ライフサイエンスコーパス: producing enzyme

1 from mutant Pseudomonas lacking its cyanide-producing enzyme.

2 of gtfB, the gene coding for a major glucan producing enzyme.

3 directly associates with and activates a ROS-producing enzyme.

4 -phosphate 5-kinase (PIP5K) Ialpha, a PIP(2)-producing enzyme.

5 he activity of the two major endocannabinoid-producing enzymes.

6 alyte or biosensors by combination with NADH producing enzymes.

7 FeFe hydrogenases are the most efficient H2-producing enzymes.

8 ve pentose phosphate pathway and other NADPH-producing enzymes.

9 es filled with reactive oxygen species (ROS)-producing enzymes.

10 aling manipulation to determine the major PA producing enzymes.

11 ABATH) lineage of plant secondary metabolite-producing enzymes.

12 on of both PPAR-gamma and its natural ligand-producing enzyme 12/15-lipoxygenase (12/15-LOX) in IL-4-

13 cells, as expression of the quinolinic acid-producing enzyme 3-hydroxyanthranilate oxygenase (3-HAO)

14 tonylated/acetylated factors, a crotonyl-CoA-producing enzyme ACSS2 (acyl-CoA synthetase short chain

15 Through depletion of the cAMP producing enzyme Adenylate Cyclase 2 (AC2) and the use o

16 eases enterocyte expression of retinoic-acid-producing enzymes Adh1, Aldh1a1, and Rdh7, reducing reti

17 be the major cysteine-degrading and sulfide-producing enzyme aerobically but not anaerobically.

18 d macrophage expression of the retinoic acid-producing enzyme aldehyde dehydrogenase family 1, subfam

19 le kinases that regulate the activity of ROS-producing enzymes and ion channels.

20 S1P levels, with associated activation of NO-producing enzymes and reduction of aortic inflammation.

21 e effect is "universally observable" for ATP-producing enzymes and that "enzymatic phosphorylation is

22 increased specific activities of other NADPH-producing enzymes and the finding that glucose utilizati

23 ase (XOR), a prototypic superoxide O(2)(.-) -producing enzyme, and neuronal nitric oxide synthase (NO

24 Autotaxin (ATX) is a key LPA-producing enzyme, and we hypothesized that ATX contribut

25 elated proteins, antioxidant proteins, NADPH-producing enzymes, and anti-inflammatory genes using oli

26 ve focused primarily on the levels of NO, NO-producing enzymes, and cGMP in various tissues.

27 monstrate that key crotonyl-coenzyme A (CoA)-producing enzymes are specifically induced in endodermal

28 rosclerosis and heart disease, and these TMA-producing enzymes are therefore important drug targets.

29 n and the enzymatic activity of the estrogen-producing enzyme aromatase.

30 dehydrogenase type 1 (11B-HSD1), a cortisol-producing enzyme, as a putative brain cortisol marker in

31 Spatial asymmetries of RA and RA-producing enzymes, as have been found in the eyes of mic

32 ndicate that the induction of the asparagine-producing enzyme ASNS acts as an adaptive mechanism to c

33 Here, we report that the acetyl-CoA-producing enzyme, ATP citrate lyase (ACLY), is a key reg

34 Knockout of Lpar3 or inhibition of the LPA-producing enzyme autotaxin (ATX) in pregnant mice leads

35 y would express transcript for the major LPA-producing enzyme autotaxin.

36 ction, because it has no effect on the Abeta-producing enzymes beta- and gamma-secretases, but promot

37 r Blvra, the gene that encodes the bilirubin-producing enzyme biliverdin reductase, attenuates itch.

38 (PAG, Cystathionine-gamma-lyase [CSE, H(2)S-producing enzyme] blocker; 50 mg/kg) 1 hour before coron

39 ]-hydrogenases are the best natural hydrogen-producing enzymes but their biotechnological exploitatio

40 Here we show that upon stress, the ATP-producing enzyme Cdc19 forms inactive amyloids, and that

41 We found upregulation of the oxysterol-producing enzymes CH25H and CYP7B1 and increased concent

42 null mutant of the major plasma membrane ROS-producing enzyme complex, rbohd/f does not suppress the

43 ack of potent/specific inhibitors for H(2) S-producing enzymes contributes to this problem.

