ライフサイエンスコーパス: profound

1 iologic ramifications of this prediction are profound.

2 d less attention despite often being equally profound.

3 HT effects on the metabolome were profound; 62% of metabolites significantly changed with

4 mitochondrial respiration (rotenone) caused profound actin filament loss, blocked RhoA/ROCK signalli

5 trates, for the first time to our knowledge, profound activity of the menin-MLL1 inhibitor as a singl

6 carcinoma (HCC) because of the potential for profound adverse events and large variations in survival

7 e of the methylation changes, we observed no profound alterations in the blood transcriptome of indiv

8 Chronic inflammatory diseases cause profound alterations in tissue homeostasis, including un

9 led; instead, burn injury leads to long-term profound alterations that must be addressed to optimize

10 that formed the 66 Ma Chicxulub crater had a profound and catastrophic effect on Earth's environment,

11 Prior work has established profound and enduring effects of MAS on memory in males.

12 osed of millions of tunable connections is a profound and far-reaching open question.

13 gle enzyme required for rRNA methylation has profound and highly specific effects on organismal devel

14 Urban activities have profound and lasting effects on the global carbon balanc

15 upon Policaptil Gel Retard administration is profound and of systemic nature, despite being originate

16 Only high-quality colonoscopy yielded profound and stable reductions in CRC incidence and mort

17 Patients with COVID-19 showed profound and sustained T CD4(+) (P = 0.002), CD8(+) (P <

18 The profound and widespread deactivation of the cortex in th

19 Septic patients who died had early, profound, and sustained suppression of innate and adapti

20 d target engagement in vivo and demonstrated profound anti-inflammatory and anti-fibrotic efficiency

21 eptor-alpha (PPAR-alpha) agonist that exerts profound anti-inflammatory effects in animal models.

22 d ATR triggers lethal replication stress and profound antitumor effects.

23 formation of T(SCM) cells, resulting in more profound antitumor responses and prolonged host survival

24 Disruption of H1 function results in a profound architectural remodelling of the genome, which

25 e suboptimal depletion of CD8(+) T cells and profound ART-induced suppression of virus replication, c

26 ts coupled with random forest analysis shows profound (AUC = 0.92, p-value = 3.16E-8) MP-induced alte

27 ates and invasiveness and RNA-Seq revealed a profound basal impact on gene expression (~ 2300 genes;

28 d.SIGNIFICANCE STATEMENT Motherhood requires profound behavioral and physiological adaptations to ena

29 men consistently outlive men, which suggests profound biological foundations for sex differences in s

30 toimmune arthritis with joint remodeling and profound bone loss.

31 Given the profound burden of progressive multiple sclerosis, and t

32 Both FTY720 and BAF312 caused a profound CD4+ and CD8+ T cell depletion in blood and lun

33 a single chromosome is capable of inducing a profound cell state transition, thereby linking genomic

34 ndothelial and immune cells, hence causing a profound cellular and biological reconfiguration via mul

35 e genetic and immunological levels remains a profound challenge.

36 er the past decade has been characterized by profound challenges supporting clinical workflow, impedi

37 cipated that this new approach may lead to a profound change in both nucleation research and industri

38 This transformation process represents a profound change in wooded environments, disrupting origi

39 ed into marine ecosystems, but also recorded profound changes at the base of marine food webs.

40 Such changes can lead to profound changes in behavior, but little is known about

41 ischemia and reperfusion, is associated with profound changes in key processes of intercellular commu

42 Furthermore, we observed profound changes in lipid metabolism following VLCD but

43 ly conserved DNA-binding regions can lead to profound changes in protein function.

44 elops complex daily rhythms characterized by profound changes in the association, from gene expressio

45 Fear of predation can induce profound changes in the behaviour and physiology of prey

46 ment with a DNA hypomethylating agent causes profound changes in the pancreatic cancer microenvironme

47 thors show that gemcitabine treatment causes profound changes in the pancreatic cancer microenvironme

48 rdinates to the RSNO oxygen atom, leading to profound changes in the RSNO electronic structure and re

49 We conclude that HD is accompanied by profound changes of DNA methylation levels in three mamm

50 unique maternal physiology, characterized by profound changes to multiple organ systems.

