ライフサイエンスコーパス: progress through

1 involved both apoptosis and necrosis, which progressed through 12 to 14 hours after exposure.

2 We found that RGPs progress through a coherent program in which their proli

3 n that, in vivo, human CD56(bright) NK cells progress through a continuum of differentiation that end

4 The treated cells progress through a first S phase with kinetics similar t

5 ow that flat CRCs do not develop de novo but progress through a flat adenomatous stage to invasive ca

6 n pauses where the replication fork needs to progress through a gene cluster that is transcribed in t

7 that rhabdomyosarcomas represent an arrested progress through a normal transitional state that is reg

8 e subcellular luminal branches or makes them progress through a particular trajectory within the cyto

9 The method delays fluid progress through a porous channel by diverting fluid int

10 However, normal cells usually have to progress through a precancerous lesion state before beco

11 Lymphocyte development requires cells to progress through a series of stages, each associated wit

12 The organoid hair cells also progress through a similar dynamic developmental pattern

13 uate organ mass, the daughters of stem cells progress through a transit-amplifying phase displaying r

14 s a multistep process where oligodendrocytes progress through a well coordinated differentiation prog

15 slet cells expanded in monolayers for months progressed through a reversible epithelial-to-mesenchyma

16 n a tightly controlled microbial environment progresses through a choreographed succession of bacteri

17 Cancer develops and progresses through a clonal evolutionary process.

18 Tumor development progresses through a complex path of biomechanical chang

19 , termed pluripotency, is highly dynamic and progresses through a continuum of naive, formative and p

20 Here, a given site progresses through a sequence of resource and species st

21 The bacterial microbiota of biopsy specimens progresses through a systematic series of changes that c

22 y similar to subventricular zone stem cells, progressing through a near-identical neurogenic program.

23 ld, beginning with philosophy of science and progressing through a series of substantive research and

24 Secondary structure elements are progressing through a small number of discrete states in

25 Assembling Gag forms immature capsids by progressing through a stepwise pathway of assembly inter

26 Untreated HIV-1 infection progresses through acute and asymptomatic stages to AIDS

27 ng continue to develop new disorders as they progress through adolescence.

28 le differentiation, produce a hair shaft and progress through all stages of the hair follicle cycle.

29 from seeds obtained from regenerated plants progressed through all developmental stages and had the

30 ing the spermine synthase-encoding gene SPS1 progressed through all stages of appressorial developmen

31 The assembly process is believed to progress through an alternating series of RNA conformati

32 iding neural stem cells, called neuroblasts, progress through an intrinsic temporal patterning progra

33 The origin of life is believed to have progressed through an RNA world, in which RNA acted as b

34 hat for small initial viral load the disease progresses through an asymptomatic course, for intermedi

35 The APC is essential for cells to progress through anaphase, exit from mitosis, and preven

36 tumor, starting with an avascular tumor and progressing through angiogenesis and vascularized tumor

37 Research has progressed through application of molecular techniques i

38 Each subunit sequentially progresses through ATP, ADP and apo states while the ass

39 We used an in vitro cell system that progressed through basophilic, polychromatic, orthochrom

40 These effects evolved as monkeys progressed through behavioral sessions, because increasi

41 tiates from multiple replication origins and progresses through bidirectional replication forks to en

42 f p53 restored the ability of these cells to progress through both G1/S and mitosis, leading to their

43 ofilament structure as the tip spontaneously progresses through both catastrophe and rescue.

44 emale -UNmale = 27.5%, P < 0.05), and 3) IGT progresses through both parental lineages (glucose toler

45 2 years, 57.7% female) living in 28 LMICs on progress through cascades of care (condition diagnosed,

46 TR-mediated checkpoints and allowed cells to progress through cell cycle in the presence of DSBs.

47 radual transcription profile change as cells progress through cell-cycle stages.

48 erosis is a chronic inflammatory process and progresses through characteristic morphologic stages.

