ライフサイエンスコーパス: prohibitin

1 binding sites in the 1-kb promoter region of prohibitin.

2 repression of E2F-mediated transcription by prohibitin.

3 ns and a potential tumor suppressor protein, prohibitin.

4 ndent on the concerted activity of BASP1 and prohibitin.

5 y transfects mature adipocytes by binding to prohibitin.

6 by knockdown of the mitochondrial chaperone, prohibitin.

7 ction between Syk and the chaperone protein, prohibitin.

8 ination with BAF155, BAF170, HDAC1, p300 and prohibitin.

9 Expression of prohibitin 1 (PHB), a multifunctional protein in the cel

10 Prohibitin 1 (PHB), a protein implicated in the regulati

11 ified an interaction with two host proteins, prohibitin 1 (PHB1) and PHB2.

12 itro studies suggest that flavaglines target prohibitin 1 (PHB1) as a ligand, but this has not been e

13 tional ablation of the mitochondrial protein Prohibitin 1 (PHB1) in SCs causes a severe and fast prog

14 Prohibitin 1 (PHB1) is a highly conserved protein that i

15 Prohibitin 1 (PHB1) is a highly conserved, ubiquitously

16 Prohibitin 1 (PHB1) serves pleiotropic cellular function

17 chondria are heavily affected by ablation of prohibitin 1 and demyelination occurs preferentially in

18 -shaped structure consists of 11 alternating prohibitin 1 and prohibitin 2 molecules.

19 Whether the homologous protein prohibitin 1 has a similar role, and whether prohibitins

20 These results identify a role for prohibitin 1 in myelin integrity and advance our underst

21 Here, we show that deletion of prohibitin 1 in Schwann cells minimally perturbs develop

22 Prohibitin-1 (PHB) is a multifunctional protein previous

23 The function of prohibitin-1 (PHB1) in adipocyte mitochondrial respirati

24 Prohibitin-1 (PHB1) is an evolutionarily conserved pleio

25 ) database, show high similarity to those of prohibitin-1 and prohibitin-2 proteins, respectively, re

26 ers of small gene families with at least two prohibitin-1 homologs and four prohibitin-2 homologs.

27 When we downregulated expression of prohibitin-1 using a Tobacco rattle virus-based (TRV), v

28 e mutant, phb-2(ad2154), a point mutation in prohibitin 2 (E130K) protects worms from drug-induced in

29 binds with high affinity and specificity to prohibitin 2 (PHB2), a highly conserved protein that reg

30 fy the inner mitochondrial membrane protein, prohibitin 2 (PHB2), as a crucial mitophagy receptor inv

31 sing cells exhibited increased expression of prohibitin 2 (Phb2), involved in the regulation of mitoc

32 iously showed that the mitochondrial protein prohibitin 2 can localize to the axon-Schwann-cell inter

33 The human prohibitins prohibitin 1 and prohibitin 2 have been proposed to act as scaffolds with

34 Thus, prohibitin 2 is implicated in a previously uncharacteriz

35 icate that direct binding of hemiasterlin to prohibitin 2 is unlikely.

36 consists of 11 alternating prohibitin 1 and prohibitin 2 molecules.

37 otic mitophagy and demonstrate a function of prohibitin 2 that may underlie its roles in physiology,

38 b-2, which encodes the mitochondrial protein prohibitin 2.

39 erum from prediabetic mice lacking beta-cell prohibitin-2 (a model of monogenic diabetes) patients wi

40 requires the prohibitin ring complex subunit prohibitin-2 (PHB2) at the mitochondrial inner membrane.

41 Here, we report that prohibitin-2 (PHB2), a single-span membrane protein, is

42 Liver prohibitin-2 deficiency caused excessive proteolytic cle

43 In mice, Bif-1 bound prohibitin-2 during renal ischemia/reperfusion injury, a

44 at least two prohibitin-1 homologs and four prohibitin-2 homologs.

