ライフサイエンスコーパス: progressive aphasia

1 is of FTD (behavioral variant FTD or primary progressive aphasia).

2 anguage network in logopenic variant primary progressive aphasia.

3 c memory deficit in semantic variant primary progressive aphasia.

4 s and patients with semantic variant primary progressive aphasia.

5 arietal regions in logopenic variant primary progressive aphasia.

6 epresent a fourth variant of 'mixed' primary progressive aphasia.

7 , making this syndrome distinct from primary progressive aphasia.

8 tests; hence, none met criteria for primary progressive aphasia.

9 hanges that occur in the variants of primary progressive aphasia.

10 multimodal diagnostic evaluation of primary progressive aphasia.

11 and non-fluent (n = 39) variants of primary progressive aphasia.

12 inguish this syndrome from other variants of progressive aphasia.

13 ationship between semantic dementia (SD) and progressive aphasia.

14 , and therapeutic potential in patients with progressive aphasia.

15 gh detailed studies of patients with primary progressive aphasia.

16 yndrome-specific atrophy patterns in primary progressive aphasia.

17 to characterize the heterogeneity of primary progressive aphasia.

18 the non-fluent agrammatic variant of primary progressive aphasia.

19 ophy and eight for logopenic variant primary progressive aphasia.

20 rtaucipir signal in semantic variant primary progressive aphasia.

21 language network in each variant of primary progressive aphasia.

22 atrophy pattern in semantic variant primary progressive aphasia.

23 the non-fluent/agrammatic variant of primary progressive aphasia.

24 highly variable in individuals with primary progressive aphasia.

25 most patients with semantic variant primary progressive aphasia.

26 type C consistently led to semantic primary progressive aphasia.

27 logical and neuroimaging features of primary progressive aphasia.

28 al fluency and grammar impairment in primary progressive aphasia.

29 = 54) and semantic (n = 96) variant primary progressive aphasias.

30 ocessing of non-verbal sounds in the primary progressive aphasias.

31 s the harbinger of degenerative disease: the progressive aphasias.

32 nsecutive series of 20 patients with primary progressive aphasia [12 with progressive non-fluent apha

33 n predominant clinical features were primary progressive aphasia (22 patients [25.0%]), behavioral-va

34 a, 14 patients with semantic variant primary progressive aphasia, 25 patients with Alzheimer's diseas

35 bjects with the logopenic variant of primary progressive aphasia, 6 age-matched patients with AD, and

36 This study used patients with primary progressive aphasia, a clinical dementia syndrome charac

37 gains of function in a patient with primary progressive aphasia, a degenerative disease of the human

38 affected in the nonfluent variant of primary progressive aphasia, a neurodegenerative disorder with t

39 tients with the nonfluent variant of primary progressive aphasia (age, 67.0 +/- 7.4 y; 4 women) and 8

40 essive aphasia than semantic variant primary progressive aphasia (all P < 0.05).

41 ral variant, semantic and non-fluent primary progressive aphasia) along with associated three-repeat

42 speech samples for 50 patients with primary progressive aphasia, along with neurodegenerative and no

43 Patients with logopenic variant primary progressive aphasia also showed significant hypersynchro

44 mporal dementia and semantic variant primary progressive aphasia (also called semantic dementia) are

45 atients with the semantic variant of primary progressive aphasia, also known as semantic dementia, an

46 ral variant frontotemporal dementia, primary progressive aphasias, Alzheimer's disease, Parkinson's d

47 on derived from the semantic variant primary progressive aphasia analysis was strongly connected with

48 ntia, 10 had the semantic variant of primary progressive aphasia and 10 had the non-fluent agrammatic

49 28 TDP-C patients, 18 with semantic primary progressive aphasia and 10 with other syndromes.

50 , 12 patients with logopenic variant primary progressive aphasia and 13 patients with posterior corti

51 Thirty-five patients with primary progressive aphasia and 29 control subjects were recruit

52 ed 15 patients with semantic variant primary progressive aphasia and 57 patients with Alzheimer's dis

53 AD with severe language problems and primary progressive aphasia and a near splice-site mutation in C

54 emporal dementia or semantic variant primary progressive aphasia and a structural MRI (n = 478).

