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3 lution native MS analysis of 0.8- to 2.3-MDa prokaryotic 30S, 50S and 70S ribosome particles and the
4 exo- and endoribonuclease RNase J, the only prokaryotic 5'->3' ribonuclease that is commonly present
5 reveal conserved dynamical behaviors in four prokaryotic actin homologs: MreB, FtsA, ParM, and crenac
6 e majority of the conformational dynamics of prokaryotic actins can be explained by treating the four
7 ymerization dependencies of the structure of prokaryotic actins, suggesting mechanisms for how these
11 -associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a b
13 sight for understanding the evolution of the prokaryotic aldehyde dehydrogenase superfamily and their
16 embrane protein by comparing the shapes of a prokaryotic and a eukaryotic sodium/proton antiporter ho
19 ute compatible with the physiologies of both prokaryotic and eukaryotic cells and is widely synthesiz
20 ted the effect of DNA extracted from diverse prokaryotic and eukaryotic cells in tau misfolding and a
21 d utility of this approach to eliminate both prokaryotic and eukaryotic cells was demonstrated by pai
22 ning proteins execute essential functions in prokaryotic and eukaryotic cells, but their biogenesis i
23 anslocases and insertases have been found in prokaryotic and eukaryotic cells, the Sec61 complex and
27 ect of drought on the overall composition of prokaryotic and eukaryotic communities was weak, a subse
30 hort tandem repeats (STRs) are found in many prokaryotic and eukaryotic genomes, and are commonly use
32 could be recombinantly expressed by diverse prokaryotic and eukaryotic hosts and was found to co-sed
38 rovide a unified view of TA elements in both prokaryotic and eukaryotic organisms and highlight their
40 harbor a large repertoire of metabolites of prokaryotic and eukaryotic origin that play important ro
45 suggests a general mechanism by which other prokaryotic and eukaryotic regulatory proteins can be co
46 and significant differences between how the prokaryotic and eukaryotic ribosomes recognize the UBP,
52 method can be applied for precise mapping of prokaryotic and eukaryotic type II topoisomerases cleava
53 host specificity, IMG/VR v.2.0 now separates prokaryotic and eukaryotic viruses, utilizes known proph
56 er individual subunits, can be produced from prokaryotic and human expression platforms, can employ a
57 anslational control of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystem
58 ubstrate L-cysteine, a reaction catalyzed by prokaryotic and mammalian cysteinyl-tRNA synthetases (CA
61 utionary classifications, we have added more prokaryotic and plant genomes to the phylogenetic gene t
67 rsatile and high-throughput method to evolve prokaryotic aTF specificity and transfer functions in a
69 highest abundances of many genes involved in prokaryotic C degradation, ammonification, and nitrifica
70 al process of in vivo protein synthesis in a prokaryotic cell containing several thousand unique mRNA
74 the number of spacers in a CRISPR array of a prokaryotic cell which maximizes its protection against
75 CRISPR adaptive immunity pathways protect prokaryotic cells against foreign nucleic acids using CR
76 cognized by the DNA replication machinery in prokaryotic cells and reveal that Ada contributes to mut
77 l (phage) infection, a small fraction of the prokaryotic cells are able to integrate a small sequence
81 is a core biological process that occurs in prokaryotic cells at high speeds ( approximately 1 nucle
82 volutionary transitions, during which simple prokaryotic cells gave rise to complex eukaryotic cells.
84 nd lack of membrane-based DNA encapsulation, prokaryotic cells still organize and scale their nucleoi
85 ar vesicles (EVs) secreted by eukaryotic and prokaryotic cells to transport lipids, proteins, and nuc
87 nce space, performing disparate functions in prokaryotic cells, including cellular defense, cell-shap
90 RNAs that require processing for maturation, prokaryotic cellular mRNAs generally follow an 'all-or-n
93 ecies as well as genetically programming new prokaryotic chassis for a suite of fundamental and biote
96 vidence of multiple modes of organization in prokaryotic chromosomes and yield insights into the evol
97 the bulk of Earth's bacterial and archaeal ("prokaryotic") clades and to estimate their overall globa
98 , FUS, and alpha-synuclein toxicity, whereas prokaryotic ClpB and hyperactive variants were ineffecti
103 evaluated the structure and diversity of the prokaryotic communities from a range of highly saline so
104 Salinity had a secondary role in shaping prokaryotic communities in these highly saline samples s
105 cons to elucidate the attached and suspended prokaryotic community dynamics within three nonchlorinat
106 ransporters indicates that the heterotrophic prokaryotic community is geared toward the utilization o
107 elected across plant genetic groups: 3.7% of prokaryotic community members and 4.9% of fungal communi
109 tripartite SMC-kleisin complexes, including prokaryotic condensin, eukaryotic cohesin, and eukaryoti
110 We isolated a novel bacterial strain from a prokaryotic consortium associated to the psychrophilic m
111 are functionally interchangeable with their prokaryotic counterpart, TIG1 was not able to complement
113 By analogy with the better characterized prokaryotic Cu-ATPases, ATP7B is assumed to be a single-
119 l functional STING homologues encoded within prokaryotic defence islands, as well as a conserved mech
120 the recognition of foreign nucleic acids by prokaryotic defence systems involves common principles.