45 Glial-specific deletion of Prohibitin-2 in mice impairs axo-glial interactions and

46 inal tryptophan-344 not only prevented Bif-1/prohibitin-2 interaction but also reduced prohibitin com

47 tosis, supporting a pathogenic role of Bif-1/prohibitin-2 interaction.

48 er dysfunction (i.e. the hepatocyte-specific prohibitin-2 knockout (Hep-Phb2(-/-)) mice).

49 In prohibitin-2 knockout mice, expression of L-OPA1Delta by

50 both lean beta-Phb2(-/-) (beta-cell-specific prohibitin-2 knockout) mice and obese db/db (leptin rece

51 Bif-1 and prohibitin-2 may regulate mitochondrial dynamics.

52 high similarity to those of prohibitin-1 and prohibitin-2 proteins, respectively, reported from yeast

53 chondrial inner membrane by interacting with prohibitin-2 to disrupt prohibitin complexes and induce

54 nalysis indicated that Bif-1 interacted with prohibitin-2 via its C-terminus.

55 , Bif-1 translocated to mitochondria to bind prohibitin-2, resulting in the disruption of prohibitin

56 the molecular interaction between Bif-1 and prohibitin-2.

57 PROHIBITIN 3 (PHB3) was identified in both BRI1 and BAK1

58 Two allelic forms (C versus T) of the prohibitin 3'UTR exist, and carriers of the less common

59 xamined the tumor suppressor activity of the prohibitin 3'UTR in human breast cancer cells.

60 Thus, the C allele of prohibitin 3'UTR produces a functional RNA, whereas a si

61 t senescence is PHB1, the yeast homologue of prohibitin [3], a rodent gene initially identified as a

62 The identification of prohibitin, a "scaffold protein", as a propigmentation e

63 w that the CKGGRAKDC peptide associates with prohibitin, a multifunctional membrane protein, and esta

64 We recently observed that prohibitin, a potential tumor suppressor protein, binds

65 Prohibitin, a potential tumor suppressor protein, has be

66 Prohibitin, a potential tumor suppressor, is known to in

67 Prohibitin, a protein with cell-cycle regulatory activit

68 prohibitin 1 has a similar role, and whether prohibitins also play important roles in Schwann cell mi

69 , we show that the nuclear-encoded mammalian prohibitin and BAP37 proteins are present in mitochondri

70 We demonstrate that prohibitin and BASP1 cooperate to recruit the chromatin

71 ough interruption of the association between prohibitin and Brg-1/Brm without affecting the prohibiti

72 of several genes, including up-regulation of prohibitin and elevated sensitivity to a relatively nonc

73 chromatography revealed unexpected roles for prohibitin and mitochondrial F1F0-adenotriphosphatase in

74 tress response within retinal cells, such as prohibitin and MMP2, may serve as novel biomarkers and t

75 oisomerase 1 inhibitor, led to the export of prohibitin and p53 from the nucleus to the mitochondria.

76 8-2 formed a multimeric protein complex with prohibitin and the ring finger protein 2 (RNF2).

77 the identification of pyruvate carboxylase, prohibitin, and a subunit of ATP synthase in the prepara

78 ectrometry, we identified 3 proteins (VDAC1, prohibitin, and mitofilin) relevant to AD that interact

79 We show that an E2F repressor, prohibitin, and the chromatin modifiers Brg1/Brm are req

80 ribosome biogenesis genes, (2) mitochondrial prohibitins, and (3) chromatin regulators.

81 and specific distribution in normal tissue (prohibitin/annexin A2 in white adipose tissue) or cancer

82 Prohibitin appears to induce p53-mediated transcription

83 ATAD3 and prohibitin are tightly associated with the mitochondrial

84 Prohibitins are a highly conserved family of proteins th

85 Prohibitins are highly conserved proteins mainly implica

86 PID (proliferation, ion, and death) because prohibitins are involved in proliferation and cell cycle

87 We identified prohibitin as a potential target in mediating the therap

88 tifunctional membrane protein, and establish prohibitin as a vascular marker of adipose tissue.

