ライフサイエンスコーパス: prodynorphin

1 ors: Proopiomelanocortin, proenkephalin, and prodynorphin.

2 as c-fos, fos-related antigen-2 (fra-2), and prodynorphin.

3 s the opioid neuropeptide precursor protein, prodynorphin.

4 icotropin-releasing hormone, vasopressin, or prodynorphin.

5 f the proNKB neurons were immunoreactive for prodynorphin.

6 evated GluR2 was accompanied by decreases in prodynorphin.

7 tified a putative enhancer upstream of Pdyn (prodynorphin), a gene encoding an opioid neuropeptide im

8 in neural and cardiac tissues and represses prodynorphin and c-fos gene expression by binding to DNA

9 and regulates Ca2+-induced transcription of prodynorphin and c-fos genes.

10 ding protein that represses transcription of prodynorphin and c-fos genes.

11 of DREAM to DNA response elements (DREs) in prodynorphin and c-fos genes.

12 AM for specific DNA response elements in the prodynorphin and c-fos genes.

13 intake of the CHO diet resulted in levels of proDynorphin and Dynorphin A1-17 that were similar in th

14 Immunolabeling for prodynorphin and enkephalin revealed numerous immunoposi

15 In addition, we examined two genes (prodynorphin and FK506 binding protein 5) that are stron

16 CFA also induced an upregulation of prodynorphin and neurokinin-1 (NK-1) in dorsal horn neur

17 duced phospho-ERK primarily colocalized with prodynorphin and NK-1 in superficial dorsal horn neurons

18 transcriptional regulation of genes, such as prodynorphin and NK-1.

19 ding to DNA to activate the transcription of prodynorphin and other downstream genes in pain control.

20 There were no differences in proDynorphin and proEnkephalin mRNA levels in the ARC (0

21 ofluorescence to explore the distribution of prodynorphin and proNKB immunoreactivity in the rat hypo

22 alamic projections of fibers expressing both prodynorphin and proNKB provide evidence that these neur

23 othalamus where neuronal somata coexpressing prodynorphin and proNKB-immunoreactivity were identified

24 rons in the pre-locus coeruleus that express prodynorphin, and for satiation of sodium appetite.

25 use and rat, including tyrosine hydroxylase, prodynorphin, and galanin.

26 erated from three precursors, proenkephalin, prodynorphin, and proopiomelanocortin, by sequential pro

27 y neurons in the pre-locus coeruleus express prodynorphin, and that these neurons are a critical neur

28 localized in some puncta and fibers, but the prodynorphin antibody additionally labeled cell bodies.

29 Peptides derived from proenkephalin and prodynorphin are broadly distributed in the brain, and m

30 n volunteers bearing the (T) allele of PDYN (prodynorphin) at rs1997794 showed reduced fear extinctio

31 date genes revealed by our screening, namely prodynorphin, BDNF, and MHC class I molecules, to the fa

32 prefrontal cortex (PFC)-driven excitation of prodynorphin-containing neurons in the BNST.

33 Immunohistochemical analysis showed prodynorphin content increased in the nucleus accumbens

34 o study the basal and evoked release of this prodynorphin derived peptide in the spinal cord of ureth

35 NL induced a sustained release of endogenous prodynorphin-derived opioid peptides that activated an a

36 These observations suggest that prodynorphin-derived peptides have a much more pervasive

37 igators to contain perikarya that synthesize prodynorphin-derived peptides, except the pedunculoponti

38 inhibitory SDH interneurons derived from the prodynorphin (DYN) lineage, a population that synapses d

39 LID, including overexpression of DeltaFosB, prodynorphin, dynorphin A, cyclin-dependent kinase 5, an

40 on, blocks swim stress-induced activation of prodynorphin (encodes dynorphin) in the NAc.

41 3 (SCA23) is caused by missense mutations in prodynorphin, encoding the precursor protein for the opi

42 s in the brain associated with inhibition of prodynorphin-expressing (Pdyn-expressing) and of proenke

43 Here we report that PVH prodynorphin-expressing (PVH(PDYN)) neurons, which notab

44 othermia, whereas chemogenetic activation of prodynorphin-expressing neurons in the arcuate or the pa

45 ressor DREAM acts constitutively to suppress prodynorphin expression in spinal cord neurons.

46 s in the ventral brainstem, distinguished by prodynorphin expression, which we named LJA5.

47 in the parabrachial nucleus that express the prodynorphin gene (hereafter, PB(Pdyn) neurons) monitor

48 onsistent with this result, mice lacking the prodynorphin gene did not show a stress-induced potentia

49 s have demonstrated that stress may increase prodynorphin gene expression, and kappa opioid agonists

50 esis, transgenic mice possessing a disrupted prodynorphin gene showed no increase in immobility or st

51 Here, mice lacking the prodynorphin gene were studied for sensitivity to non-no

52 Prodynorphin-immunopositive cell bodies consisted of two

53 Dynorphin and prodynorphin immunoreactivities colocalized in some punc

54 ts with an ShA history showed an increase in prodynorphin immunoreactivity in both the nucleus accumb

55 The localization of prodynorphin immunoreactivity to pyramidal cells suggest

56 calized with and decreased the expression of prodynorphin in nucleus accumbens medium spiny neurons,

57 Furthermore, deletion of prodynorphin in the BNST and chemogenetic inhibition of

58 al increases expression of pCREB, c-Fos, and prodynorphin in the superficial dorsal horn, changes tha

59 dditionally, we investigated whether arcuate prodynorphin-ir (immunoreactive) neurons expressed the n

60 cleus expressed NK3R, and nearly 100% of the prodynorphin-ir neurons contained nuclear ERalpha.

