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1 lly sterile, whereas opaque cells are mating-proficient.
2 the 193 tumors with < 20 mutations were MMR-proficient.
3 l mtDNA isolation is relatively low-cost and proficient.
5 sized in high yields using an innovative and proficient acoustic cavitation technology and well chara
9 osms amended with alginate particles and the proficient alginolytic bacterium Alteromonas macleodii s
10 ra)-deficient mice reconstituted with Csf2ra-proficient alveolar macrophages were subjected to differ
11 ) plus PARPis enhance PARPi efficacy in BRCA-proficient AML subtypes, breast, and ovarian cancer open
13 were compared among antiviral RNA silencing-proficient and -deficient strains in the EP155 backgroun
14 biochemical characterization of these FIP1C-proficient and -deficient tumor models revealed that FIP
18 s in developing lymphocytes from both c-NHEJ-proficient and c-NHEJ-deficient mice, demonstrating that
19 row macrophages derived from adult male CCR3-proficient and CCR3-deficient mice to study the role of
20 Thus, spatially uniform inhibition allows proficient and flexible coding in hippocampal CA1 by sup
21 -deficient (muMT) mice and transfer of IL-10-proficient and IL-10-deficient B cells to muMT mice.
24 ferential equations (ODEs) are attained by a proficient and reliable technique namely optimal homotop
25 tion (CLIP) in vitro, carried out on standby-proficient and standby-deficient tisB mRNAs, we provide
26 nvolved in priming replication, are also TLS proficient and therefore may play important roles in dam
27 ging to know whether a NICU is becoming more proficient, and it is not usually apparent whether concu
32 ion, we discovered that TET enzymes are also proficient as direct N-demethylases of cytosine bases.
36 y hospitals and outpatient clinics were very proficient at collecting induced sputum specimens for th
38 siveness to proinflammatory stimuli but were proficient at endocytosis of particulate and soluble mat
41 e frequent because APOBEC3A itself is highly proficient at generating DNA breaks, whose repair can tr
42 axonomic profiling and binning programs were proficient at high taxonomic ranks, with a notable perfo
46 erred CD8gamma13 T-cell clone was remarkably proficient at preventing chlamydia immunopathology, wher
47 nch by only one initial seed, so that RRS is proficient at quantifying extensive amounts of neurite o
49 ction Service, clinical laboratories must be proficient at rapidly recognizing isolates suspicious fo
50 ing in their natural environments need to be proficient at recognizing and responding to changes in f
52 the prototype foamy virus (PFV) intasome is proficient at stable capture of nucleosomes as targets f
54 citly assumes that task specialists are more proficient at their jobs than generalists and specialist
59 d Diels-Alderase was converted into the most proficient biocatalyst for [4+2] cycloadditions known.
60 nds of mutagenesis and screening to afford a proficient biocatalyst for enantioselective cleavage and
61 cancer cell line PC-3 (PC3) along with STAT3-proficient breast cancer cell lines (MDA-MB-231, SUM149)
62 air and genomic stability not only in c-NHEJ-proficient but also -deficient human G1-phase cells.
63 itized DNA-dependent protein kinase (DNA-PK)-proficient but not DNA-PK-deficient glioblastoma cells,
66 antigen (PCNA) monoubiquitination in Poleta-proficient but not in Poleta-deficient XPV (Xeroderma pi
76 y (HRD) is a viable strategy to sensitize HR proficient cancers to DNA targeted therapies in order to
78 e Amsterdam criteria and had mismatch repair-proficient cancers with no previously associated mutatio
79 and homologous recombination (HR) DNA repair-proficient cancers, including central nervous system (CN
81 t morbidities, emphasizing whole cultures of proficient care rather than the traditional emphasis on
83 of cleaved caspase-3 using human- and mouse-proficient caspase-3 cancer cell lines and human-deficie
87 e transfer of activated TNF-R1-deficient or -proficient CD8(+) T cells in CD8-deficient mice bearing
90 ction donors are used, COIN enriches for HDR-proficient cells among heterogeneous cell populations.
