ライフサイエンスコーパス: profile

1 t, and central circadian rhythm by melatonin profile.

2 browning, antioxidant capacity and phenolic profile.

3 depending on their transplant phase and risk profile.

4 ete response rates with an acceptable safety profile.

5 ectroscopy to determine the reaction kinetic profile.

6 ess their efficacy, safety, and risk-benefit profile.

7 tified on the base of their MS fragmentation profile.

8 APC altered the p120-catenin protein isoform profile.

9 els significantly narrows the resulting peak profile.

10 exosomes by exploiting their surface protein profile.

11 respectively) followed a strict oral/aboral profile.

12 ons were histologically- and/or anatomically-profiled.

13 tilized for measuring label-free GPCR signal profiles.

14 is revealed significant differences in these profiles.

15 Each subgroup displayed different molecular profiles.

16 with distinct survival and therapy response profiles.

17 genes for lung cancer using gene expression profiles.

18 ty of patients studied using gene expression profiles.

19 lity, metabolic responses, and transcriptome profiles.

20 nd inflammatory phenotypes to wild type (WT) profiles.

21 from parallel transcriptomic and epigenomic profiles.

22 ar libraries for studying structure-activity profiles.

23 eristics, which converged with broad genetic profiles.

24 ures with human blood DNA methylation (DNAm) profiles.

25 hnology to enable saturated domain insertion profiling.

26 ent and accurate alignment-based metagenomic profiling.

27 tomic single-cell atlases with protein-level profiling.

28 ll biology, pathogenicity and transcriptomic profiling.

29 nables intracellular deubiquitinating enzyme profiling.

30 rts are propelled by advances in single cell profiling.

31 molecule through single-cell gene expression profiling.

32 e we used multiplexed single-cell RNA-seq to profile 198 cancer cell lines from 22 cancer types.

33 ical images is reduced to a multidimensional profile, a collection of extracted image-based features.

34 porter cell lines and activity-based protein profiling (ABPP) chemical proteomics to identify the pro

35 For 41 of 83 testable MoAs, phenomic profiles accurately ranked the reference compounds (AUC-

36 inhibitors have a unique polypharmacological profile across the kinome.

37 ocial status-dependent brain gene expression profiles across vertebrates, yet social status and repro

38 Furthermore, a texture profile analysis was carried out in addition to the meas

39 The gene expression profiling analysis showed that PRLT2/89-33 has an inhere

40 ML blasts generated an inflammatory cytokine profile and activated NK cells.

41 This study described the clinical profile and associated outcomes among patients with HF h

42 Here, we explore the transcriptional profile and DNA replication timing (RT) under mild repli

43 ce revealed a global change in immunological profile and impaired recruitment and activation of T cel

44 ructural basis of this particular inhibition profile and laid the foundation for further developments

45 reveal novel associations between metabolite profile and sensory quality, by integrating non-target m

46 lore the associations between maternal lipid profile and small-for-gestational-age neonates.

47 ated the strong potential of using molecular profiles and drug activity data of PDX tumors in develop

48 nd pMos revealed distinct baseline signaling profiles and far greater heterogeneity than previously d

49 s key for a reliable comparison of metabolic profiles and for unknown biomarker identification that i

50 shikawa cells revealed unique transcriptomic profiles and global miRNA downregulation.

51 l was assessed by comparing the predicted PK profiles and parameters with the observed data from publ

52 estinal digestion for differences in peptide profiles and peptide bioactivities.

53 oteins have unknown or inaccessible activity profiles and so cannot be targeted by such strategies.

54 asthma and controls for nasal transcriptome profiling and applied network-based and probabilistic ca

55 Using complexome profiling and biochemical analyses, we have explored the

56 ence-based assays, and by analyzing ribosome-profiling and mass spectrometry (MS) data.

57 nship may exist between gut dysbiosis, miRNA profiling and SCFA level in response to intestinal infla

58 important tool for high-throughput N-glycan profiling and, upon use of tandem MS, for structure dete

59 hibited similar plaque morphology, viral RNA profile, and replication kinetics.

