ライフサイエンスコーパス: prohibitively

1 ck at the more exposed diradical center, was prohibitively (35.9 kcal/mol) higher in energy.

2 length-scale transmission lines, making them prohibitively area-inefficient for modern semiconductor

3 y be of limited use to study in isolation or prohibitively challenging to manipulate in situ.

4 ith experimental techniques is however still prohibitively challenging.

5 pristine crystals absent of defects has been prohibitively challenging.

6 inhibitors has historically been considered prohibitively challenging.

7 ect measurements of oxygen consumption prove prohibitively challenging.

8 education and empowerment have proved to be prohibitively complex and/or ineffective.

9 the signal used for detection or the use of prohibitively complex instrumentation, and prospects for

10 However, mass spectra are often prohibitively complex when fragment ions are analyzed fo

11 oscopic descriptions of these systems can be prohibitively complex.

12 owering the dose of 6OHDA below toxic levels prohibitively compromises its antitumor effect.

13 , existing maximum-likelihood methods can be prohibitively computationally expensive, especially sinc

14 atory specimens, though this practice can be prohibitively costly and can be associated with an incre

15 age sequencing data for these genes would be prohibitively costly and computationally demanding.

16 tional cloning and sequencing approaches are prohibitively costly and labor-intensive.

17 s, next-generation sequencing (NGS) is still prohibitively costly for routine use in generalized HIV

18 a constant external power source and can be prohibitively costly in resource-limited settings and Sc

19 dary purposes when obtaining such consent is prohibitively costly or burdensome, as long as mechanism

20 delivered on a population scale they can be prohibitively costly, suggesting more sustainable models

21 informative about the future signal are also prohibitively costly.

22 individual being studied, but this is often prohibitively costly.

23 and approaches, a situation that can become prohibitively cumbersome and which can defeat the purpos

24 gy, due in large part to the requirement for prohibitively cumbersome experimental procedures and dau

25 This task is often prohibitively difficult and time-consuming.

26 But this is prohibitively difficult at experimental level.

27 oping without deteriorating crystallinity is prohibitively difficult but scientifically crucial to un

28 le experiments in central axon terminals are prohibitively difficult but the biophysical requirements

29 s interaction mapping in humans has remained prohibitively difficult due to computational and statist

30 f brain function and behaviour, but is often prohibitively difficult for non-experts to implement and

31 ng, especially for thin films, because it is prohibitively difficult for trillions of clusters to coh

32 n inference makes optimal predictions but is prohibitively difficult to compute.

33 freefall to explore quantum systems that are prohibitively difficult to create on Earth.

34 -way functions are inexpensive to fabricate, prohibitively difficult to duplicate, admit no compact m

35 Simply stated, it is prohibitively difficult to replicate the native electro-

36 omprehensive species-level identification is prohibitively difficult with traditional methods.

37 yses of human antibody repertoires have been prohibitively difficult, primarily owing to their massiv

38 ecular species in cellular tomograms remains prohibitively difficult.

39 at could otherwise guide efforts through the prohibitively expansive design space.

40 for prostate cancer screening are currently prohibitively expensive (due to the high costs of imagin

41 ing each candidate gene from every region is prohibitively expensive and computational methods that s

42 hput sequencing technology, but still can be prohibitively expensive and laborious when community sam

43 xtraction of 18O/16O from water is generally prohibitively expensive and often is designed to interfa

44 r fabrication over large areas, which can be prohibitively expensive and time consuming using convent

45 mmercially available pure compounds is often prohibitively expensive and time-consuming, and many lab

46 hful simulation of the entire scale range is prohibitively expensive at high Reynolds numbers.

47 to mouse studies that are better models but prohibitively expensive at scale.

48 is compound is commercially available but is prohibitively expensive because of the circuitous routes

49 reover, large-scale datasets typically incur prohibitively expensive computation overhead and thus re

50 Hence, it is prohibitively expensive computationally to apply density

51 By exploiting precomputed data, the often prohibitively expensive computations associated with hig

52 os, simulations of the entire population are prohibitively expensive due to computational demands pla

53 reasing sampling depth to levels that can be prohibitively expensive due to physical limits on molecu

54 particle sizer spectrometers-SMPS -which is prohibitively expensive for developing nations.

