ライフサイエンスコーパス: prodromal

1 s ability to detect treatment effect in aMCI/prodromal AD (pAD) clinical trial populations.

2 prospectively enrich a study population with prodromal AD (PDAD) defined by cerebrospinal fluid (CSF)

3 c patients with a positive amyloid scan have prodromal AD and a poor prognosis for dementia within 3

4 ever, the status of this receptor in mild or prodromal AD has remained the subject of controversy.

5 however, the emergence of these deficits in prodromal AD is unclear.

6 pal gyrus, and precuneus) in highly educated prodromal AD patients but not in poorly educated prodrom

7 C partly overlapped those of highly educated prodromal AD patients but were less extended.

8 resent findings suggest that highly educated prodromal AD patients can cope better with the disease t

9 compared between highly and poorly educated prodromal AD patients in both directions to identify reg

10 e severe hypometabolism than poorly educated prodromal AD patients in the left inferior and middle te

11 Highly educated prodromal AD patients showed more severe hypometabolism

12 poorly educated subgroup (42 controls and 36 prodromal AD patients) and a highly educated subgroup (4

13 highly educated subgroup (48 controls and 28 prodromal AD patients).

14 romal AD patients but not in poorly educated prodromal AD patients.

15 However, during the preclinical or prodromal AD stages (i.e. in amyloid positive controls,

16 n interregional correlation analysis in each prodromal AD subgroup to explore metabolic connectivity.

17 heimer's disease (AD) and may be a marker of prodromal AD that can be used to identify individuals wi

18 silon4 (APOE4) and clinical progression from prodromal AD to clinical dementia.

19 CSF samples, including 309 with AD, 287 with prodromal AD, 399 with stable mild cognitive impairment,

20 erlying neuropathological changes, including prodromal AD, and may be a potentially useful clinical m

21 he observations of neuronal hyperactivity in prodromal AD, we propose that this APOE4-driven hyperact

22 ta imaging facilitates accurate detection of prodromal AD.

23 markers that have the potential to identify prodromal AD.

24 ory and visual measures for the detection of prodromal AD.

25 h other markers that signal the emergence of prodromal AD.

26 s that olfactory function is associated with prodromal AD.

27 Prominent subtypes included prodromal Alzheimer disease (8.2%) and cerebrovascular d

28 selection of individuals at preclinical and prodromal Alzheimer disease (AD) will depend on the prac

29 ve reserve) in highly educated patients with prodromal Alzheimer disease (AD).

30 tia annually, whereas those with subtypes of prodromal Alzheimer disease and stroke progressed at ann

31 with Alzheimer's disease were classified as prodromal Alzheimer's disease (n = 38) and Alzheimer's d

32 available biomarkers to classify subjects as prodromal Alzheimer's disease according to International

33 t studies have explored ASL MRI in early and prodromal Alzheimer's disease and have reported areas of

34 n of disease-specific language impairment in prodromal Alzheimer's disease could enhance clinicians'

35 d group or the International Working Group-2 prodromal Alzheimer's disease group could be considered.

36 Prodromal Alzheimer's disease offers an opportunity to t

37 subtle brain changes can be detected during prodromal Alzheimer's disease stages.

38 magnetic resonance imaging) in patients with prodromal Alzheimer's disease via spatial correlations i

39 Prodromal Alzheimer's disease was diagnosed at a median

40 drome (257 [66%] asymptomatic, 48 [12%] with prodromal Alzheimer's disease, and 83 [21%] with Alzheim

41 ical ratings of dementia among patients with prodromal Alzheimer's disease, and some measures suggest

42 The trial enrolled individuals with prodromal Alzheimer's disease, defined according to the

43 on the NTB primary endpoint over 2 years in prodromal Alzheimer's disease.

44 al volume in late-life depression are due to prodromal Alzheimer's disease.

45 Connect on cognition and related measures in prodromal Alzheimer's disease.

46 of the earliest in vivo imaging evidence of prodromal Alzheimer's disease.

47 r how these same nuclei appear vulnerable in prodromal Alzheimer's disease.

48 on for the treatment of mild to moderate and prodromal Alzheimer's disease.

49 was 61% compared to 22% for subjects without prodromal Alzheimer's disease.