51 ects the cell cycle checkpoint, resulting in profound chromosomal instability.

52 In severe cases, profound circulatory failure can result.

53 (IP) during the Late Quaternary, a period of profound climate and anthropic changes.

54 ess to a critical value of ~30 unit cells, a profound conductivity reduction accompanied by unexpecte

55 xpected interaction with phospholipids, with profound consequences for cellular metabolism.

56 antation-dominated south-central Chile, with profound consequences for ecosystem processes and resili

57 of resources and the need to search can have profound consequences for mosquito populations' capacity

58 erannual variability of seed crops (CVp) has profound consequences for plant populations and food web

59 ronmental driver for evolutionary change has profound consequences for understanding past and future

60 rols tissue-wide intestinal immunity and has profound consequences on the mucosal barrier and invasiv

61 s accumulate over the population, leading to profound consequences when analysing the set of all gene

62 19 epidemic in a refugee settlement may have profound consequences, requiring large increases in heal

63 Strong H1 depletion causes a profound de-repression of several classes of repetitive

64 osite kidney outcome (defined as a sustained profound decline in eGFR, chronic dialysis, or transplan

65 They lead to a transient, profound decrease in circulating human eosinophils withi

66 cids from the interswitch region resulted in profound defects in lymphopoiesis.

67 ad expression of mTEC progenitor markers and profound defects in TEC differentiation.

68 ings demonstrated that p75(-/-) mice exhibit profound deficits in responses to taste and tactile stim

69 Prenatal alcohol exposure (PAE) leads to profound deficits in spatial memory and synaptic and cel

70 nt but not STAT3-mutant patients exhibited a profound depletion of ILC3s, and to a lesser extent ILC2

71 from healthy donor neutrophils, we observed profound differences as compared to the soluble variant

72 These findings indicate profound differences between soft and stiff cells regard

73 harsh conditions in early life often lead to profound differences in adult life expectancy.

74 However, we found profound differences in CB1 densities across species, wi

75 Additionally profound differences in crystallization characteristics

76 action of their triplet motifs determine the profound differences in KCNQ1 functional modulation by K

77 Irrespective of the profound differences in recombination rates observed bet

78 Furthermore, CREST exploits the profound differences in sex-specific genetic maps to cla

79 onal populations produce subpopulations with profound differences in the methylome, cellular physiolo

80 We observed profound differences in viral load and CD4(+) T cell act

81 Profound differences were found, including: 1) term preg

82 ing beta1 or beta4 spectrin alone, including profound disruption of AIS Na(+) channel clustering, pro

83 ry for catalyzing their replication, lead to profound disturbances of cellular proteostasis, resultin

84 However, despite the profound diversity among ctenophores, basal neuroanatomi

85 Here, we identify for the first time a profound dysregulation in the expression of relevant spl

86 Because of the profound ecological and economic impacts of many non-nat

87 mate change affects organisms worldwide with profound ecological and evolutionary consequences, often

88 can drastically alter ocean ecosystems, with profound ecological and socioeconomic impacts(1-8).

89 Recurrent sex chromosome drive can have profound ecological, evolutionary, and cellular impacts

90 amino acid substitutions (L92A/I94A) had the profound effect of switching shoot gravity responses fro

91 Due to the profound effect of temperature on mitochondrial function

92 This study demonstrates the profound effect of the enzyme on cellular motility, grow

93 ions to AR-mediated transcription can have a profound effect on carcinogenesis and tumor growth.

