ライフサイエンスコーパス: proliferative capacity

1 ls of exhaustion markers, and display robust proliferative capacity.

2 wann cells display a transient diminution of proliferative capacity.

3 y can always acquire mutations that increase proliferative capacity.

4 Functionally, AD cells gained transient proliferative capacity.

5 ead to a long-lived memory state with potent proliferative capacity.

6 self-renewability, enhanced multipotency and proliferative capacity.

7 compared with blood, suggesting a diminished proliferative capacity.

8 th KIR2DS2(-) NK cells, independent of their proliferative capacity.

9 ry-associated polyfunctionality and enhanced proliferative capacity.

10 lls also had different memory phenotypes and proliferative capacity.

11 y, allowing analyses of their clonogenic and proliferative capacity.

12 rs, limited cytokine production, and reduced proliferative capacity.

13 MCMV challenge, in part due to a diminished proliferative capacity.

14 es, and their entire T cell pool had reduced proliferative capacity.

15 d from the cell cycle and lost most of their proliferative capacity.

16 with increased endogenous GLS2 and restored proliferative capacity.

17 functions in cancer cells might limit their proliferative capacity.

18 arker, suggesting that cells have lost their proliferative capacity.

19 s evidenced by higher cytokine secretion and proliferative capacity.

20 thro-megakaryocytic precursors with enhanced proliferative capacity.

21 scent cells with longer telomeres and higher proliferative capacity.

22 uppression may be inversely related to their proliferative capacity.

23 tention of CD34(+) progenitors with enhanced proliferative capacity.

24 effects of canonical Wnt signaling on their proliferative capacity.

25 ssociated with cancer, a disease of enhanced proliferative capacity.

26 s (HCECs) and contributes to their decreased proliferative capacity.

27 The product was only noted in cells with low proliferative capacity.

28 videnced by increased cytokine secretion and proliferative capacity.

29 ction of SM-myosin heavy chain and increased proliferative capacity.

30 d cell population capable of retaining their proliferative capacity.

31 table, but essentially irreversible, loss of proliferative capacity.

32 n of two properties: pluripotency and a high proliferative capacity.

33 oduction, electron transport efficiency, and proliferative capacity.

34 trical stimuli is influenced by the cellular proliferative capacity.

35 ecially T-bet(+) ILC3s, and diminished their proliferative capacity.

36 in IESCs, we observe significantly increased proliferative capacity.

37 f two properties: pluripotency and unlimited proliferative capacity.

38 an important role in the regulation of their proliferative capacity.

39 idence of thymopoiesis, and sustained T-cell proliferative capacity.

40 wing tumor cells with augmented survival and proliferative capacities.

41 dissimilar morphologies and self-renewal and proliferative capacities.

42 t in integrin beta5 have lower migration and proliferative capacities.

43 n protein production and increase the cell's proliferative capacities.

44 ntiated effector memory cells with preserved proliferative capacity, a finding confirmed by in vitro

45 vascular smooth muscle cells, but given low proliferative capacity, a significant effect of the vari

46 ove through the oncogenic process of gaining proliferative capacity, acquiring angiogenic, invasive,

47 f the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's

48 m Utox+ meth users had a significantly lower proliferative capacity after stimulation with a number o

49 ction of ribosomes and a failure to maintain proliferative capacity after stimulation.

50 oil was tested for its cytotoxicity and anti-proliferative capacity against LoVo and HepG2 cancer cel

51 ing aging despite heterogenous reductions in proliferative capacity, allowing aged muscle to mount a

52 uorescence, gene and protein expression, and proliferative capacity analysis.

53 gest that most ganglionic cells retain their proliferative capacities and postpone differentiation.

54 llus organoid cultures revealed an increased proliferative capacity and a lowered cyclooxygenase 2 (C

55 y competent, demonstrating a normal in vitro proliferative capacity and a preserved ability to produc

56 nduced a multifunctional CD4 population with proliferative capacity and ability to secrete interleuki

57 epithelial cells, epithelial cells' limited proliferative capacity and absence of cell lines.

