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1 hat coexpress mesenchymal markers and may be profibrogenic.
2 gocytosis of apoptotic hepatocytes by HSC is profibrogenic.
3 sis of apoptotic bodies by stellate cells is profibrogenic.
4 s the most upstream component regulating the profibrogenic action of TGF-beta and suggest that inhibi
5 orming growth factor beta (TGF-beta)-induced profibrogenic actions by regulating the expression of TG
6 nipulation of Hh signaling demonstrated that profibrogenic actions of Rac1 were mediated by its abili
7 concomitantly with extensive alterations and profibrogenic activation of reactive cholangiocytes and
8 gen alpha1(I) messenger RNA, and blunting of profibrogenic activities of transforming growth factor b
9 ulatory properties of HSCs might promote the profibrogenic activity of B cells.
10 cultured in vitro, are a major target of the profibrogenic agent transforming growth factor-beta (TGF
11                       Here, we show that the profibrogenic agonist, transforming growth factor beta1,
12 iferative neoplasms, increased production of profibrogenic and angiogenic cytokines and related alter
13 ession of eosinophil-specific chemokines and profibrogenic and angiogenic mediators.
14 or wound repair, amplifies the expression of profibrogenic and chemokine transcripts, and appears up-
15 atrix proteins (fibronectin and collagen I), profibrogenic and proinflammatory factors (TGF-beta, con
16 ition, G2/M arrest and aberrant secretome of profibrogenic and proinflammatory factors in uric acid-s
17                                Expression of profibrogenic and proinflammatory genes was reduced in l
18 tory phenotype, which is proinflammatory and profibrogenic, and the intrinsic intracellular activatio
19  peroxidase enzymes possess a well-conserved profibrogenic capacity to stimulate the migration of fib
20  attenuates hepatic inflammation and several profibrogenic changes in mice fed a Western diet.
21 ix transcripts that may be due to underlying profibrogenic changes in this group.
22 1 led to elevated intrahepatic levels of the profibrogenic chemokine CCL3 and an increase in GFAP(+)
23 evations of alanine aminotransferase and the profibrogenic chemokine MCP-1 (CCL-2), greater viral div
24                               Interestingly, profibrogenic connective tissue growth factor was induce
25  stressed and dead hepatocytes instigate the profibrogenic crosstalk with HSC and macrophages, includ
26 ding HIV coinfection, including increases in profibrogenic cytokine expression and secretion, generat
27                  Here, we show that a potent profibrogenic cytokine TGF-beta1 significantly induced t
28                      TGF-beta is the pivotal profibrogenic cytokine that activates HSC, yet other mol
29  beta (TGF-beta) is an antiproliferative and profibrogenic cytokine that signals through a receptor c
30 rming growth factor-beta (TGFbeta), a master profibrogenic cytokine, is a promising therapeutic targe
31       Although TGFbeta is considered a major profibrogenic cytokine, local production of TGFbeta by H
32                                    Leptin, a profibrogenic cytokine, plays an important role in the d
33 ition, hepatic collagen gene expression, and profibrogenic cytokines (eg, transforming growth factor-
34 osis factor alpha, IL-6, IL-8, IL-1beta) and profibrogenic cytokines (IL-13), chemokines (CCL1, CCL2,
35 ting that hepatic PAR-2 activation increases profibrogenic cytokines and collagen production both in
36 of TGF-beta family genes, which are known as profibrogenic cytokines in the pathogenesis of pulmonary
37 tial and ability to secrete inflammatory and profibrogenic cytokines suggests they play an important
38 of Th1 and Th17/Th 22, and anti-inflammatory/profibrogenic cytokines.
39 2Y14 ligands and their receptor constitute a profibrogenic DAMP pathway that directly links cell deat
40 rcinogenesis and suppresses inclusion of the profibrogenic EDA exon in fibronectin 1.
