ライフサイエンスコーパス: proapoptotic

1 t signaling node that is either mitogenic or proapoptotic.

2 Treatments with the autoantibodies induced proapoptotic activities and suppressed the surface expre

3 ression reverses shPUM antiproliferative and proapoptotic activities.

4 ession (RT-PCR) studies confirmed the strong proapoptotic activity (increase in p53, decrease in v-my

5 rotein kinase B (AKT) pathway and shows high proapoptotic activity against chronic lymphocytic leukem

6 minal region of Bax, directly activating its proapoptotic activity by inducing a conformational chang

7 -15 signals in macrophages to suppress their proapoptotic activity by inhibiting TNF and nitric oxide

8 death in neoplastic cells by re-engaging the proapoptotic activity induced by unliganded dependence r

9 is, VDAC2 controls both the localization and proapoptotic activity of BAK.

10 Here we show that GSK-3beta inactivates the proapoptotic activity of HLXB9 by phosphorylating HLXB9

11 It is unclear whether the antiproliferative/proapoptotic activity of oncogenes can be pharmacologica

12 cells carrying the ELANE mutations evade the proapoptotic activity of the NE mutants in SCN patients.

13 seudokinase 3) is a stress-induced gene with proapoptotic activity that was previously described as h

14 eubiquitinases with micromolar IC50, and its proapoptotic activity was studied on several cancer cell

15 We combined these assays of CL-induced proapoptotic activity with structural and dynamic studie

16 e, an iminosugar endowed with an interesting proapoptotic activity, has been accomplished using an en

17 whereas the short isoform (Mcl-1S) displays proapoptotic activity.

18 t in part, because of the engagement of PTCH proapoptotic activity.

19 inally, we evaluate the IL-11Ralpha-targeted proapoptotic agent bone metastasis-targeting peptidomime

20 lling but also potently sensitize PEL to the proapoptotic agents tumor necrosis factor alpha and etop

21 illing and the sensitization of PEL cells to proapoptotic agents.

22 poorly responsive to current therapies with proapoptotic agents.

23 , leading to cell cycle arrest and with both proapoptotic and anti-angiogenic activities.

24 regulators of apoptosis and consist of both proapoptotic and antiapoptotic factors.

25 s dictated by a shift in the balance between proapoptotic and antiapoptotic gene expression programs.

26 significant antioxidant, antiproliferative, proapoptotic and antibacterial activities of raspberry p

27 rogramming, which resulted in suppression of proapoptotic and cell-cycle-regulatory target genes.

28 dings, significantly increased expression of proapoptotic and proinflammatory factors was also found

29 This process is regulated by proapoptotic and prosurvival members of the B-cell lymph

30 c-Abl plays both proapoptotic and prosurvival roles, and our findings sug

31 ey regulator of the cellular balance between proapoptotic and prosurvival sphingolipids.

32 s studies on prodigiosin, including possible proapoptotic anticancer properties, we investigated how

33 were due to an exaggerated activation of the proapoptotic arms of the endoplasmic reticulum stress re

34 study was to further clarify the role of the proapoptotic B-cell lymphoma 2 homology domain 3 (BH3)-o

35 corticoids converges on the induction of the proapoptotic B-cell lymphoma-family protein Bim to produ

36 enuates PIM1-mediated phosphorylation of the proapoptotic BAD and activates BAD-dependent apoptosis.

37 ns and NF-kappaB-independent inactivation of proapoptotic BAD protein.

38 orylation, and mitochondrial localization of proapoptotic Bad.

39 phosphorylated H2AX, but not degradation of proapoptotic BAK in the cSCCs.

40 of functional involvement in evasion of the proapoptotic barrier.

41 rs in response to a cellular upregulation of proapoptotic Bax, as small interfering RNA (siRNA)-media

42 otein FPV039 promiscuously binds to cellular proapoptotic Bcl-2 and engages all major proapoptotic Bc

43 a mitochondrial size that is permissive for proapoptotic BCL-2 family function.