125 ircRNA immunity has considerable parallel to prokaryotic DNA restriction modification system that tra
128 unlabeled membrane-reconstituted Glt(Ph), a prokaryotic EAAT homologue, with millisecond temporal re
131 s we demonstrate for the first time that the prokaryotic-enriched anionic lipid Cardiolipin (CL) play
132 carboxylase and appears to have evolved from prokaryotic enzymes that bind negatively charged substra
133 ong the >120 modified ribonucleosides in the prokaryotic epitranscriptome, many tRNA modifications ar
135 r is unlike those of all other characterized prokaryotic ferritins and instead resembles an animal H-
136 Our results expand the repertoire of known prokaryotic filament-forming CCRPs and demonstrate that
137 tion to the factors discussed should improve prokaryotic gene detection and the comparability of ribo
139 e AssessORF, a new approach for benchmarking prokaryotic gene predictions based on evidence from prot
141 and consequent selection and fixation of the prokaryotic genes in the new eukaryotic setting are larg
143 graphy, Assembly, RefSeq, viral genomes, the prokaryotic genome annotation pipeline, Genome Workbench
145 lt, very few simulators are adapted to model prokaryotic genome evolution while accounting for recomb
147 ides genome quality scores for all available prokaryotic genome sequences with a user-friendly Web-in
149 usage biases are found in all eukaryotic and prokaryotic genomes and have been proposed to regulate d
150 ias is a universal feature of eukaryotic and prokaryotic genomes and plays an important role in regul
151 this problem by reconstructing 60,664 draft prokaryotic genomes from 3,810 faecal metagenomes, from
154 of new spacers during CRISPR adaptation, and prokaryotic genomes that encode Ago nucleases are enrich
155 enome evolution with comparative analysis of prokaryotic genomes to estimate the relative contributio
156 MC, Bookshelf, genome data viewer, Assembly, prokaryotic genomes, Genome, BioProject, dbSNP, dbVar, B
157 l insights into the SD sequence variation in prokaryotic genomes, identifies a simple design principl
158 earches in 101 mycobacterial and ~4500 other prokaryotic genomes, we assessed the relative conservati
159 abundant autonomous transposable elements in prokaryotic genomes, which play a key role in prokaryoti
163 es iron homeostasis in eukaryotes, while the prokaryotic homolog from Novosphingobium aromaticivorans
165 Here we present crystal structures of a prokaryotic homolog of the mammalian transporters in com
166 of ZIP2 that was based on the structure of a prokaryotic homolog, Bordetella bronchiseptica ZrT/Irt-l
167 of function, as previously reported for the prokaryotic homolog, the Erwinia chrysanthemi ligand-gat
171 free and can be produced in high yields in a prokaryotic host, such as Escherichia coli In conclusion
173 his tradeoff implies an optimal size for the prokaryotic immune repertoire in the observational range
174 and their associated (Cas) proteins encode a prokaryotic immune system that protects against viruses
176 palindromic repeats (CRISPR) machineries are prokaryotic immune systems that have been adapted as ver
178 d colleagues have expanded the repertoire of prokaryotic influence over eukaryotic physiology to incl
179 s notable evolutionary conservation with the prokaryotic insertases(4,5), suggests that eukaryotic TM
180 ertain eukaryotic intermediary processes and prokaryotic intermediary or biodegradative metabolism.
