ライフサイエンスコーパス: proliferative effect

1 hibits MMP activity, has no significant anti-proliferative effect.

2 ro IGF-I induced both an antiapoptotic and a proliferative effect.

3 tase, which appeared to be essential for the proliferative effect.

4 polyphosphate levels and abrogates the anti-proliferative effect.

5 in they undergo apoptosis, counteracting the proliferative effect.

6 prediabetes overlaps with, and negates, its proliferative effects.

7 atherosclerotic, anti-inflammatory, and anti-proliferative effects.

8 t-dependent, manifesting both inhibitory and proliferative effects.

9 alonate pathway with a statin attenuated pro-proliferative effects.

10 nt but does not significantly alter the anti-proliferative effects.

11 reonine kinase which has anti-viral and anti-proliferative effects.

12 rr virus (EBV) oncogenes exert potent B cell proliferative effects.

13 ects of insulin, whereas IR-A rather signals proliferative effects.

14 thetic lethality with antibody-mediated anti-proliferative effects.

15 eta-cells versus possible adverse pancreatic proliferative effects.

16 that this property is essential to its anti-proliferative effects.

17 n EMCA cells and observed cytotoxic and anti-proliferative effects.

18 ogenous PR abrogated progestin-mediated anti-proliferative effects.

19 These ligands exhibits anti-proliferative effect against the PC-3 and DU-145 cells (

20 ptide mimetic that exhibits significant anti-proliferative effects against erbB-2-dependent breast ca

21 1/2 plus autophagy displays synergistic anti-proliferative effects against PDA cell lines in vitro an

22 ts and vegetables, has shown remarkable anti-proliferative effects against various malignant cell lin

23 This protein also exhibits proliferative effects, although little is known about th

24 in either order resulted in synergistic anti-proliferative effects, although the mechanism of synergy

25 e E (GE) was found to exhibit excellent anti-proliferative effects among the tested xanthones.

26 r transcription factor, which possesses anti-proliferative effects and is frequently silenced in ovar

27 cytes is a pathway by which Shh produces its proliferative effects and offers a potential therapeutic

28 The anti-proliferative effects and related changes in cell cycle

29 The anti-proliferative effects and the selective killing of HSCs,

30 s, such as rheumatoid arthritis, without the proliferative effect associated with traditional estroge

31 f rheumatoid arthritis without the classical proliferative effects associated with estrogens.

32 ression of MAST1 or MAST2 gene fusions has a proliferative effect both in vitro and in vivo.

33 ective inhibitor of CARM1 that exhibits anti-proliferative effects both in vitro and in vivo and, to

34 the permissive temperature does not exert a proliferative effect but causes p53-mediated apoptosis,

35 in the liver can have both antiapoptotic and proliferative effects, but it is unclear which liver cel

36 Progesterone did not alter E2's proliferative effects, but testosterone reduced E2-induc

37 ve glucose homeostasis, TZDs also exert anti-proliferative effects by a mechanism that is unclear.

38 e results suggest that adiponectin can exert proliferative effects by activating Ras signaling pathwa

39 at quinoxaline antibiotics could exert anti- proliferative effects by inhibition of chromosomal DNA r

40 t anti-inflammatory, anti-apoptotic and anti-proliferative effects by modulating intracellular signal

41 al CDK4/6 degradation produced enhanced anti-proliferative effects compared to CDK4/6 inhibition, CDK

42 y and G(2)-M phase to contribute to its anti-proliferative effect, degradation of activated Akt and B

43 stinct hormonal context, having pro- or anti-proliferative effects, depending on the estrogen/progest

44 uses p53-mediated apoptosis, i.e., the tal-1 proliferative effect depends on the integrity of the cel

45 pathways correlates with a significant anti-proliferative effect, due to cell-cycle regulation leadi

46 However, the casual link between cell proliferative effects during liver regeneration and meta

47 We also evaluated the anti-proliferative effects (IC(50)) of these samples on tripl

48 s mediate prominent differentiative and weak proliferative effects; (iii) the antiproliferative and a

49 IGF-I receptor alone but had an even greater proliferative effect in cells overexpressing both the IG

50 CDO had a potent anti-proliferative effect in colorectal cell lines, yet, a si

51 that TM is not cytotoxic, but exerts an anti-proliferative effect in ECC-1 cells.

52 these in males commensurate with a decreased proliferative effect in male hPASMCs.

