ライフサイエンスコーパス: progressive

1 death; the clinical course in MLIII is less progressive.

2 t the chromatin level, aging associates with progressive accumulation of epigenetic errors that event

3 Further analysis revealed progressive accumulation of photoaging-related changes a

4 lder without previous systemic treatment for progressive advanced or metastatic STS who had Eastern C

5 nts with visual emphysema at CT demonstrated progressive airflow obstruction with lower values of rat

6 rized by persistent respiratory symptoms and progressive airflow obstruction.

7 one (ben-dex) in patients with persistent or progressive AL amyloidosis after >= 1 prior therapy.

8 on-induced cognitive dysfunction (RICD) is a progressive and debilitating health issue facing patient

9 ctose-containing substrates and onset of the progressive and fatal neurodegenerative lysosomal storag

10 Idiopathic pulmonary fibrosis (IPF) is a progressive and heterogeneous interstitial lung disease

11 mental periodontitis was associated with the progressive and increased presence of Th17 and Treg-rela

12 in KMT2B are associated with an early-onset, progressive and often complex dystonia (DYT28).

13 eurons, which potentially contributes to the progressive and selective dopaminergic neurotoxicity in

14 , that two Sfxn3 (-/-) mouse lines developed progressive and severe outer retinal degeneration.

15 cy and safety of vandetanib in patients with progressive and symptomatic MTC.

16 ly underway, the disease is typically slowly progressive, and objective, imaging-based biomarkers are

17 ents (cardiac death, MI, unstable angina, or progressive angina) at latest follow-up.

18 tients with the nonfluent variant of primary progressive aphasia (age, 67.0 +/- 7.4 y; 4 women) and 8

19 guage functions and often damaged in primary progressive aphasia (PPA).

20 al atrophy, left temporal lobe for logopenic progressive aphasia and medial and lateral temporal lobe

21 erior cortical atrophy and 22 with logopenic progressive aphasia) that had undergone baseline and 1-y

22 affected in the nonfluent variant of primary progressive aphasia, a neurodegenerative disorder with t

23 yndrome-specific atrophy patterns in primary progressive aphasia.

24 act as risk factors for yet to be discovered progressive ataxias.

25 the preclinical stage, which is mediated by progressive atrophy of grey matter indicative of increas

26 In addition, she reported progressive back pain since she was 5 years old.

27 57 year-old female presented with 1 year of progressive, bilateral, peripheral vision loss, photopsi

28 s of primary sclerosing cholangitis (PSC), a progressive biliary tract disease without approved medic

29 Treatment of periodontitis aims to halt progressive bone and attachment loss and regenerate peri

30 culture-negative at euthanasia and displayed progressive bony encapsulation of the screw.

31 tington's disease (HD) gene carriers undergo progressive brain changes during the course of disease,

32 tic factors, and medication that may explain progressive brain changes in BD.

33 e progressive extensions to Cactus to create Progressive Cactus, which enables the reference-free ali

34 Our study indicates that mHTT could cause progressive cardiac conduction system pathology that cou

35 PRKAG2 syndrome is a progressive cardiomyopathy characterized by high rates o

36 outer subpial surface compared to secondary progressive cases.

37 ose that this molecular switch acts to drive progressive cell commitment, remodeling the epigenomic l

38 th the absence of enamel rods, and underwent progressive cell pathology throughout enamel development

39 ed over time and were potentially favored by progressive cell proliferation.

40 the central hearing pathway most probably by progressive central white matter degeneration.

41 Progressive cerebellar atrophy was also noted.

42 (AD) is characterized by amyloid plaques and progressive cerebral atrophy.

43 usceptibility factor for Moyamoya disease, a progressive cerebrovascular disorder that often leads to

44 ), we observed cell cycle arrest, apoptosis, progressive change to a glial morphology and reduction i

45 Furthermore, our data show progressive changes in vasculature and maturation of den

46 baseline eGFR, 48 ml/min per 1.73 m(2)), 117 progressive CKD events, 183 noncancer deaths, and 116 ca

47 in Alzheimer's disease (AD), contributing to progressive cognitive decline.

48 jority of individuals with SCD will not show progressive cognitive decline.