55 We found that both semantic variant primary progressive aphasia and Alzheimer's disease are signific

56 conclude that both semantic variant primary progressive aphasia and Alzheimer's disease are signific

57 Both semantic variant primary progressive aphasia and Alzheimer's disease had atrophy

58 l regions, and both semantic variant primary progressive aphasia and behavioural variant frontotempor

59 Logopenic variant primary progressive aphasia and developmental dyslexia both mani

60 underlies verbal fluency deficits in primary progressive aphasia and further confirm the role of the

61 al atrophy, left temporal lobe for logopenic progressive aphasia and medial and lateral temporal lobe

62 However, recent primary progressive aphasia and normal neurophysiological studie

63 with atypical phenotypes, such as logopenic progressive aphasia and posterior cortical atrophy.

64 ndrome and that varieties such as logopaenic progressive aphasia and progressive apraxia of speech ma

65 d meet criteria for semantic variant primary progressive aphasia and semantic dementia, patients with

66 sociative agnosia, semantic forms of primary progressive aphasia and semantic dementia.

67 t FTD, non-fluent/agrammatic variant primary progressive aphasia and semantic variant PPA.

68 sound perception and recognition in primary progressive aphasia and specific disorders at perceptual

69 nguistic assessments in the study of primary progressive aphasia and the three most prevalent neurode

70 ent presented at age 54 years with logopenic progressive aphasia and, at autopsy, showed both frontot

71 tical atrophy than logopenic variant primary progressive aphasia) and higher-order visual network (lo

72 89 patients with semantic variant of primary progressive aphasia, and 30 patients with Huntington dis

73 antic variant and non-fluent variant primary progressive aphasia, and 46 healthy controls) described

74 nts (27.0%) with semantic variant of primary progressive aphasia, and 6 of 30 patients (20%) with Hun

75 cortical atrophy, logopenic variant primary progressive aphasia, and corticobasal syndrome).

76 the French composer who also suffered from a progressive aphasia, and painted his best-known work, 'B

77 ve difficulties in logopenic variant primary progressive aphasia, and predicts phenotypic diversifica

78 n = 34) or semantic (n = 37) variant primary progressive aphasia-and 100 cognitively normal individua

79 of these impacted neural networks in primary progressive aphasia are lacking.

80 phenotypes such as logopenic variant primary progressive aphasia are more commonly associated with Al

81 ristics of early and mild disease in primary progressive aphasia are poorly understood.

82 Revisions of criteria for logopenic primary progressive aphasia are proposed to address these challe

83 fty-eight autopsies of patients with primary progressive aphasia are reported.

84 The primary progressive aphasias are rare, language-led dementias, w

85 volution of the logopenic variant of primary progressive aphasia as a distinct clinical entity and to

86 to one patient with semantic variant primary progressive aphasia before repeating 18F-flortaucipir sc

87 e understanding of logopenic variant primary progressive aphasia beyond the lens of an exclusive lang

88 er leftward asymmetry for tangles in primary progressive aphasia but not in the amnestic Alzheimer-ty

89 n recognition in semantic variant of primary progressive aphasia', by Bertoux et al. (doi:10.1093/bra

90 speech production in each variant of primary progressive aphasia, by quantifying speech output along

91 Primary progressive aphasia cases demonstrated leftward asymmetr

92 A review of published primary progressive aphasia cases with adequate clinical and his

93 re not universal and that individual primary progressive aphasia cases with Alzheimer pathology exist

94 Francisco Memory and Aging Center's primary progressive aphasia cohort (n = 198) for history of lang

95 ng was increased in semantic variant primary progressive aphasia compared to controls in the temporal

96 ogressive aphasia; logopenic variant primary progressive aphasia), compared to 25 healthy age-matched

97 comprehension in 51 individuals with primary progressive aphasia, composed of all clinical variants a

98 c syndromes (Alzheimer's disease and primary progressive aphasia) converge over time into a de-differ

99 es included frontotemporal dementia, primary progressive aphasia, corticobasal syndrome, and Alzheime