50 ing Group-2 criteria, 308 (40%) subjects had prodromal Alzheimer's disease.

51 was 50% compared to 21% for subjects without prodromal Alzheimer's disease.

52 ing Group-1 criteria, 850 (53%) subjects had prodromal Alzheimer's disease.

53 impairment, which is often considered to be prodromal Alzheimer's disease.

54 positive cognitively unimpaired, n = 62) and prodromal (amyloid-beta-positive mild cognitive impairme

55 alpha-synuclein was increased by twofold in prodromal and clinical Parkinson's disease when compared

56 oted increased regional CBF of patients with prodromal and early stage clinical Alzheimer's disease,

57 esting the preservation of nAChRs during the prodromal and early stages of AD.

58 , focusing on these issues in the context of prodromal and early-stage Parkinson's disease.

59 aging helps detect functional changes in the prodromal and more advanced stages of AD and is a marker

60 Microglial activation appears at the prodromal and possibly at the preclinical stage of Alzhe

61 w trials are indeed evaluating treatments at prodromal and preclinical stages.

62 Prior substance use and ages at onset of prodromal and psychotic symptoms were determined by stan

63 e associated with an earlier age at onset of prodromal and psychotic symptoms.

64 This is relevant for both prodromal and symptomatic patient populations where pote

65 ed across models and correlate well with the prodromal and symptomatic stages of behavior.

66 ectivity in cognitively normal, preclinical, prodromal, and AD dementia individuals.

67 Such prodromal astrocyte dysfunctions may represent novel the

68 able age of onset and absence of established prodromal biomarkers might render infeasible existing mo

69 e logistic regression to distinguish between prodromal cases and controls.

70 Because high pulsatility could represent prodromal cerebrovascular changes that damage the brain

71 Such prodromal changes in astrocytes may represent novel ther

72 scription factor as a candidate regulator of prodromal changes in HD.

73 Recognition of these prodromal changes may be important in future management

74 opportunity to investigate the pathogenesis, prodromal changes, and time course of the disease in liv

75 scent male patient originally presented to a prodromal clinical research program with severe obsessiv

76 s, may represent a paraviral exanthem with a prodromal coryzal phase, sudden eruption of fairly monom

77 he lifespan is integral to understanding the prodromal course of many neuropsychiatric illnesses and

78 also improve the specificity of diagnoses of prodromal degenerative brain disease.

79 ence of DNH on high-field SWI could identify prodromal degenerative parkinsonism in iRBD.

80 loping severe dementia, rejected the link to prodromal depressive and manic phases, and reduced the e

81 l patients had pleocytosis, and 3 had severe prodromal diarrhea of unknown etiology.

82 ndings are in accordance with a hypothesized prodromal disease phase spanning 10 to 20 years.

83 patients contributed tissues obtained in the prodromal disease phase, whereas 18 Parkinson disease pa

84 in their sleep quality resembling signs of a prodromal disease stage.

85 bserved that sustained GH expression reduced prodromal disease symptoms and eliminated progression to

86 e, motor, and psychiatric changes (so-called prodromal disease).

87 w clinical benefit in established, early, or prodromal disease, or in those with high AD risk.

88 compared with 207 patients with PD, DLB, or prodromal DLB to assess if scores were higher in DLB com

89 rium may, in some cases, represent early or 'prodromal' DLB.

90 ore feature of schizophrenia that is seen in prodromal, drug-naive, and chronic schizophrenic patient

91 ere excluded, indicating that this was not a prodromal effect.

92 stic performance, disability/impairment, and prodromal factors.

93 ical visual orienting may represent an early prodromal feature of an ASD, and abnormal functional spe

94 sults suggest that depressive symptoms are a prodromal feature of dementia or that the 2 share common

95 History can include prodromal features (eg, rapid eye movement sleep behavio

96 son's disease (PD), and on the prevalence of prodromal features among individuals at risk, we collect

97 ing carriers of LRRK2 and GBA mutations have prodromal features of Parkinson's disease that correlate

98 All had a prodromal febrile illness preceding neurological symptom

99 Although the prodromal females had smaller intracranial volume measur

100 A combination of age >5 years (AUC = 0.77), prodromal fever and respiratory symptoms >6 days (AUC =

101 A combination of age >5 years (AUC=0.77), prodromal fever and respiratory symptoms >6 days (AUC=0.

102 F CXCL13 was associated with the presence of prodromal fever or headache (P = .01), limited response

103 trol in individuals deemed to be potentially prodromal for psychotic illness.

