ライフサイエンスコーパス: prohibitive

1 mbrane systems where isotope labeling may be prohibitive.

2 wever, their analysis can be computationally prohibitive.

3 n this population are substantial and likely prohibitive.

4 ations one-by-one can become computationally prohibitive.

5 ombination in other genotypes have been cost prohibitive.

6 The costs can be prohibitive.

7 l-to-all local association studies otherwise prohibitive.

8 ize, and comorbidities gradually become less prohibitive.

9 tional cost of the Monte Carlo method can be prohibitive.

10 e, GCTA becomes increasingly computationally prohibitive.

11 es of large data sets may be computationally prohibitive.

12 mber of subjects remains both cost- and time-prohibitive.

13 ecause its analysis is often computationally prohibitive.

14 om the risk of re-do aortic valve surgery is prohibitive.

15 rgery is not feasible or if surgical risk is prohibitive.

16 e cost of direct experimental testing can be prohibitive.

17 larger, such pair-based calculation becomes prohibitive.

18 location to the water phase is energetically prohibitive.

19 arking spaces potentially make systems costs prohibitive.

20 patients in whom surgical risk is considered prohibitive.

21 inate and the cost disadvantages become less prohibitive.

22 here assay costs or platform limitations are prohibitive.

23 genome-scale models remains computationally prohibitive.

24 mentation and running costs are perceived as prohibitive.

25 ficulty of the full quantum problem had been prohibitive.

26 to the length of the sequence, which can be prohibitive.

27 experimental protein interaction networks is prohibitive.

28 d search, which is otherwise computationally prohibitive.

29 where the monetary cost of continuous ART is prohibitive.

30 groups, a process that can be energetically prohibitive.

31 itching different tools together etc. can be prohibitive.

32 nalogues of 1 were found to be energetically prohibitive.

33 progressively more expensive and eventually prohibitive.

34 in the genome because it is computationally prohibitive.

35 development of a specific resource would be prohibitive.

36 of stress ulcer gastrointestinal bleeding is prohibitive.

37 elated hemorrhage is substantial, and may be prohibitive.

38 s are limited and drug development costs are prohibitive.

39 the simulation, which can be computationally prohibitive.

40 track of large numbers of mutant animals is prohibitive.

41 sive economic costs, making eradication cost-prohibitive.

42 sical computation of those quantities can be prohibitive.

43 rtunately, such large samples are often cost prohibitive.

44 computing the cophenetic distance can become prohibitive.

45 m joint-calling for each analysis can become prohibitive.

46 er of nodes-a task that is often practically prohibitive.

47 in broadly applicable segmentation models is prohibitive.

48 data collection may be challenging and cost prohibitive.

49 ossible multi-drug combinations remains cost-prohibitive.

50 s, and if available, they are extremely cost prohibitive.

51 quired to detect occupancy declines would be prohibitive.

52 dual change had so far been methodologically prohibitive.

53 ding or accurate but time consuming and cost prohibitive.

54 cently, have been either unavailable or cost prohibitive.

55 candidate compounds, exhaustive screening is prohibitive.

56 es required for in-person recruitment can be prohibitive.

57 re biased, lack sequencing depth or are cost prohibitive.

58 ough the significant cost of the drug may be prohibitive.

59 complicates such toxicities and may even be prohibitive.

60 multiple miRNAs, fast, robust, and not cost-prohibitive.

61 sensitivity and specificity, and/or are cost-prohibitive.

62 xperiments are often time-consuming and cost prohibitive.

63 but recording uniformly sampled data is time-prohibitive.

64 hods are cumbersome, time consuming and cost-prohibitive.

65 avoidance when the costs of doing so are not prohibitive.(4-9) However, one recent meta-analysis indi

66 used by Na(+)-coupled transporters to avoid prohibitive activation barriers for charge translocation

67 , and interventions to improve management of prohibitive adverse events.

68 exactly two datasets, and/or they require a prohibitive amount of computational resources.

69 articular set of partition functions takes a prohibitive amount of time and space.

70 very large data-sets for which they require prohibitive amounts of CPU-time and memory.

71 production rate, but this approach requires prohibitive amounts of data in high-dimensional systems.

72 e of human experts, in addition to requiring prohibitive amounts of training data.

73 al pulmonary valve replacement in previously prohibitive anatomies.

74 No donor was excluded because of prohibitive anatomy.

75 bly is still a necessity, which becomes cost-prohibitive and a logistical challenge with increasing s

76 biochemical and functional analysis is cost-prohibitive and inefficient.

77 s normal mode motions can be computationally prohibitive and is often unnecessary.