44 nduces target cell apoptosis by cleaving the proapoptotic Bcl-2 family member Bid, which, together wi

45 e responses, decitabine also upregulated the proapoptotic BCL-2 family member BNIP3, which is known t

46 Deletion of the proapoptotic Bcl-2 family members Bax and Bak inhibits b

47 m the mitochondria, which is promoted by the proapoptotic Bcl-2 family protein, Bax.

48 ies and do not depend on the presence of the proapoptotic Bcl-2 family proteins Bax or Bak, indicatin

49 e for binding BH3 peptides and does not bind proapoptotic Bcl-2 family proteins Bax or Bak.

50 sociated apoptosis is mediated mainly by the proapoptotic BCL-2 family proteins BIM and BMF, and thei

51 While it is established that all proapoptotic Bcl-2 homology 3 (BH3)-only proteins bind a

52 ) blocked the mitochondrial translocation of proapoptotic Bcl-2 members and ER stress.

53 The proapoptotic Bcl-2 protein Bax by itself is sufficient t

54 in response pathway to systematically define proapoptotic BCL-2 protein composition after stress and

55 Proapoptotic BCL-2 proteins converge upon the outer mito

56 were found to regulate the expression of the proapoptotic Bcl-2 proteins DP5 and PUMA and consequent

57 ross talk between a key family of miRNAs and proapoptotic Bcl-2 proteins in human pancreatic beta-cel

58 manifested by capturing and neutralizing the proapoptotic Bcl-2 proteins via their BH3 death domains.

59 lar proapoptotic Bcl-2 and engages all major proapoptotic Bcl-2 proteins.

60 otein-protein interactions between anti- and proapoptotic Bcl-2 proteins.

61 oteins to date, FPV039 engaged with cellular proapoptotic Bcl-2 with affinities comparable with those

62 e-9 and was linked to an accumulation of the proapoptotic Bcl-2-family member Noxa.

63 he serine (S)184 phosphorylation site of the proapoptotic Bcl2 family member Bax as an anticancer str

64 of c-MYC and subsequent upregulation of the proapoptotic BCL2 family member PUMA, whereas inhibition

65 pathway, which results in suppression of the proapoptotic BCL2-family member protein BIM (BCL2L11).

66 is locus, two common variants located at the proapoptotic BCL2L11 gene associated with UACR: rs116907

67 ion factor that binds and transactivates the proapoptotic BCL2L11 locus encoding BIM.

68 unotoxins also reduce the levels of selected proapoptotic BH-3-only proteins.

69 d TrkA and transcriptional regulation of the proapoptotic BH3 family members BimEL, Harakiri,and Puma

70 egrated stress response, which activated the proapoptotic BH3 protein Noxa and its downstream targets

71 was also a significant up-regulation of the proapoptotic BH3-containing protein, PUMA.

72 d cell leukemia 1 (MCL1) inhibitor S63845, a proapoptotic BH3-mimetic therapy, significantly decrease

73 ly induced transcriptional activation of the proapoptotic BH3-only molecule BIM, while BCL6 was requi

74 Here we show that loss of the proapoptotic BH3-only protein Bim or, to a lesser extent

75 al studies have revealed that binding of the proapoptotic BH3-only protein PUMA induces significant u

76 s by specific regulation of the mRNA for the proapoptotic BH3-only protein, Bim.

77 We found that BIM-EL, a proapoptotic BH3-only protein, is hydroxylated by EglN3

78 y repressing the gene egl-1, which encodes a proapoptotic BH3-only protein.

79 ed to generate cells deficient for all eight proapoptotic BH3-only proteins (OctaKO) and those that l

80 binding pocket in structures of Bcl-xL with proapoptotic BH3-only proteins.

81 Lastly, we demonstrated that proapoptotic Bim interacts with antiapoptotic Bcl-2 memb

82 The proapoptotic BIM protein is an important mediator of glu

83 IL-4 blocked upregulation of proapoptotic Bim protein levels induced by BCR crosslink

84 h increased levels of nuclear FOXO3A and the proapoptotic BIM protein.