104 This pathway might be involved in the prodromal gastric dysmotility observed in patients with

105 Performance of the three prodromal HD groups was characterised by insidious and s

106 longitudinal studies of cognitive decline in prodromal HD have not stratified samples based on diseas

107 This work identifies a specific prodromal HD phenotype associated with a prominent and p

108 ate that clinical trials may be conducted in prodromal HD using the outcome measures and methods spec

109 hed and clinically relevant endophenotype of prodromal HD.

110 In severe cases, the painful prodromal hemorrhagic colitis is complicated by potentia

111 In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in m

112 feasibility of preventive clinical trials in prodromal Huntington disease (HD).

113 Prodromal Huntington's disease (prHD) is associated with

114 Twenty prodromal Huntington's disease and 19 healthy control in

115 e of torque development, in individuals with prodromal Huntington's disease and healthy controls and

116 ate of torque development were found between prodromal Huntington's disease and healthy controls, the

117 pment were observed between individuals with prodromal Huntington's disease and healthy controls.

118 Cognitive, motor and psychiatric changes in prodromal Huntington's disease have nurtured the emergen

119 isted of gene-negative controls (n = 16) and prodromal Huntington's disease individuals (n = 48) with

120 xpanded but not yet manifesting the disease (prodromal Huntington's disease) are compared with subjec

121 l magnetic resonance imaging connectivity in prodromal Huntington's disease, despite the spectrum of

122 function (Stroop Test, Trail Making Test) in prodromal Huntington's disease, which instead were relat

123 n and striatal pathology in individuals with prodromal Huntington's disease.

124 athology (r = 0.71-0.60) in individuals with prodromal Huntington's disease.

125 l magnetic resonance imaging connectivity in prodromal Huntington's disease.

126 al reorganization of whole-brain networks in prodromal Huntington's disease.

127 This patient had a prolonged nonspecific prodromal illness before developing respiratory symptoms

128 ikely to be related to regional variation in prodromal illnesses.

129 measurements of sleep and cAMP/PKA could be prodromal indicators of disease, and serve as therapeuti

130 It evolves through 4 phases: prodromal, initial, established, and resolving.

131 e that IJA is an important target for future prodromal intervention trials.

132 ommended in human STEC infections during the prodromal intestinal phase, and the toxicity of polymyxi

133 The prodromal males had significantly smaller intracranial v

134 efine a subtype of depression representing a prodromal manifestation of Alzheimer disease.

135 motor enactment of dreams and is a potential prodromal marker of Parkinson's disease (PD).

136 owed that gait characteristics are potential prodromal markers for Parkinson disease (PD).

137 Several risk and prodromal markers of PD are associated with gut microbio

138 Established risk and prodromal markers of PD as well as factors related to di

139 isease onset and how they relate to risk and prodromal markers of PD.

140 ehavior in preadolescent children and may be prodromal markers of risk for dysphoria.

141 Among risk and prodromal markers, physical activity, occupational solve

142 Together with other prodromal markers, quantitative gait characteristics can

143 stimates of the relative predictive value of prodromal markers, which can be used to stratify patient

144 established DLB and AD, as well as in their prodromal, mild cognitive impairment (MCI) phases.

145 nd entorhinal cortex was only observed among prodromal (mildly amnestic) individuals.

146 Our HD OVT73 sheep are a prodromal model and exhibit minimal pathology and no det

147 arker and reveals the potential existence of prodromal molecular patterns in blood that could be used

148 subgroup of twins with signs of subclinical, prodromal MS in the clinically healthy cotwin.

149 approach was applied to assess patients with prodromal (n = 28) and mild (n = 7) AD.

150 nprecedented opportunity to directly observe prodromal neurodegenerative states, and potentially inte

151 Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheim

152 In patients with prodromal or mild AD, one year of monthly intravenous in

153 72) of aducanumab (BIIB037) in patients with prodromal or mild Alzheimer disease.