100 veraging machine learning on a large primary progressive aphasia dataset, delineated four distinct ne

101 atrophy and the logopenic variant of primary progressive aphasia, differ from amnestic AD in distribu

102 while patients with semantic variant primary progressive aphasia discounted delayed rewards more stee

103 The Alzheimer's disease pathology in primary progressive aphasia displayed multiple atypical features

104 nsecutive series of 18 patients with primary progressive aphasia (eight with semantic variant, six wi

105 rtical-to-entorhinal tangle ratio in primary progressive aphasia establishes clinical concordance of

106 asal syndrome, and nonfluent-variant primary progressive aphasia) exhibited higher globus pallidus SU

107 years], nine with non-fluent variant primary progressive aphasia [five female; 67.4 (8.1) years] and

108 asia (nonfluent PPA; n = 15), fluent primary progressive aphasia (fluent PPA; n = 7), and amyotrophic

109 entral auditory impairment exists in primary progressive aphasia for non-linguistic stimuli.

110 .8) years], 12 with semantic variant primary progressive aphasia [four female; 66.9 (7.0) years], nin

111 t to that seen in the fluent form of primary progressive aphasia (fPPA), a neurodegenerative disease

112 cits, helping to dissociate semantic primary progressive aphasia from semantic dementia.

113 stinguishing the semantic variant of primary progressive aphasia from the partially overlapping group

114 over, patients with semantic variant primary progressive aphasia had a significantly more prominent d

115 Patients with primary progressive aphasia had deficits of non-verbal sound ana

116 up, all participants with non-fluent primary progressive aphasia had evolved either corticobasal dege

117 developmental learning disability in primary progressive aphasia has been reported.

118 he connected speech of patients with primary progressive aphasia has often been dichotomized simply a

119 ore making a definitive diagnosis of primary progressive aphasia has promoted diagnostic specificity,

120 Observations in semantic variant primary progressive aphasia have inspired an alternative model f

121 atients with logopenic and nonfluent primary progressive aphasia have some deficits recognizing emoti

122 ssociated with syntactic deficits in primary progressive aphasia in a number of structural and functi

123 logical relationships in subtypes of primary progressive aphasia in hopes of utilizing language pheno

124 nset and to the logopenic variant of primary progressive aphasia in one family.

125 We examined 39 patients with primary progressive aphasia including logopenic variant (n = 14,

126 nt presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzhe

127 Primary progressive aphasia is a clinical syndrome defined by pr

128 Primary progressive aphasia is a clinical syndrome that encompas

129 Primary progressive aphasia is a neurodegenerative clinical synd

130 Primary progressive aphasia is a neurodegenerative disease that

131 Primary progressive aphasia is a neurodegenerative syndrome char

132 Primary progressive aphasia is a syndrome characterized by progr

133 l categorization of patients presenting with progressive aphasia is an area of controversy.

134 Progressive aphasia is best seen as a composite of two c

135 The logopenic variant of primary progressive aphasia is characterized by early deficits i

136 y contribute to the phenomenology of primary progressive aphasia is not established.

137 or natural kinds in semantic variant primary progressive aphasia is related in part to disease in vis

138 red four neuroanatomical subtypes of primary progressive aphasia, labelled S1 (left temporal), S2 (in

139 ecutive deficits), logopenic variant primary progressive aphasia (language deficits), and posterior c

140 Patients with logopenic variant primary progressive aphasia ('language variant of Alzheimer's di

141 rogressive aphasia; semantic variant primary progressive aphasia; logopenic variant primary progressi

142 = 10), and a third variant termed logopenic progressive aphasia (LPA; n = 10).

143 t subjects with logopenic variant of primary progressive aphasia (lvPPA) have beta-amyloid (Abeta) de

144 ipants with the logopenic variant of primary progressive aphasia (lvPPA) performed a recognition task

145 cortical atrophy (PCA), 12 logopenic primary progressive aphasia (lvPPA), 20 behavioural variant FTD

146 hy/PCA-AD; n = 103 logopenic variant primary progressive aphasia/lvPPA-AD; n = 35 behavioural variant

147 cortical atrophy in semantic variant primary progressive aphasia may follow connectional pathways wit

148 Atrophy (n = 16); logopenic variant Primary Progressive Aphasia (n = 15); and amnestic syndrome with

149 51) and individuals with unspecified primary progressive aphasia (n = 16).