85 lular domain and beta-catenin, deficiency of proapoptotic Bim, increased proliferation, and survival

86 cl-XL, but related to the degradation of the proapoptotic Bim.

87 factor receptor and increased expression of proapoptotic BIM.

88 and less consistently with downregulation of proapoptotic Bmf, Hrk, and BimEL A major role for Mcl-1

89 rately up-regulated c-Myc and down-regulated proapoptotic Bmf, unlike most mature B cells in the adul

90 iciency augments virus-induced activation of proapoptotic c-Jun N-terminal kinase (JNK) signaling.

91 red, which normally drives expression of the proapoptotic C/EBP homologous protein (CHOP).

92 cells and is required for activation of the proapoptotic Ca(2+)-Erk pathway that is selectively acti

93 AMPK phosphorylated proapoptotic caspase-6 protein to inhibit its activation

94 PIDDosome-PIDD-RAIDD-caspase-2 complex-is a proapoptotic caspase-activation platform of elusive sign

95 chanism by which mitochondria and downstream proapoptotic caspases regulate the activation of antivir

96 hibit apoptosis via inhibiting activation of proapoptotic caspases.

97 This is mediated partly via suppression of proapoptotic cathepsin D (CatD) via cocomplexing of the

98 ramidase, the only enzyme known to hydrolyze proapoptotic ceramide, generates sphingosine, which is t

99 o death caused by proteotoxic agents and the proapoptotic chemotherapeutic LCL-161.

100 arming (REW) during interbout arousal (IBA), proapoptotic conditions that are lethal to nonhibernatin

101 ene signature and new vulnerabilities to the proapoptotic drug, ABT-263.

102 ak-dependent apoptosis in response to common proapoptotic drugs like doxorubicin and staurosporine, b

103 The proapoptotic effect of copanlisib was associated with DL

104 and CXCR1 signaling pathways to reverse the proapoptotic effect of the IL-32gamma isoform, leading t

105 ations suggested a potent antiproliferative, proapoptotic effect of the nanodrug in the metastatic ce

106 on of the tTA gene and a tTA-regulated Lshid proapoptotic effector gene.

107 tor 2alpha, nuclear XBP1, and the downstream proapoptotic effector nuclear C/EBP homologous protein.

108 er cells deficient in ISR and the downstream proapoptotic effector, CHOP, promoting tumor growth and

109 significantly greater antiproliferative and proapoptotic effects beyond those achieved by monotherap

110 o avoid glutathione depletion and rescue the proapoptotic effects due to FGF blockade.

111 Our results suggest that, in contrast to its proapoptotic effects in vitro, selective PT Mfn2 deficie

112 rella" that protects cholangiocytes from the proapoptotic effects of bile salts by maintaining them d

113 eas antagomirs to miR-15a/16-1 abolished the proapoptotic effects of BL-8040.

114 ATIP3 silencing improves the proapoptotic effects of paclitaxel and induces mitotic a

115 The proapoptotic effects of S1PR2 are phenocopied by ectopic

116 s and directly binds and inhibits Casp8p41's proapoptotic effects.

117 ncer during chronic inflammation through its proapoptotic effects.

118 were elevated and likely contributed to the proapoptotic environment observed in PAP.

119 m, and deregulated inflammatory reaction and proapoptotic environment, as well as the lysophosphatidy

120 , we sought to better define the role of the proapoptotic ERR-beta2 isoform in GBM.

121 factor KEAP1, the phosphatase PGAM5 and the proapoptotic factor AIFM1.

122 ls and prevented nuclear accumulation of the proapoptotic factor apoptosis inducing factor.

123 creases in inhibitory phosphorylation of the proapoptotic factor Bad and activating phosphorylation o

124 tly aggravated OGD-induced expression of the proapoptotic factor Bim and proinflammatory cytokines MC

125 g a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B

126 MAPK pathway and attenuated induction of the proapoptotic factor BIM.

127 tion and proteasomal degradation of the host proapoptotic factor Siva1.

128 melanocyte differentiation gene MITF and the proapoptotic factor SOX9, thereby preventing differentia

129 is, implying that the T4SS also elaborates a proapoptotic factor(s).

