ライフサイエンスコーパス: progenitor B-cell

1 Cre knockin animals to delete Hdac3 in early progenitor B cells.

2 ubiquitination in mature B cells, but not in progenitor B cells.

3 ine leukemia virus induces transformation of progenitor B cells.

4 terol depletion or overexpression of RGS1 in progenitor B cells.

5 nts may lead to neoplastic transformation of progenitor B cells.

6 atively, in the growth arrest of transformed progenitor B cells.

7 turation arrest and accumulation of abnormal progenitor B cells.

8 he entire 2.4-Mb V(H) locus in mouse primary progenitor B cells abrogates rearrangement of both V(H)-

9 STAT5) activation occurs frequently in human progenitor B-cell acute lymphoblastic leukemia (B-ALL).

10 FAK)-VLA4 pathway plays an important role in progenitor B cell adhesion and migration.

11 istone H3 Lys27 trimethylation (H3K27me3) in progenitor B cells and B-ALLs, and 'bivalent' genes with

12 gion gene assembly in T lineage cells and in progenitor B cells and have also implicated 3'Ekappa as

13 bone marrow, RGS1 mRNA expression is low in progenitor B cells and high in mature B cells, implying

14 A deficiency led to expansion of bone marrow progenitor B cells and mature B cells in secondary lymph

15 nation-activating gene-initiated IgH DSBs in progenitor B cells and that these dicentrics can be prop

16 sults from the niche competition between pre-progenitor-B cells and myeloid progenitors, leading to a

17 Thus, in G1-arrested, Lig4-deficient progenitor B cells are functionally end-joining suppress

18 Our findings imply that progenitor B cells are intolerant to centriole loss but

19 and H3K4me3 at their promoters in wild-type progenitor B cells are preferentially overexpressed in t

20 y a gradual WAPL downregulation mechanism in progenitor-B cells as opposed to a strict developmental

21 biclonal lesions in which we determined the progenitor B cell by immunoglobulin heavy chain (IgH) ge

22 uclease initiates Igh V(D)J recombination in progenitor B cells by binding a J(H)-recombination signa

23 Interleukin 7-dependent progenitor B-cell clones and lines expressing B220 and C

24 cohesin-unloading factor, was low in primary progenitor B cells compared with v-Abl-transformed proge

25 Progenitor B cells deficient in Pax5 are developmentally

26 ee broken ends in Lig4-deficient G1-arrested progenitor B cells, deletion of Ku70 increases DSB rejoi

27 ses: (i) the Janus kinase/STAT5 pathway (ii) progenitor B-cell differentiation and (iii) the CDKN2A t

28 ects of pre-B cell development, causing most progenitor B cells expressing this H chain to be elimina

29 We report that after CXCL12 stimulation of progenitor B cells, focal adhesion kinase (FAK) and PI3K

30 chain variable region exons are assembled in progenitor-B cells, from V(H), D, and J(H) gene segments

31 of the Il7r locus at the earliest stages of progenitor B cell generation.

32 V(D)J recombination DSBs occur in developing progenitor B cells in the bone marrow, we sought to eluc

33 Accordingly, SOCS3 expression was low in progenitor B cells, increased in immature B cells, and h

34 Sustained adhesion of progenitor B cells is associated with prolonged FAK acti

35 and that the turnover rate of APE2-deficient progenitor B cells is nearly normal.

36 endonucleases in Lig4-deficient G1-arrested progenitor B cell lines is suppressed by Ku.

37 itor B cells compared with v-Abl-transformed progenitor B cell lines that lacked contraction and RAG

38 g is abrogated in Lig4-deficient G1-arrested progenitor B cell lines, joining of RAG-generated DSBs i

39 tion, DNA-PKcs deletion in G1/G0-phase mouse progenitor B cell lines, significantly impairs V(D)J rec

40 deleting IGCR1 or 3'Igh-CBEs in mice and/or progenitor-B cell lines.

41 matic increase in the frequency of specified progenitor B-cells marked by expression of a lambda5 (Ig

42 wnregulation of WAPL, a cohesin unloader, in progenitor-B cells neutralizes CBEs, allowing DJ(H)-RC-b

43 ell transcription factors to generate either progenitor B cell or mixed B/myeloid-like leukemias.

44 Exactly how progenitor B cells perform the task of balancing prolife

45 5 (CCR5) expression and function of primary progenitor B-cell populations in human bone marrow.

46 by signaling through CCR5, could affect all progenitor B-cell populations through a novel mechanism

47 signal transduction events that control the progenitor B cell (pro-B cell) to precursor B cell (pre-

48 expression was more efficient in generating progenitor B cells (pro-B cells) compared with the more

49 Development of progenitor B cells (ProB cells) into precursor B cells (

50 d deregulation of CBE impediments in primary progenitor B cells promotes RAG scanning of the V(H) loc

51 Progenitor-B cells recombine their immunoglobulin (Ig) l

52 Progenitor B cells reside in complex bone marrow (BM) mi

53 profile analysis of interferon-beta-treated progenitor B cells revealed enhanced Daxx expression, wi

54 gous to human chromosome 21q22 confers mouse progenitor B cell self renewal in vitro, maturation defe

55 early B cell factor (EBF) are blocked at the progenitor B cell stage prior to immunoglobulin gene rea

56 deletion cooperated with E2A-PBX1 to expand progenitor B cell subpopulations, increasing penetrance

57 In mouse progenitor B cells, the CTCF-binding element (CBE)-ancho

58 ation process called "rearrangement" forming progenitor B cells, then a Darwinian process of lineage

59 ferentiation, proliferation, and survival of progenitor B cells, this transcription factor may play a

60 We studied pre-pro-B cells and Rag(-/-) progenitor-B cells to determine whether Ig locus contrac

61 ic compartment resulted in a blockage of the progenitor B-cell-to-precursor B-cell development in bon

62 -deficient mice also succumb reproducibly to progenitor B cell tumors, demonstrating that Artemis is

63 Primary progenitor B cells undergo a mechanistically undefined c

64 of increased production of CD19+CD43+CD45R+ progenitor B cells upon the siRNA-mediated decrease in P