150 ariants, including logopenic-variant primary progressive aphasia (n = 25), posterior cortical atrophy

151 progressive biparietal syndrome (n = 2) and progressive aphasia (n = 6).

152 se, semantic dementia and non-fluent primary progressive aphasia (n = 9 each) were contrasted with co

153 Research Center (semantic variant of primary progressive aphasia, n = 7; behavioural variant frontote

154 n = 13; behavioural variant, n = 14; primary progressive aphasias, n = 21) and 27 control subjects.

155 The non-fluent/agrammatic variant of primary progressive aphasia (naPPA) is a young-onset neurodegene

156 the non-fluent/agrammatic variant of primary progressive aphasia (naPPA), but well-controlled clinica

157 three different clinical variants: nonfluent progressive aphasia (NFPA; n = 11), semantic dementia (S

158 tia (bvFTD n=64), non-fluent variant primary progressive aphasia (nfvPPA n=36), semantic variant prim

159 hasia (svPPA), 14 non-fluent variant primary progressive aphasia (nfvPPA) and 12 semantic behavioural

160 arker cascades in non-fluent variant primary progressive aphasia (nfvPPA) and behavioural variant FTD

161 n patients with nonfluent/agrammatic primary progressive aphasia (nfvPPA) and progressive supranuclea

162 The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) is a neurodegenerative synd

163 asia (svPPA), (4) non-fluent variant primary progressive aphasia (nfvPPA) or (5) early onset Alzheime

164 svPPA), five with non-fluent variant primary progressive aphasia (nfvPPA)) and 17 healthy control sub

165 termed non-fluent/agrammatic variant primary progressive aphasia (nfvPPA), or exist as two completely

166 dementia (bvFTD), nonfluent variant primary progressive aphasia (nfvPPA), posterior cortical atrophy

167 dson syndrome (PSP-RS) and nonfluent primary progressive aphasia (nfvPPA), where underlying frontotem

168 ing the three canonical syndromes of primary progressive aphasia (non-fluent/agrammatic variant prima

169 fficulty, in patients with nonfluent primary progressive aphasia (nonfluent PPA; n = 15), fluent prim

170 This study selected 15 patients with progressive aphasia on broad criteria, excluding only th

171 arger groups of patients with either primary progressive aphasia or a typical amnestic dementia.

172 ociated with the semantic variant of primary progressive aphasia or behavioural variant frontotempora

173 Cases with predominant primary progressive aphasia or extra-pyramidal syndromes were ex

174 erior cortical atrophy, or logopenic primary progressive aphasia), or MCI with uncommon AD or other p

175 ressive aphasia, or semantic variant primary progressive aphasia), or mild cognitive impairment; the

176 disease dementia, logopenic variant primary progressive aphasia, or posterior cortical atrophy), FTL

177 emporal dementia, non-fluent variant primary progressive aphasia, or semantic variant primary progres

178 mporal dementia and semantic variant primary progressive aphasia patients alone confirmed this result

179 asal syndrome, and nonfluent-variant primary progressive aphasia patients had a pallidal SUVr above t

180 fluent variant and logopenic variant primary progressive aphasia patients very well from healthy cont

181 to a lesser extent or not at all in primary progressive aphasia patients whose syntax was relatively

182 temporal lobar degeneration; and 103 primary progressive aphasia patients).

183 ic and symmetric pathology cause the primary progressive aphasia phenotype, characterized by relative

184 ant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA) and corticobasal syndrome (CBS

185 uage productions of individuals with primary progressive aphasia (PPA) and healthy individuals.