94 ifically in biological processes that have a profound effect on cell physiology and that are related

95 Although extracellular force has a profound effect on cell shape, cytoskeleton tension, and

96 Results of genetic testing can have a profound effect on clinical management decisions.

97 activation of canonical Wnt signaling has a profound effect on melanoma growth and is able to counte

98 f the nitrogen-containing defects can have a profound effect on the diamond material and its properti

99 h a diagnosis of childhood cancer can have a profound effect on the entire family unit, its impact on

100 al treatment during sample preparation has a profound effect on the melting of a pure substance, and

101 blated (immature vs. mature podocytes) has a profound effect on the urinary phenotype due to its crit

102 nd that firstly, cell number has a much more profound effect than sequencing depth on the ability to

103 The results demonstrate (i) the profound effect these parameters have on the (1)H to (13

104 y our calculations, most triad mutations had profound effects consistent with direct regulation of re

105 matrix (ECM) of the surrounding tissues have profound effects on a wide variety of cellular functions

106 als, harsh conditions in early life can have profound effects on adult physiology, including the stre

107 hip between cells and their environment with profound effects on cellular lifestyle and longevity.

108 ism, and response to drug treatment may have profound effects on cellular survival and lead to the de

109 The changing global climate is having profound effects on coastal marine ecosystems around the

110 Cooperative behaviour can have profound effects on demography.

111 Alterations in macronutrient intake can have profound effects on energy intake and whole-body metabol

112 intensity under a warming climate will have profound effects on forests, potentially changing these

113 ifferentiation driven by the microbiota with profound effects on nutrient homeostasis.

114 esire to mitigate infection risk, are having profound effects on other vital aspects of care, includi

115 ctivity, exercise, and aerobic capacity have profound effects on regulating intrahepatic lipids and m

116 therapies are being developed which may have profound effects on the care of surgical patients.

117 ispersal/establishment capacity) having more profound effects on the current population structuring o

118 Global environmental change is having profound effects on the ecology of infectious disease sy

119 and receptor-associated proteins, which have profound effects on the overall receptor structure, func

120 ely in phytophagous insects and often exerts profound effects on the phenotype and fitness of its hos

121 al modifications in metal complexes can have profound effects on their biological activities.

122 ibility of these changes is urgent given the profound effects that humans are having on the natural w

123 urnover to a standard modification cycle has profound effects, including significantly reducing the s

124 n the composition of the microbiota may have profound effects, linked with an increased risk of devel

125 In seeking mechanisms underlying these profound effects, we now show that normal gut and skin g

126 The profound efficacy, yet associated toxicity of pan-BET in

127 ts with LQTS compared to controls, with more profound EMW negativity in patients with symptomatic LQT

128 l of structure-based ATP production predicts profound energy stress in older OHCs.

129 ing-related lung tumors are characterized by profound epigenetic changes including scrambled patterns

130 These data point to profound epigenetic effects of Stattic that are independ

131 -cell immunotherapy to treat HIV that led to profound expansion and improved function of CAR T cells

132 Patients with hippocampus lesions suffer profound failures in episodic memory.

133 These results were especially profound for the remnant riparian fringe, which suggests

134 Nutrient changes due to milling were most profound for thiamin (-69%), IDF (-66%) followed by phyt

135 taneous activation of multiple sites driving profound freezing behavior and bradycardia that are not

136 t the two DEE mutations in TRPM3 result in a profound gain of channel function, which may lie at the

137 intriguing bonding and oxidation states with profound geological implications.

138 OVID-19 who were dead at Day 28.Conclusions: Profound global lymphopenia and a "chemokine signature"

139 tiation whilst miR-934 inhibition results in profound global transcriptome changes associated with ne

140 Yeast lacking both Hrd1 and Ste24 exhibit a profound growth defect, consistent with overlapping func

141 ice homozygous for del10 exhibit moderate-to-profound hearing loss at 4 weeks of age as measured by t

142 In the setting of liver cirrhosis (LC), profound hemostatic changes occur, which affect primary

143 Despite its profound historical importance, little is known of the o

144 ICH induction in male mice caused profound HN loss in the affected hemisphere.

145 Profound hyponatremia (<125 mmol/L) and lower baseline o

146 e tissue hypoxia in EAE is associated with a profound hypoperfusion of the inflamed spinal cord.

147 ape featured a deranged interferon response, profound immune exhaustion with skewed T cell receptor r

148 ans a wide range of symptoms, sometimes with profound immune system involvement.

