ライフサイエンスコーパス: pro-drug

1 oxic: air cytotoxicity ratio compared to the pro-drug.

2 isomer of a complex nucleoside monophosphate pro-drug.

3 l lines in the presence of ganciclovir (GCV) pro-drug.

4 ctivation of isoniazid, an anti-tuberculosis pro-drug.

5 ractive prospect as a pediatric erythromycin pro-drug.

6 agent (in this case, NO) from a photoactive pro-drug.

7 ommonly used therapeutics and also activates pro-drugs.

8 ing the blood stream are similar for the two pro-drugs.

9 the efficacy of lactone-containing drugs and pro-drugs.

10 ivity was predictive of sensitization to the pro-drug (2-20-fold sensitization), with cell death rest

11 Cells were incubated with PpIX pro-drug 5-aminolevulinic acid (5-ALA) at 0, 1, 2, 3, an

12 se gene followed by exposure to the nontoxic pro-drug 5-FC may be a potential strategy to selectively

13 or catalyzes the deamination of the nontoxic pro-drug, 5-fluorocytosine (5-FC), thus converting it to

14 enzyme activity and resistance to the toxic pro-drug 6-thioguanine.

15 f these mice with the artificial chromophore pro-drug, 9-cis-retinyl acetate, partially protected inf

16 These pro-drugs achieve pharmacological activity only after en

17 us, prophylactic delivery of RBC-targeted PA pro-drugs activated selectively at the site of clot form

18 results in the laboratory, including enzyme-pro-drug activating systems, correction of genetic mutat

19 NMR studies reveal the key steps in pro-drug activation and the effect of activated NAMI-A s

20 ening cell killing ability through cytotoxic pro-drug activation.

21 both known drug importers and the only known pro-drug activator, and links more than fifty additional

22 Dicarbomethoxy (pro-drug) analogues of [(124/125)I]4d and [(11)C]4e (i.e

23 hould be replaced by investments in modular (pro)drug and nanocarrier design.

24 l TNPs comprising a fluorescent platinum(IV) pro-drug and a clinically tested polymer platform (PLGA-

25 This PVA bound ATRA can then act as a pro-drug and accumulate within the skin to allow for the

26 Benznidazole is a pro-drug and is bio-activated within the parasite by the

27 FAD-dependent enzyme which activates cancer pro-drugs and stabilizes several oncosuppressors.

28 ting as a Phase II enzyme, activating cancer pro-drugs and stabilizing p53 and p73alpha oncosuppresso

29 ir ability to activate anti-inflammatory azo pro-drugs and to detoxify azo dyes.

30 f cytotoxin release, enzymatic activation of pro-drugs, and secretion of physiologically active biomo

31 r sebaceous gland size, indicating that this pro-drug approach was critical to obtain the desired act

32 Capecitabine (CAP) is a 5-FU pro-drug approved for the treatment of several cancers a

33 e properties of proteasome inhibition by the pro-drug are the same as the specific proteasome inhibit

34 cetylcysteine, a membrane-permeable cysteine pro-drug, as a potential disease-modifying intervention

35 A novel structure of paAzoR1 with the azo pro-drug balsalazide bound within the active site was de

36 in this study is 80% open-ring form and 20% pro-drug, beta-lactone form.

37 sult of a previously unknown function of the pro-drug, beta-lactone ring form of lovastatin to inhibi

38 tively activated in vivo by SPHK2, other S1P pro-drugs can be phosphorylated to cause lymphopenia thr

39 itized cancer cells in tissue culture to the pro-drug CB1954 and promoter activity was predictive of

40 itroreductase enzyme in combination with the pro-drug CB1954 in a suicide gene therapy strategy.

41 eductase sensitize human cancer cells to the pro-drug CB1954.

42 ace functionalization, a polymerizable siRNA pro-drug conjugate with a degradable, disulfide linkage

43 Furthermore, the incorporation of pro-drug converting enzyme, herpes simplex virus thymidi

44 protease) and a cleavable peptide-chromogen (pro-drug) covalently incorporated into a hydrogel, was i

45 oxic tumor regions using a hypoxia-activated pro-drug delayed AR to ICIs in murine Msh2 KO tumors.

46 , we sought to design a family of HP-beta-CD pro-drug delivery vehicles, known as polyrotaxanes (PR),

47 The success of the pro-drug depends on (a) elimination of the unacceptably

48 report here the design and synthesis of new pro-drugs, derived from co-drugs combining a NEP and an

49 age administration of tributyrin, a butyrate pro-drug, elicited an almost 50% increase in non-rapid-e

50 inistered to children as a suspension of the pro-drug erythromycin A 2'-ethyl succinate.

51 Two inhibitors, captopril and fosinopril (a pro-drug ester of fosinoprilat), were tested for larvici

52 response to dosing with TCA cycle metabolite pro-drug esters, suggesting that the high levels of cell

53 Activation of the pro-drug ethionamide is regulated by the Baeyer-Villiger

54 tars appeared to be less susceptible to this pro-drug even after 72 h exposure.

55 of toxic compounds, enzymatic activation of pro-drugs, expression of tumor suppressor or apoptotic p

56 Isotretinoin is a pro-drug for all-trans retinoic acid, which can induce l

57 chieved only by i.v. administration may be a pro-drug for formation of H(2)O(2), and that blood can b

58 The addition of acyclovir (ACV), a pro-drug for the inhibition of cell proliferation, resul

59 tition assays revealed that these amides are pro-drugs for parent aniline 2.