78 ith some reports finding increased morbidity prohibitive and others finding increased morbidity accep

79 ation of large real networks computationally prohibitive and traps large graphs into high energy conf

80 The cost of this gold standard can be prohibitive, and alternative approaches are needed.

81 CPD was placed in 8 patients; one had prohibitive aortic arch anatomy.

82 runtime and main memory usage, which become prohibitive as dataset size grows past twenty-five taxa.

83 iques is computationally expensive, becoming prohibitive as the number of predictors and the number o

84 symbolic calculations, which quickly becomes prohibitive as the problem size increases.

85 the cost/benefit ratio of an intervention is prohibitive, as supported by pharmacoeconomic data, comm

86 methods to generate mitogenomes can be cost-prohibitive at scale.

87 aries that is south facing and does not have prohibitive attributes (designated wetland, forested lan

88 esign of an aryne precursor to overcome this prohibitive barrier.

89 that monomeric NO dissociation is subject to prohibitive barriers on Ag metal and is thus unlikely to

90 However, these methods are usually prohibitive because of reagent safety concerns, limiting

91 ces are limited and its cost becomes rapidly prohibitive beyond the milligram scale.

92 their processing overhead quickly becomes a prohibitive bottleneck.

93 Typically, this is prohibitive, but in weak-field spectroscopy we can move

94 The lack of prohibitive cardiovascular effects and the generally acc

95 7SK.P-TEFb interaction was not caused by any prohibitive changes in 7SK but by the dephosphorylation

96 r size or function, absence of symptoms, and prohibitive comorbidities.

97 th a large number of observations involves a prohibitive computational burden.

98 the lack of global optimum guarantee and the prohibitive computational complexity have been the bottl

99 istency and poor reliability, or suffer from prohibitive computational complexity.

100 on energy stability parameters, which are of prohibitive computational cost in large scale applicatio

101 been so far largely unfeasible due to their prohibitive computational cost.

102 vibrational motion of interfacial water and prohibitive computational costs at the first-principles

103 over multiple possible future states incurs prohibitive computational costs.

104 pace of a mechanism-based model can impose a prohibitive computational demand.

105 for large numbers of genomes at once, due to prohibitive computational demands.

106 t to apply to rare variants because of their prohibitive computational time and poor ability.

107 in performing functional mapping arise from prohibitive computational times required as well as from

108 y, off-target effects present a real but not prohibitive concern that should be considered for RNAi e

109 ecommended for all persons over 6 mo without prohibitive contraindications, including most cancer pat

110 d giving up on disease treatment (27.6%) and prohibitive cost (21%).

111 The prohibitive cost and limited availability of tracers cou

112 The prohibitive cost and scarcity of the noble-metal catalys

113 However, its large size, prohibitive cost and structural complexity hamper its po

114 vibrational modes remains elusive due to the prohibitive cost associated with constructing and diagon

115 set of the population to survive without the prohibitive cost of constantly expressing resistance mac

116 The prohibitive cost of platinum for catalyzing the cathodic

117 ials discovery but is challenging due to the prohibitive cost of searching the vast design space of c

118 characterized comprehensively because of the prohibitive cost of standard technologies and the techni

119 arch studies or clinical practice due to the prohibitive cost, time, and expertise required.

120 rovide an escape, except at a high, possibly prohibitive cost.

121 t half-life (T(1/2) = 45.6 min) on site, and prohibitive cost.

122 Because of prohibitive costs and the required length of follow-up,

123 excellent electro-optical properties, but at prohibitive costs and throughput for many applications.

124 time but are often constrained by either the prohibitive costs associated with commercial platforms o

125 sh species remain unknown, partly due to the prohibitive costs associated with sourcing commercial fi

126 Prohibitive costs for clinical assessment of periodontal

127 means for detecting infectious disease, but prohibitive costs have impeded their use in resource-lim

128 are systems for diagnosis is hindered by the prohibitive costs of existing chloride sensors.

129 absence of suitable analytical tools and the prohibitive costs of systematic numerical exploration of

130 ficantly higher resolution without incurring prohibitive costs or increasing the amount of sample req

131 Giving up on treatment and prohibitive costs remain primary reasons for not seeking

132 omen included poor knowledge of drug safety, prohibitive costs, and self-treatment practices, used by

133 e-scale exposures are still very rare due to prohibitive costs, the availability of replicated habita

134 atterns with tremendous depth, it comes with prohibitive costs.

135 hetic difficulties, process complexities and prohibitive costs.