60 S was used to study cognitive and behavioral profiles, and 375 patients to study neuroimaging charact

61 can help build past (century-scale) climatic profiles, and better understand coral persistence, parti

62 ss-linking and isolation by pull-down target profiling, and to rescue disease-relevant splicing of ta

63 The phenolic profile, antioxidant, antibacterial and hepatotoxic prop

64 ogical, cell biological, and gene expression profiling approaches, we report here multiple lines of e

65 roved efficacy and a more favorable toxicity profile are poised to alter the landscape of RET-depende

66 tin proteomics, we found that ubiquitination profiles are different among polarized murine macrophage

67 s demonstrate that complex PCB 11 metabolite profiles are formed in HepG2 cells that warrant further

68 of dopamine on larger-scale neural activity profiles are less well-understood.

69 The therapeutic profile as well as the resistance onset were characteriz

70 ell wall composition was analysed by glycome profiling assay.

71 All DMB/MBEN assessed by DNA methylation profiling belonged to the SHH-INF subgroup.

72 s study, free and bound phenolic acids (PAs) profile, betaine and choline contents were quantified in

73 We identified and profiled both neuronal (glutamatergic and GABAergic) and

74 icted to bind to the 3'-UTR of mouse MR were profiled by qRT-PCR after aldosterone stimulation.

75 Spatially-resolved molecular profiling by immunostaining tissue sections is a key fea

76 Here, we present prokaryotic expression profiling by tagging RNA in situ and sequencing (PETRI-s

77 zed Notch regulation by examining expression profiles (by quantitative reverse transcription polymera

78 High-quality concentration profiles can be obtained from noisy 1D and 2D NMR data w

79 We demonstrate that bioactive lipid profiles can be readily detected from three-dimensional

80 eactions, such as thresholding of expression profiles, can significantly change model content.

81 his study sought to evaluate the demographic profile, clinical features, topographic features, and bi

82 eek 48, DOR at 100 mg had a favorable safety profile compared with EFV or DRV+r and a favorable toler

83 th EFV or DRV+r and a favorable tolerability profile compared with EFV.

84 a more favorable metabolic and histological profile compared with those with nonlean NAFLD (P < 0.05

85 he CVGN models the distribution of the pulse profile conditioned on a given streaking trace measureme

86 revealed PE-fed larvae retain an expression profile consistent with normal intestinal function but a

87 Transcriptional profiling coupled with T cell receptor (TCR) sequencing

88 intervention for HBV infection, despite high-profile data supporting its success with human immunodef

89 DNA and cDNA 16S rRNA gene profiling demonstrated that the microbial community was

90 roach using Argonaute eCLIP-seq and ribosome profiling, demonstrating that CARP defines a comprehensi

91 RNA-seq tape strip profiling detected distinct immune and barrier signature

92 d proanthocyanidin contents, and woody aroma profile did not change because of the film-treatment.

93 Fecal bacterial profile differed between IBS subtypes, while the mucosa-

94 ation by developing techniques to purify and profile differentiation stage-matched late erythroblast

95 tivities; and more recently, transcriptional profile differentiation.

96 Whereas canonical chromothripsis profiles display oscillations between two copy-number st

97 Transcriptome profiling displayed that TGF-beta pathway activation and

98 ke morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensor

99 rning model DeepMS on WGS somatic mutational profiles enable us identify more comprehensive context-b

100 sed to characterise their sugar and phenolic profiles, flavonoid content, as well as colour parameter

101 in accordance with the WHO's target-product profile for a triage test.

102 g reward are linked and together form a risk profile for drug use or abuse, particularly in young adu

103 ntensity correction in which the z intensity profile for each synapse is modelled as a Moffat functio

104 ape content has increased to 2428 structural profiles for 1900 TFs from 39 different species.

105 We validated the clinical profiles for all three CT signatures in the replication

106 ninferior to sorafenib and to compare safety profiles for patients with advanced HCC.

107 evelopment, biomarker detection, and protein profiling for diagnostic applications.