58 that are already characterized by increased proliferative capacity and aggressive tumorigenic phenot

59 f the c-myb gene leads to a slightly reduced proliferative capacity and an aberrant and accelerated d

60 have decreased migratory prowess and reduced proliferative capacity and an altered cytokine/growth fa

61 CQL4 in BLM-deficient cells leads to reduced proliferative capacity and an increased frequency of sis

62 IC)-infected melanocytes displayed increased proliferative capacity and biological features more remi

63 ant contributor to sarcoidosis CD4(+) T-cell proliferative capacity and clinical outcome.

64 finite lifespan in culture that limits their proliferative capacity and clinical use.

65 Their proliferative capacity and cytokine production (IFN-gamm

66 ed tumor-infiltrating Tregs and restores the proliferative capacity and cytokine production of CD4+CD

67 in CD8(+) T cells increased the generation, proliferative capacity and cytotoxicity of Tim-3(+) cell

68 epitope-specific T cells displayed enhanced proliferative capacity and delayed cytokine kinetics.

69 uration of these interactions may affect the proliferative capacity and differentiation of the activa

70 E also contains Sox2(+) cells with sustained proliferative capacity and disrupted pituitary different

71 ficient, terminally mature NK cells retained proliferative capacity and exhibited heightened reconsti

72 AT1-deficient CD4(+) T cells maintain higher proliferative capacity and expression of effector cytoki

73 asp2(-/-) tumor cells displayed an increased proliferative capacity and extensive aneuploidy that coi

74 mbryonic stem cells (ESCs) have an unlimited proliferative capacity and extensive differentiation cap

75 rogenitors is required for maintaining their proliferative capacity and for the production of proper

76 Neutrophils are deprived of proliferative capacity and have a tightly controlled lif

77 ine-mediated priming phase, and enhanced the proliferative capacity and hepatic regeneration ratio in

78 ific CD4(+)CD25(+)FoxP3(-) T cells with high proliferative capacity and IFN-gamma production, indicat

79 ng immune function in NOD2(-/-) mice, T cell proliferative capacity and IL-2 production were not impa

80 ure to activate Treg telomerase may restrict proliferative capacity and increase apoptotic susceptibi

81 h together programmed their robust secondary proliferative capacity and interferon-gamma (IFN-gamma)-

82 trated that MSCs in ITP patients had reduced proliferative capacity and lost their immunosuppressive

83 ellular state of the NSC by preserving their proliferative capacity and modulating their cell cycle p

84 populations, these lymphocytes had increased proliferative capacity and more efficiently reconstitute

85 e-cell sequencing, directly demonstrated the proliferative capacity and multipotency of this populati

86 of postnatal blood vessels, possessing high proliferative capacity and potential to generate endothe

87 are endothelial precursor cells with a high proliferative capacity and pro-angiogenic potential.

88 lymphoid organ Tregs had significant ex vivo proliferative capacity and produced cytokines like inter

89 egulator of ILC2 bioenergetics that controls proliferative capacity and proinflammatory functions pro

90 ed insulin secretion can result from reduced proliferative capacity and reduced islet function.

91 ho kinase inhibitor, greatly increased their proliferative capacity and resulted in efficient immorta

92 e marrow progenitor cells leads to increased proliferative capacity and survival, as well as a partia

93 sociated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying i

94 We assessed proliferative capacity and telomere length using flow-fl

95 intenance of HSCs by directly reducing their proliferative capacity and that IFN-gamma impairs restor

96 genitor cells, which were required to retain proliferative capacity and to prevent premature differen

97 ck-in megakaryocyte progenitors have reduced proliferative capacity and undergo increased cell death,

98 n Abi3bp shRNA construct, displayed a higher proliferative capacity and, under differentiating condit

99 activity, p16, and p53 expression and lower proliferative capacity), and an increased PGE2, IL-6, IL

100 e fact that cancer cells are known for their proliferative capacity, and adult cardiomyocytes are, ex

101 a hallmark of cancer, a disease of enhanced proliferative capacity, and aneuploid cells are frequent

102 exhibits markedly altered cytoarchitecture, proliferative capacity, and degree of cell death.

103 ion of reactive oxygen and nitrogen species, proliferative capacity, and glycolytic enzyme levels.

104 e present study, we evaluated the viability, proliferative capacity, and in vivo engraftment of myoge

105 hibited decreased Th1 cytokine secretion and proliferative capacity, and reduced Lck expression.

