim both in vitro and in mice.

221 Increasing Grx1 reduces the pro-apoptotic protein Bim expression through regulating

222 hat was 'rescued' by genetic deletion of the pro-apoptotic protein Bim or transgenic expression of Bc

223 A shared target of miR-17~92 miRNAs is the pro-apoptotic protein BIM, central to life-death decisio

224 dd45alpha, the tumor suppressor PTEN and the pro-apoptotic protein Bim.

225 nting the proteasome mediated degradation of pro-apoptotic protein BIM.

226 ry cytokine leptin, and incurred loss of the pro-apoptotic protein C/EBP homologous protein (CHOP).

227 In this manner, treatments that increase pro-apoptotic protein expression increase the efficacy o

228 Now, Simon et al. identify the pro-apoptotic protein Puma as a key factor in this cell

229 NOXA is a pro-apoptotic protein that functions by binding the BCL2

230 One primary pro-apoptotic protein that responds to both PERK and Ire

231 BAX is a pro-apoptotic protein that transforms from a cytosolic m

232 -ATPase (SERCA), and decreases levels of the pro-apoptotic protein thioredoxin-interacting protein (T

233 ell apoptosis through induction of CHOP, the pro-apoptotic protein, and sensitizes cells to lipopolys

234 f 1, 2 and 10mg/kg could alter the levels of pro-apoptotic protein, Bax, anti-apoptotic protein, Bcl-

235 ), an outer mitochondrial membrane-targeting pro-apoptotic protein, can be used for light-mediated in

236 Death receptor 5 (DR5), a cell surface pro-apoptotic protein, triggers apoptosis upon ligation

237 gy to Bax and Bak, has been proposed to be a pro-apoptotic protein.

238 l-2 and Bcl-xL), while reduced expression of pro-apoptotic proteins (AIF and Bax).

239 pha) significantly reduced the expression of pro-apoptotic proteins (Bax and PUMA) and autophagic pro

240 onsequent DNA fragmentation, accumulation of pro-apoptotic proteins (p27, p53, p89 PARP fragments), a

241 e include the BH3 sequence shared with other pro-apoptotic proteins and an unexpected sequence locate

242 for death" by elevated BCL-2, which binds to pro-apoptotic proteins and holds them in check.

243 ses in the mitochondrial levels of activated pro-apoptotic proteins Bax and Bid, and to a lesser exte

244 ition as evidenced by an upregulation of the pro-apoptotic proteins Bax, cleaved caspase-3, and downr

245 ntrations at the mitochondria surface of the pro-apoptotic proteins Bax/Bak.

246 We find that levels of the BH3-only pro-apoptotic proteins Bim and Noxa are proteasomally re

247 s such as Bax and Bak mediate the release of pro-apoptotic proteins from the mitochondria by clusteri

248 Furthermore, the expression levels of the pro-apoptotic proteins of CHOP/GADD153 and caspase-12 we

249 BCL-2 inhibition drives sequestered pro-apoptotic proteins to MCL-1 and vice versa, explaini

250 s, the pore opens, increasing the release of pro-apoptotic proteins, and ultimately resulting in cell

251 We report that unlike other pro-apoptotic proteins, Bim contains two distinct bindin

252 he mitochondrial envelope and the release of pro-apoptotic proteins, leading to cell death.

253 -apoptotic proteins to counter expression of pro-apoptotic proteins, WM samples expressed both pro- a

254 complementary set of anti-proliferative and pro-apoptotic proteins.

255 guously into the Bax-like Bcl-2 subfamily of pro-apoptotic proteins.

256 activation of BNIP3 and BNIP3L, which encode pro-apoptotic proteins.

257 dependent kinase inhibitors and upregulating pro-apoptotic proteins.