49 fections became less frequent as individuals progressed through childhood and young adulthood, they o

50 As monkeys progressed through choice sequences toward rewards, amyg

51 tical question as to how DNA replication can progress through chromatin, which is inhibitory to all D

52 them will provide great insight as vaccines progress through clinical trials.

53 urate evaluation of GSK2140944 potency as it progresses through clinical trial development.

54 e crucial in evaluating JNJ-Q2 potency as it progresses through clinical trial development.

55 cial for evaluating GSK1322322 potency as it progresses through clinical trials.

56 roneedles and thermal ablation are currently progressing through clinical trials for delivery of macr

57 to the development of new compounds that are progressing through clinical trials.

58 ace validity in this system as most patients progress through consecutive stages, and none revert to

59 The study shows that both reactions progress through coordination between the boron and the

60 in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integrat

61 ot embryonic, cycling cardiomyocytes fail to progress through cytokinesis and subsequently binucleate

62 ression of HEF1 leads to failure of cells to progress through cytokinesis, whereas depletion of HEF1

63 romosome segregation, procyclic trypanosomes progressed through cytokinesis to produce one nucleated

64 Ameloblasts progress through defined stages of development as enamel

65 The development of the cerebral cortex progresses through defined stages including neural proli

66 ng idiopathic infantile nystagmus, which has progressed through determining the role of the FRMD7 gen

67 s key to understanding how cells and tissues progress through development and respond to external cue

68 Animals must adjust their metabolism as they progress through development in order to meet the needs

69 t that governs the decision of the animal to progress through development.

70 her newly composed ribosomes are required to progress through development.

71 It has made significant technical progress through developments in source, algorithm and i

72 nship between gaze and locomotion as the bat progresses through different phases of insect pursuit.

73 ronic infection with hepatitis B virus (HBV) progresses through different phases.

74 neous histological/architectural change that progresses through different stages ranging from isolate

75 of the urinary bladder appear to evolve and progress through distinct molecular pathways.

76 Thus, germ cells progress through distinct, sequential regulatory states,

77 n the infected cytoplasm, have been shown to progress through disulfide-bonded Vp1 folding intermedia

78 eiosis that persist unrepaired as germ cells progress through DNA repair-competent phases of spermato

79 m-up material design have been significantly progressed through DNA-based approaches.

80 Adult marrow progressed through double-positive and single-positive s

81 ractions between T cells and dendritic cells progress through dynamic contact stages in vivo consisti

82 itude of molecular pathways are necessary to progress through each cellular milestone, yet the underl

83 elopment of peripheral B cells and failed to progress through early B-cell development at the pro-B-

84 called modified Blalock-Taussig shunt allows progress through early life to an age and weight at whic

85 eripheral subcutaneous tumors, tumorigenesis progresses through early reversible stages, and Tax is s

86 China has rapidly progressed through epidemiological and demographic trans

87 or maternal-perinatal health; and accelerate progress through evidence, advocacy, and accountability.

88 y cortex (GC) span this sensorimotor divide, progressing through firing-rate epochs that culminate in

89 ge IV non-small-cell lung cancer (NSCLC) who progress through first-line therapy have poor progressio

90 Animals that possess MSR typically progress through four stages of behavior when facing a m

91 is it required for the normal human cell to progress through G1 and the remainder of interphase.

92 Second, normal cells can progress through G1 in its entirety without centrioles.

93 cell acquires most of the cell cytoplasm and progresses through G1 into the next mitotic cell cycle.

94 Using CENP-F as a marker for progress through G2, we also show that sustained inhibit

95 the knock-in mutation (Tcf3(DeltaN/DeltaN)) progress through gastrulation without apparent defects,

96 tablish the anteroposterior axis but fail to progress through gastrulation.