154 the model can also identify individuals with prodromal or preclinical Parkinson's disease in prospect

155 chosis symptoms (ie, no longer qualifying as prodromal) or clinical judgment that the reported sympto

156 time of blood sampling, having a history of prodromal pain, or the extent of acute pain.

157 ence was seen in the positivity rate between prodromal Parkinson disease patients and controls when u

158 uclein positivity was seen in 22 of 39 (56%) prodromal Parkinson disease subjects and 30 of 67 (45%)

159 cientific commentary refers to 'Evolution of prodromal Parkinson's disease and dementia with Lewy bod

160 s characterize peripheral synucleinopathy in prodromal Parkinson's disease and explore cellular mecha

161 tructural imaging biomarkers associated with prodromal Parkinson's disease dementia may allow for the

162 an be explained by reverse causation because prodromal Parkinson's disease is often associated with n

163 One such manifestation of prodromal Parkinson's disease is rapid eye movement (REM

164 disease', 'Stress and Parkinson's disease', 'Prodromal Parkinson's disease', 'Non motor symptoms and

165 potentially provides a cognitive marker of 'prodromal' Parkinson's disease that might be useful in t

166 Prodromal participants from PREDICT-HD were stratified b

167 notype, which might reflect vulnerability of prodromal patients to substance abuse.

168 dementia had scores similar to clinical and prodromal patients with DLB but higher scores compared w

169 udies in differential diagnosis, identifying prodromal patients, and the evaluation of treatment effe

170 NMC with probability rates for prodromal PD above 50% had higher frequencies of hypertr

171 cs can play an important role in identifying prodromal PD and progression within this phase.

172 lls, and refined animal models to argue that prodromal PD can be defined as a disease of impaired int

173 ts showed a worsening in motor and non-motor prodromal PD features.

174 tile dysfunction, PD family history, and the prodromal PD probability showed no significant microbiom

175 tudy including 10 with prevalent PD, 25 with prodromal PD, and 25 controls who never developed PD.

176 tive dysfunction can be considered a sign of prodromal PD.

177 llectively, we have created a mouse model of prodromal PD.

178 re investigations into treatment targets for prodromal PD.

179 dopamine transporter density consistent with prodromal PD.

180 elp identify subjects at high risk of having prodromal PD.

181 linical and imaging features associated with prodromal PD/DLB in patients with LOD.

182 k of TBI was greater in PD patients in their prodromal period across all age and sex groups, with HRs

183 Yet, the genes that are altered in the prodromal period and their regulators, which present opp

184 mine the time-to-TBI in PD patients in their prodromal period compared to population-based controls.

185 sociation between PD and a recent TBI in the prodromal period of PD.

186 sible that the risk of TBI is greater in the prodromal period of PD.

187 ington's disease mutation, starting from the prodromal period prior to motor diagnosis.

188 compared time-to-TBI in PD patients in their prodromal period to controls.

189 ication of ill people even at incubation and prodromal periods of illness.

190 There has been much interest in the prodromal phase and the possibility of preventing SZ by

191 sible to identify Parkinson's disease in its prodromal phase and to promote neuroprotective intervent

192 The concept of a long, intermediary, prodromal phase between the first appearance of amyloid

193 There is a long prodromal phase between the formation of protein aggrega

194 of frank psychosis is usually preceded by a prodromal phase characterized by attenuated psychotic sy

195 t risk for Parkinson disease (PD) during the prodromal phase could clarify disease mechanisms and all

196 Aborting the acute painful episode at the prodromal phase could potentially prevent or minimize ti

197 established and suggests the existence of a prodromal phase for the disease.

198 after donepezil treatment in MCI, which is a prodromal phase of AD, using voxel-based morphometry.

199 n increase in depressive symptoms during the prodromal phase of AD.

200 avioural symptoms in the mildly symptomatic, prodromal phase of autosomal dominant Alzheimer's diseas

201 ish gait impairments and trajectories in the prodromal phase of PD, identifying which gait characteri

202 siologic events operate in unison during the prodromal phase of the crisis: vaso-occlusion, inflammat

203 C4 depletion started at prodromal phase, and C4 was lowest after the maximum sev

204 ssues from Parkinson disease patients in the prodromal phase.