108 aracterization of tumors, multigenetic tumor profiling for targeted therapeutic selection remains lim

109 xteen tape strips were collected for RNA-seq profiling from 19 infants/toddlers (<5 years old; lesion

110 Transcriptional profiling, functional assays, and acute in vivo myeloid-

111 The peptide profile generated after in vitro and in vivo digestion s

112 However, unbiased methods to profile GxE genome-wide are nascent and, as we show, can

113 rther improve clinical response and toxicity profiles has grown.

114 ations that could distinctly differentiate 3 profiles: healthy volunteers, intermediate mHLA-DR septi

115 age >18 years; activated B-cell (ABC) DLBCL profile, HGBCL, NOS, high genetic complexity, 1q21-q44 g

116 Consistent pharmacokinetic profiles, high target specificity, and robust antitumor

117 phery, APOE2 drove distinct blood metabolome profile highlighted by the upregulation of lipid metabol

118 We used single-cell RNA sequencing to profile human skeletal muscle tissues from embryonic, fe

119 multaneous characterization of the drug load profile (i.e., stoichiometric distribution of the number

120 NA translation; ranging from codon occupancy profiling, identification of actively translated open re

121 Rat miRNA profiles identified TBI across all acute and chronic int

122 Methylome and transcriptome profiling identified several inflammatory responses and

123 iched immunodominant spike-specific antibody profile in convalescents was confirmed in a larger valid

124 t mice had an altered eosinophil recruitment profile in development.

125 ts of fertilization on P fractions in a soil profile in Mollisol.

126 esponses and had a manageable adverse events profile in patients with relapsed or refractory DLBCL wh

127 ingle-agent therapy with a manageable safety profile in patients with treatment-naive, or relapse or

128 ecies, linked to an adequate pharmacokinetic profile in rodents, and antinociceptive properties in th

129 demonstrating alteration of the E2 antigenic profile in several cases, and one design led to improvem

130 OVID-19 ARDS exhibits a distinct immunologic profile in the lungs, with a depleted and exhausted CD4

131 We detected RNA-seq profiles in 96 of 100 of samples (96%), with 4123 and 53

132 By contrast, comparison of PhotoPPI profiles in cells experiencing metabolic or redox stress

133 s and the promotion of T(h)1 gene expression profiles in GC T(fh) cells.

134 e, we identify corresponding transcriptional profiles in human glioblastoma and describe patient-deri

135 rms differ substantially in their expression profiles in plant organs and in response to environmenta

136 overall changes in the systemic inflammation profiles in subpopulation of TB patients.

137 n of immunologic, microbial, and metabolomic profiles in the host.

138 easurements of transcriptomic and epigenomic profiles in the same individual cells provide an unprece

139 position and architecture, component release profiles in the skin could be independently tuned to all

140 ts, oomycetes and fungi has shown that P450s profiles in these organisms are affected by their lifest

141 6S amplicon sequencing to identify bacterial profiles in young (3 to 7 y) and adult (12 to 23 y) anim

142 of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for

143 Unbiased transcriptional profiling in an adult-onset Pkd2 mouse model before cyst

144 In this study, we performed metabolite profiling in both brain (n = 109) and matching serum sam

145 ally resolved in situ cell-surface proteomic profiling in discovering regulators of brain wiring.

146 We show application of STRIPE-seq to TSS profiling in yeast and human cells and show that it can

147 transgenic mice showed a healthier metabolic profile, including ameliorated fibrosis and inflammation

148 re allocated kidneys with lower Kidney Donor Profile Index (median 30% versus 35%, P < 0.001) but lon

149 ace phenotype and NanoString gene expression profiling indicated the closest steady-state counterpart

150 to successfully determine the pH-solubility profile, intrinsic solubility, common-ion effect, pK(a),

151 Image-based profiling is a maturing strategy by which the rich infor

152 Gas chromatography-mass spectrometry profiling is the most established method for the analysi

153 PCF exhibited a distinguished profile (lignans, stilbenes) and antioxidant capacity, e

154 elease and optimal modulation of the release profiles limit their clinical use.