97 reaction of an aldehyde with an amine, which progresses through generally unstable, hydrated and dehy

98 f hematopoietic progenitors from fibroblasts progresses through hemogenic precursors that are Prom1(+

99 MD although various promising approaches are progressing through human clinical trials.

100 t retinal disease in the diabetic milieu may progress through inflammatory and neuroretinal stages lo

101 e-associated molecular patterns (DAMPs), and progressing through innate and adaptive immune responses

102 The tobacco addiction treatment field is progressing through innovations in medication developmen

103 Glomerular vascular development progressed through intermediate stages akin to those inv

104 ontinuously monitor research investments and progress, through international platforms such as a Glob

105 ) reformation and into an intact NE as cells progress through interphase.

106 Countries made progress through interventions from within and outside t

107 We progress through its joining the aquaporin family as a w

108 the secretion of surface-active proteins to progress through its life cycle.

109 en exchange rates as phosphoglycerate kinase progresses through its catalytic cycle have been measure

110 parum, the parasite slows its metabolism and progresses through its developmental cycle at a reduced

111 ally all the tissues of the body, and tumors progress through many different stages during their deve

112 Nevertheless, when autophagy progressed through maturation stages, HIV was degraded.

113 round and support reproductive cells as they progress through meiosis and pollen maturation.

114 infertility due to failure of germ cells to progress through meiosis I and hypogonadism.

115 iosis II and form dyads, while some, as they progress through meiosis II, cause a defect in chromosom

116 phosphorylated on multiple residues as cells progress through meiosis.

117 d DNA damage and apoptosis, yet collectively progressed through meiosis and spermiogenesis and genera

118 ls is set early in development, with oocytes progressing through meiosis later in life.

119 intain nuclear integrity as germ cell nuclei progress through meiotic development and migrate for gam

120 on leaving the niche, enter into meiosis and progress through meiotic prophase [1].

121 e II alpha-dependent mitotic decatenation to progress through metaphase.

122 Rates of decline and progress through milestones measured using the scale var

123 DN3 thymocytes to exit the G2/M checkpoint, progress through mitosis and further differentiate.

124 ulation of mitosis, allowing mutant cells to progress through mitosis at the expense of genomic integ

125 d an increase in the time taken for cells to progress through mitosis from nuclear envelope breakdown

126 Cultures of snf2Delta yeast were found to progress through mitosis slowly.

127 urveillance enables BRCA2-deficient cells to progress through mitosis with under-replicated DNA, whic

128 stimulated in synchronous HeLa cells as they progress through mitosis, and these proteins are activat

129 FoxM1 null or depleted cells fail to progress through mitosis, as expression of several mitot

130 pho-H2AX-positive and BrdUrd -positive cells progress through mitosis, demonstrating a link between p

131 overexpressed and is essential for cells to progress through mitosis.

132 ntromere cannot be stretched; however, cells progress through mitosis.

133 Although viable, these cells are slow to progress through mitosis.

134 of the reduced ability of cardiomyocytes to progress through mitosis.

135 tic actin-dependent changes in shape as they progress through mitosis; they round up upon mitotic ent

136 the single-stranded recombinant AAV2 vectors progressed through mitosis in the absence of the helper

137 Cells treated with AZD1152 progressed through mitosis with misaligned chromosomes a

138 Most irradiated cells progressed through mitosis without significant delay, bu

139 To test this model, we blocked cells from progressing through mitosis and found that prolonged met

140 Developing hGOs progressed through molecular and morphogenetic stages th

141 Sp1(-/-) cells progress through most embryonic stages of blood cell dev

142 hat as epidermal progeny differentiate, they progress through multiple spatiotemporal transition stat

143 Human embryonic stem cells progress through multiple stages in their path to neural

144 endrocytes, the myelinating glia of the CNS, progress through multiple transitory stages before termi

145 fteen passes generated an adapted virus that progressed through multiple cycles in cultured D2F2/E2 c

146 genic differentiation but disappear as cells progress through myogenesis, concomitant with the destru

147 ous cause of morbidity and mortality despite progress through neurobiological research in identifying

148 inhibition, to helping the replication fork progress through non-nucleosomal protein-DNA complexes.

149 completely blocked in cortex hydrolysis and progresses through outgrowth to produce colonies at a fr

150 Aged apoE4 TR mice progressed through pentylenetetrazol-induced seizure sta

151 into human clinical trials and successfully progressed through phase 1 studies.