106 other hPAFc subunits, alters the morphology, proliferative capacity, and tamoxifen sensitivity of ERa

107 timal cell size whereby cellular fitness and proliferative capacity are maximized.

108 ts (MEFs) lacking Tm5NM1, which have reduced proliferative capacity, are insensitive to inhibition of

109 In addition, proliferative capacity as well as markers of injury and

110 e that consumed ethanol (EtOH) had a reduced proliferative capacity as well as the ability to kill IA

111 pairment of resident cardiac progenitor cell proliferative capacity associated with altered canonical

112 ther suggesting persistence of cardiomyocyte proliferative capacity beyond the perinatal period.

113 s accompanied by restoration of keratinocyte proliferative capacity both in vivo and in vitro and by

114 on of p27(kip1) in Hrd1-null T-cells rescues proliferative capacity but not the production of cytokin

115 Dysfunctional telomeres limit cellular proliferative capacity by activating the p53-p21- and p1

116 ter fourth transfection increased fibroblast proliferative capacity by an additional 15.2 +/- 1.1 PDs

117 Cancer cells acquire unlimited proliferative capacity by either re-expressing telomeras

118 e further determined that N1ICD maintains EC proliferative capacity by increasing mitochondrial mass

119 A trend towards increased proliferative capacity by pathogenic ovine isolates was

120 We conclude that PDH-KO cells maintain proliferative capacity by utilizing glutamine to supply

121 cadherin transition (N-Cadh(low+)); retained proliferative capacity (c-myc(+)); irregular stemness (S

122 of gene expression reflecting differences in proliferative capacity, cell adhesion functions and mito

123 Furthermore, the proliferative capacity (cellular output) of individual a

124 use myeloid progenitors that showed enhanced proliferative capacity compared to cells transduced with

125 asts from R258C patients exhibited increased proliferative capacity compared with controls, consisten

126 ilution assay was used for the assessment of proliferative capacity comparing T cell-dependent and T

127 iPSCs produced myeloid cells with increased proliferative capacity, constitutive activation of granu

128 Loss of proliferative capacity correlated with a switch from the

129 r mixed-effects model analyses show that the proliferative capacity, cytokine production, and kinetic

130 o association between antiviral efficacy and proliferative capacity, cytotoxicity, polyfunctionality,

131 cells are counterbalanced by their increased proliferative capacity, driving the efficacy of the RTE

132 rneal endothelial cells (HCECs) have limited proliferative capacity due to "contact-inhibition" at G1

133 majority of HIV-specific CD8(+) T cells lose proliferative capacity during chronic infection, T cells

134 chronic stimulation retained functional and proliferative capacity during latency and subsequent rea

135 ts were able to recover their morphology and proliferative capacity during prolonged culture in mediu

136 Lymphocytes with reduced proliferative capacity exhibited increased proliferation

137 efforts to generate mature hepatocytes with proliferative capacity for cell-based therapeutics and f

138 that giant Hodgkin and RS cells have little proliferative capacity, further supporting small mononuc

139 To test the effect of oxidative stress on proliferative capacity, HCECs cultured from young donors

140 KT cells that probably impart differences in proliferative capacity, homing, and effector functions.

141 ype counterparts, these cells show increased proliferative capacities in response to polyclonal stimu

142 idermal DeltaNp63alpha expression along with proliferative capacity in a conditional FIH-1 transgenic

143 er, differentiated melanocytes may also have proliferative capacity in animals, and the potential for

144 CD25+ cells exhibited a striking increase in proliferative capacity in coculture with CD4 T cells tha

145 ce limitations to mitochondrial function and proliferative capacity in tendon-derived fibroblasts, re

146 Cardiomyocytes retain some proliferative capacity in the neonates but lose it in ad

147 EryP progenitors exhibited remarkable proliferative capacity in the yolk sac immediately befor

148 the goal of identifying targets to heighten proliferative capacity in this setting.

149 tional cell lines decreases self-renewal and proliferative capacity in vitro and tumor initiation and

150 evel of mitochondrial metabolism and reduced proliferative capacity in vitro, compared with controls.