183 The emergence of eukaryotes from ancient prokaryotic lineages embodied a remarkable increase in c
185 vious studies suggest that most, if not all, prokaryotic LRS membrane proteins serve as inhibitors of
195 ound that it is sufficient to permeate model prokaryotic membranes using synchrotron x-ray diffractio
196 vely bends membranes and, when inserted into prokaryotic membranes, induces the formation of cristae-
197 short-term (within-day) thermal responses of prokaryotic metabolic rates are typically more sensitive
198 Hydrogen sulfide (H(2)S) participates in prokaryotic metabolism and is associated with several ph
199 icability of both tools, we analyzed the 139 prokaryotic metagenomes of TARA Oceans and revealed the
202 eptococcus pneumoniae NADPH oxidase (NOX), a prokaryotic model system for exploring structure and fun
203 arch on Na(+)/H(+) exchange has been done in prokaryotic models, mainly on the NhaA Na(+)/H(+)-exchan
204 d demonstrate that elements key to anaerobic prokaryotic molecular nanomachines, including Fe, V, Ni,
206 Here, we used the same strategy on another prokaryotic Na(V) channel, Na(V)Sp1, to test whether equ
214 Here we report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na(+)/substrate-bound
216 From this data set, we recovered 739,880 prokaryotic operational taxonomic units (OTUs, 16S-V4 ge
217 sposon-containing plasmid DNA, it penetrates prokaryotic or eukaryotic cells and integrates the targe
218 channels and transporters in eukaryotic and prokaryotic organisms by responding to ions or nucleotid
219 ergence of PSII, as found today in anaerobic prokaryotic organisms that use carbon monoxide as an ene
224 We identify distinct 6mA sensor domains of prokaryotic origin within the MPND deubiquitinase and AS
227 t there exist globally about 0.8-1.6 million prokaryotic OTUs, of which we recovered somewhere betwee
229 Because uncharacterized proteins involved in prokaryotic oxidative stress response are rare, we sough
231 olecular interplay between the plant and the prokaryotic partner is that, at least in certain legumes
233 from the genome in a manner identical to the prokaryotic pattern by incising 7 nt 5' and 3 or 4 nt 3'
234 sDNA-binding property different from YdbC, a prokaryotic PC4-like protein from Lactococcus lactis, bu
235 cyanobacteria opens the possibility of using prokaryotic photosynthetic cells in biotechnological app
238 assembling molecules with important roles in prokaryotic physiology with marked potential for synthet
241 es of barbiturates bound to GLIC, a cationic prokaryotic pLGIC with excellent structural homology to
243 regions of beta, designated as beta-c1, for prokaryotic production to be used in NMR spectroscopy.
244 Our findings suggest that Mcc is the first prokaryotic protein with prion properties which harnesse
247 pable of Q de novo synthesis, salvage of the prokaryotic Q precursors preQ(0) and preQ(1) also occurs
250 Here, we report a class of de novo-designed prokaryotic riboregulators that provide ultraspecific RN
251 RNase H (RNH) nascent chains stalled on the prokaryotic ribosome in vitro We found that ribosome-sta
252 differential impact of m(4)C methylation on prokaryotic ribosomes and eukaryotic mitochondrial ribos
255 also found in bacteria and archaea; whether prokaryotic Rqc2 has an RQC-related function has remaine
256 cing (PETRI-seq)-a low-cost, high-throughput prokaryotic scRNA-seq pipeline that overcomes these tech
258 istidine protein kinases (HKs) are prevalent prokaryotic sensor kinases that are central to phosphotr
259 unrecognized, but widely conserved class of prokaryotic sensory system that we refer to as the LytTR
261 ed that it was evolutionarily related to the prokaryotic serine palmitoyltransferase, identified in t
263 d for metal-responsive regulation of several prokaryotic single-component metalloregulators, and we b
264 tion crystal structure of the complete NavMs prokaryotic sodium channel in a fully open conformation.
266 ntinuous cultivation alters the structure of prokaryotic soil microbiota after soil domestication, in
267 This report of sterol essentiality in a prokaryotic species advances our understanding of sterol
269 een as a crucial process in the evolution of prokaryotic species, but until recently it was thought t
270 omponent of the respiratory chain of diverse prokaryotic species, including pathogenic bacteria.
271 an occur among genomes belonging to the same prokaryotic species, with only a fraction of genes being
273 r loop cysteine and FXN binding, and why the prokaryotic system does not require a similar FXN-based
274 ry histories with proteins involved in a few prokaryotic systems and a multitude of eukaryotic proces
275 Spatially organized molecular components in prokaryotic systems imply compartmentalization without t
278 o the suicidal THI4 pathway: (i) nonsuicidal prokaryotic THI4s that lack the active-site Cys residue
279 Here, we present the crystal structure of a prokaryotic TMEM175 channel from Chamaesiphon minutus, C
280 activated by MtPrpR, a member of a family of prokaryotic transcription factors whose structures and m
283 foundly impact the evolution and function of prokaryotic translation initiation and other RNA-mediate
288 on of an iron-dependent mechanism regulating prokaryotic tryptophan biosynthesis that may indicate th
289 data support the identification of the first prokaryotic two-component protein system related to the
290 to these lipids, while plastidial lipids of prokaryotic type were characterized by the overwhelming
291 -incision patterns have been discovered: the prokaryotic type, which removes the damage in 11-13-nucl
292 defensin) protein; and the first report of a prokaryotic-type ribosomal protein in a eukaryotic virus
293 to as pupylation, the covalent attachment of prokaryotic ubiquitin-like protein Pup to lysine side ch
294 or antimicrobial drug discovery if issues of prokaryotic versus eukaryotic selectivity and antibiotic
295 dy, deep sequencing was used to characterize prokaryotic viral communities associated with honey bees
299 roteins are commonly found in eukaryotic and prokaryotic viruses, where they play important roles in
300 fold centred around Emc3 that resembles the prokaryotic YidC insertase and that delineates a largely