152 undergone extensive clinical testing and has progressed through phase III clinical trials, continued

153 a transitory apoptotic response and the skin progressed through phases of hyperplasia and dysplasia.

154 public-company-sponsored clinical trials are progressing through phases 1-3.

155 All patients had progressed through platinum-based chemotherapy.

156 Many drugs have progressed through preclinical and clinical trials and h

157 he identification of AT13387 (35), which has progressed through preclinical development and is curren

158 ed a net reproduction number for individuals progressing through presymptomatic and symptomatic stage

159 expression analysis suggests that the hESCs progress through primitive streak or mesendoderm to meso

160 Postnatal spermatogonial stem cells (SSCs) progress through proliferative and developmental stages

161 Although many tumor cells did not progress through Ptx-induced mitotic arrest, tumor signi

162 pic hypogonadism characterised by failure to progress through puberty, indicating the involvement of

163 was rapid compared with Fg, but both cargoes progressed through Rab4(+), Rab11(+), and von Willebrand

164 As ecosystems progress through recovery, it is important to estimate a

165 Chk1 S301 phosphorylation increases as cells progress through S and G2 and that both Cdk1 and Cdk2 ar

166 that fail to interact with Skp2 and cyclins progress through S phase with similar kinetics as wild t

167 inue to synthesize DNA slowly and eventually progress through S phase, suffering severe DNA damage th

168 nds to MBF to repress transcription as cells progress through S phase.

169 e same group of E2F1-3 target genes as cells progress through S phase.

170 nal effectors that commit cells to enter and progress through S phase.

171 ional program that commit cells to enter and progress through S phase.

172 eriments show that ORC disassembles as cells progress through S phase.

173 inue to synthesize DNA slowly and eventually progress through S-phase, suffering severe DNA damage th

174 synthesis, decreases in the number of cells progressing through S phase and cell proliferation, wher

175 Cells lacking miR-155 are inefficient in progressing through S phase and spontaneously undergo ap

176 nscript-based markers were used to track the progress through senescence, and indicated that limiting

177 ical neurons responded to sensory stimuli by progressing through sequences of states, identifiable on

178 B cell progenitors progress through sequential and mutually exclusive state

179 Diseases normally progress through several stages.

180 erobic conditions did not become dormant and progressed through several developmental stages until da

181 ercent volume per ameloblast) as ameloblasts progress through six defined developmental stages.

182 ction of these lesions increases as children progress through staged surgical reconstruction, with mu

183 These diseases progress through stages.

184 follicle is a cyclic biological system that progresses through stages of growth, regression, and qui

185 We employed a rat liver cancer model that progresses through stages similar to those of human live

186 he classical dogma of "diabetic nephropathy" progressing through stages of albuminuria, leading to de

187 ) undergo lifelong cyclical transformations, progressing through stages of rapid growth (anagen), reg

188 generally believed that tumours develop and progress through stepwise accumulation of mutations in d

189 r discovery the beta-lactam antibiotics have progressed through structural generations, each in respo

190 itial reaction were characterized, and their progress through subsequent washing with diethyl ether a

191 Here we show that burrowers can progress through such sediments by using a mechanically

192 opriately regulate the Notch program as they progress through T cell development.

193 ne programs that change dynamically as cells progress through T cell differentiation.

194 As we progress through the 21st century, modern analytical pla

195 The alternative replication cannot progress through the A/T-rich FRA16B fragile site, while

196 rmediate states these proteins adopt as they progress through the ATP hydrolysis cycle is key to unde

197 d protein modification and that infected ECs progress through the autophagosome pathway by LC3 dual f

198 of the Trp195 loop and are linked to enzyme progress through the catalytic cycle, including donor su

199 cells are unable to replicate their DNA and progress through the cell cycle and that the NASP(-/-) n

200 Centrioles must duplicate as cells progress through the cell cycle but it is unclear how th

201 cleation, whereas megakaryocytes continue to progress through the cell cycle but skip late stages of

202 ity of let-7 oscillate as neural progenitors progress through the cell cycle by in situ hybridization

203 role of the CaM-Ks on cell proliferation and progress through the cell cycle in breast cancer cells.