49 Alzheimer's disease (AD) causes unrelenting, progressive cognitive impairments, but its course is het

50 ic obstructive pulmonary disease (COPD) is a progressive condition of chronic bronchitis, small airwa

51 must be considered in patients with HCM and progressive conduction system disease.

52 The progressive consumption growth of non-steroidal anti-inf

53 rineural deafness, spastic quadriparesis and progressive cortical and cerebellar atrophy in an effort

54 tical thinning in healthy subjects, we found progressive cortical atrophy on vertex-wise analysis in

55 al cortex is the main striatal afferent, and progressive cortico-striatal disconnection characterizes

56 f stabilization and survival, a relentlessly progressive course, akin to IPF, is seen in a minority.

57 ble, ranging from minor, stable disease to a progressive course, whereas all patients with IPF experi

58 teractions in the Nordic seas, caused by the progressive decay of Northern Hemisphere ice-sheets.

59 We observed progressive dechlorination of 2,3,7,8-TeCDD only in bott

60 ited monogenic disorders, characterized by a progressive decline in kidney function due in part to th

61 A progressive decline in maximum heart rate (mHR) is a fun

62 lpha-glucosidase activity in patients, and a progressive decline in mobility and respiratory function

63 showed neuron loss that correlated with the progressive decline of cognitive and motor performance.

64 neurodegenerative disorder, resulting in the progressive decline of cognitive function in patients.

65 s a gradual depletion of CD4 T cells, with a progressive decline of host immunity.

66 d decline of neurogenesis is paralleled by a progressive decline of regenerative capacity.

67 of compound motor action potentials showed a progressive decrease in all nerves, with different kinet

68 thermore, patients with SCD showed a greater progressive decrease in blood flow than did the controls

69 an incinerator fly ash pretreatment showed a progressive decrease in methane production rates and poo

70 we found different patterns of changes: (i) progressive decrease in NREM sleep duration and consolid

71 ampal neuron structure and connectivity with progressive deficits in long-term potentiation and spati

72 on neurogenerative disorder characterized by progressive degeneration in the frontal and temporal lob

73 ha-syn aggregates, accelerate the severe and progressive degeneration of parvalbumin-positive (PV(+))

74 riolar material in the postnatal brain, with progressive degenerative ciliary and behavioral phenotyp

75 Here, we show at progressive degrees of resolution that the most abundant

76 Progressive deletion of N-terminal residues revealed an

77 t-Jakob disease (sCJD) presents as a rapidly progressive dementia which is usually fatal within six m

78 sex of mice, but the muscle mutation caused progressive denervation, acetylcholine receptor (AChR) c

79 tive autoimmune response against apoB with a progressive derangement in clinical disease.

80 drop' had previously failed, with associated progressive deterioration in the patient's clinical stat

81 o understand the molecular determinants of a progressive deterioration of functional integrity of mit

82 Aging, or senescence, is a progressive deterioration of physiological function with

83 ses and cell senescence, both culminating in progressive deterioration of renal function.

84 coordination of WG differentiation with the progressive differentiation of photoreceptor neurons.

85 odulatory therapies, patients may still face progressive disability because of failure of myelin rege

86 5% CI, 161-274 Gy; n = 13) and patients with progressive disease (116 Gy; 95% CI, 81-165 Gy; n = 9) (

87 0.017-0.518), but increased the frequency of progressive disease (OR, 2.717; 95% CI, 1.391-5.304).

88 her whole-body MRI enables identification of progressive disease (PD) earlier than CT and bone scinti

89 ations at baseline, co-acquired mutations at progressive disease (PD), and the clonal evolution remai

90 Twenty-three (32%) patients with progressive disease according to PERCIST5 had controlled

91 ent emphysema at CT were more likely to have progressive disease and increased mortality at 5 years c

92 ients in this trial, 184 had symptomatic and progressive disease at baseline.

93 ion Whole-body MRI enabled identification of progressive disease before CT in most participants with

94 ded independent central review (BICR) showed progressive disease for the patient.

95 PGSs stratified patients with high risk for progressive disease indicated by worse prognostic outcom

96 Progressive disease leads to pathologic tissue remodelin

97 ignificance in patients classified as having progressive disease on the basis of irRC.

98 ery 4 weeks thereafter (28-day cycles) until progressive disease or toxicity.