55 its potential toxicity, natural hepcidin is prohibitively expensive for human application and has un

56 ovide high-quality intake data but have been prohibitively expensive for large epidemiologic studies.

57 haracterizing genetic variation but is still prohibitively expensive for large samples.

58 synthesis for their preparation, and/or are prohibitively expensive for large-scale application.

59 ever, classical HLA typing methods are often prohibitively expensive for large-scale studies.

60 bundance of training examples and may become prohibitively expensive for many applications.

61 h next-generation sequence (NGS) data remain prohibitively expensive for many investigators.

62 ing ancient genomes to high coverage remains prohibitively expensive for most laboratories.

63 existing clinical methods for this test are prohibitively expensive for the underprivileged global p

64 igital PCR (ddPCR), however, the hardware is prohibitively expensive for widespread utility.

65 TIPS should be regarded as experimental and prohibitively expensive in Child's class A cirrhosis.

66 Although single-cell sequencing can be prohibitively expensive in large cohorts, computationall

67 kidney injury can be life-saving, but can be prohibitively expensive in low-income settings.

68 es individual testing of at-risk individuals prohibitively expensive in many settings.

69 labeling' by expert clinicians, which can be prohibitively expensive or practically impossible becaus

70 od organisms, and developing a new model was prohibitively expensive or time-consuming.

71 n genome-wide chromatin contact map is still prohibitively expensive owing to large genome sizes and

72 nds, serve as practical replacements for the prohibitively expensive Rh-complexes previously used for

73 rocess modular and controllable and to avoid prohibitively expensive surface representations, we embe

74 to DNA oligonucleotides, they are typically prohibitively expensive to chemically synthesize, and un

75 ouses with residual insecticide, is becoming prohibitively expensive to implement and new approaches

76 enome-wide association studies (GWAS), it is prohibitively expensive to sequence all cohort members.

77 However, it is prohibitively expensive to sequence all the samples from

78 tality, are a threat to health-care workers, prohibitively expensive to treat, and are therefore a se

79 iations, next-generation sequencing is still prohibitively expensive when applied to large samples.

80 sampling of conformational space, and become prohibitively expensive when exploring the collective dy

81 n be dried, this renders the capture process prohibitively expensive(8,9).

82 models rely heavily on fetal tissues, can be prohibitively expensive, and are often complicated to ge

83 Subtissue labeling is prohibitively expensive, and only rough annotations of t

84 However, manual analysis can be prohibitively expensive, creating a bottleneck between c

85 cycle is usually considered computationally prohibitively expensive, especially in solvated systems.

86 teins and de novo immunoassay development is prohibitively expensive, few candidate biomarkers are te

87 le rates of progression of BE to EAC, and be prohibitively expensive, from a policy perspective.

88 ively evaluating all admixture graphs can be prohibitively expensive, heuristics have been developed

89 ditional QoS makes the design of CPS systems prohibitively expensive, impractical, as well as infeasi

90 ented, in large part because the vessels are prohibitively expensive, labor-intensive to use, and are

91 s and devices for cancer diagnosis are often prohibitively expensive, limiting their reach and impact

92 treatment did not occur since miticides were prohibitively expensive, or a centralised choice was mad

93 cases and their direct simulation can become prohibitively expensive, precluding thorough analysis.

94 st hundreds of millions of dollars, which is prohibitively expensive.

95 e when employing FSM, whereas SB systems are prohibitively expensive.

96 statistically significant genomic result is prohibitively expensive.

97 at the sites, with low-incidence sites being prohibitively expensive.

98 can shift the ICER into a cost range that is prohibitively expensive.

99 thesis of each desired DNA template is often prohibitively expensive.

100 radiolabeled derivatives is laborious and/or prohibitively expensive.

101 erage, making whole genome duplex sequencing prohibitively expensive.

102 for AIDS has become more effective but also prohibitively expensive.

103 aditional control methods are impractical or prohibitively expensive.