151 memory cells, which are long-lived and high proliferative capacity, in the T cell zone of the spleen

152 Proliferative capacity increased in a dose-dependent man

153 These cells have decreased proliferative capacity, increased activation of senescen

154 en and CNS of these mice displayed decreased proliferative capacity, increased apoptosis, and up-regu

155 Tumor proliferative capacity is a major biological correlate o

156 egulatory relationships can unleash enhanced proliferative capacity is dependent upon the coupling of

157 clones exhibit lateral migration, and their proliferative capacity is supported by Pdgfra+ fibroblas

158 Although proliferative capacity is the strongest single discrimin

159 in vivo The expression of Ki67, a marker of proliferative capacity, is predictive of expression of v

160 ingly, Notch-active beta cells had increased proliferative capacity, leading to increased but dysfunc

161 BE3A-mediated SIRT6 degradation promoted the proliferative capacity, migration potential, and invasiv

162 lasma LPS in vivo significantly alter T cell proliferative capacity, monocyte cytokine release, and H

163 Their proliferative capacity must be tightly regulated to prev

164 oliferation throughout life, deciphering why proliferative capacity normally dissipates in adult mamm

165 Highest proliferative capacity observed for C(alc) (147.0% +/- 3

166 Age-dependent and topographical decreases in proliferative capacity observed in HCECs resulted, at le

167 ngs suggest that the self-renewal and robust proliferative capacities of memory T cells are associate

168 rming assays reveal that the engraftment and proliferative capacities of TECs diminish early in life,

169 ntreated cells, whereas the morphologies and proliferative capacities of the endothelial cells were n

170 is associated with a massive decline of the proliferative capacities of the stem cell niche in the a

171 The morphology, the self-renewal and proliferative capacities of the subclones differed.

172 Telomere shortening limits the proliferative capacity of a cell, but perhaps surprising

173 rating pool and the number of divisions, the proliferative capacity of a significant proportion of HI

174 e cardiac regeneration in mammals is the low proliferative capacity of adult cardiomyocytes.

175 th hypoxic cell growth, thereby limiting the proliferative capacity of adult cells under low oxygen t

176 lucidating the mechanism underlying the poor proliferative capacity of adult pancreatic beta-cells is

177 This restraint might be because of the poor proliferative capacity of aged donor hepatocytes or the

178 l, our data indicate that the intrinsic over-proliferative capacity of APC(-/-) cells is not uncontro

179 MOZ was required to maintain the proliferative capacity of B-cell progenitors, even in th

180 Neocortex expansion is largely based on the proliferative capacity of basal progenitors (BPs), which

181 proliferation while having no effect on the proliferative capacity of beryllium-responsive CD4(+) T

182 circulating blood cell counts and increased proliferative capacity of bone marrow derived cells.

183 ) (Cdkn1a), a factor associated with reduced proliferative capacity of both hematopoietic and neurona

184 We conclude that the aberrant proliferative capacity of Brca1(-/-) luminal progenitor

185 Examination of the proliferative capacity of C/EBPalpha-S193A livers showed

186 SF does not impair the antitumor function or proliferative capacity of CAR T-cells in vitro We conclu

187 is a form of cellular aging that limits the proliferative capacity of cells.

188 ion resulted in significant reduction in the proliferative capacity of cells.

189 rimarily reflects increases in abundance and proliferative capacity of cortical progenitors and in th

190 The proliferative capacity of CSP cells was also tested afte

191 e single-cell pick-up assay, we examined the proliferative capacity of cultured PGCs in response to W

192 onship between prometaphase duration and the proliferative capacity of daughter cells.

193 ase not only in the percentages but also the proliferative capacity of different populations of cardi

194 The proliferative capacity of differentiated acinar cells ma

195 stem cells, and its set point determines the proliferative capacity of differentiated cell lineages b

196 helial NO synthase coupling and enhanced the proliferative capacity of ECs and circulating endothelia

197 ion and hypoplasia, accompanied by a reduced proliferative capacity of epidermal progenitor cells.

198 t premature differentiation and sustains the proliferative capacity of epidermal stem and progenitor

199 e data identify Yap1 as a determinant of the proliferative capacity of epidermal stem cells and as an

200 The proliferative capacity of HIV- and PPD-specific response

201 kade of the IL-10 pathway augmented in vitro proliferative capacity of HIV-specific CD4 and CD8 T cel

202 -1 and 2B4 inhibitory pathways increased the proliferative capacity of HIV-specific CD8(+) T cells.