149 The precise mechanism leading to profound immunodeficiency of HIV-infected patients is st

150 Notably, despite this profound immunodeficiency, mice chronically infected wit

151 activation of systemic immunity, followed by profound immunodepression that promotes life-threatening

152 response pathways in the cancer cell and the profound immunomodulatory effects of sustained ER stress

153 ar spectroscopy and microscopic imaging with profound impact broadly.

154 inical and nonclinical staff affected by the profound impact COVID-19 had on our city.

155 Droplet-based techniques have had a profound impact in chemistry, owing to their ability to

156 tures of neurovascular devices, would have a profound impact in the research, diagnosis, and treatmen

157 Due to the profound impact of temperature on physiology and behavio

158 The profound impact of the tumour microenvironment, reflecte

159 d States, early childhood caries (ECC) has a profound impact on a child's quality of life, represents

160 c secondary organic aerosol (SOA) can have a profound impact on aerosol growth and size distribution

161 Epitope density has a profound impact on B cell responses to particulate Ags,

162 Childhood environment can have a profound impact on brain structure and function.

163 nutrition and postnatal leptin surge have a profound impact on ciliogenesis in the hypothalamus of n

164 rt activity of this vacuolar exchanger has a profound impact on cytosolic homeostasis.

165 ings infer that elevated temperatures have a profound impact on global N cycling processes with impli

166 use in the middle of the 20th century had a profound impact on modern medicine and human wellbeing.

167 nequality violations in quantum theory had a profound impact on our understanding of the correlations

168 navirus 2019 (COVID-19) pandemic will have a profound impact on radiology practices across the countr

169 However, agricultural land use has a profound impact on SOC dynamics, and few studies have ex

170 Conclusion: PSMA PET/CT has a profound impact on stage and management of PCa patients

171 ed flux through spillover pathways causing a profound impact on the accumulation of multiple primary

172 modifications by bacterial pathogens have a profound impact on the course of infection.

173 can therefore play a causal role and have a profound impact on the excitatory-to-inhibitory balance

174 Zika virus (ZIKV) infection has a profound impact on the fetal nervous system.

175 Vaccines have had a profound impact on the management and prevention of infe

176 the tumor microenvironment (TME) can have a profound impact on the metabolic activities of immune, s

177 Our results reveal the profound impact that fishing has had on reef shark popul

178 To fully recognize the profound impact that these ecosystems have had on the ev

179 clude that mitonuclear interactions can have profound impacts on both physiological performance and t

180 urban land and its expansion have exhibited profound impacts on global environments.

181 through arthropod reproductive tissues have profound impacts on host reproduction, health and evolut

182 osine (m(6)A) on viral and cellular RNAs has profound impacts on infection outcome.

183 enes, and argue that HGT has undoubtedly had profound impacts on plant evolution as a whole.

184 eans; its hydroclimatic variations can exert profound impacts on the marine ecosystem in the Amazon p

185 ressures placed on them, and this could have profound impacts on the natural world.

186 nd L924P, with severe infantile epilepsy and profound impairment.

187 physiology and predict drug response, having profound implications for drug discovery and development

188 The answer has profound implications for molecular evolution and our ab

189 the United States, any incidence could have profound implications for patients.

190 solvation to functionality, which could have profound implications for protein engineering.

191 These results have profound implications for the study of this key GTPase i

192 critical component of tumor metabolism, with profound implications for tumorigenesis and treatment re

193 rotein level, but not at the RNA level, with profound implications for understanding transcriptional

194 is imminent if not already passed, which has profound implications for water resources and riverine h

195 of semiconductors and it is expected to have profound implications on semiconductor field.

196 pattern separation in memory coding may have profound implications that could explain cognitive abili

197 The actin cytoskeleton is of profound importance to cell shape, division, and intrace

198 ent and theory in electrocatalysis is one of profound importance.

199 Importantly, weightlifting training profound improved whole-body glucose clearance and skele

200 These differences were more profound in early compared with advanced stages of fibro

201 lammatory condition of the arteries that has profound incidence and increasing prevalence.