104 that were previously either unattainable or prohibitively expensive.

105 es, large-scale experiments typically remain prohibitively expensive.

106 , and processing all patches individually is prohibitively expensive.

107 single cell or sorted cell sequencing may be prohibitively expensive.

108 he expression of recombinant proteins can be prohibitively expensive.

109 aditional hydraulic models are infeasible or prohibitively expensive.

110 rinding can accelerate cation release but is prohibitively expensive.

111 e pixel-array detectors are not available or prohibitively expensive.

112 t-principles calculations have so far proven prohibitively expensive.

113 eted Human Papillomavirus (HPV) vaccines are prohibitively expensive.

114 ber of possible secondary targets makes this prohibitively expensive.

115 A strategy of culturing all children may be prohibitively expensive.

116 s and oral valganciclovir are unavailable or prohibitively expensive.

117 screening more often than every 10 years was prohibitively expensive; annual rehydrated FOBT plus sig

118 ling of solvent and solute dynamics is often prohibitively expensive; however, the master equation of

119 s have found only limited use because of the prohibitively fast decay of their excited states.

120 However, the AAV input doses required were prohibitively high and posed serious risk of toxicity.

121 d homolysis or concerted rearrangement faces prohibitively high barriers (DeltaH(calc)/DeltaH(*)(calc

122 responding thermal reactions usually possess prohibitively high barriers and have garnered significan

123 and distal oxygen atoms of this species have prohibitively high barriers to carry out the aromatic hy

124 and new contexts is, however, limited by its prohibitively high commercial cost.

125 ure p) in porous media, and usually requires prohibitively high computational expense due to its non-

126 esis routes to produce such ceramic NWs have prohibitively high cost.

127 ly to a limited pool of chemicals or come at prohibitively high cost.

128 owing to the limited raw resource supply and prohibitively high cost.

129 ool in population-scale analyses, due to its prohibitively high cost.

130 o differences in licensure status as well as prohibitively high costs.

131 and deployment of autonomous vehicles is the prohibitively high economic and time costs required to v

132 the migratory insertion needs to overcome a prohibitively high energy barrier.

133 However, the prohibitively high energy consumption of heat-induced ev

134 tates leading to ReCH(2)CH(2)Re linkages are prohibitively high in energy.

135 ure calculations attribute this finding to a prohibitively high interconversion barrier of approximat

136 However, the prohibitively high number of possible interactions withi

137 er, conventional NMR platforms require often prohibitively high numbers of cells to achieve significa

138 wever, the materials used to date have shown prohibitively high optical losses, which are incompatibl

139 veloped therapies offering marginal gains at prohibitively high prices.

140 However, it still presents prohibitively high production costs compared to more mat

141 and severe tortuosity may place patients at prohibitively high risk or render common femoral access

142 fter high-dose conditioning regimens imposes prohibitively high risks of morbidity and mortality for

143 limited to 6 hours on the OCS system due to prohibitively high vascular resistance, edema, and worse

144 ed on utilitarian grounds-active smokers are prohibitively high-risk because of anticipated poor long

145 ked anions and Na(+) complexes are, however, prohibitively high.

146 n the hydrophobic part of the bilayer is not prohibitively high.

147 e and cost in an era where these factors are prohibitively high.

148 an RCT with HIV incidence as its outcome are prohibitively high.

149 ier for the organic base DBU was found to be prohibitively high.

150 The perception that RYGB has prohibitively-high perioperative risks among CKD patient

151 en preferred to RYGB based on perceptions of prohibitively-high perioperative risks surrounding RYGB.

152 g such additives rely on expensive reagents, prohibitively impacting the cost of recycling these inex

153 er ~10-nm spatial scales for ~1 ns, which is prohibitively impractical with QM.

154 ptics, but they have typically suffered from prohibitively incoherent emission.

155 increase, manual tracking of objects becomes prohibitively inefficient and slow, necessitating automa

156 mography have been applied to muscle but are prohibitively invasive, sensitive to motion artifact, an

157 the intake-balance method, this technique is prohibitively labor-intensive and expensive, requiring r

158 The frozen bank of allogeneic CTLs is less prohibitively labour intensive and expensive for wide sc

159 uorescence in situ hybridization (FISH), are prohibitively labour-intensive on a genomic scale.