155 Overall, we have established the eicosanoid profiles linked to inhibition of COX-1 in platelets and

156 esized that variants with similar expression profiles may be the product of biological noise, while t

157 publicly available microarray data (n = 303 profiles) measured in livers of fathead minnows after ex

158 resolution in situ acoustic doppler current profile measurements at seven study sites within the upp

159 sholds (CCL1/3/4/5/XCL1); and T(M) chemokine profiles modulated by persisting viral Ags exhibit both

160 se of this study was to examine the clinical profile, myocardial remodeling, and survival of patients

161 itol (4,5)-bisphosphate (PIP(2)) interaction profile near intracellular loop (ICL) 2/TM3 at the G-pro

162 tion to CVD could depend on specific patient profiles.Objectives: To evaluate the effect of OSA on ca

163 her explored its application in the N-glycan profile of a biotherapeutic monoclonal antibody and was

164 study was to compare the efficacy and safety profile of a single XEN-microstent in different types of

165 Analysis of the substrate profile of AldC suggests that this enzyme functions as a

166 The safety profile of BNT162b2 was characterized by short-term, mil

167 This suggests that the profile of cardiovascular changes noted in adults with S

168 These variations mean that the profile of cardiovascular disease differs between low-in

169 side effects and improve the pharmacokinetic profile of chemotherapeutic drugs.

170 In this research, the first carbohydrate profile of GWA honeydew honey, a sample of GWA honeydew

171 to obtain the most comprehensive metabolite profile of HBV.

172 mation and reversed the exacerbated fibrotic profile of Map3k8 (-/-) mice.

173 A global profile of mitochondrial salvage and cell survival was o

174 n this study, we analysed the transcriptomic profile of P. aeruginosa cells isolated from lungs of in

175 volatile compounds characterizing the aroma profile of palinca were esters, particularly ethyl ester

176 more, the molecular, metabolic, and clinical profile of patients with reduced muscle endurance was de

177 However, a rescue in the expression profile of pluripotency factors was not obtained.

178 In conclusion, the upregulated ISG profile of RdRP mice is mostly triggered early postnatal

179 um.Objectives: To define the transcriptional profile of sputum cells and its implication in the patho

180 ide a quantitative measure of the population profile of target molecules.

181 fferences in the 3-dimensional (3D) pressure profile of the LES and hiatal contraction between health

182 ty by six methods and determine the chemical profile of the pitomba fruit peel and pulp by electrospr

183 s behavior in terms of how the concentration profile of the polymer-length distribution adjusts to ch

184 disease is endemic, irrespective of the HBGA profile of the population.

185 ents, do not provide information on the time profile of these adverse events or reflect the continuou

186 rn demonstrating a specific immunomodulatory profile of these cells.

187 To define the transcriptional profile of this airway immune dysfunction, we performed

188 Furthermore, we identified the transcript profile of two cell states expressing germ cell factors,

189 f this work was to characterize the volatile profile of virgin pistachio oils produced from eight cul

190 Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 n

191 The blubber steroid hormone profiles of 52 female humpback whales migrating along th

192 iyne ADC creation, while the pharmacological profiles of at least two of the generated ADCs compare w

193 Using the expression profiles of brain region-specific GCN edges, we determin

194 We compared the molecular profiles of canine gliomas with those of human pediatric

195 gnificant differences exist between allergen profiles of commercial extracts and the profiles of envi

196 higher-than-normal cell-cycle transition and profiles of cytokine release that resembled those of nor

197 have studied the frequencies and activation profiles of dendritic cells and monocytes present in the

198 The measurements reveal time profiles of dissolved O(2) in each sample vial, from whi

199 shell) and showed complex and heterogeneous profiles of dopamine binding during self-administration

200 rgen profiles of commercial extracts and the profiles of environmental samples from dwellings.

201 d for examination of residue-specific glycan profiles of EPO was established.

202 discloses the in vitro and cellular activity profiles of GSK789, a potent, cell-permeable, and highly

203 k will involve further exploring metabolomic profiles of human kidneys as a function of age, sex, and

204 the modeling of individual cancer metabolic profiles of hundreds to thousands of samples in the Canc

205 n cardiotoxicity risk and structural/binding profiles of individual KIs.