205 However, the long biochemical and cellular prodromal phases of the disease suggest that dementia is

206 pe 2 diabetes are both characterized by long prodromal phases, challenging the study of potential ris

207 ted REM sleep behaviour disorder (iRBD) is a prodromal phenotype for the body-first type.

208 findings are predictive of initiation of the prodromal / preclinical phase of LOAD for women in midli

209 ihood of cardiac syncope were mood change or prodromal preoccupation with details (n = 323; sensitivi

210 ponent of MS and the construction of the MDS prodromal probability score.

211 ophrenia was correlated with the severity of prodromal psychopathologic and neuropsychological impair

212 ex, both higher symptom levels of anxiety or prodromal psychosis and lower cognitive ability were ass

213 ditional regional associations with anxiety, prodromal psychosis, and cognitive ability.

214 e onset of schizophrenia in individuals with prodromal psychotic symptoms, is predominantly localized

215 ptoms, prior antibiotic treatment, prolonged prodromal respiratory symptoms and fever, and extrapulmo

216 ptoms, prior antibiotic treatment, prolonged prodromal respiratory symptoms and fever, and extrapulmo

217 uals 12-35 years old who meet criteria for a prodromal risk syndrome convert to psychosis within 2 ye

218 atter loss has been observed in patients and prodromal samples.

219 followed by the emergence of hand tremor, a prodromal sign of the disease.

220 A prodromal stage characterized by psychiatric disturbance

221 Because mild cognitive impairment (MCI) is a prodromal stage for dementia, we sought to evaluate whet

222 n in language integrity, detectable from the prodromal stage in a subset of patients with Alzheimer's

223 Early assessment at the preclinical or prodromal stage is in a great demand since treatment aft

224 ith AD and mild cognitive impairment (MCI, a prodromal stage of AD) with a meta-analytical technique.

225 ty of indication bias, because people in the prodromal stage of dementia might be preferentially pres

226 at the semantic variant can be preceded by a prodromal stage of focal left anterior temporal atrophy

227 histories from normal cognition through the prodromal stage of mild cognitive impairment (MCI) to cl

228 der, and constipation may develop during the prodromal stage of PD and precede PD diagnosis by years.

229 n PD, with mild cognitive impairment being a prodromal stage of PD with dementia (PDD).

230 lation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.

231 cleinopathies, since RBD represents an early prodromal stage of synucleinopathy when neuropathology m

232 is now known to be evident in the immediate prodromal stage of the condition.

233 he symptoms that accompany migraine from the prodromal stage through the headache phase suggest that

234 ents with mild cognitive impairment (MCI), a prodromal stage to dementia, and 17 cognitively intact,

235 oups compared to controls, especially at the prodromal stage, involving the temporo-parietal cortex.

236 cortices (FC) as a biomarker for AD and its prodromal stage, mild cognitive impairment (MCI).

237 from the identification of biomarkers at the prodromal stage.

238 be suitable as a biomarker of early- or even prodromal-stage PD.

239 have application for early detection during prodromal stages of AD.

240 f memory function across the preclinical and prodromal stages of AD.

241 changes in language were evident during the prodromal stages of Alzheimer's disease, with two-thirds

242 hat can be used to identify pre-clinical and prodromal stages of disease in addition to fully symptom

243 ture T1D risk can only be identified at late prodromal stages of disease indicated by markers such as

244 hese regions may be affected earliest during prodromal stages of FAD, while cortical atrophy may occu

245 hich tau induces neuronal dysfunction during prodromal stages of tauopathy and define tau-driven path

246 g and affects neuronal function during early prodromal stages of tauopathy remains unclear.

247 n) dimensions in Alzheimer's disease and its prodromal stages.

248 n in those with mild cognitive impairment, a prodromal state for Alzheimer's disease, and dementia.

249 Postpartum blues (PPB) is often a prodromal state for postpartum depression (PPD), with se

250 d of detecting Alzheimer disease (AD) in its prodromal state is needed for patient stratification in

251 the Alzheimer's disease (AD) continuum, the prodromal state of mild cognitive impairment (MCI) prece

252 ted clinical progression to psychosis from a prodromal state.