160 nded observations, however, requires storing prohibitively large amounts of data.

161 mpler 2-methoxyethylidene system that show a prohibitively large barrier for the methoxy shift and a

162 cial and edge roughness combine to realize a prohibitively large coercivity to overcome within the Co

163 as heart failure is challenging and requires prohibitively large cohort sizes in genome-wide associat

164 y challenging because massive graphs incur a prohibitively large computational load.

165 n physics and physical chemistry, due to the prohibitively large computational resources that would b

166 aker nature of the terCBz donor results in a prohibitively large DeltaE(ST) (0.68-0.77 eV).

167 mia due to high beta cell densities creating prohibitively large diffusional distances for nutrients.

168 To avoid prohibitively large dissipation requires both preventing

169 tion about ancestral processes and producing prohibitively large files when applied to the biobank-sc

170 contain poorly tolerated elements and/or are prohibitively large for many applications.

171 or even hundreds of gigabytes of disk space, prohibitively large for many users.

172 stream approaches require a number of qubits prohibitively large for near-term hardware.

173 diverse communities traditionally requires a prohibitively large number of species-interaction coeffi

174 It is generally believed that prohibitively large pressures would be required to suppr

175 r algorithm to de novo polymer design with a prohibitively large search space.

176 The prohibitively large solution space of all possible netwo

177 Inadequate heat dissipation can lead to prohibitively large temperature rises that degrade perfo

178 ed to control a dynamical complex network is prohibitively large when there are only a few control in

179 pace of feasible RNA secondary structures is prohibitively large, and accurate prediction of function

180 o detect such interactions may be considered prohibitively large, making a meta-analysis of published

181 synonymous codons, the mRNA design space is prohibitively large-for example, there are around 2.4 x

182 of families required to do this reliably is prohibitively large.

183 to reconstruct consensus genomes can become prohibitively large.

184 cs data sets that were previously considered prohibitively large.

185 g., Et, pTol), and a Mes substituent is even prohibitively large.

186 rder (HCs with evidence of AD pathology) are prohibitively large.

187 optimization, are restricted by the current, prohibitively lengthy syntheses required to construct th

188 toxin concentrations, which can make studies prohibitively long (potentially months).

189 ause stimulating neurons one by one requires prohibitively long experiments.

190 times associated with these interactions are prohibitively long for interrogation using atomistic sim

191 The computations can become, however, prohibitively long for the change in the free energy upo

192 in high resolution and SNR without requiring prohibitively long integration times.

193 conventional optimization methods result in prohibitively long times and use of resources.

194 heorem, direct real-time simulations must be prohibitively long to achieve suitably sharp resolution

195 ransplantation in patients in countries with prohibitively long waiting times or at risk of deteriora

196 at the mobile phase to column temperature is prohibitively long.

197 0-100 mum equilibration times already become prohibitively long.

198 nomenon and the timescale for melting can be prohibitively long.

199 extinction in the absence of control may be prohibitively long.

200 We find detection accuracy to be prohibitively low in all assessments, both in terms of s

201 est that the cells themselves must then have prohibitively low internal error rates.

202 mplified shotgun libraries (LASLs), which is prohibitively low throughput, and whole-genome amplifica

203 sible only for favorable amino acids or with prohibitively low yields.

204 However, catalytic activity onsets at prohibitively negative potentials and is highly dependen

205 to use H2 as a clean source of electricity, prohibitively rare and expensive precious metal electroc

206 s been regarded as "gold standard," although prohibitively resource- and labor-intensive.

207 large-scale experimental validation remains prohibitively resource-intensive.

208 of superior design configurations, but would prohibitively rise the demand for computational resource

209 whom mechanical circulatory support would be prohibitively risky due to a hypercoagulable state, a co

210 Some argue that arboreal bipedalism was prohibitively risky for hominins whose increasingly mode

211 term toxicities can make these interventions prohibitively risky, particularly for older adults.