44 Increased expression of lactate-producing enzymes correlated with improved memory in con

45 these mice, increased expression of lactate producing enzymes correlated with poorer memory performa

46 is response is coordinated by the LXR-ligand-producing enzyme CYP27A1, which was upregulated in damag

47 hat Mtb-infected mice deficient in the H(2)S-producing enzyme cystathionine beta-synthase (CBS) survi

48 We found that mice lacking the H2S-producing enzyme cystathionine gamma-lyase (CSE) exhibit

49 ealed the selective up-regulation of the H2S-producing enzyme cystathionine-beta-synthase (CBS) in co

50 ment of H(2)S or overexpression of the H(2)S-producing enzyme cystathionine-gamma-lyase (CSE) attenua

51 The H2S-producing enzyme cystathionine-gamma-lyase (CSE) was exp

52 Conversely, silencing of the H(2)S-producing enzyme cystathionine-gamma-lyase abolishes NO-

53 ociated with downregulation of the key H(2)S producing enzyme cystathionine-y-lyase (CTH) and reducti

54 this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is

55 nhibiting activity of the CO-regulated H(2)S producing enzyme, cystathionine-gamma-lyase (CSE), reduc

56 ing surface using polyphosphonate chemistry, producing enzyme density contrasts of glass over aluminu

57 study investigates the role of the main 2-AG producing enzyme diacylglycerol lipase alpha (DAGL-alpha

58 receptor-5 to the 2-arachidonoyl-sn-glycerol-producing enzyme, diacylglycerol lipase-alpha (endocanna

59 y that low NMNAT2, the critical neuronal NAD producing enzyme, drives retinal susceptibility to neuro

60 The main IdoA-producing enzyme, DS epimerase 1 (DS-epi1), together wit

61 PH oxidase, the main reactive oxygen species-producing enzyme during inflammation, is activated in sp

62 dase, the main reactive oxygen species (ROS)-producing enzyme during inflammation, is up-regulated in

63 ow that myeloperoxidase (MPO), a key oxidant-producing enzyme during inflammation, is upregulated in

64 l diphosphate and geranylgeranyl diphosphate-producing enzymes, DXS3, DXR, HDR, and GGPPS1, were foun

65 The adenosine producing enzyme ecto-5'-nucleotidase (5'-NT) is not nor

66 applicable to the immobilization of any H2O2 producing enzyme, enabling rapid monitoring of many none

67 h activate yeast and mammalian PtdIns(3,5)P2-producing enzymes, Fab1 and PIKfyve, respectively.

68 reported to date for each of these ceramide-producing enzymes from a medicinal chemistry perspective

69 parvalbumin and the gamma-aminobutyric acid-producing enzyme GAD67.

70 r mark is also dependent on the crotonyl-CoA-producing enzyme GCDH.

71 ccharomyces cerevisiae homologue of the GABA-producing enzyme glutamate decarboxylase (GAD) that is r

72 LC7A2 and crotonyl-coenzyme A (crotonyl-CoA)-producing enzyme glutaryl-CoA dehydrogenase (GCDH) with

73 creased PA accumulation and inhibition of PA-producing enzymes had opposite effects on circadian cloc

74 ses in hydrogen sulfide and hydrogen sulfide-producing enzymes have been implicated in several human

75 ath (PCD) in neurons, but the underlying ROS-producing enzymes have not been identified.

76 e investigated if mice lacking the histamine producing enzyme HDC share the morphological and cytolog

77 fection in mice induces expression of the CO-producing enzyme heme oxygenase (HO1) and that CO is sen

78 ene Hmox2, encoding the carbon monoxide (CO) producing enzyme, heme oxygenase-2 (HO-2), exhibit OSA,

79 pting this response by silencing these H(2)S producing enzymes impairs T cell activation, and prolife

80 es homologues of hydrazonoacetic acid (HYAA)-producing enzymes, implicating HYAA in alpha-diazoester

81 is the predominant hydrogen sulfide (H(2) S)-producing enzyme in endothelial cells (ECs).

82 IDH1 is the most strongly upregulated NADPH-producing enzyme in glioblastoma (GBM).

83 future discovery of drugs targeting this TMA-producing enzyme in human gut.