186 have been described in patients with primary progressive aphasia (PPA) but their diagnostic value and

187 The dementia syndrome of primary progressive aphasia (PPA) can be caused by 1 of several

188 Primary progressive aphasia (PPA) defines a group of neurodegene

189 Primary Progressive Aphasia (PPA) is a behaviorally focal dement

190 Primary progressive aphasia (PPA) is a clinical dementia syndrom

191 Primary progressive aphasia (PPA) is a clinical syndrome charact

192 Primary progressive aphasia (PPA) is a focal dementia characteri

193 Primary progressive aphasia (PPA) is a neurodegenerative clinica

194 Primary progressive aphasia (PPA) is a neurodegenerative dementi

195 Primary progressive aphasia (PPA) is a neurodegenerative syndrom

196 Primary progressive aphasia (PPA) is a neurodegenerative syndrom

197 Primary progressive aphasia (PPA) is a progressive language diso

198 Noninvasive brain stimulation in primary progressive aphasia (PPA) is a promising approach.

199 Primary progressive aphasia (PPA) is an uncommon degenerative de

200 Primary progressive aphasia (PPA) is characterized by an isolate

201 The semantic variant of primary progressive aphasia (PPA) is characterized by the combin

202 Primary progressive aphasia (PPA) refers to a disorder of declin

203 s in a large cohort of patients with primary progressive aphasia (PPA) variants defined by current di

204 predominantly right-sided, semantic Primary Progressive Aphasia (PPA) when left-sided, and semantic

205 nd genetic study of 31 patients with primary progressive aphasia (PPA), a decline in language functio

206 Primary progressive aphasia (PPA), a selective neurodegeneration

207 in up to one third of patients with primary progressive aphasia (PPA), but clinical features that pr

208 In the nonfluent variant of primary progressive aphasia (PPA), degeneration of the posterior

209 s in the management and treatment of primary progressive aphasia (PPA), however, there are gaps in ed

210 trophic lateral sclerosis (ALS), and primary progressive aphasia (PPA), including 281 AD, 256 ALS, 39

211 non-fluent, and semantic variants of primary progressive aphasia (PPA), progressive supranuclear pals

212 In primary progressive aphasia (PPA), speech and language difficult

213 luent variant or semantic variant of primary progressive aphasia (PPA), unspecified PPA, progressive

214 word retrieval is a main symptom of primary progressive aphasia (PPA).

215 es like Alzheimer's disease (AD) and primary progressive aphasia (PPA).

216 guage functions and often damaged in primary progressive aphasia (PPA).

217 re-dominant pattern of deposition in primary progressive aphasia (PPA).

218 nerative dementia syndromes, such as primary progressive aphasias (PPA), have traditionally been diag

219 aphasia, PSA) and neurodegeneration (primary progressive aphasia, PPA) have overlapping symptomatolog

220 nsecutive autopsies on patients with primary progressive aphasia, primary diagnosis was Alzheimer's d

221 and resultant language impairment in primary progressive aphasia reflect complex interactions among t

222 syntactic comprehension deficits in primary progressive aphasia reflect not only structural and func

223 ge network for the logopenic variant primary progressive aphasia region of interest, and the higher v

224 the non-fluent/agrammatic variant of primary progressive aphasia relates to the strength of connectiv

225 lso known as the semantic variant of primary progressive aphasia, remains unclear.

226 al patients in both semantic variant primary progressive aphasia samples.

227 study included 270 participants with primary progressive aphasia seen for research in the UCL Queen S

228 hasia (non-fluent/agrammatic variant primary progressive aphasia; semantic variant primary progressiv

229 ological process in semantic variant primary progressive aphasia, should be further studied as a poss

230 mical phenotypes do exist within the primary progressive aphasia spectrum, but that these are noisy,

231 phy in non-fluent/agrammatic variant primary progressive aphasia spreads over time from a syndrome-sp

232 as matched in age and gender to each primary progressive aphasia subgroup (n = 20, age = 65 +/- 5 yea

233 predilection for one or more of the primary progressive aphasia subtypes.

234 white matter tracts in the different primary progressive aphasia subtypes.

235 antic dementia (SD)/semantic-variant primary progressive aphasia subtypes.