206 the genome-wide copy number aberration (CNA) profiles of individual vitreous-isolated B cells were ch

207 The clinical profiles of individuals with post-stroke aphasia demonst

208 The gene expression profiles of invading microtumors were analyzed by incorp

209 is of methylation, transcriptome, and genome profiles of more than 400 BE and EAC tissues, along with

210 cted only minor changes in the translational profiles of neurons.

211 proaches to measure the spatial and temporal profiles of NT and NM release in the brain using genetic

212 The immune profiles of patients who recovered from moderate COVID-1

213 T cell immune responses and transcriptional profiles of PBMC, reinforcing the importance of early TI

214 ial findings provide the correct anthocyanin profiles of pigmented corns, and emphasise the importanc

215 olutionary divergence in the DNA methylation profiles of populations derived from the spring relative

216 e tested the hypothesis that gene expression profiles of protein-coding genes expressed in peripheral

217 ds has highlighted new SAR, and low toxicity profiles of pyroglutamides herein described are clues fo

218 of the generated ADCs compare well with the profiles of the corresponding clinically approved ADC Ka

219 gnature short-term synaptic plasticity (STP) profiles of the inhibitory parvalbumin (PV) and somatost

220 ative growth factor signature A, whereas the profiles of those with who developed severe disease had

221 Targeted gene expression (GE) profiling of 184 genes using nCounter technology was per

222 ctroscopy was used for unambiguous metabolic profiling of albedo, flavedo and juice samples.

223 The profiling of bacterial communities by the sequencing of

224 A combination of molecular and functional profiling of bone marrow and peritoneal cells provided a

225 Serial profiling of ctDNA in a subset correlated with treatment

226 ncing as a diagnostic tool is leading to the profiling of drug resistance to inform clinical practice

227 Metabolomic profiling of fasting serum was performed using a global,

228 integrative network analysis of multi-omics profiling of four cortical areas across 364 donors with

229 has enabled the simultaneous transcriptomic profiling of individual cells under different biological

230 Transcriptional profiling of oxidative stress-producing CNS innate immun

231 Proteomic and phosphoproteomic profiling of primary tumors alone successfully distingui

232 d an experimental pipeline for comprehensive profiling of small exRNAs isolated from cell culture.

233 trait loci, elucidated by direct epigenetic profiling of specific human tissues, may contribute towa

234 id tissues (GALTs) that allows unprecedented profiling of the adaptive immune system in submucosal an

235 Using genome-wide profiling of the H3K27ac histone modification, we identi

236 Using RNA-seq profiling of the intima of lesions, here we identify a m

237 Gene expression profiling of the isolated cell protrusions suggested tha

238 Profiling of these 300 strains, using parallel (DCyFIRsc

239 raw ingredients) along with the anthocyanin profiles (on cooked samples) were negative correlated wi

240 onization is also characterized by a laminar profile opposite to that of lower frequencies.

241 eomics, the autosampler was first applied to profiling protein expression in single MCF10A cells usin

242 Overall, KinCon profiling provides additional mechanistic insights into

243 ution mass spectrometry (HRMS) combined with profiling qualitative metabolomics for the analysis of t

244 that downward movement of SOC along the soil profile reduces SOC loss under warming.

245 A specific gene expression profile, referred to as ECM3 (Extracellular Matrix Clust

246 In this study, we profiled resistance to the anti-influenza drug laninamiv

247 Urinary metabolite profiles revealed decreases in acetaminophen-sulfate met

248 Clustering analysis of the copy number profiles revealed that malignant B cells derived from di

249 tide-level matching strategy, our DeltaSILAC profiling revealed a global, unexpected delaying effect

250 scriptomic, proteomic, and phospho-proteomic profiling revealed enrichment of Hippo/YAP and c-MYC sig

251 Ribosome profiling (Ribo-seq) is a powerful technology for global

252 to monitor the individuals' drug transcourse profiles (semi)continuously and longitudinally.