89 analysis in breast cancer cells, identifying prohibitin as a vitamin D target gene.

90 These observations, collectively, establish prohibitin as an endogenous neuroprotective protein invo

91 ropose that OCIAD1 acts as an adaptor within prohibitin assemblies to stabilize and/or chaperone CYC1

92 ein that forms a complex with supramolecular prohibitin assemblies.

93 Although prohibitin associates with, and recruits, Brg-1 and Brm

94 Knockout of two Arabidopsis type-II prohibitins (AtPHB2 and AtPHB6) results in a decreased a

95 recruits, Brg-1 and Brm independently of Rb, prohibitin/Brg-1/Brm-mediated transcriptional repression

96 ogen antagonists, and thereby also implicate prohibitin/Brg1/Brm as potentially important targets for

97 ollectively, these findings suggest that the prohibitin/Brg1/Brm node is a major cellular target for

98 ling pathway in Ramos cells could inactivate prohibitin, but this had no effect on Rb function.

99 The depletion of prohibitin by small interfering RNA or antisense techniq

100 As seen with BASP1, prohibitin can associate with phospholipids.

101 d box region of E2F for repression; further, prohibitin can effectively inhibit colony formation indu

102 The potential tumor suppressor protein prohibitin can prevent cell proliferation and this requi

103 Southern blot analysis confirmed that the prohibitin cDNA clone was of P. carinii origin.

104 In prohibitin-competent mice, elongation of liver mitochond

105 ased by S. Typhi interacts with the membrane prohibitin complex and inhibits IL-2 secretion from T ce

106 prohibitin-2, resulting in the disruption of prohibitin complex and proteolytic inactivation of the i

107 Bif-1-deficiency inhibited prohibitin complex disruption, OPA1 proteolysis, mitocho

108 -1/prohibitin-2 interaction but also reduced prohibitin complex disruption, OPA1 proteolysis, mitocho

109 anscriptional regulation and uncover a BASP1-prohibitin complex that plays an essential role in the P

110 ined the molecular organization of the human prohibitin complex within the mitochondrial inner membra

111 The structure of the dome-shaped prohibitin complex, a dodecamer of PHB1-PHB2 dimers, was

112 by interacting with prohibitin-2 to disrupt prohibitin complexes and induce OPA1 proteolysis and ina

113 This study reveals an average of about 43 prohibitin complexes per crista, covering 1-3% of the cr

114 activity and cotransfection of an antisense prohibitin construct reduces p53-mediated transcriptiona

115 Repression by prohibitin correlates with histone deacetylation on prom

116 Prohibitin could bind to heterochromatin protein 1 (HP1)

117 Prohibitin could inhibit the activity of E2Fs 1, 2, 3, 4

118 Prohibitin could repress the transcriptional activity of

119 the recruitment of different corepressors by prohibitin, depending on the type of growth arrest.

120 r respiratory chain supercomplex assembly in prohibitin-depleted neurons.

121 n/flotillin/HflK/C domain (also known as the prohibitin domain or band 7 domain).

122 ohibitin and Brg-1/Brm without affecting the prohibitin-E2F interaction.

123 Prohibitin exerts beneficial effects on neurons by reduc

124 Prohibitin expression was detected cutaneously, with mor

125 miR-128 can downregulate prohibitin expression, and subsequently promote apoptosi

126 Two members of the prohibitin family of proteins, Phb1 and Phb2, were deter

127 and novel proteins, including members of the Prohibitin family.

128 illin protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) superfamily, fr

129 AtHIR proteins contain the stomatin/prohibitin/flotillin/HflK/C domain (also known as the pr

130 ities were found between FliL-C and stomatin/prohibitin/flotillin/HflK/C domains of scaffolding prote

131 e basis of amino acid sequence homology with prohibitin from mammalian sources.