99 was administered (100 mg) twice a day until progressive disease or unacceptable toxic effects occurr

100 asyn is likely occurring in both initial and progressive disease stages, and preventing truncation ma

101 Type 2 diabetes (T2D) is a progressive disease whereby there is often deterioration

102 CG is considered a progressive disease with variable rates of progression.

103 rtial response) and nonresponders (stable or progressive disease) according to PERCIST1 and PERCIST5

104 therapy protocol (8 Complete Response and 11 Progressive Disease) were evaluated for serum SEVs size,

105 In cases of progressive disease, an additional evaluation was perfor

106 onse, 17 cases as stable disease, 5 cases as progressive disease, and 14 cases as HPD.

107 ve and disease-free, eight (16%) had died of progressive disease, and one patient (2%) each had died

108 rsus 18% +/- 32% in patients with stable and progressive disease, respectively.

109 tocellular adenomas were more likely to show progressive disease, with hepatic nuclear factor 1alpha-

110 erichia coli sepsis), each in the setting of progressive disease.

111 i-RNAs targeting developmental processes and progressive downregulation of repeat-associated siRNAs f

112 This was associated with an irreversible and progressive drop of blood glucose levels.

113 iangiogenic therapies, virtually all develop progressive, drug-refractory disease.

114 The cause of geographic atrophy (GA), a progressive dry form of age-related macular degeneration

115 Patients have variable risks of progressive ductopenia, cholestasis, and biliary fibrosi

116 erized by a dry cough, persistent fever, and progressive dyspnea and hypoxia, sometimes accompanied b

117 Progressive dyspnea on exertion had developed after she

118 These individuals experienced early onset progressive dystonia with predominant cervical, bulbar,

119 ly hypotonic child and a sibling pair with a progressive encephalopathic syndrome.

120 Progressive end-organ damage, partly related to a system

121 r time in the whole region, accompained by a progressive enhancement of the crude VBAC rate, we found

122 A second dynamic signature showed progressive enrichment for type 2 inflammation, T(H)17 s

123 We find a progressive evolution in the scale and precision of chro

124 Here we describe progressive extensions to Cactus to create Progressive C

125 Huntington's Disease (HD) is a progressive, fatal neurodegenerative condition.

126 variants likely catalyze the pathologic and progressive features of COPD when expanded to high numbe

127 ompositional and mechanical changes create a progressive feed-forward loop in which enhanced matrix d

128 , characterized by the combination of a slow-progressive feedforward process and a fast-reactive feed

129 disease, and myelodysplasia that can lead to progressive fibrosis and eventually cirrhosis of the liv

130 nce of hepatic stellate cell activation, and progressive fibrosis.

131 se of unknown cause that is characterized by progressive fibrotic lung remodeling.

132 Non-alcoholic steatohepatitis (NASH) is a progressive form of Non-alcoholic fatty liver disease (N

133 accumulation of disabilities associated with progressive forms of MS (P-MS).

134 assess the safety and efficacy of MD1003 in progressive forms of multiple sclerosis in a larger, mor

135 eterogeneous disease with rapidly and slowly progressive forms.

136 , shows that genomic signals can distinguish progressive from stable disease even 10 years before his

137 ons for which various substitutions produced progressive functional changes; we consider these evolut

138 s can help characterise the underpinnings of progressive functional decline in HD.

139 This study highlights that progressive gender egalitarian values at a national leve

140 s commonly perform glaucoma surgery to treat progressive glaucoma.

141 on documented stereophotographic evidence of progressive glaucomatous change in the appearance of the

142 nd 7 months of age revealing significant and progressive glial activation and vulnerability of spinal

143 e characteristic features of LCDD, including progressive glomerulosclerosis, nephrotic-range proteinu

144 In this retrospective study, progressive growing GANs were used to synthesize mammogr

145 Age-related hearing loss is a progressive hearing loss involving environmental and gen

146 noelectrical transducer current, and develop progressive hearing loss, becoming deaf by 8 months of a

147 aC mice degenerate over time, giving rise to progressive hearing loss.

148 two affected family members presenting with progressive heart valve disease early in life.

149 utated or both and histologically confirmed, progressive, HER2-negative, metastatic breast cancer wer

150 an recapitulate the salient features of this progressive human disease.