84 PpcA was the only recognizable oxaloacetate-producing enzyme in Methanopyrus kandleri, a hydrotherma

85 2c44, a major epoxyeicosatrienoic acid (EET) producing enzyme in mice, leads to impaired hepatic insu

86 rectly enhances the activity of the main ROS-producing enzyme in microglia, NADPH oxidase 2 (NOX2), a

87 euronal nitric oxide synthase (NOS-I, the NO-producing enzyme in neurons).

88 stathionine gamma-lyase (CSE), a major H(2)S producing enzyme in prostate tissue, was reduced in both

89 athionine gamma-lyase (CSE) is a major H(2)S-producing enzyme in the cardiovascular system that uses

90 genase (12-LOX), a highly expressed oxylipin-producing enzyme in the human platelet, is an essential

91 ying that CYP1B1 is not a major pregnenolone-producing enzyme in the periphery.

92 tathione S-transferases, is the major LTC(4)-producing enzyme in tissues and that its integrated func

93 e found a decline in total sulfide and H(2)S-producing enzymes in dystrophin/utrophin knockout mice.

94 We used immunostaining to identify 15-HETE-producing enzymes in EGCs and tissues.

95 strated by the spatial distribution of H(2)S-producing enzymes in human necrotic, nonnecrotic, and ca

96 R, with gene duplications giving rise to 25S-producing enzymes in more recent Solanum species.

97 h can be easily coupled to hydrogen peroxide producing enzymes in order to develop oxidase based reag

98 f urolithin A and genes encoding urolithin A-producing enzymes in patients with inflammatory bowel di

99 tions of the finding of widespread guanidine-producing enzymes in photosynthetic eukaryotes as a so f

100 hput screening of other thermostable glucose-producing enzymes, including those applicable to commerc

101 We found that a nitric oxide-producing enzyme, inducible nitric oxide synthase (iNOS)

102 guided by the guanosine monophosphate (GMP)-producing enzymes inosine monophosphate dehydrogenase (I

103 The synthesis of the inulin and inulin producing enzyme (IPE) in B. stercoris PE was verified u

104 bout the three-dimensional structures of TMA-producing enzymes is important for microbiota-targeted d

105 oribosyltransferase (NAPRT), a second NAD(+)-producing enzyme, is amplified and overexpressed in a su

106 ther acid sphingomyelinase (Asm), a ceramide-producing enzyme, is implicated in the development of hH

107 e gamma-lyase (CSE), 1 of 3 hydrogen-sulfide-producing enzyme, is predominantly localized in the vasc

108 st-translational processing of the histamine-producing enzyme, L-histidine decarboxylase (HDC), leads

109 se of up-regulation of the alternative NADPH-producing enzymes malic enzyme and isocitrate dehydrogen

110 t change in enzyme activity of another NADPH-producing enzyme, malic enzyme; (5) IL-1beta-induced NO

111 metal-dependent regulation of a metallophore-producing enzyme might also take place in vivo, which co

112 c component of major reactive oxygen species-producing enzyme NAD(P)H oxidase.

113 ed the integrin-FN fragment complex, the ROS-producing enzyme NADPH oxidase 2 (NOX2), and SRC, a redo

114 talk with the reactive oxygen species (ROS)-producing enzyme NADPH oxidase-4 (Nox4) in the pathogene

115 (iNOS) or the nox2 subunit of the superoxide-producing enzyme NADPH oxidase.

116 p47(phox), a cytosolic component of the ROS producing enzyme, NADPH oxidase, and the increase in amo

117 resses high levels of hydrogen sulfide (H2S) producing enzymes, namely, cystathionine beta-synthase (

118 eural crest, we have identified the ceramide-producing enzyme neutral sphingomyelinase 2 (nSMase2) as

119 ese nuances make HDH a globally prominent N2-producing enzyme, next to nitrous oxide (N2O) reductase

120 Inhibition of NAD -producing enzyme nicotinamide phosphoribosyl transferase

121 to production of ROS through the superoxide-producing enzyme NOX2.

122 was regulated by the reactive oxygen species-producing enzyme NOX4, both through DNA damage and incre

123 expression of the gene encoding the H(2)O(2)-producing enzyme Nox4, which is normally repressed by Bc

124 ntial for CAF targeting, focusing on the ROS-producing enzyme NOX4, which is upregulated by CAF in ma

125 , ONC-213 affected alphaKGDH, a pivotal NADH-producing enzyme of the TCA cycle, to induce a mitochond

126 ssing VKORC1, the reduced vitamin K cofactor-producing enzyme of the vitamin K-dependent gamma-carbox

127 nase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation.