132 suggest that the regulated translocation of prohibitin from the nucleus to the mitochondria facilita

133 ar export signal at the C-terminal region of prohibitin; fusion of the nuclear export signal (NES) of

134 of E2F1 is sufficient for being targeted by prohibitin; fusion of this region to GAL4-VP16 construct

135 ly that microinjection of RNA encoded by the prohibitin gene 3'untranslated region (3'UTR) blocks the

136 e finding that TCM62 and the analogous human prohibitin gene also inhibit mammalian cell death follow

137 total P. carinii protein indicated that the prohibitin gene is transcribed and translated in vivo.

138 In mammals, the prohibitin gene product has been shown to negatively reg

139 slices was markedly neuroprotective, whereas prohibitin gene silencing increased neuronal vulnerabili

140 The P. carinii prohibitin gene was expressed in vivo in human fibroblas

141 A cDNA clone encoding the P. carinii prohibitin gene was isolated from a P. carinii cDNA libr

142 ve amino-terminal membrane-docking domain of prohibitin had no effect on its ability to suppress cell

143 ons in the nucleus, a mitochondrial role for prohibitin has also been proposed.

144 At the same time, prohibitin has been implicated in mediating the proper f

145 The sub-cellular localization of prohibitin has been variously attributed to the mitochon

146 Though prohibitin has potent transcriptional functions in the n

147 The protective effect of prohibitin has potential translational relevance in dise

148 Sequences with high similarity to prohibitins have been identified in a number of plant sp

149 Prohibitins, highly conserved mitochondrial proteins, ha

150 Highly conserved prohibitin homologues have been identified in mammals [9

151 The prohibitin homology domain of the slit diaphragm protein

152 iple for the assembly of proteins containing prohibitin homology domains.

153 tance proteins, and proteins of the stomatin/prohibitin/hypersensitive response family, suggesting th

154 To determine the importance of prohibitin in androgen-stimulated growth, we used transi

155 direct physical interaction between VDR and prohibitin in cell lysates was not detectable.

156 Sustained expression of prohibitin in intestinal epithelial cells in vitro and i

157 lts provide the first evidence of a role for prohibitin in mitochondrial inheritance and in the regul

158 Earlier studies had proposed a role for prohibitin in modulating cellular senescence, but the un

159 Upregulation of prohibitin in neuronal cultures or hippocampal slices wa

160 ation prompted us to investigate the role of prohibitin in neuronal death and survival.

161 we evaluated the functional significance of prohibitin in relation to the cellular response to vitam

162 Targeting a proapoptotic peptide to prohibitin in the adipose vasculature caused ablation of

163 Confocal microscopy showed localization of prohibitin in the nucleus as well as the mitochondria of

164 ined suggest a potential role for P. carinii prohibitin in the regulation of P. carinii proliferation

165 gs provide new insights into the function of prohibitin in transcriptional regulation and uncover a B

166 he current study documents the expression of prohibitins in human and rodent islets and their key rol

167 ibitin (Tet-On model), the overexpression of prohibitin inhibited cell proliferation and enhanced vit

168 Prohibitin interacts with BASP1, colocalizes with BASP1

169 Prohibitin is a candidate tumor suppressor gene located

170 Prohibitin is a growth regulatory gene that has pleiotro

171 Prohibitin is a growth-suppressive protein that has mult

172 We believe that prohibitin is a novel regulator of E2F activity that res

173 We believe that prohibitin is a novel regulator of E2F function which ch

174 It therefore seems that the regulation of prohibitin is a vital part of the cellular growth respon

175 Because prohibitin is also expressed in blood vessels of human w

176 Prohibitin is an essential mitochondrial protein that ha

177 These results suggest that prohibitin is capable of modulating Rb/E2F as well as p5

178 The data presented here also show that prohibitin is capable of physically interacting with p53

179 Upon apoptotic stimulation by camptothecin, prohibitin is exported to perinuclear regions where it l

180 pic immunolabeling studies demonstrated that prohibitin is localized to neuronal mitochondria.

