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1 ely due to rapid rebindings (so-called quasi-processivity).
2 polarity by promoting anterograde transport processivity.
3 location velocity but slightly increased its processivity.
4 nding, suggesting a structural basis for its processivity.
5 ned by telomerases with lower than wild-type processivity.
6 1 and TEB, but not RPA, increased telomerase processivity.
7 rtant for sequence specificity and unwinding processivity.
8 transcription elongation and RNA polymerase processivity.
9 1 gives equivalent enhancement of telomerase processivity.
10 gase, Ube3c/Hul5, which enhances proteasomal processivity.
11 the ssDNA base also influences translocation processivity.
12 tility of kinesin and for the maintenance of processivity.
13 nction, and therefore enhances transcription processivity.
14 In isolation, gp5 is a DNA polymerase of low processivity.
15 pt4/5, both of which stimulate transcription processivity.
16 ng and diminished telomerase repeat addition processivity.
17 esulted in increased off-rates and decreased processivity.
18 s can be realized at high levels of reaction processivity.
19 and to stimulate telomerase repeat addition processivity.
20 in mediating ubiquitin transfer and reaction processivity.
21 in determining motor velocity, pausing, and processivity.
22 of TOP1 above its basal rate, enhancing its processivity.
23 ation forms and arbitrary levels of reaction processivity.
24 ing activity or changes in RNA polymerase II processivity.
25 ng that L11 also contributes to tuning motor processivity.
26 oting the docked state to augment telomerase processivity.
27 mes in the context of transcription rate and processivity.
28 l and mechanistic property that can modulate processivity.
29 alytic activity, but drastically reduced its processivity.
30 ubule plus ends in a manner dependent on its processivity.
31 at this amino acid on helix 6 contributes to processivity.
32 y include an increase in its repeat addition processivity.
33 strong influence of these pockets on enzyme processivity.
34 e enzymes and have long been associated with processivity.
35 ly affects transcriptional and translational processivity.
36 rNTPs also lower replisome processivity.
37 s on the Escherichia coli replisome rate and processivity.
38 ion is the glycosylation reaction, not chain processivity.
39 which has been implicated in changing Dnmt3a processivity.
40 rm comprising 10 subsites, which facilitates processivity.
41 model of the factors that enhance unwinding processivity.
42 c domain play a major role in the control of processivity.
43 tes fast but is a weak helicase with limited processivity.
44 tions with TPP1/POT1 to stimulate telomerase processivity.
45 rms," revealing avidity facilitates enhanced processivity.
46 reak, significantly increasing its unwinding processivity.
47 force production but at a cost to speed and processivity.
48 rane protein proOmpA does not depend on SecA processivity.
49 and for 17alpha-hydroxylation, suggestive of processivity.
50 le electrostatic interactions also increases processivity.
51 TPase cycle to produce functional changes in processivity.
52 s leading to loss of telomerase activity and processivity.
53 -Abetan stabilizers increase gamma-secretase processivity.
54 However, all three MCM proteins have similar processivities.
55 and R346M, were found to decrease kinesin-3 processivity 10-fold and thus approach kinesin-1 levels.
58 DNA damage and impairs DNA replication forks processivity after UV irradiation, leading to increased
61 d structure-function relationships governing processivity and a better understanding of the potential
62 y function of MeV C is to improve polymerase processivity and accuracy, rather than uniquely to antag
64 1 also appears to digest chromatin with high processivity and at rates similar to naked DNA in vitro.
65 bility to rationally design increases in pol processivity and catalytic efficiency through computatio
68 signals and generally increase transcription processivity and elongation rate, contributing for trans
69 ces of changes in telomerase repeat addition processivity and expression level on telomere elongation
70 like transcript cleavage factors enhance the processivity and fidelity of archaeal and eukaryotic RNA
71 activity, the zinc finger also regulates the processivity and fidelity of PrimPol's extension activit
72 e a kinetic framework for explaining kinesin processivity and for mapping structural differences to f
73 ingle nucleotide at a normal rate, they lack processivity and have reduced repetitive exonuclease rat
75 d in diauxic cells, but strains with reduced processivity and normal Pol II elongation rates have nor
76 ution or when clustered on a surface, albeit processivity and resistance toward capping protein (CP)
77 esigned unique kinetic assays to analyze the processivity and stability of the pol delta holoenzyme.
78 ture engineering is required to overcome the processivity and the intrinsic DNA binding affinity of d
79 tion supporting enhanced ATPase activity and processivity and the other supporting nucleotide excisio
80 ination between motor heads is essential for processivity and the variation of peripheral structural
81 lication primers and increases transcription processivity and thereby serves as a molecular switch be
82 nome-wide analyses that show high RNA Pol II processivity and transcription activity at MSL target ge
84 how the E. coli replisome can maintain high processivity and yet possess the flexibility to bypass o
85 he inference results, suggesting that enzyme processivity and/or collaboration can produce the observ
86 nzymes exhibit low RNA binding activity, low processivity, and alterations in nucleotide recognition,
90 ochondrial genome replication, transcription processivity, and respiratory function in normal cells.