130 function by regulating the expression of the proapoptotic factor, Bcl2l11, and by modulating the stre

131 lls by actively driving the degradation of a proapoptotic factor, SIVA1.

132 re elevation of a unique set of HuR-targeted proapoptotic factors was documented.

133 cessive Ca(2+), or kill neurons by releasing proapoptotic factors.

134 volve around inhibiting its sequestration of proapoptotic factors.

135 is specifically facilitates the induction of proapoptotic Fas ligand upon TCR restimulation, accounti

136 optosis, but the mechanisms that control its proapoptotic function are poorly understood.

137 BCL-2 family proteins BIM and BMF, and their proapoptotic function is conserved between mouse and hum

138 s provide strong evidence that targeting the proapoptotic function of Kv2.1 is an effective and highl

139 RNA restored proper phosphorylation and the proapoptotic function of the GCR.

140 Bim and Nur77, two TCR-induced proteins with proapoptotic function, Bim has been shown to be importan

141 oxidase activity that represents its pivotal proapoptotic function, but we do not observe evidence fo

142 in ligase Fbxo45, resulting in loss of Par-4 proapoptotic function.

143 by mechanisms that may not be related to its proapoptotic function.

144 RAIL-induced cell death, consistent with its proapoptotic function.

145 ol of genes clustered around prosurvival and proapoptotic functions among others.

146 ing the switch between the proautophagic and proapoptotic functions of beclin 1 and ATG5 during infla

147 gamma-glutamylcyclotransferase 1 (Chac1), a proapoptotic gamma-glutamyl cyclotransferase that deplet

148 nd doxorubicin and impaired the induction of proapoptotic gene APAF1 following treatment.

149 We found that high expression of the proapoptotic gene Bcl2-interacting mediator of cell deat

150 FNAR KO Tregs had a higher expression of the proapoptotic gene Bim and higher frequency of active cas

151 xpression, whereas reduced expression of the proapoptotic gene coding Bcl2-associated X protein was o

152 bition of p53 and enhancing p53's effects on proapoptotic gene expression and apoptosis in breast can

153 f epithelial HuR as a contextual modifier of proapoptotic gene expression in intestinal cancers, acti

154 ad box o3 (FOXO3a), leading to repression of proapoptotic gene expression, because the immunosuppress

155 ell death by tipping the balance in favor of proapoptotic gene expression.

156 wal was associated with a downregulatory and proapoptotic gene program enriched within T cells.

157 strain of SINV was engineered to express the proapoptotic gene reaper from Drosophila.

158 nsactivator (tTA) or ectopic expression of a proapoptotic gene, such as head involution defective (hi

159 .g., XIAP and GADD45B) and downregulation of proapoptotic genes (e.g., CASP8 and APAF1) in infected P

160 sed expression of Fas, caspases, and related proapoptotic genes and decreased expression of Ets-1 and

161 panded type I IFN-specific response includes proapoptotic genes and potentiates toxicity triggered by

162 a regulator of the transcription of several proapoptotic genes and through its binding interactions

163 omplex maintains repressive chromatin around proapoptotic genes Bim and BMF and regulates multiple my

164 ucleus, thus inhibiting transcription of the proapoptotic genes CD95/Fas and caspase 7 and de-repress

165 ival and increased the expression of several proapoptotic genes during cellular stress.

166 Further, CRRL269 inhibited proapoptotic genes expression using a polymerase chain r

167 RER also mediates P53-dependent induction of proapoptotic genes following DNA damage, and the chromat

168 apoptosis, through activation of its target proapoptotic genes NOXA and PUMA.

169 tumors, the expression of a subset of these proapoptotic genes predicts good outcome and their expre

170 rovide mechanisms by which RET represses the proapoptotic genes through direct interaction with and p

171 Some proapoptotic genes were downregulated in caspase-3-profi

172 IRER mediates the expression of surrounding proapoptotic genes, and we use an in vivo reporter of th

173 d set of type I IFN-specific ISGs, including proapoptotic genes, have weak ISRE motifs.