53 Ectopic expression of BLM causes anti-proliferative effect in p53 wild type, but not in p53-de

54 PPARgamma has an anti-proliferative effect in pre-adipocytes and mammary epith

55 the DDM exhibiting a strong synergistic anti-proliferative effect in the ES2 and the TOV21G cells.

56 have been associated primarily with an anti-proliferative effect in vitro and in vivo.

57 KLF5 has a pro-proliferative effect in vitro and is induced by mitogeni

58 lism or activity level and exhibited an anti-proliferative effect in vitro.

59 ins of BRD4, have been shown to exhibit anti-proliferative effects in a range of malignancies.

60 d PL and TRAIL demonstrated significant anti-proliferative effects in a triple-negative breast cancer

61 Acid exerts pro-proliferative effects in Barrett's-associated esophageal

62 fore and during the treatment suggested that proliferative effects in BM may have preceded effects on

63 ve metabolite of vitamin D(3), mediates anti-proliferative effects in cells by regulating the express

64 synthetic processing intermediates also have proliferative effects in colonic mucosa and in some oeso

65 l program causes potent, NOTCH-specific anti-proliferative effects in cultured cells and in a mouse m

66 This is associated with anti-apoptotic and proliferative effects in epithelial progenitors, whereas

67 hese data indicate that Nef induces multiple proliferative effects in podocytes in culture and that n

68 ate that a key event in the artemisinin anti-proliferative effects in prostate cancer cells is the tr

69 nstrated previously to have significant anti-proliferative effects in several leukemia models.

70 ing human amphiregulin was examined for anti-proliferative effects in the human skin-severe combined

71 receptor (ER)-beta is thought to exert anti-proliferative effects in the normal prostate but support

72 verexpression of the H30N enzyme causes anti-proliferative effects in vitro and anti-tumor effects in

73 ignaling pathways mediating CAMKII-dependent proliferative effects in vivo are poorly understood.

74 These early-age neurotrophic and neurogenic (proliferative) effects in the Arg-61 mouse may be an ina

75 In addition, the proliferative effects induced by E2 and G-1 in these cel

76 ZD4547 (1-5 microM) demonstrated potent anti-proliferative effects, inhibition of stemness, and suppr

77 ement of neuronal nitric-oxide synthase, the proliferative effect is mediated via an NO/cyclic guanos

78 Dexamethasone-induced anti-proliferative effects may confer protection from radioth

79 y through which estrogen, independent of its proliferative effect, may induce heparanase overexpressi

80 rapamycin pathway and/or by facilitating the proliferative effect mediated by growth factors such as

81 Ras (N17) failed to significantly reduce the proliferative effect mediated by the sst(4) receptor but

82 PI3K effectors, it is able to reproduce the proliferative effect of activated Ras.

83 Anti-proliferative effect of AICAR is mediated through activa

84 The objective was to compare the anti-proliferative effect of anthocyanin-rich plant extracts

85 The anti-proliferative effect of asTORi in vitro and in vivo is t

86 vestigated whether TGFbeta mediates the anti-proliferative effect of atRA and BMS453 in normal breast

87 The pro-proliferative effect of BDNF was attenuated by TrkB kina

88 However, the proliferative effect of Bmp signaling appears to be inde

89 teins (cdk6R31C) was found to inactivate the proliferative effect of cdk6 and increase cytoplasmic lo

90 The anti-proliferative effect of CO in vitro requires the activat

91 gainst IGF-II to cell cultures inhibited the proliferative effect of CRD-BP knockdown, suggesting tha

92 rather than c-myc mRNA levels, mediates the proliferative effect of CRD-BP knockdown.

93 The proliferative effect of elevated [Ca2+]o was associated

94 The proliferative effect of estradiol requires the availabil

95 id (EPA, C20:5) shifted the pro-survival and proliferative effect of estrogen to a pro-apoptotic effe

96 To further test the proliferative effect of FGF-4 in cardiac cushion expansi

97 Thus, the proliferative effect of fibronectin in combination with

98 FK506 competitively reversed the proliferative effect of FK1012 but had no influence on t

99 tes is unclear, we hypothesize that the anti-proliferative effect of FOXO3 was dependent on lowering

100 In addition, the proliferative effect of GRP on neuroblastoma cells (SK-N

101 /Akt pathway, at least in part, mediates the proliferative effect of HIMF.

102 are interchangeable for IRS to transduce the proliferative effect of IL-4.