258 ose integrated action drives upregulation of pro-apoptotic Puma, which, unexpectedly, is confined to

259 netic and transcriptomic data demonstrates a pro-apoptotic reactivation of the cell cycle in post-mit

260 g ligand (TRAIL; TNFSF10) receptor (TR) is a pro-apoptotic receptor whose contribution to chronic cho

261 Dysfunction of Bax, a pro-apoptotic regulator of cellular metabolism is implic

262 nd EZH2 in PAX3-FOXO1 RMS cells impaired the pro-apoptotic response, whereas the overexpression of FB

263 letion of Hdac1 with Hdac2 mediates a robust pro-apoptotic response.

264 A pro-apoptotic role for AMPK is suggested by the finding

265 e death and/or fibrosis, suggesting that the pro-apoptotic role of IRF3 is independent of TLR signali

266 Both mutations showed pro-apoptotic sensitization by reduced phosphorylation o

267 n treatment produced prolonged activation of pro-apoptotic Ser(727) p-STAT1 and suppressed Tyr(705)-p

268 reting a pore-forming protein (perforin) and pro-apoptotic serine proteases (granzymes) into the syna

269 that, given a variable, slowly accumulating pro-apoptotic signal arising from anti-apoptotic protein

270 otic signal, or (2) all the cells generate a pro-apoptotic signal but the majority silences this path

271 inhibition: (1) only a few cells generate a pro-apoptotic signal, or (2) all the cells generate a pr

272 nduced p75(NTR) and attenuates activation of pro-apoptotic signaling and cell death.

273 ng technique to measure early changes in net pro-apoptotic signaling at the mitochondrion ("priming")

274 that KU55933 upregulated p53 and subsequent pro-apoptotic signaling in tubular epithelia of cisplati

275 tenuates pro-oxidative, pro-inflammatory and pro-apoptotic signaling mediated by inducible nitric oxi

276 The resulting release of pro-apoptotic signaling proteins leads to cell destructi

277 deficiency on hippocampal dopamine-dependent pro-apoptotic signaling were studied in mechanically ven

278 t, and kidneys, are profoundly refractory to pro-apoptotic signaling, leading to cellular resistance

279 of PKCdelta is necessary and sufficient for pro-apoptotic signaling.

280 ry through the upregulation of p53-dependent pro-apoptotic signaling.

281 mice against ventilationinduced hippocampal pro-apoptotic signaling.

282 iratory chain defect, metabolic disturbance, pro-apoptotic signalling, and oxidative stress.

283 formation of predisposed cells by inhibiting pro-apoptotic signals and activating tumor-promoting ER

284 ignant transformation, our study reveals how pro-apoptotic signals can elevate ROS past a previously

285 19) use the RIP-Tag mouse model to show that pro-apoptotic signals mediated by the Activin B-ALK7 axi

286 hat represses FOXO-mediated transcription of pro-apoptotic Smac/DIABLO orthologue, Hid in germline st

287 his system is particularly responsive to the pro-apoptotic sphingolipid ceramide and that this respon

288 Ceramide is a pro-apoptotic sphingolipid with unique physical characte

289 UCH37 localizes to the promoters of E2F1 pro-apoptotic target genes such as caspase 3, caspase 7,

290 We showed previously that P53 pro-apoptotic target promoters are enriched with H3K9me3

291 e that in response to P53 stabilization, its pro-apoptotic target promoters become enriched with the

292 AP II ser5-CTD phosphorylation on these same pro-apoptotic target promoters, which correlated with re

293 /10B apoptosis-inducing ligand (TRAIL) based pro-apoptotic therapies that induce death receptor signa

294 e ROS past a previously hypothesised 'lethal pro-apoptotic threshold' to induce death; an observation

295 induce the intracellular upregulation of the pro-apoptotic transcription factor DDIT3 which is associ

296 ctions, including negative regulation of the pro-apoptotic transcription factor p53.

297 the sensing surface that are related to the pro-apoptotic treatment.

298 Following a pro-apoptotic trigger, cytosolic BAX is activated and tr

299 The p53 pro-apoptotic tumour suppressor is mutated or functional

300 In contrast, IFNgamma increased pro-apoptotic TXNIP post-transcriptionally via induction