174 s increase cytoprotective genes and decrease proapoptotic genes, improve immune clearance of Abeta, a

175 ownstream of expression of the p53-regulated proapoptotic genes.

176 ncreased expression levels of p53-regulated, proapoptotic genes.

177 type I and type II IFN-stimulated genes and proapoptotic genes.

178 tor FOXO1, causing elevated transcription of proapoptotic genes.

179 uded a few tumor-suppressor (CDH1, RCAN) and proapoptotic (GLIPR1, FAS) genes.

180 nhanced activity of the antihypertrophic and proapoptotic GSK-3beta molecule.

181 ta indicate that delayed proinflammatory and proapoptotic host responses to arenavirus infection coul

182 to characterize the systems-level impact of proapoptotic human truncated BID on the cellular network

183 reduced immunosuppression requirements with proapoptotic immunosuppression and among rejection-free

184 showed that the XPO1 inhibitor selinexor is proapoptotic in CLL cells and disrupts B-cell receptor s

185 lidated that the synergistic action of these proapoptotic JAK1 targets is obligatory for the remodeli

186 signalosome, and removing ASK1 abrogated the proapoptotic kinase activity of IRE1alpha.

187 tide-functionalized nanoparticles imbued the proapoptotic "KLA" peptides (amino acid sequence: KLAKLA

188 tter functional axis involves suppression of proapoptotic lysosomal protein cathepsin D by promotion

189 consequent suppression of lysosome-localized proapoptotic mature CatD.

190 gesting that at high levels, STAT3 activates proapoptotic mechanisms and induces apoptosis in CLL cel

191 Unlike Bax, a proapoptotic member of the Bcl-2 family, Bcl-xL is not c

192 These results show that UBR5 downregulates proapoptotic MOAP-1 and suggest that UBR5 can confer cis

193 ion, was associated with upregulation of the proapoptotic molecule Bid, and was blocked by Bcl2 overe

194 f caspases and that granzyme B activates the proapoptotic molecule Bid.

195 tumor suppressor PTEN, ERK phosphatases, the proapoptotic molecule Daxx, and the Hedgehog pathway tra

196 f AKT, B55beta induced the expression of the proapoptotic molecule Hrk in response to cytokine withdr

197 s' tumors characterized by low levels of the proapoptotic molecule p53-upregulated modulator of apopt

198 was attributable to a dramatic reduction in proapoptotic molecules Bim, Bax, and Fas in CD28(null) T

199 ever, increasing evidence also suggests that proapoptotic molecules can contribute to the development

200 Lactogens mitigate expression of proapoptotic molecules in the ER stress pathway that are

201 ch leads to activation of a p53-independent, proapoptotic network centered on nuclear relocalization

202 Finally, LinTT1-guided proapoptotic NWs exerted strong anti-glioma activity in

203 oduction of bax or a bax mutant incapable of proapoptotic oligomerization equally restored neuronal C

204 is a tumor suppressor that can induce either proapoptotic or prosenescent posttranslational modificat

205 We identified inhibition of proapoptotic p53 upregulated modulator of apoptosis (PUM

206 led a multifaceted role for Bcl-2 in binding proapoptotic partners including Bax, Bak, Bik, and Bim.

207 ), which suggests that p53 promotes both the proapoptotic pathway and postapoptotic events.

208 In addition, proapoptotic pathways are activated in P1 knock-in preme

209 ld-type MEFs, indicating that EGR1 modulates proapoptotic pathways following VEEV infection.

210 Herein, we engineered proapoptotic peptide nanoparticles from mitochondria-dis

211 to-PISA) of spherical micelles consisting of proapoptotic peptide-polymer amphiphiles.