203 The proliferative capacity of HIV-specific CD8+ T cells was

204 simplicity of this system and the unlimited proliferative capacity of Hoxb8-FL cells will enable stu

205 tein expression can be used to determine the proliferative capacity of hPSC-derived cardiomyocytes.

206 Specifically, ANG reduces the proliferative capacity of HSPC while simultaneously incr

207 Telomere shortening limits the proliferative capacity of human cells, and age-dependent

208 pe will be required in order to exploit high proliferative capacity of human embryonic stem cells and

209 downstream of Dvl2 cooperate to maintain the proliferative capacity of human glioblastomas.

210 uld represent a mechanism that moderates the proliferative capacity of human hippocampal progenitors,

211 al differentiation markers and increases the proliferative capacity of human primary keratinocytes.

212 This segregation coassociated with the proliferative capacity of iNKT cells between the 2 group

213 As the proliferative capacity of interstitial macrophages decli

214 ceptor signaling is required to maintain the proliferative capacity of ISCs.

215 The proliferative capacity of Ki-67+ perivascular macrophage

216 The ex vivo proliferative capacity of M. tuberculosis-specific CD4 T

217 possible mechanism contributing to impaired proliferative capacity of M. tuberculosis-specific CD4 T

218 transport iron and that their absence limits proliferative capacity of mammalian cells.

219 genesis but necessary for achieving the full proliferative capacity of MCs.

220 ven partial inhibition of MOZ may reduce the proliferative capacity of MEIS1, and HOX-driven lymphoma

221 The proliferative capacity of melanoma cells was suppressed

222 nes (including BCL2) and resulted in reduced proliferative capacity of melanoma cells.

223 mice are characterized by limited number and proliferative capacity of MK progenitors.

224 Ectopic FOXM1 rescues the proliferative capacity of MYC- or p53-mutant cells in sp

225 Here, we report that the proliferative capacity of MYC-driven normal and neoplast

226 ber explants demonstrated an increase in the proliferative capacity of myofiber-associated satellite

227 tent with a model in which exhaustion of the proliferative capacity of naive T cells causes a sharp d

228 ment to control the exit from quiescence and proliferative capacity of NB as well as neuron productio

229 A more robust in vitro proliferative capacity of nCPCs, compared with aCPCs, co

230 ed Notch1 or its ligand Jagged1 expanded the proliferative capacity of neonatal cardiomyocytes; this

231 region-specific sets of genes to control the proliferative capacity of neural progenitors, ensuring t

232 e reported that FoxO maintains the long-term proliferative capacity of neural stem/progenitor cells (

233 a distinct downstream effectors to alter the proliferative capacity of NPCs.

234 We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro an

235 liferate, but blockade of B7-H1 restored the proliferative capacity of old CD8(+) T cells to a level

236 Increased proliferative capacity of outer progenitors is further p

237 ations of mouse epidermis robustly increases proliferative capacity of p63(+) epidermal progenitor ce

238 n of B cell memory; instead, SpA reduced the proliferative capacity of PCs that entered the BM, dimin

239 Instead, miR-17~92 increased the proliferative capacity of Rb/p107-deficient retinal cell

240 ve neonatal hypocellularity due to decreased proliferative capacity of rescued apical and outer radia

241 ring rechallenge, indicating that the robust proliferative capacity of RTEs was maintained independen

242 Despite their compromised proliferative capacity of RUNX1S291fs/Ezh2-null MDS cell

243 of Sox2(+) cells and suggest that persistent proliferative capacity of Sox2(+) cells may underlie the

244 Short telomeres block the proliferative capacity of stem cells, affecting their po

245 are driven by cell-intrinsic changes in the proliferative capacity of TECs, and further show that yo

246 required for the metabolic reprogramming and proliferative capacity of Th17 cells.

247 transcriptional activator, conferring higher proliferative capacity of the affected cells.

248 sion of any one of these lncRNAs reduces the proliferative capacity of the cells.

249 ines of evidence have challenged the lack of proliferative capacity of the differentiated cardiomyocy

250 To sustain the proliferative capacity of the epidermis, HNRNPK is neces

251 tor for PCO in this study, whereas intrinsic proliferative capacity of the individual's lens epitheli

252 epithelia; blocking this pathway reduces the proliferative capacity of the intestinal stem cells.