151 from 1 institution identified patients with progressive Humphrey VF defects secondary to TED-CON.

152 A progressive increase in LV/RV dimensions was observed in

153 ons of the CH(2) stretching modes indicate a progressive increase in the chain conformational order w

154 s did not show a correlation with age, but a progressive increase in the mutation rate was observed a

155 A progressive increase in the number of functional MOC-OHC

156 duction in the need for oxygen therapy and a progressive increase in the P/F (PaO2, oxygen partial pr

157 Operative time decreased with the progressive increase of procedures.

158 l, collagen I and III showed a selective and progressive increase over time.

159 the frontal and parietal regions, and (iii) progressive increases in individual slow wave slope and

160 in stathmin mutants also reveals a degree of progressive instability and neurodegeneration that was n

161 Subcutaneous immunotherapy stimulates progressive integration of mite-induced Th cell-associat

162 s read out locations in chromatic space from progressive integration of signals relayed by V1.

163 r intestinal transplantation in the event of progressive intestinal failure-associated liver disease,

164 his multicenter study demonstrated early and progressive involvement of upper extremity muscles in Du

165 bilateral disease; 53 of 116 eyes (46%) had progressive KC; and 9 of 116 eyes (8%) had acute hydrops

166 We enrolled 612 eyes of 391 subjects with progressive keratoconus (n = 589), pellucid marginal deg

167 mice induced 2,8-DHA nephropathy, leading to progressive kidney disease, characterized by crystal dep

168 ls, but repair can also lead to fibrosis and progressive kidney disease.

169 stitial fibrosis is an important mediator of progressive kidney dysfunction in DN.

170 ypertension and organ damage, and ultimately progressive kidney failure.

171 de spectrum of clinical phenotypes including progressive kyphoscoliosis, joint hypermobility, hypoton

172 vestibular areflexia syndrome (CANVAS) is a progressive late-onset, neurological disease.

173 t therapy responses with both regressive and progressive liver metastases in the same patient (best v

174 Although the course of BD is often progressive, longitudinal brain imaging studies are scar

175 rtension (PAH) is a disease characterized by progressive loss and remodeling of the pulmonary arterie

176 Ageing OHCs also exhibited the progressive loss of afferent and efferent synapses.

177 intestinal failure-associated liver disease, progressive loss of central vein access, and repeated li

178 familial, age-related disorder caused by the progressive loss of dopamine (DA) neurons in the substan

179 MP load therefore does not contribute to the progressive loss of mtDNA quality that occurs as mice ag

180 disruption of AIS Na(+) channel clustering, progressive loss of nodal Na(+) channels, and seizures.

181 y the disappearance of notochordal cells and progressive loss of proteoglycan (PG).

182 We demonstrate that aging is associated with progressive loss of SSCs and diminished chondrogenesis i

183 levant regions of the forebrain demonstrated progressive lysosomal storage and microglial activation

184 associated with severe developmental delay, progressive microcephaly with brachycephaly, optic atrop

185 one and future macular atrophy may represent progressive migration and loss of retinal pigment epithe

186 olgi in a temporal order consistent with the progressive molecular processing sequence described by t

187 In mice, a Psap saposin D mutation caused progressive motor decline and dopaminergic neurodegenera

188 phaS mice and the PD-like resting tremor and progressive motor decline of 3K alphaS mice.

189 D249N/D249N)) mutation that recapitulate the progressive motor dysfunction with tremor, dystonia and

190 iquitously, a condition sufficient to induce progressive motor symptoms and premature death, but gene

191 tting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) represents a huge clinical challen

192 remitting MS and GM atrophy in patients with progressive MS are the most relevant variables.

193 within 5 years of presentation) of secondary progressive MS at 30 years were presence of baseline inf

194 elapsing multiple sclerosis (MS) and primary progressive MS has led to a conceptual shift in the unde

195 HTR2A is differentially methylated in progressive MS independent of genotype.

196 te drugs for repurposing in the treatment of progressive MS.

197 ho sequences in relation to the diagnosis of progressive multifocal leukoencephalopathy and to review

198 in transplant patients causing nephropathy, progressive multifocal leukoencephalopathy, Merkel cell

199 n dysfunction syndrome and predicting new or progressive multiple organ dysfunction syndrome, compare

200 tients with a confirmed diagnosis of primary progressive multiple sclerosis (PPMS) is uncertain.