212 r between the two ligands was designed to be prohibitively short, so that unfavorable protein-protein

213 re optical setups and algorithms that can be prohibitively slow and complex, limiting widespread adop

214 However, complete circuit reconstruction is prohibitively slow and may not be necessary for many pur

215 This approach is often considered to be prohibitively slow and/or computationally expensive but

216 d general graph search algorithms, which are prohibitively slow as putative metabolic networks may ex

217 under conditions when spontaneous folding is prohibitively slow as to compete with other non-producti

218 stic simulations of such multiscale BRNs are prohibitively slow due to high computational cost for th

219 og K), the current implementation of CFGL is prohibitively slow even for a moderate number of genes a

220 historically been considered fast, but it is prohibitively slow for building trees from increasingly

221 ype likelihoods can reduce this bias, but is prohibitively slow for genome-wide applications.

222 flexibility, standard implementations can be prohibitively slow for large datasets and complex transc

223 only used tool for this task, RNAalifold, is prohibitively slow for long sequences, due to a cubic sc

224 cally with sequence length, and is therefore prohibitively slow for long sequences.

225 on alloy was shown to catalyze the otherwise prohibitively slow formation of abiogenic CH(4) from dis

226 te that the search for a cognate site may be prohibitively slow if a TF has a low copy number and is

227 m anoxic seawater is unlikely because of its prohibitively slow nucleation rate even in supersaturate

228 ng operation in a way that improves upon the prohibitively slow optimal serial max-finding computatio

229 First, the computational method may be prohibitively slow or difficult to implement for large d

230 al densitometry to distinguish cone types, a prohibitively slow process.

231 gand environment that resembles NHase is not prohibitively slow so as to disallow catalytic action in

232 t blood flow velocities in these vessels are prohibitively slow, non-invasive time-of-flight magnetic

233 ium halide complex (the boronate pathway) is prohibitively slow.

234 ransfer of gaseous NO2 into bulk solution is prohibitively slow.

235 ity due largely to xylose fermentation being prohibitively slower than that of glucose.

236 thin films of chiral materials are typically prohibitively small for their direct photocurrent observ

237 y is commonly unknown or they are present in prohibitively small numbers.

238 sting methods are computationally-intensive, prohibitively so in the case of nationwide biobanks.

239 omputationally expensive task, in some cases prohibitively so.

240 1,3-glucosyl dioxanium ions is thwarted by a prohibitively strong flagpole interaction of the C-2-O-b

241 ing) except in the cases where inhibition is prohibitively strong.

242 Current tools are prohibitively time consuming and do not efficiently util

243 n of the entirety of all recordings would be prohibitively time consuming and expensive.

244 robust methods such as Bayesian networks are prohibitively time consuming to apply to tens of thousan

245 This level of sensitivity could be prohibitively time consuming, but CloudBurst uses the op

246 "capture and detection" probes, which can be prohibitively time-consuming and expensive in a drug dis

247 However, manual classification can be prohibitively time-consuming and expensive, limiting how

248 quired to adequately sample diversity can be prohibitively time-consuming and expensive.

249 y insightful electrochemical measurements, a prohibitively time-consuming task when performing compre

250 As a result, instances which were once prohibitively time-consuming to solve are brought into t

251 nal methods used by existing networks become prohibitively time-consuming, so an alternative strategy

252 micrometers, making ultrastructural analysis prohibitively time-consuming.

253 es, and reconstruction procedures can become prohibitively time-consuming.

254 hic rates of communities of species is often prohibitively time-intensive and expensive.

255 of computations in the O(n(2)) algorithm is prohibitively time-intensive.

256 like B cell depletion, pan-T cell aplasia is prohibitively toxic.

257 st 5 kcal/mol higher activation barriers and prohibitively unfavorable product energies.

258 ., substrate one-electron oxidation) becomes prohibitively uphill, the ETPT pathway occurs.

259 Furthermore, these limitations scale prohibitively with increasing model size.

260 blem where computational methodologies scale prohibitively with system size.

261 However, the effect of age was not prohibitively worse, and is comparable to the effects of