103 ed the antiapoptotic effect of IGF-I and the proliferative effect of IL-6 in the myeloma cell lines.

104 Here we show that the proliferative effect of IL-7 is more pronounced on CD4(+

105 ing the renewal of T cells by inhibiting the proliferative effect of IL-7.

106 tivity is necessary for the IRS-1/2-mediated proliferative effect of IL-9 and IL-4, Akt activation is

107 effect of FK1012 but had no influence on the proliferative effect of interleukin 3.

108 These results demonstrate the marked proliferative effect of intravenously infused EGF in the

109 Bilateral nephrectomy did not diminish the proliferative effect of KGF on urothelium, suggesting th

110 R2 receptor-blocking antibody prevented the proliferative effect of low-dose TNF-alpha.

111 H]thymidine incorporation, thus ruling out a proliferative effect of malignant cells on the surroundi

112 not dorsal growth, and that it mediates the proliferative effect of midline N signaling in a ventral

113 anslation in polysomes, and reduces the anti-proliferative effect of mTOR kinase inhibitors.

114 This proliferative effect of NECA was inhibited by the additi

115 ts is one possible mechanism to modulate the proliferative effect of Notch in the committed osteoblas

116 l rat hippocampal cultures, we show that the proliferative effect of NPY on nestin(+) precursor cells

117 significantly suppressed, confirming an anti-proliferative effect of PAI-2.

118 flammatory cytokines in vivo can inhibit the proliferative effect of PDGF on human RPE and, at the sa

119 Formation of heterodimers enhances the anti-proliferative effect of PF4 on endothelial cells in cult

120 Here we report a direct proliferative effect of platelets on cancer cells both i

121 The proliferative effect of platelets was not dependent on d

122 The proliferative effect of platelets was reduced by fixing

123 Interestingly, the anti-proliferative effect of PRMT5 inhibition was also partia

124 small molecule inhibitor, augmented the anti-proliferative effect of RAPA on EBV+ B cell lymphomas.

125 Knockdown of c-myc blocks the proliferative effect of RNA interference with parafibrom

126 the SCF-treated tissue, suggesting a direct proliferative effect of SCF; conversely, treatment with

127 monstrate that cyclin A1 is required for the proliferative effect of Six1.

128 lized p27-null cells to demonstrate that the proliferative effect of Spy1 depends on the presence of

129 Furthermore, forskolin abolished the anti-proliferative effect of tannic acid on cholangiocyte pro

130 The anti-proliferative effect of tannic acid was associated with

131 Finally we demonstrate a distinct proliferative effect of TFF2 protein on an AGS gastric c

132 strin decreased during hypergastrinemia, the proliferative effect of TGF-alpha on ECL cells was speci

133 We now demonstrate that this proliferative effect of TGF-beta is mediated through the

134 , Sulf1 siRNA transfection enhanced the anti-proliferative effect of TGF-beta1.

135 We find that the combination of the anti-proliferative effect of the cytokine TGF- beta and the i

136 1-C, a matrix assembly domain, increased the proliferative effect of these Fn-fs.

137 The anti-proliferative effect of TM-FKHRL1 was partially reversed

138 of alpha2beta1 integrin or JAG1, reduced the proliferative effect of TNC on BTIC.

139 Hence, it is suggested that the proliferative effect of TPO is more related to activatio

140 (HER2) to determine if it modifies the anti-proliferative effect of transforming growth factor (TGF)

141 o-L-arginine methyl ester prevented both the proliferative effect of VEGF and Raf-1 activation by VEG

142 The proliferative effect of VEGF was inhibited by the extrac

143 orporation were reduced, suggesting that the proliferative effect of VEGF was restricted developmenta

144 anti-AR small interfering RNA, inhibited the proliferative effect of VIP.

145 To test the proliferative effect of Wnt-3a in vivo, we ectopically e

146 The pro-proliferative effects of 11beta-HSD2 were abrogated by 1

147 lines revealed that sensitivity to the anti-proliferative effects of 1alpha, 25(OH)2D3 was strongly

148 r, our data support a model whereby the anti-proliferative effects of 1alpha,25(OH)2D3 are mediated,

149 the use of uridine, which reverses the anti-proliferative effects of A77 1726 caused by inhibition o

150 In this study, we investigated the anti-proliferative effects of adaphostin in the human prostat

151 The pro-proliferative effects of Agr2 may explain its actions in

152 783, and leucine 784) largely abolished the proliferative effects of alphavbeta6, but none of the mu

153 ot significantly elevated, suggesting direct proliferative effects of Ang II.