201 hemispheric brain slices of 23 patients with progressive multiple sclerosis directly after autopsy, a

202 cruited 20 relapsing-remitting, 15 secondary progressive multiple sclerosis participants and 11 age-m

203 d patients (aged 25-65 years) with secondary progressive multiple sclerosis who were not on disease-m

204 or for many neurologic conditions, including progressive multiple sclerosis.

205 ultiple sclerosis including active secondary progressive multiple sclerosis.

206 ity outcomes over 12 months in patients with progressive multiple sclerosis.

207 disability and death of young men because of progressive muscle degeneration aggravated by sterile in

208 Duchenne muscular dystrophy (DMD) is a progressive muscle disease, characterized by mutations i

209 Cachexia is a progressive muscle wasting disease that contributes to d

210 myofibrillar myopathy (MFM) associated with progressive muscle weakness, cardiomyopathy, and respira

211 riants in UNC45B who exhibit childhood-onset progressive muscle weakness.

212 in biosynthesis; and resulted in late-onset, progressive myelin thinning in the CNS of adult mice (bo

213 g was performed in 2 unrelated families with progressive myoclonus epilepsy.

214 nts in SLC7A6OS are a novel genetic cause of progressive myoclonus epilepsy.

215 most common valvular heart disease, causes a progressive narrowing of the aortic valve as a consequen

216 Due to its progressive nature and unclear aetiology the only treatm

217 oes not reflect the pathological features or progressive nature of the disease.

218 every neighborhood strata and increase with progressive neighborhood socioeconomic deprivation.

219 e points, network-based statistics unraveled progressive network degeneration originating from the mo

220 Progressive neurocognitive decline and death were explai

221 brain volume loss is not due to generalized, progressive neurodegeneration, but may be mediated by sp

222 Mutations in NHE6 cause complex, slowly progressive neurodegeneration.

223 ing functional autophagy develop early onset progressive neurodegeneration.

224 Huntington's disease is a progressive neurodegenerative disease caused by expansio

225 Alzheimer's disease is a progressive neurodegenerative disease characterized neur

226 Prion disease is a rapidly progressive neurodegenerative disorder caused by misfold

227 Parkinson's disease (PD) is a progressive neurodegenerative disorder involving dopamin

228 Mutations in the MECP2 gene cause the progressive neurodevelopmental disorder Rett syndrome(3-

229 yperactive startle reflex), severe postnatal progressive neurological abnormalities (including abnorm

230 come critical in understanding the long-term progressive neurological disorder.

231 deficiency disorder that is characterized by progressive neurological injury culminating in death, ty

232 Understanding the progressive neuropathologic changes that occur in AD-and

233 Upon progressive neutralization of the H4, its radius of gyra

234 ydrological network and the influence of the progressive northward advance of the desert in a long-te

235 the recurrent laryngeal nerve following the progressive opening of the esophageal prosthesis.

236 Glaucoma is a group of progressive optic neuropathies that share common biologi

237 world continue to be affected and experience progressive or even fatal disease.

238 outcomes ranging from bacterial clearance to progressive or latent infection.

239 However, the uncertainty of a lesion's progressive or stable phenotype complicates understandin

240 Injection of cerulein for 2 days induced progressive pancreatitis in T7K24R mice, but not in cont

241 characterized by hypoplastic bone marrow and progressive pancytopenia.

242 1a-5p was significantly downregulated in non-progressive patients after FOLFIRINOX.

243 lic pathogenic HPDL variants as a cause of a progressive, pediatric-onset spastic movement disorder w

244 These recordings revealed progressive phase shifts in activity, indicating that th

245 strating associations of Mtb bacteremia with progressive phenotypes of latent infection and active pu

246 verely reduced electroretinograms (ERGs) and progressive photoreceptor degeneration, which is presume

247 rophages, and micelle-treated mice displayed progressive physiological clearance of gold, with >85% e

248 te-specific beta-PIX knockout mice developed progressive proteinuria and kidney failure with global o

249 r a high-value reward (sucrose pellets) in a progressive ratio lever-pressing task.