60 PXS-5120A, in a pro-drug form (PXS-5129A, 12o), displayed anti-fibrotic

61 Salicylate and its pro-drug form aspirin are widely used medicinally for th

62 etastatin A-4 (CA-4) in phosphate and serine pro-drug forms is under phase II clinical trials.

63 oxylate group will simplify the synthesis of pro-drug forms of 5-NIC for characterization in cell-inf

64 In vivo we demonstrate that the pro-drug formulation reduces application site inflammati

65 ceptor agonists, led by the immunomodulatory pro-drug FTY720, has revealed that S1P signaling is an i

66 HSV-TK converts the pro-drug ganciclovir (GCV) into a toxic nucleotide analo

67 a 21-day ablation phase induced by the HSVtk pro-drug, ganciclovir (GCV), oocyte numbers declined due

68 This lead compound and its phosphate pro-drug have potent in vivo antimalarial activity after

69 Triggered release of siRNA from the pro-drug hydrogels was observed under a reducing environ

70 dly abrogates the lactacystin and lovastatin pro-drug inhibition of the proteasome.

71 bit the HMG-CoA reductase enzyme, lovastatin pro-drug inhibits the proteasome but does not inhibit HM

72 tion process involving the N-acyl-asparagine pro-drug intermediates preamicoumacins, which are hydrol

73 orts as this is the target of the first line pro-drug isoniazid.

74 agement and activation of the antitubercular pro-drug isoniazid.

75 ible for activation of the anti-tuberculosis pro-drug isoniazid.

76 hypoxic tumor regions with hypoxia-activated pro-drugs like TH-302, which may substantially delay the

77 Consumption of glucosinolates, pro-drug-like metabolites abundant in Brassica vegetable

78 roscopy revealed that the fluorescein-tagged pro-drug localizes to the nuclei of A459 cells.

79 ese observations suggest that CpTK-activated pro-drugs may be an effective strategy for treating cryp

80 anti-tumor immune response, or delivering a pro-drug metabolizing enzyme that will render the tumor

81 In this study, we examined self-assembling pro-drug nanoconjugates of naturally derived antitumor e

82 strate the functionality and action of a new pro-drug nucleotide for CRC.

83 utathione S-transferase pi (GSTpi)-activated pro-drug, O(2)-[2,4-dinitro-5-[4-(N-methylamino)benzoylo

84 Nelarabine (506U78) is a soluble pro-drug of 9-beta-D-arabinofuranosylguanine (ara-G), a

85 ation of an approved oral ARV, and (3) an LA pro-drug of an approved oral ARV.

86 The ethyl ester pro-drug of compound 15 (compound 22) shows substantial

87 Treatment of mdx myotubes with a pro-drug of methylprednisolone also reduced calpain subs

88 phenylbutyrate (GPB), a liquid triglyceride pro-drug of PBA, containing no sodium and having favorab

89 PZA is a pro-drug of pyrazinoic acid (POA), whose target of actio

90 OG is a pro-drug of the ACC inhibitor 5-(tetradecyloxy)-2-furoic

91 y have shown that Minnelide, a water-soluble pro-drug of triptolide (anti-cancer compound), decreases

92 e are some interesting approaches, including pro-drugs of propofol such as Aquavan (MGI Pharma, Bloom

93 Mazindane (26) was found to be a pro-drug, oxidizing (5-H --> 5-OH) to mazindol on rat st

94 lacetate/phenylbutyrate (administered as the pro-drug phenylbutyrate) (OP) combined are synergistic a

95 ammonio derivative to construct a platinated pro-drug possessing 11 copies of a carboplatin analogue

96 Clopidogrel is an oral antiplatelet pro-drug prescribed to 40 million patients worldwide who

97 nds are bicyclic nitroimidazoles that act as pro-drugs, requiring activation by a mycobacterial enzym

98 is to encourage the development of effective pro-drug strategies to increase the intracellular levels

99 of its in vitro and in vivo evaluation as a pro-drug targeted at prostate cancer cells.

100 Heroin acts as a pro-drug that allows rapid and complete central nervous

101 , 6-mercaptopurine is a clinically important pro-drug that is activated by conversion into 6SG by cel

102 It is demonstrated that largazole is a pro-drug that is activated by removal of the octanoyl re

103 Pyrazinamide is a pro-drug that is converted into pyrazinoic acid (POA) by

104 Here, we identified curcumin as a pro-drug that requires oxidative activation into reactiv

105 argue for the notion of immunotherapies as "pro-drugs" that act to augment or modulate T cells, whic

106 ells can be achieved by gene-directed enzyme pro-drug therapy (GDEPT).

107 tations by targeting a thrombin-activated PA pro-drug to circulating red blood cells (RBCs).

108 d that blood can be a delivery system of the pro-drug to tissues.

109 t the possibility of using hypoxia activated pro-drugs to localize treatments for neuropathic pain an

110 e been synthesized and evaluated as putative pro-drug tracers.

111 onsible for activation of isoniazid (INH), a pro-drug used to treat tuberculosis infections.

112 classes of azo dyes and activate several azo pro-drugs used in the treatment of inflammatory bowel di

113 ganciclovir (GCV) or its orally bioavailable pro-drug valganciclovir (VGCV).

114 Meanwhile, screening pro-drug variants enabled surmounting cell permeability

115 r arylation of diazeniumdiolates form stable pro-drugs which have found application in hypertension,

116 ed that an appropriately engineered peptidyl pro-drug will release active cytotoxic agent strictly wi

117 Gemcitabine is a pro-drug with active metabolites generated intracellular

118 d due to the difficulty of developing stable pro-drugs with slow kinetics of NO release.