92 protein interactions to guide reactivity and processivity, and their control has become one of the ma
93 the negative effects of primase and rNTPs on processivity are overcome by the extra grip on DNA provi
97 quantify myosin II filament dwell times and processivity as functions of ATP concentration, providin
98 -terminal extension in CsxA, which conferred processivity because of the existence of a second produc
99 define the key principles that underlie its processivity but also to define the mechanistic basis of
100 processive enzyme and that disruption of its processivity by biochemical mutations or small molecules
102 nslocation based on the regulation of dynein processivity by discrete cargo-associated features.
103 t the Acm1 D-box extension inhibits reaction processivity by perturbing the normal interaction with D
104 ccessory subunit binds to p140 and increases processivity by preventing polgamma's dissociation from
105 evidence that BICD2N and dynactin stimulate processivity by regulating individual dynein complexes,
106 scherichia coli NusG increases transcription processivity by suppressing RNAP pausing, whereas Bacill
108 Using variants of MutS and the replication processivity clamp to impair mismatch repair, we find th
110 ubunit of the replicative polymerase and the processivity clamp, which sets a kinetic barrier to rest
113 ther FEN family members can be stimulated by processivity clamps such as proliferating cell nuclear a
114 RNA methylation, regulate RNA polymerase II processivity, co-transcriptional splicing, and stability
115 A:DNA heteroduplexes with moderately greater processivity compared with its duplex DNA:DNA counterpar
116 n experimental data, we analyze velocity and processivity data on the T7 helicase and provide unique
119 ve-site cavity important for repeat addition processivity, determine how they contribute to duplex an
120 e than kinesin-1 to external forces, but its processivity diminishes steeply with load, and the motor
122 mporally controls RNA polymerase II (Pol II) processivity during transcription elongation through cyc
123 ore, we provide an overview of how ratcheted processivity emerges from pulsed events, and how tissue-
124 ved with helicases to increase the unwinding processivity even if the velocity remains unaffected.
125 tive catalytic activity, and compromised DNA processivity, even in the presence of the p55 accessory
126 t in contrast to the unwinding velocity, the processivity exhibits a universal increase in response t
127 NA mismatch, MutS, MutL, and the replication processivity factor (beta-clamp or PCNA) activate the la
129 at interactions with proteins other than the processivity factor beta play a role under certain condi
130 oliferating cell nuclear antigen (PCNA), the processivity factor for DNA replication, plays a central
131 f replication protein A (RPA), MRN acts as a processivity factor for Exo1, retaining the exonuclease
133 by bacteriophage Xp10 acts as an elongation processivity factor of RNAP of host bacterium Xanthomona
134 oduct 45 (gp45, also known as DNA polymerase processivity factor or sliding clamp) obtained during ch
138 replication and acts in conjunction with the processivity factor proliferating cell nuclear antigen (
139 dulated by the nontemplate strand and by the processivity factor Spt4/5, both of which stimulate tran
140 lex with Pol II and acts as an ATP-dependent processivity factor that helps Pol II across a nucleosom
141 protein A (RPA) functionally cooperate as a processivity factor to stimulate HCV replication by HCV
143 e, two DNA polymerases, and two thioredoxin (processivity factor) molecules was determined by single-
144 omotrimeric DNA sliding clamp and polymerase processivity factor, is loaded onto the primer-template
145 pted by BPLF1, which deubiquitinates the DNA processivity factor, PCNA, and inhibits the recruitment
150 roteins, homologs of Clip170 and EB1, act as processivity factors for Kip2, helping it overcome dynei
152 n also increased the estimated translocation processivity from 1750 to >9000 bp before helicase disas
153 anscriptases (TGIRTs) with high fidelity and processivity have been used for a variety of RNA sequenc
154 ) memory T cells increases RNA polymerase II processivity, histone acetylation, and baseline HIV-1 tr
156 deletion of the TPR2 subdomain, required for processivity, impaired primer extension beyond the abasi
158 r length has been shown to directly modulate processivity in different kinesin families; for example,
159 ceeds with an effectively uniform conversion processivity in either direction limited by the bounds o
160 resent here a comprehensive investigation of processivity in P450 11B2-catalyzed reactions using stea
162 e discovered that TIN2 stimulated telomerase processivity in vitro All of the TIN2 isoforms stimulate
170 s then performed by the PcrA helicase, whose processivity is critically promoted by its interaction w
171 leading to a mechanochemical cycle in which processivity is determined by the race between unbinding
175 sin-1, kinesin-2 is less processive, and its processivity is more sensitive to load, suggesting that
176 ize between PhoA and OmpA, we find that SecA processivity is not influenced by the sequence of the pr
177 inherently distributive enzyme but that some processivity is present, i.e. some of the 17alpha-OH pre
178 l element believed to regulate the degree of processivity is the neck-linker, a short peptide of 12-1
181 nd of entire FtsZ filaments/bundles, and the processivity length of treadmilling of FtsZ filament/bun
182 y is more sensitive to load, suggesting that processivity may be controlled by different gating mecha
183 on and suggest that similar factor-dependent processivity may be shared by other members of the DEAD-
184 le-stranded DNA, and the increased unwinding processivity may contribute directly to the antimutator