181 matin immunoprecipitation assays showed that prohibitin is needed for the recruitment of HP1gamma to

182 we report that the transcriptional repressor prohibitin is part of the WT1-BASP1 transcriptional repr

183 Here we show that prohibitin is predominantly nuclear in two breast cancer

184 We found that prohibitin is upregulated also in the ischemic tolerance

185 cerebellar fastigial nucleus, we found that prohibitin is upregulated in mitochondria.

186 BAP37, a protein with sequence similarity to prohibitin, is thought to be involved in lymphocyte func

187 In addition, prohibitin level had no significant effect on the vitami

188 on in cell cycle, while cells with increased prohibitin levels showed a clear reduction in the percen

189 Prohibitin, like Rb, could repress transcription from SV

190 It thus appears that prohibitin may be inhibiting apoptosis by downregulating

191 sponse to androgen stimulation in LNCaPs and prohibitin may have a nuclear regulatory role in cell-cy

192 he data with complex I activity suggest that prohibitin may stabilize the function of complex I.

193 of a negative regulator of the cell cycle (a prohibitin) may at least partially explain the delayed d

194 Prohibitin mediated transcriptional repression required

195 itin-mediated repression of E2F and relieves prohibitin-mediated growth suppression.

196 Prohibitin-mediated recruitment of HP1gamma occurred in

197 c-Raf-1, and Raf-1 could effectively reverse prohibitin-mediated repression of E2F activity.

198 of a dominant-negative Brg-1 or Brm releases prohibitin-mediated repression of E2F and relieves prohi

199 Surprisingly, prohibitin-mediated repression of E2F could not be rever

200 kinase, and cyclins D and E had no effect on prohibitin-mediated repression of E2F1, but all of these

201 coprotein, SV40 large T antigen, can reverse prohibitin-mediated suppression of E2F-mediated gene tra

202 -VP16 construct could make it susceptible to prohibitin-mediated, but not Rb-mediated repression.

203 Using mice lacking prohibitin membrane scaffolds as a model of neurodegener

204 Here we show that a subset of prohibitin molecules are present in the nucleus where it

205 A prohibitin mutant that could not bind to Rb was impaired

206 show that the camptothecin-induced export of prohibitin occurs preferentially in transformed cell lin

207 rane integrity, such as heat shock proteins, prohibitin, or nucleophosmin, as well as to the up-regul

208 in treatment, but this increase is absent in prohibitin overexpressing cells.

209 we report the design of a new generation of prohibitin peptide-based therapeutics engineered to targ

210 lopment of next-generation adipose-targeting prohibitin peptides, capable of curbing adipocyte expans

211 C and possible roles of AR cofactors such as prohibitin (PHB) are poorly understood.

212 ome-wide siRNA screening, we have identified prohibitin (PHB) as an essential factor in self-renewal

213 Previously, we have shown that human sperm Prohibitin (PHB) expression is significantly negatively

214 Prohibitin (PHB) has been reported to play a crucial rol

215 nsgenic mouse model, Mito-Ob, overexpressing prohibitin (PHB) in adipocytes.

216 Prohibitin (PHB) is a cell cycle regulatory protein, kno

217 Prohibitin (PHB) is a highly conserved protein that has

218 Prohibitin (PHB) is an evolutionarily conserved and ubiq

219 Our previous studies showed that prohibitin (PHB) levels are decreased during colitis and

220 inhibited by the synthetic flavagline FL3, a prohibitin (PHB)-binding drug.

221 ng the tumour suppressor and AR corepressor, Prohibitin (PHB).

222 ne-containing transmembrane adaptor proteins prohibitin (Phb)1 and Phb2 bind to CD86.