91 present in both repair-defective and repair-proficient cells and was strongest and highly significan
92 ally lethal in XRCC1-deficient compared with proficient cells as evidenced by hypersensitivity to DSB
93 nges alone mediated chemotaxis in adaptation-proficient cells but exhibited altered sensitivity to se
98 icient cells compared with homologous repair-proficient cells were more sensitive to PARGi in vitro.
99 apoptosis-necrosis continuum, apoptotically proficient cells were screened facing several apoptotic
102 e, cells with defects in MMR exist among MMR-proficient cells, as observed in healthy intestinal tiss
104 r resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt inhib
121 linically, we evaluated XRCC1-deficient and -proficient Chinese hamster and human cancer cells for sy
123 ectively, in the cohort with mismatch repair-proficient colorectal cancer (hazard ratio for disease p
125 ectal cancers, patients with mismatch repair-proficient colorectal cancers, and patients with mismatc
127 nd a molecular mechanism by which DNA ligase proficient complexes are assembled during NHEJ in mammal
132 s (GOAs) show better outcomes than their MMR-proficient counterparts and high immunotherapy sensitivi
133 ructure of a phospho-mimicking, condensation-proficient CPB mutant reveal that a disordered loop at t
137 grated transgenes, transgene removal enabled proficient differentiation of iPS cells into functional
139 how that B. subtilis and E. coli gyrases are proficient DNA-stimulated ATPases and efficiently superc
140 e fertility of oocytes containing a synapsis-proficient, DSB repair-defective mutation in a gene (Tri
141 e patient cells are homologous recombination proficient due to the low ratio of mutant to wild-type R
142 pecific hybridization, we show that excision-proficient E. coli generates leading-strand intermediate
144 ibition upregulates MAD2L2 and sensitizes HR-proficient epithelial ovarian cancer (EOC) to poly(adeno
145 such as PI3K inhibitors) might sensitise HRR-proficient epithelial ovarian cancers to PARP inhibitors
147 cloning and codon optimization supported the proficient expression of the designed vaccine in E. coli
148 nted demonstrating that use of an especially proficient 'extended FMDV 2A' coding region allows produ
150 y ATR-independent, as a HUS1 mutant that was proficient for ATR-induced checkpoint kinase 1 phosphory
151 -like structures, and thus is expected to be proficient for biomedical feature extractions in a wide
153 transposase moiety behaved normally and was proficient for integration in vitro and in Escherichia c
155 this fusogenic repair occurs in cells fully proficient for non-homologous end-joining and is not com
157 ctp1Delta, these mutants were recombination-proficient for Rec12 (Spo11 homolog)-independent break-r
158 is study we show that mammalian cells become proficient for spontaneous gene amplification when the f
161 ated with technologies that claim to collect proficient, free-living sleep measurements despite a sev
168 a redox midpoint potential of +114 mV and is proficient in 1-electron transfers to a surrogate cytoch
172 h small hydrophobic side chains are the most proficient in attracting CO2, indicating a significant c
174 can theoretically allow a trainee to become proficient in both domains and to navigate the complexit
175 ons with dominant transactivation ability is proficient in DDR and insensitive to PARP inhibition.