136 framework to prospectively detect clinically prohibitive cross-reactivity of therapeutic TCR candidat

137 oncurrent whole-breast irradiation result in prohibitive cutaneous toxicity.

138 roalgae still remains a challenge due to the prohibitive downstream cost.

139 t in vivo recordings remains computationally prohibitive due to the large number of fibers in a nerve

140 conferring the ability to inhabit otherwise prohibitive ecological niches.

141 bserved at elevated pressures because of the prohibitive energetics of the Cf(3+)/Cf(4+) couple and r

142 ding sites at R18 and K25 and further show a prohibitive energy barrier for IP6 to pass through the p

143 to launch their seeds despite its seemingly prohibitive energy cost.

144 in (35 patients), nonendocardial origin with prohibitive epicardial access because of pericardial adh

145 h, as an NP-hard problem, is computationally prohibitive even for modest-size networks.

146 ing contigs will require significant (if not prohibitive) finishing efforts.

147 ere sickle cell disease, but toxicity may be prohibitive for adults.

148 These costs are often prohibitive for analysis of large single-cell datasets.

149 owed for 3TC escape under culture conditions prohibitive for any WT viral growth.

150 ng the routine analysis of toxic metals cost-prohibitive for applications such as occupational exposu

151 iency leads to multipolar divisions that are prohibitive for cell proliferation.

152 eaction (qPCR) scale poorly and are resource prohibitive for complex communities.

153 blem, from measurements to the state, can be prohibitive for complex systems such as transitional hyp

154 that the size of the animals does not become prohibitive for end-stage evaluation or therapeutic inte

155 ich could increase the sensitivity, has been prohibitive for genome-wide screens due to its extreme c

156 mputational overhead of these methods remain prohibitive for human-genome-scale data.

157 under these conditions and thereby has been prohibitive for HXMS analyses of larger proteins and man

158 ut sample reagent and sequencing cost can be prohibitive for hypothesis-driven studies where the aim

159 5'-dicarboxylate linker; it is energetically prohibitive for it to adopt the twisted conformation req

160 most accurate method, but is computationally prohibitive for large data sets with many individuals an

161 current limits to multiplexing capacity are prohibitive for large sample sizes and impose limitation

162 l or single-nuclei approaches are often cost-prohibitive for large samples.

163 th high cost and low throughput, making them prohibitive for large scale screening of formulation lib

164 Expensive regulation of biotech crops is prohibitive for local solutions.

165 s linearly with the aggregate length becomes prohibitive for lower concentrations and is relieved via

166 l constraints that typically make osmotrophy prohibitive for macroscopic life forms.

167 mples, the low throughput has made them cost prohibitive for many applications.

168 costs, and cooling requirements that remain prohibitive for many applications.

169 cost associated with a hybrid suite remains prohibitive for many centers.

170 sequence data on a population scale is still prohibitive for many laboratories.

171 e significant cost of applying, which can be prohibitive for many students, the paucity of diverse me

172 easing running time to O(N(2)), rendering BP prohibitive for modern-day big-data.

173 toxicities of myeloablative conditioning are prohibitive for most adults with this disease.

174 ce the short-lived 15O tracer, which is cost-prohibitive for most clinical PET centers.

175 This task is far from trivial, and can be prohibitive for non-bioinformaticians.

176 and placing of individual crystals-a process prohibitive for producing devices at high density and wi

177 effective and well established, can be cost-prohibitive for proof-of-concept and early stage work, l

178 cost of closed anaerobic photobioreactors is prohibitive for protein production.

179 a, sample acquisition is invasive, making it prohibitive for routine and sequential screening of airw

180 -up but remain logistically and economically prohibitive for routine screening in resource-limited se

181 t programs; however, these vaccines are cost-prohibitive for routine use in LMICs.

182 regimens required for BMT to succeed are too prohibitive for routine use.

183 me and labor intensive, and the costs remain prohibitive for scaling phenotyping to wider use-cases.

184 aracterizing telomeres at this resolution is prohibitive for short read sequencing approaches, and is

185 ies, whole-genome shotgun sequencing is cost-prohibitive for species with complex genomes.

186 he full permutation approach computationally prohibitive for the newer arrays that contain tens of th

187 eyed 10 Gbit s(-1) systems and is absolutely prohibitive for today's (>)100 Gbit s(-1) coherent syste

188 pment may prove both time-consuming and cost-prohibitive for treatment of all forms of RP.

189 ty of the linking function, which has proved prohibitive for understanding the complex dynamics exhib

190 all genetic variants, but it is financially prohibitive for well-powered GWAS studies.