253 lammatory response, and the regenerative and proliferative capacity of the intestine following an acu

254 role for this orphan GPCR in regulating the proliferative capacity of the intestine.

255 T cells completed, no change in the per cell proliferative capacity of the remaining Ag-specific T ce

256 somatic mosaicism correlates poorly with the proliferative capacity of the tissue and rates of cell t

257 eir telomere length set point determines the proliferative capacity of their differentiated progeny.

258 in true naive T cell precursors and impaired proliferative capacity of their VM cousins--combine to r

259 In addition, the proliferative capacity of these NCC is also diminished.

260 CAM-1 expression is abolished, the secondary proliferative capacity of these T cells is severely curt

261 the formation of neurospheres, affected the proliferative capacity of transformed neurons and reduce

262 liferating conventional T cells, whereas the proliferative capacity of Treg cells in cell cultures re

263 Signaling mechanisms that maintain the proliferative capacity of VZ resident progenitors remain

264 lation doublings, its deficiency impairs the proliferative capacity of WI-38 cells.

265 in normal stratifying epithelia to maintain proliferative capacity or drive proliferation of squamou

266 ing livers showed little initial evidence of proliferative capacity or function.

267 LiPs in long-term culture did not lose their proliferative capacity or their hepatic differentiation

268 stigates the effects of aspirin (ASA) on the proliferative capacity, osteogenic potential, and expres

269 ed colony formation (p < 0.02), differential proliferative capacity (p < 0.001) and reduced NO bioava

270 ignificantly associated with increased tumor proliferative capacity (p = 0.0238) and borderline with

271 lymph node metastases (p = 0.0571) and tumor proliferative capacity (p = 0.0576).

272 however, values of the majority of capillary proliferative capacity parameters (ie, cell area, networ

273 with several plasma-treated, cord blood ECFC proliferative capacity parameters in the combined HIV-po

274 IncuCyte live cell imaging of 8 capillary proliferative capacity parameters were obtained from cor

275 ar stress has been associated with a loss in proliferative capacity (premature senescence) of corneal

276 d determined the effects of acrolein on cell proliferative capacity, senescence-associated beta-galac

277 in nuclear 8-OHdG staining and a decrease in proliferative capacity similar to that observed in untre

278 tment on the microarray and a reduced lympho proliferative capacity, suggesting clear differences in

279 TCM exhibit greater plasticity and proliferative capacity than effector memory T cells (TEF

280 process postinjury, despite having a higher proliferative capacity than large airway epithelial cell

281 d and third transfections had less effect on proliferative capacity than the first, revealing a refra

282 antigen-specific T cells display an impaired proliferative capacity that is caused by increased expre

283 pulation was stable over time and retained a proliferative capacity that was vastly superior to TEFF.

284 Indeed, their short lifespan, the absent proliferative capacity, their limited ability to produce

285 es of VZV-specific CD4(+) T cells, including proliferative capacity to VZV antigen stimulation and id

286 , but they exhibited a significantly reduced proliferative capacity upon secondary challenge while re

287 s of IkappaBepsilon in B cells; it regulates proliferative capacity via at least two mechanisms invol

288 When transplanted into athymic rat hearts, proliferative capacity was lower for nodal-like than wor

289 Cord blood ECFC proliferative capacity was significantly impaired by pla

290 t M. tuberculosis-specific degranulation and proliferative capacities were impaired in the HIV-infect

291 CPC differentiation, whereas CPC number and proliferative capacity were increased.

292 tact phagocytosis, and lymphocyte counts and proliferative capacity were normal.

293 perforin/granzyme-mediated cytotoxicity and proliferative capacity were not affected by APG101 treat

294 One subtype was defined by reduced proliferative capacity, whereas the other two subtypes (

295 omeres develop increased damage with reduced proliferative capacity, which suggests an important role

296 stimulated through the TCR displayed reduced proliferative capacity, which was restored by inhibiting

297 lls reduce their intercellular adhesions and proliferative capacity while gaining a mesenchymal pheno

298 pH for approximately 3 months restored their proliferative capacity while maintaining the cytoplasmic

299 to act as cryptic progenitors and reacquire proliferative capacity within the context of mucosal inj

300 d of extending telomeres and increasing cell proliferative capacity without risk of insertional mutag