204 results indicate that endothelial cells must progress through the cell cycle in order to be radiosens

205 rest in S-phase but defective cells can also progress through the cell cycle leading to nucleosome de

206 s represent different G1 subpopulations that progress through the cell cycle with distinct temporal p

207 comprise the conserved machinery that drives progress through the cell cycle, but how they do this in

208 Failing to progress through the cell cycle, Muller glia undergo rea

209 uction and the ability to synthesize DNA and progress through the cell cycle.

210 marks" genes for rapid reactivation as cells progress through the cell cycle.

211 uronal death, is required for Muller glia to progress through the cell cycle.

212 Chromosome folding is modulated as cells progress through the cell cycle.

213 n FLS leads to S-phase arrest and failure to progress through the cell cycle.

214 bility to return to quiescence and decide to progress through the cell cycle.

215 to direct observation and 273 patients whose progress through the clinic stations was timed.

216 l ensembles robustly encoded conjunctions of progress through the current route, position in the larg

217 arasites are trapped in the lumen and cannot progress through the cycle.

218 e to multi-step protocols, with major recent progress through the elegant ligand design in heterobime

219 hannels and secreted trophic factors as they progress through the endoplasmic reticulum and the Golgi

220 a striking decrease in fertility, failing to progress through the estrous cycle normally, show any si

221 Each species' rate of progress through the event scale, described by a regress

222 and TOX and exhibited an impaired ability to progress through the exhaustion developmental trajectory

223 ation of these substrates and arrays as they progress through the fabrication process.

224 salivary glands, we observed B. burgdorferi progress through the feeding tick via what we believe to

225 y depleted of all miRNAs, and they failed to progress through the first cell division, probably becau

226 re CD4(+) T follicular helper (Tfh) cells to progress through the germinal center and provide protect

227 eciation of how these networks vary as cells progress through the haematopoietic cell hierarchy.

228 tomatic bacteriuria, or pyelonephritis could progress through the IBC cascade in a well-characterized

229 ired sensitization to NK cell killing, while progress through the late lytic cycle is associated with

230 a subset of membrane-spanning cargo as they progress through the medial Golgi.

231 disease changes considerably as the lesions progress through the morphological stages identified.

232 ulate on future innovation as we continue to progress through the postgenomic era and towards deeper

233 rs with fewer academic resources and tend to progress through the ranks slower than men.

234 posed to cWnts, Bmp2-deficient cells fail to progress through the Runx2/Osx1 checkpoint and thus do n

235 promotes H2B synthesis that allows cells to progress through the S phase.

236 The ability to study live cells as they progress through the stages of cancer provides the oppor

237 se of training, subjects came to track their progress through the task more accurately, a change that

238 olymerase and general factors that allow its progress through the transcription cycle by facilitating

239 ion, virion composition and infectivity, and progress through the virus life cycle under perturbation

240 EGF-stimulated goblet cells progressed through the cell cycle expressing pERK in the

241 the last few decades, quantum chemistry has progressed through the development of computational meth

242 We previously showed that these two proteins progressed through the Golgi with distinct kinetics.

243 itory synaptic transmission as adult gerbils progressed through the process of associative learning a

244 was a smooth ramp-like change as the animal progressed through the sequence toward the reward.

245 g gastric processing, which emptied into and progressed through the small intestine.

246 a closed, ordered conformation as the enzyme progresses through the catalytic cycle.

247 We first find that as the 8-cell embryo progresses through the cell cycle, the nuclei of most -

248 rces in estimating how a population of cells progresses through the cell cycle.

249 the point of sperm entry, which subsequently progresses through the entire egg cortex.