202 iratory capacity in HPV8-E7 and an even more profound increase in HPV16-E7 expressing cells.

203 c disorders in youth and are associated with profound individual impairment and public health costs.

204 yndrome coronavirus 2 (SARS-CoV-2) incites a profound inflammatory response leading to tissue injury

205 crotizing pancreatitis is characterized by a profound inflammatory response with local and systemic i

206 ng recognition that top predators can have a profound influence on ecosystems, the persistence of lar

207 erature attributable to global warming has a profound influence on plant growth and development at al

208 Epigenetic regulation has a profound influence on stem cell fate during normal devel

209 ation and atmospheric water vapor also had a profound influence on the LST changes, but it had obviou

210 gy has been identified, the adventitia has a profound influence on the population of intimal and medi

211 he redox conditions of magma oceans may have profound influence on the redox state of subsequently fo

212 The results underscore the profound influence structural compatibility has on intri

213 of men to women in a given ecology can have profound influences on a range of interpersonal processe

214 al nature, and structure of the ASO can have profound influences on the interaction of PS-ASOs with s

215 Proteome of seminal plasma provides profound information related to the male reproductive he

216 These findings resulted in a profound insight in in vitro gastric molecular lipolysis

217 s under operando conditions that will enable profound insights into nanoscale catalytic mechanisms.

218 nical and clinical cancer imaging, providing profound insights into the complex physiological, cellul

219 rene and inorganic nanoparticles are also of profound interest in mass cytometry.

220 As a result, there has been profound interest in the study of calcifying algae, beca

221 l maximal activity when stressed, indicating profound intrinsic metabolic dysfunction.

222 Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyp

223 The profound loco-regional inflammatory response of NP creat

224 These analyses of plankton lifeforms showed profound long-term changes, which were coherent across l

225 Crowding is a profound loss of discriminability of visual features, wh

226 failures, whereas the DeltacdvB2 exhibited a profound loss of division symmetry, generating daughter

227 These data provide direct evidence that the profound loss of HCV-specific CD4+ T cell help that resu

228 ades, the Arabian Sea has also experienced a profound loss of inorganic nitrate.

229 of-function mutant (GoF) subunits results in profound lymphatic contractile dysfunction and LSM hyper

230 Alemtuzumab produced profound lymphopenia followed by gradual T cell and more

231 individuals, acute illness can also produce profound, maladaptive, cognitive dysfunction including d

232 r evolutionary trajectories during a time of profound marine ecological change.

233 Profound metabolic changes are characteristic of macroph

234 Preclinical studies have shown profound metabolic health effects after NR supplementati

235 c-MET inhibition causes profound metabolic reprogramming that can be targeted by

236 Hepatocytes undergo profound metabolic rewiring when primed to proliferate d

237 sufficient for tumorigenesis, due in part to profound metabolic stress induced by RAS activation.

238 Profound microcirculation parameter changes found before

239 smaller than previously thought, and that a profound miniaturization event occurred near the base of

240 gramming of cellular metabolism induced by a profound modification of the transcriptome, leading to g

241 Cannabinoids are notorious and profound modulators of behavioral state.

242 el 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide.

243 ent with microglia activation, we found that profound morphological changes and MHC-II and CD80 upreg

244 e clinical presentation of flaccid and often profound muscle weakness (which can invoke respiratory f

245 diotoxic and have the potential to result in profound myocardial injury.

246 HS has profound negative effects on patients' quality of life,

247 ontext of altered microtubule dynamics, with profound neurodevelopmental deficits.

248 ubunit 1) in four unrelated individuals with profound neurodevelopmental disability, muscular hypoton

249 ntion from neuroscientists but that may have profound neuroscientific implications: deep reinforcemen

250 STATEMENT Amyloid-beta (Abeta) peptides have profound neurovascular effects that may contribute to co

251 philic and neutrophilic inflammation, with a profound neutrophilic infiltration and activation in typ

252 MiR-181a targeting of RB1 leads to profound nuclear defects and GI generating aberrant cyto

253 For each species, we observed a profound paternal effect of foliage supplements on fitne

254 ial for extended duration of action and more profound pharmacology.