154 nsplant atherosclerosis is the result of the proliferative effects of anti-HLA Abs.

155 SCRT-I), as an important determinant of anti-proliferative effects of anti-miR-21.

156 Abl-deficient mice are hyporesponsive to the proliferative effects of B cell Ag receptor (BCR) stimul

157 The proliferative effects of bFGF and OSM may be via their r

158 The anti-proliferative effects of BMP4 occur more rapidly than th

159 Thus, in osteoblastic cells the acute proliferative effects of both estradiol and strain are E

160 Interestingly, while the proliferative effects of both FK1012 and AP1510 were rev

161 The anti-proliferative effects of BTK inhibition in human AML are

162 posure, are reassuring and contrast with the proliferative effects of conventional combined hormone t

163 The anti-proliferative effects of COX inhibition are rescued spec

164 Additionally, the anti-proliferative effects of deoxyanthocyanidins, have been

165 D cells and reduced their sensitivity to the proliferative effects of E2, while having no effect on t

166 TGFbeta can override the proliferative effects of EGF and other Ras-activating mi

167 ctivated protein kinases as mediators of the proliferative effects of EGF is well established.

168 mor cells may provide resistance to the anti-proliferative effects of EGR-1.

169 and investigated their role in mediating the proliferative effects of endothelin-1 (ET-1) on distal h

170 se abrogated the increased lipid content and proliferative effects of ephrin-A1 knockdown.

171 wth suppression in MCF-7 cells, but the anti-proliferative effects of ERbeta1 could be overridden by

172 tionally hyperactive AR, suggesting that the proliferative effects of ERG and PRMT5 are mediated thro

173 Direct proliferative effects of estrogen (E(2)) on estrogen rec

174 r prevention and treatment by inhibiting the proliferative effects of estrogen that are mediated thro

175 tulated role of ERbeta as a modulator of the proliferative effects of estrogen.

176 rapeutic target because ERalpha mediates the proliferative effects of estrogens on the mammary gland

177 in vitro, and that BRCA1 is required for the proliferative effects of EZH2.

178 pression of AhR expression reversed the anti-proliferative effects of flutamide.

179 se results demonstrate that rac mediates the proliferative effects of G-protein coupled receptors thr

180 Ras proteins mediate the proliferative effects of G-protein-coupled receptors (GP

181 The proliferative effects of galanin were via activation of

182 g protein DNA-binding activity prevented the proliferative effects of galanin.

183 a potential candidate to counterbalance the proliferative effects of gastrin.

184 olorectal cancers, its role in mediating the proliferative effects of gastrin1-17 (G-17) on these can

185 as a primer to sensitize hepatocytes to the proliferative effects of growth factors and offers a mec

186 tomas are known to produce GRP; however, the proliferative effects of GRP on neuroblastomas have not

187 naling pathway, we hypothesize that the cell proliferative effects of hamartin and tuberin are partly

188 Despite a clear understanding of the proliferative effects of HBx on cell cycle, a mechanisti

189 biologically active, and it neutralized the proliferative effects of human CSF-1 in a dose-dependent

190 l line as a relevant model to study the anti-proliferative effects of ICI182,780 and identified the n

191 Anti-proliferative effects of immunotherapy produce prolongat

192 is a key mediator of the anti-viral and anti-proliferative effects of interferon.

193 of events that functionally connect the anti-proliferative effects of interferons with the IRF1-depen

194 We first demonstrated the anti-proliferative effects of JNJ-527 on microglia in the ME7

195 apamycin and deferoxamine, mimicked the anti-proliferative effects of K+ channel blockers.

196 Because of the potent anti-proliferative effects of KRAS(G12D) in granulosa cells,

197 We also demonstrate proliferative effects of leptin alone and in combination

198 Mechanistically, the pro-proliferative effects of LYCAT were mediated by an incre

199 The proliferative effects of MIF may involve CD74 together w

200 -gamma-positive spots on ELISPOT, and 7) the proliferative effects of MIG/CXCL9 were mediated via an

201 ICD in the c57MG cell line recapitulated the proliferative effects of MMP7 in vitro and in vivo.

202 The anti-tumorigenic and anti-proliferative effects of N-alpha-tosyl-l-phenylalanyl ch

203 ings that RU-486 could partially prevent the proliferative effects of N-CAM, inhibition of MAP kinase

204 One approach to blocking proliferative effects of nicotine and ACh on growth of l

205 knockdown diminished the transcriptional and proliferative effects of NUP98-HOXA9.