236 nitive deficits in logopenic variant primary progressive aphasia, suggesting that degeneration of a s

237 asia (nfvPPA n=36), semantic variant primary progressive aphasia (svPPA n=25), progressive supranucle

238 The semantic variant of primary progressive aphasia (svPPA) is a clinical syndrome chara

239 The semantic variant of primary progressive aphasia (svPPA) is typically associated with

240 tia (rtFTD), (3) semantic variant of primary progressive aphasia (svPPA), (4) non-fluent variant prim

241 ant FTD (bvFTD), 13 semantic variant primary progressive aphasia (svPPA), 14 non-fluent variant prima

242 ATL): patients with semantic variant primary progressive aphasia (svPPA), a clinical syndrome associa

243 (bvFTD), eight with semantic variant primary progressive aphasia (svPPA), five with non-fluent varian

244 a, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with

245 by patients with semantic variant of primary progressive aphasia (svPPA).

246 ementia (bvFTD) and semantic variant primary progressive aphasia (svPPA).

247 ht-sided variant of semantic variant primary progressive aphasia (svPPA).

248 g state neuronal synchronizations in primary progressive aphasia syndromes.

249 s with bvFTD and semantic variant of primary progressive aphasia than in those with AD and is more li

250 imer's disease and logopenic variant primary progressive aphasia than semantic variant primary progre

251 f this area and presenting data from primary progressive aphasia that challenged this classical assum

252 e logopenic variant is a distinct subtype of progressive aphasia that may hold value as a predictor o

253 erior cortical atrophy and 22 with logopenic progressive aphasia) that had undergone baseline and 1-y

254 Within semantic variant primary progressive aphasia the right-handed and non-right-hande

255 um and caudate nucleus in non-fluent primary progressive aphasia (the corticobasal degeneration/progr

256 linical subtypes, and one subtype of primary progressive aphasia to be caused by multiple neuropathol

257 findings expand the differential of primary progressive aphasia to include prion disease.

258 ated performance in semantic variant primary progressive aphasia to ventral and medial portions of th

259 ic dementia (SD) or semantic variant primary progressive aphasia typically present with marked atroph

260 ative patients with semantic variant primary progressive aphasia underwent 11C-PBR28 and 18F-flortauc

261 egion of atrophy in semantic variant primary progressive aphasia using cortical thickness analysis in

262 of inflammation in semantic variant primary progressive aphasia using high-resolution PET and the tr

263 syntactic deficits in patients with primary progressive aphasia, using multimodal neuroimaging and n

264 The primary progressive aphasia variant pooled crude incidence was 0

265 ional spectral power changes in each primary progressive aphasia variant, compared to age-matched con

266 Each of the primary progressive aphasia variants showed different patterns o

267 owed significant differences between primary progressive aphasia variants themselves.

268 ork-specific neuronal dysfunction in primary progressive aphasia variants.

269 the non-fluent/agrammatic variant of primary progressive aphasia was derived in a group of 10 mildly

270 No subject with a diagnosis of primary progressive aphasia was identified with this mutation.

271 for all pathologies associated with primary progressive aphasia was the asymmetric prominence of atr

272 disease and the posterior insula in primary progressive aphasias was also observed.

273 gnosis of frontotemporal dementia or primary progressive aphasia, we included 70 subjects with a nega

274 tic dysfunction in logopenic variant primary progressive aphasia, we propose that a significant porti

275 mporal dementia and semantic variant primary progressive aphasia were most likely to exhibit disgusti

276 atients with the semantic subtype of primary progressive aphasia, which is associated with marked tem

277 y were addressed in 72 patients with primary progressive aphasia who collectively displayed a wide sp

278 nically into behavioral variant FTD; primary progressive aphasia with 3 subtypes, semantic, nonfluent

279 The association of logopenic primary progressive aphasia with Alzheimer's disease pathology w

280 arch has associated semantic variant primary progressive aphasia with distributed cortical atrophy th

281 Behaviourally, patients with primary progressive aphasia with non-semantic subtypes were seve

282 ealthy controls and in patients with primary progressive aphasia with relatively spared syntax, but t

283 imer's disease and logopenic variant primary progressive aphasia), with a trend towards lower (18)F-l

284 displays an atypical distribution in primary progressive aphasia yielded inconclusive results.