191 III NSCLC, the therapy was found to be cost-prohibitive from the perspective of various internationa

192 improve by orders of magnitude to reduce the prohibitive hardware overhead of current error correctio

193 toablation is restricted to small volumes by prohibitive heat generation and time(10).

194 ions for heart transplantation and otherwise prohibitive hepatic dysfunction.

195 rations, it is not known why therapeutically prohibitive high doses are needed for suppression of tum

196 with severe aortic stenosis (AS) who are at prohibitive, high, or intermediate risk for surgical aor

197 tive structures in otherwise computationally prohibitive, high-dimensionality landscapes.

198 randomized trial appears to be logistically prohibitive; however, an international registry should b

199 y HIV-infected patients, it can be toxic and prohibitive in cost.

200 Indeed, such energy losses will become prohibitive in high-temperature reactor plasmas unless a

201 are vertices, rendering them computationally prohibitive in many applications.

202 Objectively assessed operative risk was not prohibitive in many unoperated patients.

203 d require Omega(n(2)) memory, which could be prohibitive in practice when n is greater than a hundred

204 ive RABV PEP is currently resource- and cost-prohibitive in regions of the world where RABV is most p

205 at severe intestinal rejection occurs, it is prohibitive in these cases to remove the intestinal port

206 the variables and leading to computationally prohibitive inference algorithms.

207 to-vehicle (V2V) charging, often suffer from prohibitive investment costs, incompatibility to existin

208 However, prohibitive labor costs cause most institutions to delin

209 SD showed initial therapeutic promise before prohibitive legislature in the mid-1960s effectively end

210 icacy, but previous such drug strategies had prohibitive limitations.

211 sampling (GBS) lack programmability or have prohibitive loss rates.

212 ng antibodies for each PTM in a study can be prohibitive, lots of potential is lost from MS datasets

213 These can be cost-prohibitive, motivating investigations into their role i

214 characteristics of caspase-8 mutants bearing prohibitive mutations at the interdomain cleavage sites

215 tem-cell transplantation has been limited by prohibitive non-relapse-related mortality rates and by a

216 uch CRMs is a challenging problem due to the prohibitive number of sequence sets that need to be anal

217 sm of inhibition is due to a steric blockade prohibitive of substrate binding, and is distinct from t

218 hence allowing analyses that would have been prohibitive on a single computer.

219 f up to 92%, but the conditions required are prohibitive on an industrial scale.

220 e not uniformly translated into increased or prohibitive operative morbidity and mortality in this po

221 For plastic waste that is either cost prohibitive or infeasible to mechanically or chemically

222 Also, these techniques can be cost or time prohibitive or not amenable to the biological system of

223 ield-specific and are either computationally prohibitive or require intensive simulation, limiting th

224 ntact tracing either uncertain, logistically prohibitive, or both.

225 , effective whole-body dose was 4 mSv and no prohibitive organ-specific absorbed doses were found.

226 r constructing haplotypes is computationally prohibitive, our approach uses a greedy algorithm based

227 to direct chemical reactivity down otherwise prohibitive pathways.

228 ndergo successful surgical resection without prohibitive perioperative complications; (3) Completion

229 ng cardiac surgery are often thought to have prohibitive perioperative risk despite the lack of suffi

230 ational temperature variations can result in prohibitive power consumption, challenging the scalabili

231 I) complexes has been shown to be a slow and prohibitive process that generally requires elevated tem

232 t of them operate through energetically cost-prohibitive processes at high temperatures.

233 vely identified as meeting the definition of prohibitive risk and had 1-year follow-up (median: 1.47

234 A proportion of these patients is at high or prohibitive risk for surgical aortic valve replacement,

235 s with symptomatic severe aortic stenosis at prohibitive risk for surgical valve replacement.

236 le for femoral artery access and had high or prohibitive risk of complications from transthoracic acc

237 ubjects at high or extreme surgical risk and prohibitive risk of LVOT obstruction from TMVR were incl

238 tegrade LAMPOON was performed in patients at prohibitive risk of LVOT obstruction.

239 angina deemed to be at "high risk" or even "prohibitive risk" for CABG, PTCA is an alternative revas

240 al valve replacement surgery poses a high or prohibitive risk.

241 A prohibitive-risk DMR cohort was identified by a multidis

242 transcatheter mitral valve repair (TMVR) in prohibitive-risk DMR patients have not been previously r

243 review of procedural and 30-day outcomes of prohibitive-risk patients who underwent TAVR via caval-a

244 ceived approval in 2013 for the treatment of prohibitive-risk patients with primary mitral regurgitat

245 ears to be reasonably well tolerated without prohibitive risks for adverse events among selected NOAC

246 with symptomatic severe aortic stenosis with prohibitive risks for surgery.