253 boFlow pipeline that processes raw ribosomal profiling sequencing data.

254 In these cases, gene expression profiling showed diminished expression of genes required

255 RNA-Seq profiling shows differential expression of many transcri

256 eta resulted in transcriptomic and proteomic profiles similar to those of lesional PPR.

257 nsporter inhibition assays in the early ADME profiling space in drug discovery.

258 ulticolor flow cytometry and transcriptional profiling successfully predict the bipotent phenotype of

259 Recent advances in protein profiling technology has facilitated simultaneous measur

260 s on the day of blood drawing had a cytokine profile that was similar to that of non-AMD individuals.

261 In a similar fashion, we also profiled the heterogeneous cell cultures generated from

262 We profiled the impact of 22q11.2 CNVs on neurobehavioral m

263 od-mimicking, high-fat high-sucrose diet and profiled the metabolic phenotypes.

264 al that Russia had the Norwegian risk factor profile, the absolute age-standardized CVD mortality gap

265 se mapping from a streaking trace to a pulse profile, the CVGN models the distribution of the pulse p

266 role in the altered genome-wide methylation profile: the long noncoding RNA ephemeron, whose rapid u

267 th promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is a novel an

268 tained a normal basolateral membrane protein profile, they showed a reduction in the size of the K(+)

269 As such, we compared the antibody profile to HA and NA in two naturally infected human coh

270 Hits can be profiled to determine potency and the site of crosslinki

271 patterns, we correlated their sedimentation profiles to all RNAs, confirming known interactions and

272 biomarkers with a view to providing protein profiles to monitor health status.

273 engineering, isotope labeling and metabolic profiling to capture PFCs and demonstrate their function

274 n sequencing and array-based DNA methylation profiling to determine the clinically actionable genomic

275 et al. used longitudinal and deep multi-omic profiling to identify individuals with distinct BA pheno

276 We use genomic profiling to reveal strong and broad loss of neural APA

277 R repertoires and other T cell transcription profiles together with their cognate antigen specificiti

278 ogies, that scientists gained the ability to profile tumors with a resolution that allowed for granul

279 -dimensional conformation of a genome can be profiled using Hi-C, a technique that combines chromatin

280 ents, we performed comprehensive serological profiling using a high-throughput phage immunoprecipitat

281 onjunction with transcriptomic and proteomic profiling using fly heads.

282 ion sequencing technologies, gene expression profiling using RNA-seq has increased the scope of seque

283 tion, the effect of Adv36 infection on lipid profile varied between healthy individuals and individua

284 roperties were evaluated, and the peptidomic profile was assessed by LC-MS/MS.

285 types, while the mucosa-associated bacterial profile was associated with IBS symptom severity and bre

286 al characterization and CAP phytoconstituent profile was obtained by colorimetric and UHPLC-ESI-qTOF-

287 The HBV-induced gene expression profile was similar to that induced by toll-like recepto

288 Molecular profiling was successful in 93.0% of specimens.

289 echanisms underlying these distinct temporal profiles, we developed a reduced spiking model of sensor

290 Coupling pMEI genotypes with gene expression profiles, we identify pMEI-associated expression quantit

291 rapeutic efficacy and preliminary toxicology profiles were assessed and compared in vivo in an adjuva

292 y appreciated by consumers for its sensorial profile, which varies depending on the flora used by the

293 AGELLAN is attributed to the power of ligand profiling, which integrates complementary methods for li

294 These target product profiles will require further discussion and ongoing rev

295 nding by associating SN cell type expression profiles with specific disease risk.

296 xes at the SWI calculated from the simulated profiles with the negative-flux lower boundary condition

297 estigation of the lipidomic and carbohydrate profiles with the transcriptome of developing nodules re

298 th the observed DO fluxes than the simulated profiles with the zero-flux lower boundary condition.

299 By coupling in vivo ribosome profiling with genetic screening, we provide direct evid

300 evoked activations(e.g., magnitude, temporal profile) within the same populations of neurons.