41 F6-dependent ER stress pathway, mediated its profibrogenic effects by enforcing TGF-B signaling activ
42 himeric mice revealed that CCR1 mediates its profibrogenic effects in BM-derived cells, whereas CCR5
43 enous liver cells, whereas NOX2 mediates the profibrogenic effects in both endogenous liver cells and
44 imeric mice indicated that NOX1 mediates the profibrogenic effects in endogenous liver cells, whereas
45  BM-derived cells, whereas CCR5 mediates its profibrogenic effects in resident liver cells.
46 tment of fibrotic diseases and modulation of profibrogenic effects of TGF-beta.
47 relating this with the antiproliferative and profibrogenic effects of TGF-beta1.
48 intrinsic MMP activity does not constitute a profibrogenic event in the kidney.
49 2a, Saa3, S100a9, Nos2, Reg2, and Reg3g, and profibrogenic extracellular matrix genes Col1a1, Col1a2,
50       The gene encoding osteopontin (OPN), a profibrogenic extracellular matrix protein and cytokine,
51 er cancer cell growth that is induced by the profibrogenic factor leptin.
52       Conversely, scarring and levels of the profibrogenic factor TGF-beta1 were greatly reduced in G
53 mma (PPAR-gamma) and lower expression of the profibrogenic factor transforming growth factor beta1 (T
54                    TGF-beta, the most potent profibrogenic factor, acts by activating SMAD (mothers a
55 c inflammation induces production of various profibrogenic factors, progression to latter stages of n
56 f type I collagen, and reduces expression of profibrogenic factors.
57 at its genetic variant I148M potentiates the profibrogenic features of HSCs, providing a molecular me
58  with progenitor cell expansion, increase in profibrogenic gene expression and de novo collagen depos
59 , the drug significantly improved histology, profibrogenic gene expression, and tumor development, wh
60 reased concomitant with reduction of hepatic profibrogenic gene expression.
61 otensin II-mediated mitogenic signalling and profibrogenic gene expression.
62 s the expression of many proinflammatory and profibrogenic gene products in macrophages, and hence pl
63  and significantly reduced expression of the profibrogenic genes (Col1a1, Acta, Loxl2, and Tgfbeta) (
64 ent of fibrosis with increased expression of profibrogenic genes as well as skewed M2 Mvarphi phenoty
65 sponded with increased colonic expression of profibrogenic genes prior to the development of histolog
66 ar attention to specific proinflammatory and profibrogenic genes that remain active at low levels of
67  collagen expression, and several additional profibrogenic genes, while also promoting cell death.
68 evated expression of fibrillar collagens and profibrogenic genes.
69 chestrates coordinated induction of multiple profibrogenic genes.
70 lved in positively influencing expression of profibrogenic genes.
71  number with a similar level of collagen and profibrogenic growth factor gene expression in mdx(5cv)-
72 ze options to therapeutically interrupt this profibrogenic hepatocyte-macrophage-HSC network in NASH.
73                    Leptin is recognized as a profibrogenic hormone in the liver, but the mechanisms i
74 usion, these results indicate that leptin is profibrogenic in activated HSCs and can signal via the J
75 the hypothesis that loss of BMP7 activity is profibrogenic in proximal tubular cells was tested.
76          The loss of BMP7 activity per se is profibrogenic in tubular cells.
77 initially dominated by the M1 phenotype, the profibrogenic M2 phenotype increases with disease progre
78  and to respond to the neurotransmitter in a profibrogenic manner.
79 we demonstrated increased gene expression of profibrogenic markers after lipid and/or ammonia exposur
80             HCV and HIV independently induce profibrogenic markers transforming growth factor beta-1
81 is mechanism is postulated to counterbalance profibrogenic mechanisms that follow V(2)O(5) injury.
82 th factor beta (TGF-beta) is the most potent profibrogenic mediator in liver fibrosis.
83 repair and tissue remodeling, release of the profibrogenic mediator TGF-beta2 was also measured.