247 as Average Nucleotide Identity (ANI) incurs prohibitive runtime overhead.

248 s and a large number of measurements lead to prohibitive runtimes for quantum computers in isolation.

249 The DTU-STEMI pilot trial did not identify prohibitive safety signals that would preclude proceedin

250 instrumentation has made exact replications prohibitive, sharing data is now essential for ensuring

251 ufacturing engineered T cells ex vivo can be prohibitive, so programing T cells in vivo may be a viab

252 r a prospective superiority trial are likely prohibitive, studies such as these provide clinically re

253 York Heart Association class III/IV), and at prohibitive surgical risk (STS score: 13.2 +/- 7.3%).

254 ue challenge as many patients are at high or prohibitive surgical risk and, therefore, an open surgic

255 TMVR in prohibitive surgical risk patients is associated with sa

256 icate that TAVR is underutilized in high and prohibitive surgical risk patients with severe aortic st

257 ents who underwent TAVI because of a high or prohibitive surgical risk profile had died at a mean fol

258 gitation (MR) in patients with severe DMR at prohibitive surgical risk undergoing TMVR.

259 with severe symptomatic aortic stenosis and prohibitive surgical risk, the estimated benefits of tra

260 nning, and management of patients at high or prohibitive surgical risk, thus improving outcomes.

261 ed as an alternative for patients at high or prohibitive surgical risk.

262 with symptomatic aortic stenosis at high or prohibitive surgical risk.

263 itral regurgitation (MR) who were at high or prohibitive surgical risk.

264 ral regurgitation (MR) considered at high or prohibitive surgical risk.

265 h aortic stenosis at intermediate to high or prohibitive surgical risk.

266 egurgitation are also deemed at very high or prohibitive surgical risk.

267 with severe TR and right heart failure with prohibitive surgical risk.

268 xpanding TAVR in patients with severe AS and prohibitive surgical risk.

269 Current research is limited by the prohibitive time necessary to perform tree search on a r

270 Clearly, it is computationally prohibitive to analyze all network properties, but the l

271 d confounding gamma emissions of (52g)Mn are prohibitive to clinical translation, but the short-lived

272 the stage where it is becoming commercially prohibitive to conduct new studies.

273 cially their derivatives, because it is cost-prohibitive to experimentally determine all of them.

274 ortunately, it has been challenging and cost prohibitive to generate antidotes for most therapeutic a

275 d in a nonhuman host or such models are cost prohibitive to generate, including models for the human-

276 g this process, its expense and scarcity are prohibitive to large-scale commercialization.

277 ods are either impossible or computationally prohibitive to obtain.

278 l route of administration has been viewed as prohibitive to outbreak response campaigns.

279 ge number of legacy wells would make it cost-prohibitive to sample all wells for all measurements as

280 ion of a near-complete, scaffolded genome is prohibitive to small research communities due to the exp

281 cing of target regions, although it is still prohibitive to test more than a few individuals.

282 e and targeted sequencing tests is no longer prohibitive to their application.

283 k illustrates that large energetic barriers, prohibitive toward chemical reaction, may be overcome th

284 ry 2 weeks until a maximum dose of 800 mg or prohibitive toxicity was reached.

285 In the absence of disease progression or prohibitive toxicity, patients received a maximum of 16

286 ts were treated until disease progression or prohibitive toxicity.

287 y every 3 weeks until disease progression or prohibitive toxicity.

288 y every 21 days until disease progression or prohibitive toxicity.

289 gefitinib 500 mg daily until progression or prohibitive toxicity.

290 le agents in eliminating MPNST cells without prohibitive toxicity.

291 ar models, however, would be computationally prohibitive unless some independence assumptions are mad

292 large-scale sequence-similarity searches is prohibitive using even the fastest of the extant algorit

293 many areas throughout the world that renders prohibitive vegetables and crop production in general.

294 Additional analyses revealed that prohibitive voice and silence significantly mediated the

295 rd supervised machine learning may require a prohibitive volume of hand-labeled training data.

296 stom synthesis is expensive and costs can be prohibitive when a wide range of markers is to be analyz

297 However, the MRFs can be computationally prohibitive when beta strands are interleaved in complex

298 neurons, enabling experiments that would be prohibitive with biological neurons.

299 demands synapse analysis on a scale that is prohibitive with current methods.

300 ny of the technical complexities that may be prohibitive with standard laparoscopic surgery such as i