223 tic and proteomic interactions of Mdm33 with prohibitins, Phb1 and Phb2, which are key components of

224 Phb2p and its homolog, prohibitin (Phb1p), were localized to the mitochondrial

225 In yeast and mammals, prohibitins (PHBs) are considered as structural proteins

226 Prohibitins (PHBs) are highly conserved proteins that ar

227 Prohibitin physically interacts with all three Rb family

228 Our data indicate that prohibitins play a key role in plant development and sen

229 These studies show that prohibitin plays a vital role in inducing cellular senes

230 ery of a peptide corresponding to the NES of prohibitin prevented the export of prohibitin to cytopla

231 The ablation of prohibitin prevented the recruitment of HPIgamma, but no

232 The human prohibitins prohibitin 1 and prohibitin 2 have been prop

233 In addition, prohibitin protected complex I activity from the inhibit

234 We now find that prohibitin protects cells from apoptosis mediated by cam

235 of a P. carinii gene encoding the P. carinii prohibitin protein.

236 ely disrupts the Rb/Raf-1 but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding.

237 We show here that prohibitin recruits Brg-1/Brm to E2F-responsive promoter

238 Our earlier studies had shown that prohibitin represses the activity of E2F transcription f

239 These growth regulatory functions of prohibitin require a physical interaction with the Rb pr

240 Here we demonstrate that prohibitin requires the marked box region of E2F for rep

241 e of mitochondrial function and requires the prohibitin ring complex subunit prohibitin-2 (PHB2) at t

242 This is the first report to suggest that prohibitin serves as a novel vitamin D target gene, whic

243 D2, LDH-A, MNT, PTMa, ODC, NM23B, nucleolin, prohibitin, SHMT1, and SHMT2] demonstrate significant se

244 sis showed that cells with reduced levels of prohibitin showed a slight but reproducible increase in

245 omycin B could inhibit the nuclear export of prohibitin showing that it was a CRM-1-dependent event d

246 Prohibitins, stomatins, and a group of plant defense res

247 CF-7 cells expressing tetracycline-inducible prohibitin (Tet-On model), the overexpression of prohibi

248 E2F-mediated gene transcription, and targets prohibitin through interruption of the association betwe

249 Prohibitin thus appears to repress E2F-mediated transcri

250 he NES of prohibitin prevented the export of prohibitin to cytoplasm and protected cells from apoptos

251 fusion of the nuclear export signal (NES) of prohibitin to green fluorescence protein led to its expo

252 Further, HP1gamma could synergize with prohibitin to repress E2F1-mediated transcriptional acti

253 A-damaging agents causes the localization of prohibitin to specific heterochromatic foci.

254 nderstanding the functional contributions of prohibitins to the integrity and spatial organization of

255 The most potent compound, PTP-r, was prohibitin-TP01 substituted with d-arginine.

256 tinal epithelial cells in vitro and in vivo (prohibitin transgenic mice, PHB TG) resulted in a marked

257 Prohibitin up-regulation by 1alpha(OH)D5 treatment at bo

258 Prohibitin upregulation was associated with reduced prod

259 Knockdown of prohibitin was accompanied by increased number of cells

260 Prohibitin was also found to interact with the signaling

261 n the nuclei of MCF-7 cells and a portion of prohibitin was colocalized with VDR, but direct physical

262 Prohibitin was found to enhance p53-mediated transcripti

263 Confirming this, prohibitin was found to physically interact with CRM-1,

264 Confocal microscopic analysis showed that prohibitin was localized in the nuclei of MCF-7 cells an

265 pendent kinase activity, the inactivation of prohibitin was not.

266 p, a homolog of the tumor suppressor protein prohibitin, was identified in a genetic screen for suppr

267 ls that did not display the translocation of prohibitin were refractive to the apoptotic effects of c

268 requently identified proteins were ATAD3 and prohibitin, which have been identified previously as nuc

269 reported that a potential tumor suppressor, prohibitin, which interacts with retinoblastoma protein

270 Similar defects are found in cells lacking prohibitins, which are required for proper OPA1 processi

271 of quiescent Ramos cells inactivated Rb and prohibitin with different kinetics; further, while the s

272 nes were introduced: four closely related to prohibitins (Zm-phb1, Zm-phb2, Zm-phb3, and Zm-phb4), on