185 properties of the motor, we show that dynein processivity minimally requires a single active head and
187 ersegmental hopping contributes to enzymatic processivity (multiple modifications), which invoke rece
188 model in which dynactin p150 enhances dynein processivity not solely by acting as a diffusive tether
190 e activity of TFIIH suggests that Ssl2 has a processivity of approximately one DNA turn, consistent w
191 ed in a significant decrease in the flux and processivity of BDNF-Qdots along the mid-axon, an effect
192 tively, our results suggest that compromised processivity of cargo-motor assemblies contributes to hu
193 to act as a sliding platform for increasing processivity of cellular replicases and for coordinating
196 s to the proteasome gave substantially lower processivity of degradation than ubiquitin-dependent tar
202 Many different adaptor proteins activate the processivity of dynein-dynactin complexes and determine
204 scrimination against mismatches and the high processivity of group II intron RTs enable synthesis of
207 efining the key principles that underlie the processivity of KIF3AB in comparison with homodimeric pr
208 MAP7D3 increase microtubule landing rate and processivity of kinesin-1 through transient association
210 an genomes can be co-methylated owing to the processivity of methyltransferases or demethylases, yet
212 or neurons expressing FUS, both motility and processivity of mitochondrial axonal transport were redu
214 cuss the implications of this load-dependent processivity of myosin-10 as a filopodial transport moto
216 ragment synthesis in humans as it limits the processivity of pol delta on undamaged DNA and promotes
217 , Pol II catalytic activity and the rate and processivity of Pol II scanning together with promoter s
220 at is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalph
221 re, we observe that both factors enhance the processivity of RNA polymerase II through the nucleosoma
222 acetylated at K14 (H3K14ac) facilitates the processivity of RNA polymerase II to maintain the high e
224 protein TPP1 is essential for enhancing the processivity of telomerase and recruiting the enzyme to
225 relation between chromatin accessibility and processivity of ten-eleven translocation (TET) enzymes.
226 C distribution maps indicates that catalytic processivity of TET enzymes correlates with local chroma
231 ctivity of cardiac myosin was able to rescue processivity of the D179Y mutant dimers at physiological
235 tures presented here suggest a mechanism for processivity of the holoenzyme and provide a model for u
237 ormed at m.10191C differentially impeded the processivity of the mitochondrial DNA polymerase gamma (
240 thereby increasing replication accuracy and processivity of the polymerase complex.IMPORTANCE Replic
241 ta suggest that in addition to enhancing the processivity of the polymerase PCNA is an allosteric mod
242 ffected by the presence of viral RNA and the processivity of the polymerase, giving insights into the
245 The ubiquitous sliding clamp facilitates processivity of the replicative polymerase and acts as a
249 ly hydrolyzed by the enzyme, leading to high processivity of the walker movement along the track.
251 from other partner proteins to increase the processivity of unwinding in the presence of the replica
253 that Ena tetramers are tailored for enhanced processivity on fascin bundles and that avidity of multi
254 understanding the dependence of velocity and processivity on force and the nucleic acid sequence.
255 the specific subunit Rpa12.2 showed a lower processivity on naked DNA templates, which was even more
256 e-binding tail to achieve minus-end-directed processivity on single microtubules over micrometer dist
257 se hominid A3C enzymes, dimerization enables processivity on single-stranded DNA and results in highe
259 ease, but the impacts of different levels of processivity on telomere maintenance have not been exami
271 simulations suggest that, rather than KIF3A processivity resulting from strain-dependent regulation
272 e causes specific defects in repeat-addition processivity, revealing that the template recognition el
273 ixed populations of transcripts, and the low-processivity RT enzymes that are commercially available
275 the course of lagging-strand synthesis: The processivity subunit of DNA polymerase delta, Pol32, and
277 k, and consequently have a maximum speed and processivity that is three orders of magnitude greater t
280 the N-terminal tail greatly reduces GiKIN14a processivity, the resulting tailless construct GiKIN14a-
282 cule without dissociating, a feature called "processivity." Therefore, it was surprising when kinetic
283 We speculate that the weak motifs enable processivity through avidity effects and by providing st
284 We predict that the sensitivity of unwinding processivity to external force is a universal feature th
287 i replisomes have attributed this remarkable processivity to the high stability of the replisome once
288 t SARS-CoV nsp7 and nsp8 activate and confer processivity to the RNA-synthesizing activity of nsp12.
290 bits high levels of rebinding-induced pseudo-processivity, unlike other proposed advantages of the du
291 bstrate, whether DNA or chromatin, or on SMC processivity; we thus argue that this synergy may be at
292 led that the overall polymerization rate and processivity were higher for Pol than for Pol2core.
294 ive D1 modules are important for high enzyme processivity, which depends on D1 and D2 acting coordina
295 oints using the same value of the conversion processivity, which is the only kinetic parameter of the
297 compromises both telomerase recruitment and processivity, while the missense mutation in the TIN2-bi
298 Interestingly, the increase in unwinding processivity with force depends on whether the helicase
299 inated substrates were degraded with greater processivity (with a higher tendency to be unfolded and