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1 etabolism of inhaled drugs and tobacco smoke procarcinogens.
2 , is essential for the bioactivation of many procarcinogens.
3 ltered metabolic activation of tobacco smoke procarcinogens.
4 reserved tissues of rodents treated with the procarcinogens.
5  of androgenic steroids and certain aromatic procarcinogens.
6 A13 (CYP2A13) activates the nicotine-derived procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-buta
7 nt in tobacco, and activation of the tobacco procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-buta
8 0s participate in xenobiotic detoxification, procarcinogen activation, and steroid hormone synthesis.
9 ominent roles in xenobiotic detoxication and procarcinogen activation.
10 ssed in the lung and may contribute to local procarcinogen activation.
11                  CYP1A1 bioactivates several procarcinogens and detoxifies several xenobiotic compoun
12 tivation of hexamethylphosphoramide, a nasal procarcinogen, and 2,6-dichlorobenzonitrile (DCBN), a he
13 ign of chemopreventive strategies is whether procarcinogen bioactivation in an extrahepatic target ti
14                         The bioactivation of procarcinogens by cytochrome P450 2W1 may be of signific
15                          Thus, activation of procarcinogens by P450 lB1 may contribute to human tumor
16  the enzyme in tumors, in that activation of procarcinogens could lead to the accumulation of mutatio
17                                    Using the procarcinogen diethylnitrosamine (DEN) to initiate tumor
18  been shown to be formed in DNA from various procarcinogens (e.g., acrolein, malonaldehyde, vinyl chl
19 tivate nicotine and activate tobacco-derived procarcinogens [e.g., 4-[methylnitrosamino]-1-(3-pyridyl
20 none, is one of the most potent and abundant procarcinogens found in tobacco and tobacco smoke, and g
21 ic aromatic hydrocarbons (PAHs), is a potent procarcinogen generated during the combustion of fossil
22  the dispositions of reactive metabolites of procarcinogens in humans, provided that exposures are ad
23 ) are important enzymes that detoxicate many procarcinogens, including HAAs.
24 A2 can catalyze the bioactivation of several procarcinogens, indicating a potential role in chemical
25                            In all nodules of procarcinogen-induced murine hepatocellular carcinomas (
26 P450 2W1 catalyzed the activation of several procarcinogens, particularly polycyclic hydrocarbon diol
27        Metabolism of food- and tobacco-borne procarcinogens results in the exposure of DNA to toxic a
28 mportant enzymes in the detoxication of many procarcinogens, serve as a mechanism of bioactivation of
29  of benzo[a]pyrene (B[a]P), an environmental procarcinogen that activates Cyp1a1 transcriptional resp
30 yclic amines (HCAs) found in cooked meat are procarcinogens that are metabolically activated by N-hyd
31 els should be applicable to studies on other procarcinogens that require P450-mediated metabolic acti
32 ertain hepatotoxic chemicals, including some procarcinogens, their ability to monooxygenate, and ther
33 mbers, which have the capacity to metabolize procarcinogens to genotoxic carcinogens.
34 he cytochrome P450 enzymes, which metabolize procarcinogens to their activated forms.
35 key to block the conversion of environmental procarcinogens to their carcinogenic metabolites in both
36                          Two major groups of procarcinogens, tobacco-specific nitrosamines and polycy
37                                        These procarcinogens undergo metabolic activation by N-oxidati