212 reactive oxygen species and cytochrome c, a proapoptotic peroxidase that is released from mitochondr

213 udies revealed that Atg7 knockdown induced a proapoptotic phenotype in AML cells, which was manifeste

214 NORE1A acts to suppress its proapoptotic phosphorylation of p53 but enhance its pros

215 Treatment of glioma-bearing mice with proapoptotic PL3-guided NWs improved the survival of the

216 during the disease progression, however, the proapoptotic pressure on the residual beta-cell mass inc

217 exceeding a threshold level, c-MYC induced a proapoptotic program and loss of CSC potential both in v

218 administration of GILZ efficiently induces a proapoptotic program that promotes resolution of neutrop

219 If unsuccessful, the UPR initiates a proapoptotic program to eliminate the malfunctioning cel

220 ee shotgun proteomics demonstrated that both proapoptotic programmed cell death protein 5 and antiapo

221 During sepsis, ECs shift toward a proapoptotic, proinflammatory, proadhesive, and procoagu

222 increased resistance of these tumor cells to proapoptotic/pronecrotic signals.

223 e RASSF1A showed that, despite retaining its proapoptotic properties, the mutant was completely unabl

224 The proapoptotic protein B-cell lymphoma 2 (BCL-2) associate

225 ibition was dependent on the coexpression of proapoptotic protein BAD.

226 kinase that phosphorylates and inhibits the proapoptotic protein BAD.

227 rectly binds and activates the mitochondrial proapoptotic protein BAK.

228 The proapoptotic protein Bax did not differ across genotype

229 originally identified as a suppressor of the proapoptotic protein Bax to inhibit cell death in animal

230 gnaling by inhibiting recruitment of the key proapoptotic protein BAX to mitochondria.

231 sistently associated with an increase in the proapoptotic protein BAX, whereas ABT-737 caused dose-de

232 tants caused frank neurotoxicity akin to the proapoptotic protein Bax.

233 as mediated by up-regulation of the BH3-only proapoptotic protein Bcl-2-like protein 11 (Bim).

234 yclin-dependent kinase inhibitor p15 and the proapoptotic protein Bcl2l11 (Bim).

235 ration through the silencing of the BH3-only proapoptotic protein BIK and promotes the elongation of

236 progenitors and increased expression of the proapoptotic protein Bim (also known as Bcl-2L11).

237 )2 family proteins, BA treatment induces the proapoptotic protein BIM and exerts dose-dependent letha

238 roliferation, as well as a deficiency of the proapoptotic protein Bim and idiopathic PAH PAVSMC survi

239 gh GC-receptor-dependent upregulation of the proapoptotic protein BIM and proteasomal degradation of

240 on were associated with up-regulation of the proapoptotic protein Bim and the T-box transcription fac

241 FoxO1 and induced cell death by upregulating proapoptotic protein BIM via a PTEN-dependent mechanism.

242 lts in posttranslational modification of the proapoptotic protein Bim.

243 o transcriptionally induce expression of the proapoptotic protein Bim.

244 -2 and Mcl-1 and increased expression of the proapoptotic protein Bim.

245 ximal tubular cell apoptosis and upregulated proapoptotic protein expression, which were both rescued

246 RNA (miR) miR-125b, which in turn suppresses proapoptotic protein expression.

247 lpain-mediated cleavage events that generate proapoptotic protein fragments.

248 ypothesized that neuronal pentraxin (NP1), a proapoptotic protein induced by low neuronal activity, c

249 cointeracting cathepsin D, a stress-released proapoptotic protein negatively impacting HHV-8 latently

250 rom resolution and its ubiquitination of the proapoptotic protein second mitochondria-derived activat

251 PB1-F2 is a small proapoptotic protein supposed to contribute to the virul

252 1-associated protein (PSAP), a mitochondrial proapoptotic protein that forms a complex with Bax upon

253 e, we describe a novel pathway involving the proapoptotic protein Trib3 in neuronal death associated

254 tosis Inducing Factor (AIF), a mitochondrial proapoptotic protein, mediates cell death by a caspase-i

255 stic explanation by which BRCA1 can act as a proapoptotic protein.

256 rotein with high homology to the multidomain proapoptotic proteins BAX and BAK, yet Bok(-/-) and even

257 ell death was rescued with codeletion of the proapoptotic proteins Bax and Bak.