250 ve a multisynaptic pathway that sequentially progresses through the entorhinal and perirhinal regions

251 rovide continuous coordination of urea as it progresses through the filter, and well-placed alpha-hel

252 sity is generated during the reaction, which progresses through the formation of fractures.

253 mic models of the AAA(+) ATPase module as it progresses through the functional cycle.

254 Previous studies have shown that the enzyme progresses through the kinetic cycle by modulating the d

255 male -UNmale = 1.60 g, P < 0.05), 2) obesity progresses through the maternal line (percent body fat:

256 r to stably associated dimer as the spidroin progresses through the silk extrusion duct.

257 on of the transcriptome of V. cholerae as it progresses through the stages in biofilm development.

258 Spermatogenesis in Tex14(-/-) mice progresses through the transit amplification of diploid

259 As NaAtm1 progresses through the transport cycle, conformational c

260 mpleted in 1 d, with an additional 1-2 d for progressing through the analysis procedure.

261 n of telomerase subunits in cells blocked or progressing through the cell cycle as synchronized by mu

262 owed a proliferative advantage, entering and progressing through the cell cycle faster than polyploid

263 Using synchronized cells progressing through the cell cycle, pioneering microarra

264 iling of synchronously growing cell cultures progressing through the cell cycle.

265 t pathways that prevent cells with DSBs from progressing through the cell cycle.

266 ducibility of FTIR spectra recorded of cells progressing through the cell cycle; (3) insights into th

267 me-point "snapshot" of a population of cells progressing through the cycle asynchronously.

268 it, with several new diagnostic technologies progressing through the development pipeline.

269 n entering the S phase, and are deficient in progressing through the early M phase.

270 o be more prevalent and abundant in patients progressing through the esophageal adenocarcinoma cascad

271 fferences in the number of each male's sperm progressing through the female reproductive tract were a

272 n in quiescent oocytes as well as in oocytes progressing through the first meiotic division.

273 s of molecularly targeted anti-cancer agents progressing through the late stages of clinical developm

274 is examination begins at the N3 lymph nodes, progressing through the N2 and N1 lymph node stations, u

275 Ovol1-deficient germ cells were defective in progressing through the pachytene stage.

276 rate of DNA replication, blocked cells from progressing through the S phase, and inhibited prolifera

277 spore and deletion of cmpA resulted in cells progressing through the sporulation programme more quick

278 ng" cisternae that carry cargo forward while progressing through the stack.

279 f both IgH-mu- and IgL-kappa-chains, without progressing through the stage of IgH-mu-chain alone.

280 the aging process and age-related disease is progressing through the use of model organisms, how to a

281 parasites within a host - millions of them - progress through their cell cycle synchronously.

282 s undergo several cellular decisions as they progress through their life cycles inside host cells(2).

283 stocysts enter biosynthetic dormancy but can progress through their normal developmental program afte

284 Despite these advances, some patients progress through therapy and succumb to their disease.

285 ignaling, yet little is understood as to how progress through these events is regulated.

286 Little is known about how replication progresses through these regions in human cells.

287 tely, studies show that many patients do not progress through this continuum.

288 m to cause anthrax depends on its ability to progress through this life cycle in a regulated manner.

289 As cells progress through this protocol, they express genes in a

290 Wild-type cells progress through three distinct phases: a quiescent phas

291 FepA-mediated transport of FeEnt progressed through three distinct phases with successive

292 Biofilm growth progresses through three genetically programmed stages:

293 ints caused by variation in gene copy number progressed through tissue development and resulted in st

294 Due to its excellent properties, it was progressed through toxicology studies and is being teste

295 t they cannot simply be added together as we progress through training.

296 We found that TFH cells progressed through transcriptionally and functionally di

297 d by multiple scaffold morphing steps, which progressed through tricyclic pyrimido[2,3-b]azaindoles t

298 eveals how classical Red Queen conflicts can progress through unrecognized intermediates.

299 d genomic instability, Atm(KD/-) lymphocytes progressed through variable, diversity, and joining reco

300 driver mutations which enable the tumour to progress through various hallmarks of cancer.