182 nd, remarkably, TET enzymes can be similarly proficient in either oxidation of 5mC or demethylation o
183 nd cognitively capable of participating, and proficient in English, participants were randomly select
186 cally reduces transcript production in cells proficient in global NER but lacking TCR, indicating tha
188 detectable effect on transcription in cells proficient in NER but lacking TCR, indicating that NER c
189 ed?) can be decoded from peak PRP in animals proficient in odorant discrimination, but not in naive m
193 ast, cells expressing phospho-mimic EXO1 are proficient in resection even after CDK inhibition and fa
194 reasingly technological society, a workforce proficient in science, technology, engineering, and math
199 n is recruited to 5S rRNA genes as a part of proficient initiation complexes and the activity persist
200 ion DNA synthesis (TLS) polymerase Poleta is proficient, inserting both correct and incorrect nucleot
205 children have unexplained problems acquiring proficient linguistic skills despite adequate intelligen
207 response was similar in IRF-1-deficient and -proficient macrophages during gammaherpesvirus infection
211 functional specialization, leading to highly proficient microcircuits with much higher computational
213 that patients whose tumors had deficient vs proficient MMR had significantly better SAR (adjusted ha
214 Favorable DFS was observed for dMMR versus proficient MMR proximal tumors (HR, 0.71; 95% CI, 0.53 t
216 mmune checkpoint blockade in mismatch repair-proficient (MMRP) and -deficient endometrial cancer (EC)
218 allowed 1-, 2-, or 3-bp substitutions in MMR-proficient mouse embryonic stem cells as effectively as
220 21), comparing proficient (N = 11) and less proficient (N = 10) readers' performance in a widely use
221 tivation in deaf readers (N = 21), comparing proficient (N = 11) and less proficient (N = 10) readers
223 gression in rat ERBB-2 (neu) transgenic, pfp-proficient (neu(+)/pfp(+)) or pfp-deficient (neu(+)/pfp(
225 h early transient hypoglycemia would be less proficient on fourth-grade achievement tests compared wi
226 n-Smad1 and Atm-p38MAPK-Atf2 pathways in p53-proficient or -deficient cells and requires the Smad1-At
228 signaling was preserved in models that were proficient or deficient in p53, resembling standard or h
229 resistant to immunotherapy, mismatch-repair-proficient or microsatellite instability-low (pMMR-MSI-L
232 t in cyclin D1 yet retain the retinoblastoma-proficient/p16(INK4a)-deficient profile associated with
233 that significantly affected limited English proficient patients' ability to access language services
235 ally attempted to engineer IcmF to be a more proficient PCM by targeting two active site residues pre
236 straint to avoid counterproductivity, and 7) proficient performance-especially for 8) conventional go
237 tructing an in vivo-assembled, catalytically proficient peroxidase, C45, we have recently demonstrate
245 ss how the capacity to become scientifically proficient, prolific, and independent has changed in bio
247 the open-reading frame, encodes a DNA repair proficient protein and is expressed in IVS7+2T>G carrier
253 leosomes shows the opposite asymmetry in NER-proficient skin cancers, but not in NER-deficient cancer
258 ning these improvements in a mismatch repair proficient strain reduced counter-selection escape frequ
265 single-stranded DNA to form a catalytically proficient structure able to promote homology recognitio
269 Spiked swipe and water samples as well as proficient testing water standards were analyzed to vali
270 an N,N-dibenzylammonium moiety appeared more proficient than a hydroxyl group at directing the stereo
271 CE STATEMENT Behaviorally, children are less proficient than adults at understanding speech-in-noise.
272 3' primer terminus, and is surprisingly more proficient than terminal deoxynucleotidyl transferase.
278 mors, as compared with 73 in mismatch repair-proficient tumors (P=0.007), and high somatic mutation l
279 ly in hypermutated DNA mismatch repair (MMR)-proficient tumors and appear to be responsible for the b
284 cantly lower proportion of patients with MMR-proficient tumors with mutant BRAF (hazard ratio = 1.43;
286 d detected in women (59%), compared with MMR-proficient tumors without BRAF(V600E) or KRAS mutations
287 Four hundred two patients (89.3%) had MMR-proficient tumors, and 32 patients (8%) had at least 1 g
289 ing BRCAness in a much larger subset of BRCA-proficient tumors, with significant translational potent
291 1 as a potential therapeutic target in BRCA2-proficient tumors.BRCA2 is essential for the repair of D
296 we compared the differential survival of HR-proficient vs HR-deficient cells, we found that the comb
297 rewarded odorant and had difficulty becoming proficient when MLIs were inhibited by chemogenetic inte
298 uiting body development by a developmentally proficient wild-type strain under high-nutrient conditio
300 ound in nearly half of the study cohort (MMR-proficient without BRAF(V600E) or KRAS mutations) had si