255 s a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a

256 r, unlike T2D, GDM emerges in the setting of profound pregnancy-related physiologic changes in glucos

257 ed by how accustomed the United States is to profound racial inequality.

258 in patients with AMI was safe and induced a profound, rapid, and dose-related antiplatelet response.

259 Derby and exhibit a profound reduction in invasion of human epithelial cells

260 iogenesis in mouse embryo fibroblasts, but a profound reduction of BCCIP was required to abrogate its

261 nd 20 mg/kg separated by a week, resulted in profound reduction of classical pathway activity lasting

262 ase in C57BL/6 mice and is associated with a profound reduction of proliferation of MOG(35-55)-specif

263 l pathway real-time RT-PCR analysis revealed profound reductions in WNT1 expressions in RAD6B knockou

264 al excitement due to high response rates and profound regression of malignant melanomas carrying BRAF

265 pping is demonstrated through unraveling the profound relations among chemical compositions, mutual s

266 ter birth, VEGF inhibition induced rapid and profound remodeling of the endothelial, mesenchymal and

267 roducing natural killer (NK) cells induced a profound remodeling of the TME and unleashed cytotoxic T

268 architectural transformations that lead to a profound reorganization of the cellular landscape during

269 as a result of STAT5 deficiency displayed a profound resistance to experimental autoimmune encephalo

270 an vibrant political messages; it requires a profound revision of the concepts and technologies on wh

271 Obesity plays a profound role in risk for death from COVID-19, particula

272 junctional channels, which play diverse and profound roles in human physiology and diseases.

273 xtracranial lesions, imposing a distinct and profound selective pressure on tumour cells that, in tur

274 Urbanization represents a profound shift in human behaviour, and has considerable

275 ays and conclude that CysLTR2-L129Q displays profound signaling bias for Gq/11 signaling pathways whi

276 -1 promotes naive pluripotency by triggering profound signalling, transcriptomic and epigenetic chang

277 s, administration of a low dose of DT caused profound SNHL without vestibular dysfunction and had no

278 Differences in belief have profound societal impacts.

279 pH changes except for PFOSB; PFOSB underwent profound sorption reduction because its speciation occur

280 CD4(+) T cells exhibit much more profound stiffness dependency than CD8(+) T cells.

281 ar matrix genes, and this was accompanied by profound structural perturbations in the aging SC niche.

282 cured by the heterogeneity in depression and profound study/methodological differences.

283 Activation by codeine displayed profound subject variability and correlated with secreti

284 nformational changes and this manifests in a profound switch in specificity towards S29 TopoIIalpha p

285 diseases, microglial synaptic engulfment and profound synapse loss were observed.

286 Both aging and obesity are characterized by profound systemic metabolic and immunologic changes and

287 nes encoding metabolic enzymes manifested as profound systemic metabolic changes that disturb homeost

288 s topologically protected spin textures with profound technological implications for high-density inf

289 m to explain past results and underlines the profound threat anthropogenic stressors pose to fish com

290 ranscription-replication (T-R) conflicts are profound threats to genome integrity.

291 It involves a profound transcriptional and epigenetic reprogramming of

292 hibitor, in combination with statins, caused profound tumor cell death.

293 Importantly, we linked the profound tumorigenic function of HuR to its ability to s

294 te that, like humans, Dock8(-/-) mice have a profound type 2 CD4(+) helper T (T(H)2) cell bias upon p

295 notherapy, as a result of a broader and more profound understanding of cancer immunobiology, and the

296 nts can be informative for developing a more profound understanding of disease pathogenesis and ultim

297 and TLR9 in the vascular wall, resulting in profound vascular dysfunction.

298 on (PAH) is a fatal disease characterized by profound vascular remodeling in which pulmonary arteries

299 tion, cause the death of retinal neurons and profound vision loss.

300 ARI in older adults with a low prevalence of profound vitamin D deficiency at baseline.