61 Interestingly, the majority of prodynorphin-ir neurons in the arcuate nucleus expressed

62 We found that the majority of prodynorphin-ir neurons in the rat arcuate nucleus expre

63 Prodynorphin is processed into the opioid peptides, alph

64 Prodynorphin knock-out (KO) mice had normal responses to

65 In addition, knock-out mice lacking prodynorphin, KOR, or G-protein receptor kinase 3 (GRK3)

66 Antibodies against dynorphin and prodynorphin labeled puncta and fibers in laminae I, II,

67 o true: 96% of neurons in the LHA containing prodynorphin mRNA also expressed prepro-orexin mRNA.

68 loss of the orexin neurons completely lacked prodynorphin mRNA in this area, further confirming that

69 Hypothalamic Dynorphin A1-17 and proDynorphin mRNA levels are stimulated by feeding a hig

70 O, ad libitum intake of Fat/Sucrose elevated proDynorphin mRNA levels in the arcuate and Dynorphin A1

71 real-time PCR was used to show that KOR and prodynorphin mRNA levels were decreased in the NAc, wher

72 ce and orexin knock-out mice showed abundant prodynorphin mRNA-expressing neurons in the LHA, but ore

73 brain regional levels of opioid peptides and prodynorphin mRNA.

74 expressing prepro-orexin mRNA also expressed prodynorphin mRNA.

75 in neurons are activated by fasting and that prodynorphin neurons restrain food intake during schedul

76 In contrast, neither prodynorphin nor GRK3 knock-out mice showed U50,488 tole

77 tream regulatory element (DRE) of either the prodynorphin or c-fos genes.

78 Potential candidates may include a prodynorphin- or other opioid-like gene.

79 t to its origin as a duplication of either a prodynorphin- or proenkephalin-like gene.

80 id were also examined on mRNA expression for prodynorphin (PDYN) and kappa-opioid receptors (KORs) in

81 d PBN neuronal populations overlap with both prodynorphin (Pdyn) and proenkephalin (Penk) expressing

82 Here we report that in the PBN Prodynorphin (Pdyn) and Proenkephalin (Penk) mRNA expres

83 These genes included prodynorphin (PDYN) and proenkephalin (PENK), among othe

84 Rodent models implicate amygdala prodynorphin (Pdyn) as a mediator of negative affect; ho

85 In human, prodynorphin (Pdyn) gene polymorphisms might be linked t

86 the relationship of genetic variants of the prodynorphin (PDYN) gene, which is enriched in the stria

87 ing mice with a targeted inactivation of the prodynorphin (Pdyn) gene.

88 t both known and novel autoantigens, such as prodynorphin (PDYN) in APS1 patients, and intestinally e

89 strated significant increases in whole brain prodynorphin (Pdyn) mRNA in WSP mice only during EtOH wi

90 se 1 (NOS1), melanocortin 4-receptor (MC4R), prodynorphin (PDYN)).

91 Because the tyrosine hydroxylase (TH), prodynorphin (PDYN), and proenkephalin (PENK) genes cont

92 s that co-express the endogenous opioid gene prodynorphin (Pdyn).

93 population that expresses the cognate ligand prodynorphin (PDYN).

94 ndothelial nitric oxide synthase (NOS3), and prodynorphin (PDYN).

95 alized with a subset of preproenkephalin and prodynorphin positive spiny neurons within the dorsomedi

96 The prodynorphin-positive neurons in the dorsal horn were di

97 Prodynorphin (ProDYN) in the anterior pituitary gland ap

98 Messenger RNA levels of ProDynorphin (proDYN), but not pro-opiomelanocortin (POM

99 ad libitum intake resulted in mRNA levels of proDynorphin, proEnkephalin and POMC, and Dynorphin A1-1

100 on of the same diet decreases mRNA levels of proDynorphin, proEnkephalin and POMC, as well as levels

101 f neuropeptides including those derived from prodynorphin, proenkephalin, proSAAS, and amyloid precur

102 Prodynorphin/proNKB fibers were also identified in the p

103 A dense plexus of double-labeled prodynorphin/proNKB-ir fibers was found within the arcua

104 and proopiomelanocortin, proenkephalin, and prodynorphin transcript levels in cortex, hippocampus, a

105 Axonal fibers immunolabeled for prodynorphin varied in size and were found in all lamina

106 instem, distinguished by their expression of prodynorphin, which we named LJA5.

107 ere was some colocalization of dynorphin and prodynorphin with CGRP and substance P, but not with iso

108 ytic proteoforms of pro-opiomelanocortin and prodynorphin with significantly higher abundance in male

109 here was no co-localization of dynorphin (or prodynorphin) with enkephalin (or Phe-Arg-Met-enkephalin