253 s moving toward prevention strategies during prodromal states.

254 Apathy, but not depression, may be a prodromal symptom of dementia in SVD, and may be useful

255 ger, showed neurological onset earlier after prodromal symptom onset, had milder weakness, showed mor

256 ere significantly correlated with concurrent prodromal symptom severity (r = 0.27, P < 3.6 x 10(-8),

257 Olfactory deficits are a common (often prodromal) symptom of neurodegenerative or psychiatric d

258 viduals with either familial risk factors or prodromal symptomatology.

259 liefs, which in turn can lead to more severe prodromal symptoms (e.g. sleep disturbance, irritability

260 total score of more than 20 on the Scale of Prodromal Symptoms (SOPS), and had an interest in partic

261 Interview for DSM-IV Personality Disorders), prodromal symptoms (Structured Interview for Prodromal S

262 rds increased stress sensitivity, leading to prodromal symptoms and eventually psychosis.

263 h the story of an oncologist, we discuss the prodromal symptoms and signs leading to burnout and comp

264 infarction to explore their experiences with prodromal symptoms and their decision-making process to

265 Movement abnormalities were correlated with prodromal symptoms at each time period, and for several

266 cluded 256 individuals meeting the Scale for Prodromal Symptoms criteria and 141 control subjects, al

267 re associated with ALS risk and may serve as prodromal symptoms decades before ALS diagnosis.

268 However, these prodromal symptoms have not been consistently associated

269 disorders (ASD); however, it is not clear if prodromal symptoms in this area are already present in t

270 Prodromal symptoms of ASD at 6 months include a diminish

271 , apathy and anxiety are risk factors for or prodromal symptoms of incipient Alzheimer's disease.

272 )F-dopa uptake was elevated in patients with prodromal symptoms of schizophrenia (effect size, 0.75)

273 The emergence of prodromal symptoms of schizophrenia and their evolution

274 striatal (18)F-dopa uptake in patients with prodromal symptoms of schizophrenia was correlated with

275 Twenty-four patients having prodromal symptoms of schizophrenia were compared with 7

276 ventions, such as D-serine, for treatment of prodromal symptoms of schizophrenia.

277 ognitive impairment seen in individuals with prodromal symptoms of schizophrenia.

278 years; P < .001), presented more often with prodromal symptoms or active infection (33% vs 13%; P =

279 that depression could be one of the earliest prodromal symptoms or risk factors associated with the p

280 tin-associated protein-like 2 (CASPR2)], the prodromal symptoms or types of presentations often sugge

281 themes characterized their experiences: (1) prodromal symptoms varied substantially in both nature a

282 fects were observed when onset of illness or prodromal symptoms was the outcome.

283 prodromal symptoms (Structured Interview for Prodromal Symptoms), and movement abnormalities (Dyskine

284 .e., recognition and early intervention with prodromal symptoms), communication enhancement training,

285 ounced in subjects with briefer durations of prodromal symptoms, contributing factors may predominant

286 ain activities, promptly evaluating possible prodromal symptoms, training fitness personnel for emerg

287 escribing people presenting with potentially prodromal symptoms.

288 may hasten the onset of psychotic as well as prodromal symptoms.

289 Because RBD is a prodromal syndrome of Parkinson disease (or related diso

290 hose with low total Structured Interview for Prodromal Syndromes scores.

291 h risk based on the Structured Interview for Prodromal Syndromes, 176 had at least one follow-up asse

292 psychosis using the Structured Interview for Prodromal Syndromes, and for attention-deficit/hyperacti

293 atients with schizophrenia and patients with prodromal syndromes.

294 movement sleep behavior disorder (RBD) is a prodromal synucleinopathy, as >80% will eventually conve

295 arkinson disease subjects and 30 of 67 (45%) prodromal tissue blocks.

296 Prodromal tissues were obtained on average 7.0 years pri

297 regulation in childhood may be understood as prodromal to adult psychopathology.

298 such as gastroparesis and constipation, are prodromal to the cardinal motor symptoms of the disease.

299 ical and mechanistic findings supporting the prodromal value of RBD for PD, incorporating clinical an

300 tive impairment, suggesting that preclinical/prodromal YAP-dependent neuronal necrosis represents a t