128 pharmacological inhibition of either lactate-producing enzymes or lactate transporters attenuated epi

129 conclude that future coablation of both LPA-producing enzymes or of several LPA receptors may reveal

130 iency in sphingosine kinase (SphK)1, the S1P-producing enzyme, or in MC, remarkably mitigates all sig

131 as a result of increased activity of the PA-producing enzyme phospholipase D (PLD) and increased loc

132 cleotide phosphate oxidase, a key superoxide-producing enzyme, plays a critical role in microglia-med

133 ) isoform of the NADPH oxidase family of ROS-producing enzymes promotes lung oxidative stress, inflam

134 c44, a murine epoxyeicosatrienoic acid (EET)-producing enzyme, promotes insulin sensitivity, and Cyp2

135 minohydrolase-1 (but similar amounts of ADMA-producing enzyme, protein methyltransferase-1) in the hu

136 1b(+) DC2 highly expressed the retinoic-acid-producing enzyme, RALDH2, the deletion of which limited

137 xpression of the genes for mineralocorticoid-producing enzymes ranged from 50% normal in the hypermor

138 n of hESCs, whereas deletion of crotonyl-CoA-producing enzymes reduces histone crotonylation and impa

139 ng for diadenylate cyclase (DAC), a c-di-AMP producing enzyme, resulted in enhanced synthesis of extr

140 ead to transcriptional activation of melanin-producing enzymes, resulting in delayed skin pigmentatio

141 rgistic application of the aryl acetaldehyde producing enzymes results in enhanced benzylisoquinoline

142 R-Cas9-mediated deletion of MAT2A, a key SAM producing enzyme, results in an inhibition of T-cell dys

143 ns, we heterologously expressed the H(2)O(2)-producing enzyme Rhodotorula gracilis D-amino acid oxida

144 stimulates an increase in activity of NADPH-producing enzyme(s) prior to NO production and that this

145 Together, inhibition of H2S-producing enzymes sensitize lung adenocarcinoma cells to

146 polymerase 1 gene PARP1, the predominant PAR-producing enzyme, showed a 54% reduction of calcificatio

147 In addition, the cAMP-producing enzyme soluble adenylyl cyclase (sAC) is expre

148 lated by pH-dependent activation of the cAMP-producing enzyme soluble adenylyl cyclase (sAC).

149 We demonstrate that inactivation of the S1P producing enzyme, sphingosine kinase, leads to cell deat

150 made to generate inactive protein useful for producing enzyme-substrate complexes.

151 and upregulation of LIPH, an alternative LPA-producing enzyme, suggesting that this gene could functi

152 In addition, inhibition of H2S-producing enzymes suppresses critical bioenergetics para

153 n species (ROS), but the identity of the ROS-producing enzyme system(s) remains a matter of speculati

154 ne oxidase and NAD(P)H oxidase, 2 major O2*--producing enzyme systems, and their relationship with fl

155 xidase 4 (Nox4) is a reactive oxygen species-producing enzyme that is highly expressed in the endothe

156 hisms of the gene that codes for the main NO-producing enzyme, the nitric oxide synthase 1 (NOS1), ha

157 tors have been widely used for blocking acid-producing enzymes, this approach can cause various adver

158 saturase (crtI gene product), a neurosporene-producing enzyme, to lycopene.

159 re, we engineered mice lacking the serotonin-producing enzyme Tph2 in peripheral neurons but with int

160 d via the recruitment and activation of PIP2-producing enzyme, type Igamma phosphatidylinositol phosp

161 olamine-specific expression of human melanin-producing enzyme tyrosinase.

162 cells can express a receptor for the plasmin-producing enzyme urokinase-type plasminogen activator (u

163 s, the serotonin transporter (SERT) and 5-HT-producing enzymes was determined in the urothelium using

164 (driving expression of Nmnat1, a key NAD(+)-producing enzyme), was protective both prophylactically

165 , the number of sulfur atoms in H2Sn and its producing enzyme were unknown.

166 Also, inhibitors of H(2)S-producing enzymes were used to assess bacterial killing

167 amine 2,3-dioxygenase-1 (IDO1), a kynurenine-producing enzyme with effects on tumor immune escape, an

168 ever, treatment of cells with the superoxide-producing enzyme xanthine oxidase also resulted in isopr