250 -like eating behavior in female rats through progressive ratio schedule self-administration and punis

251 then assessed responding for cocaine under a progressive ratio schedule, responding under extinction

252 -administration (acquisition, dose-response, progressive ratio, extinction, cue-induced reinstatement

253 In keeping with this, progressive reduction of subcutaneous adipose tissue is

254 p topography on cortical area boundaries and progressive reduction of the area and spatial resolution

255 ools show clear signs of diversification and progressive refinement, and it seems likely that at leas

256 logy and evolution community to lead further progressive reform.

257 perty in vivo as a result of unravelling the progressive relationship between the generation of myoca

258 el, we examined whether TRPM7 contributes to progressive renal damage and fibrosis.

259 mice, a hereditary disorder characterized by progressive renal failure.

260 Progressive renal pathologies, including fibrosis, mesan

261 of injury in diabetic nephropathy (DN), and progressive renal tubulointerstitial fibrosis is an impo

262 Progressive respiratory failure is the primary cause of

263 Robust chromosome biorientation requires progressive restriction of attachment geometry, destabil

264 Cell fate commitment involves the progressive restriction of developmental potential.

265 The model includes the implementation of progressive restrictions after the first case confirmed

266 generation whereas homozygous mice exhibited progressive retinal degeneration.

267 Progressive rod-cone degeneration (PRCD) is a small prot

268 immediate, sporadic axon damage followed by progressive secondary axon damage.

269 ory distress syndrome (ARDS) that is rapidly progressive, severe, and refractory to conventional ther

270 nt molecular process underlying aging is the progressive shortening of telomeres, the structures that

271 He was admitted to evaluate progressive shortness of breath and dry cough of 1-month

272 undamentally change our understanding of the progressive, site-specific nature of CLN1 disease pathog

273 xplain the typical decaying envelope and the progressive spacing of the spikes.

274 idated in an independent cohort of secondary progressive (SPMS) patients, but not in a third cohorts

275 induced rodent model of NAFLD, we observed a progressive stepwise reduction in the expression and act

276 efined by specific criteria as persistent or progressive stromal keratouveitis or an adverse event) w

277 identify genetic determinants of survival in progressive supranuclear palsy (PSP).

278 (18) F]-flortaucipir-PET and died with FTLD (progressive supranuclear palsy [PSP], n = 10; corticobas

279 ss cohorts), vascular dementia (AUC=92.13%), progressive supranuclear palsy or corticobasal syndrome

280 ple system atrophy, frontotemporal dementia, progressive supranuclear palsy, corticobasal syndrome an

281 rug treatment of frontotemporal dementia and progressive supranuclear palsy.

282 ports of chronic traumatic encephalopathy, a progressive tauopathy.

283 tion is not impacted by telomere shortening, progressive telomere dysfunction impaired hepatic endode

284 Progressive telomere shortening during lifespan is assoc

285 atic treatments currently available for this progressive, terminal disease.

286 l MRI scans in all participants and compared progressive thinning between groups using linear mixed e

287 Early data are now accumulating in progressive thyroid cancers treated with single-agent IC

288 chronic state of low-grade inflammation and progressive tissue infiltration by immune cells and incr

289 rate an effective synthesis strategy via the progressive transformation of non-van der Waals (non-vdW

290 mproving Earth system models (ESMs) with the progressive understanding on the fast processes manifest

291 our modified protocols resulted in a slowly progressive uveitis, with retinal scars and atrophy obse

292 (n = 2), stable mild exudation (n = 1), and progressive vasoproliferation with traction leading to p

293 Developmental analysis reveals a progressive, ventral-to-dorsal maturation of telencephal

294 terogeneous cardiac disease characterized by progressive ventricular enlargement and reduced systolic

295 In a young child with bilateral rapidly progressive vision loss and macular disturbance, blood f

296 A 52-year-old female patient presented with progressive vision loss in the right eye.

297 on maximum tolerated glaucoma medications or progressive visual field and optic nerve head changes de

298 Thalamo-striatal progressive volumetric deficit associated with symptomat

299 o presented with numbness of the right hand, progressive weakness in both lower limbs and weight loss

300 pendent acute GVHD process was observed with progressive weight loss, tissue damage, and death censor