258 Moreover, REST inhibited the Mn-induced proapoptotic proteins Bcl-2-associated X protein (Bax) a

259 plicing changes modulate the function of the proapoptotic proteins BIM and BAX, JNK signaling, and en

260 ated ATM and P53 as well as other downstream proapoptotic proteins such as PUMA, Bax, and cleaved cas

261 stress coincides with greater expression of proapoptotic proteins.

262 ts apoptosis by ubiquitinating and degrading proapoptotic proteins.

263 1 and enhancing p53-induced up-regulation of proapoptotic PUMA.

264 It is a proapoptotic Ras effector and plays an important role in

265 mpts to stimulate the extrinsic pathway with proapoptotic receptor agonists (PARAs) have been disappo

266 the cyclin-dependent genes (p15 and p21) and proapoptotic regulators (NOXA and PERP), attenuated prol

267 and IL-5 alone significantly diminished the proapoptotic response to dexamethasone.

268 t life span of monocytes and their antiviral proapoptotic response to infection.

269 observed that HCV-RNA transfection induces a proapoptotic response within HTR8 that could affect the

270 al, whereas long-lasting activation favors a proapoptotic response.

271 pathways dominated by ATF4-driven stress and proapoptotic responses.

272 This proapoptotic role also required the BRCA1-A complex memb

273 data unravel new molecular mechanisms for a proapoptotic role of miR-125b in monocytes and identify

274 it transitions from a respiratory role to a proapoptotic role.

275 meayamycin B promotes the generation of the proapoptotic, short splicing variant (MCL1-S) and dimini

276 kade, inhibition of mitogenic signaling, and proapoptotic signal induction in basal and mesenchymal s

277 S-dependent activation of the ATM and CaMKII proapoptotic signaling cascades.

278 ined endogenous SirT1 activity and prevented proapoptotic signaling in metabolically stressed HepG2 c

279 tyrosine kinases, was used to impinge on the proapoptotic signaling pathway activated by oxidized KCN

280 hifting Ras signaling away from prosenescent/proapoptotic signaling pathways.

281 cell lines triggered cell death through PTCH proapoptotic signaling.

282 MV) prevents the activation of caspase-8 and proapoptotic signaling.

283 MEK and ERK, and heightened the activity of proapoptotic small-molecule navitoclax, a BCL-2 family i

284 n-dependent induction of BIM short, a highly proapoptotic splice variant of BIM in IL-15-activated NK

285 anisms of EC protection from cell-extrinsic, proapoptotic stimuli have not been investigated.

286 , in its ability to confer cytoprotection to proapoptotic stimuli, and in maintaining endothelial cel

287 K1 and SphK2) catalyze the conversion of the proapoptotic substrate d-erythrosphingosine to the promi

288 rosurvival AKT/mTOR pathways and stimulating proapoptotic survivin and BAX pathways.

289 at Ser-249, leading to transcription of its proapoptotic target gene, Bcl-2-interacting mediator of

290 creased apoptosis and elevated expression of proapoptotic targets Noxa and Puma seen in Hdac8-deleted

291 a group of genes that are hypoxia-inducible proapoptotic targets of p53, including inositol polyphos

292 CD19L to the soluble extracellular domain of proapoptotic TNF-related apoptosis-inducing ligand (sTRA

293 ism, resistance to oxidative stress, and the proapoptotic transcription factor CHOP (GADD153/DDIT3).

294 This defect is mediated by the proapoptotic transcription factor p53, a sensor of DNA d

295 otein (CHOP), the major ER stress-associated proapoptotic transcription factor, protected fibroblasts

296 omes activated and, in turn, counteracts the proapoptotic transcriptional program induced by TNF-alph

297 PRIGHTLY-expressing melanocytes, whereas the proapoptotic tumor suppressor gene DPPIV/CD26 was down-r

298 ER burden of ZnT8 to protect beta-cells from proapoptotic UPR during chronic low-grade inflammation.

299 It is the activation of this proapoptotic UPR in pancreatic beta-cells that has been

300 The proapoptotic Xbp1s role in FOB cells starkly contrasts w