84  activator inhibitor 1 (PAI-1), an important profibrogenic mediator, was significantly increased in b
85 ges to express proinflammatory cytokines and profibrogenic mediators (TIMP1 and type I collagen) at t
86 c disease via inhibition of the induction of profibrogenic mediators after acute or chronic oxidative
87                               A reduction in profibrogenic mediators, including transforming growth f
88  resulting in release of proinflammatory and profibrogenic mediators.
89 rminal kinase (JNK) is activated by multiple profibrogenic mediators; JNK activation occurs during to
90 appaB signaling, followed by production of a profibrogenic mesenchymal transition in primary human sm
91 iac fibroblasts are activated and exist in a profibrogenic microenvironment in allografts undergoing
92 liver to actively create an inflammatory and profibrogenic microenvironment.
93   CCL11 induced the up-regulation of several profibrogenic molecules such as fibroblast growth factor
94 2 during activation and after stimulation by profibrogenic molecules.
95 fter PHx resulted in strongly down-regulated profibrogenic mRNA, reduced serum ALT levels and improve
96 se in collagen synthesis and conversion to a profibrogenic myofibroblast phenotype.
97 n in CLD, especially for proinflammatory and profibrogenic non-classical CD14 + CD16+ monocytes.
98                                         As a profibrogenic or antifibrogenic driver, microRNAs (miRNA
99 ote hepatic fibrosis in mice and to induce a profibrogenic phenotype in human HSCs.
100 to create a microenvironment that promotes a profibrogenic phenotype through the induction of transfo
101                HIV accentuates an HCV-driven profibrogenic program in hepatocyte and hepatic stellate
102                            IL-17A has proven profibrogenic properties in liver disease making it an i
103  CB2 receptor and explored its effect on the profibrogenic properties of IL-17.
104 ckdown of PNPLA3 significantly decreases the profibrogenic protein alpha-smooth muscle actin (P < 0.0
105                                              Profibrogenic release of mitochondrial DAMP mitochondria
106               ASK1 inhibition suppresses the profibrogenic release of mitochondrial deoxyribonucleic
107 nctional regulator promoting either anti- or profibrogenic response, depending on milieu.
108 uced proinflammatory response but limits the profibrogenic response, regulating collagen production i
109           Inhibiting apoptosis decreased the profibrogenic response.
110 lymphocytes and elicit a proinflammatory and profibrogenic response.
111 ice) significantly increase inflammatory and profibrogenic responses in fibroblast (in vitro) and car
112 ensin II and mediates angiotensin II-induced profibrogenic responses in primary rat mesangial cells.
113 ugments transforming growth factor-B-induced profibrogenic responses in underlying lung fibroblasts v
114    OPN is Hh-regulated and directly promotes profibrogenic responses.
115 pidermal proliferation and homeostasis and a profibrogenic role for c-Rel in the skin, and identify a
116                                 However, the profibrogenic role of HIV on hepatocytes and hepatic ste
117 DN1 reverted inflammation-induced hepatocyte profibrogenic signaling and cell fate and suppressed the
118 des a novel link between proinflammatory and profibrogenic signals.
119  isolated from wild-type (WT) mice were more profibrogenic than those from OPN knockout (Opn(-/-)) mi
120   CXCR4 receptor activation by SDF-1alpha is profibrogenic through its effects on HSC activation, fib
121 istry identified increased NET expression of profibrogenic tissue factor and IL-17.
122 at, on relaxin binding, they switch from the profibrogenic to the pro-resolution phenotype.
123 rtension and twofold to fourfold increase in profibrogenic transcripts Col1a1 [procollagen alpha1(I)]
124 g Zac1 is sufficient to induce signatures of profibrogenic transformation.
125 eine-cysteine chemokine ligand 5 [CCL5]) and profibrogenic (transforming growth factor beta1, collage
126 rring properties, and is up-regulated by the profibrogenic type 2 cytokine IL-13.

 
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