206 Recent studies have suggested that the proliferative effects of p21(ras) may depend on signalin

207 The proliferative effects of P2RX7 blockade were associated

208 In unstressed cells, the anti-proliferative effects of p53 are restrained by mouse dou

209 tors RIIA and RIIB are required for the full proliferative effects of Pdx-1 in rat islets.

210 In addition, the protective and proliferative effects of plasminogen activator inhibitor

211 ncovering the mechanistic basis for the anti-proliferative effects of potential anti-HER3 antibody th

212 ating that both factors are required for the proliferative effects of progastrin.

213 by TRAF6-binding peptide abrogated the anti-proliferative effects of RANKL, suggesting the critical

214 Our results indicate that the pro- and anti-proliferative effects of ROS can be independently modula

215 antagonism in vitro significantly decreases proliferative effects of Shh in cultured CGNPs.

216 ors, but how cells become insensitive to the proliferative effects of Shh is not well understood.

217 In contrast, shYY2 reversed the anti-proliferative effects of shYY1, and shYY2 particularly a

218 The proliferative effects of sodium ascorbate on the male ra

219 eptor was first suggested by the strong anti-proliferative effects of soluble heparin-like molecules

220 ether with classic ER signaling, mediate the proliferative effects of synthetic estrogens such as tam

221 In conclusion, the anti-proliferative effects of tannic acid in cholangiocytes i

222 ted against IL-1alpha could abate the growth proliferative effects of TGF-beta without compromising i

223 odies against IL-1alpha prevented the growth proliferative effects of TGF-beta.

224 t1-expressing neural crest and that the anti-proliferative effects of Tgfbeta depend on Arf in vivo.

225 ours were particularly sensitive to the anti-proliferative effects of the agent.

226 The anti-proliferative effects of the prototype of a new class of

227 nsgenic mice were also hypersensitive to the proliferative effects of the skin tumor promoter, 12-0-t

228 The anti-proliferative effects of these micelles have been tested

229 increase in active TGFbeta mediates the anti-proliferative effects of these retinoids, a TGFbeta-bloc

230 uggests an additional mechanism for the anti-proliferative effects of this drug.

231 gest new therapeutic targets to modulate the proliferative effects of this growth factor.

232 human and murine cells, suggestive that the proliferative effects of TNF-alpha may be limited to ery

233 ingle TP53 target gene required for the anti-proliferative effects of TP53 during pharmacological act

234 sensitizes prostate cancer cells to the anti-proliferative effects of vitamin E and that this activit

235 nd forced expression of MBP-1 exerts an anti-proliferative effect on a number of human cancer cells.

236 modulatory drug lenalidomide had direct anti-proliferative effect on activated B-cell like DLBCL sphe

237 is factor (TNF) ligand superfamily and has a proliferative effect on both normal and tumor cells.

238 kt phosphorylation and showed a greater anti-proliferative effect on EBV+ B lymphoma lines compared t

239 ietin-1 as well as angiopoietin-2 exhibit no proliferative effect on endothelial cells.

240 Trametinib has a strong anti-proliferative effect on established GB cell lines, stem

241 In vitro, DMOG had no proliferative effect on HC, but conditioned supernatant

242 tion of this pathway abrogates adiponectin's proliferative effect on HSCs.

243 confirmed initially that EVO exerted an anti-proliferative effect on human epithelial ovarian cancer

244 pression of p202 was associated with an anti-proliferative effect on human prostate cancer cells.

245 ogen activator inhibitor (PAI)-2 has an anti-proliferative effect on keratinocytes.

246 IL-7 has a predominantly proliferative effect on mature CD4(+)CD3(+)CD8(-) and CD

247 We found that lithium treatment had a pro-proliferative effect on neural progenitors, but neuronal

248 In contrast to its proliferative effect on primary B cells, SGN-14 inhibite

249 CNTF does not, however, have a proliferative effect on responsive cells, but rather enh

250 EMD had a significant proliferative effect on SVF cells, when compared with 2%

251 ctor (KGF or FGF7) has a differentiative and proliferative effect on the epithelium of the developing

252 lls and downstream signaling, as well as its proliferative effect on the MK lineage.

253 nd that has recently been shown to have anti-proliferative effects on a number of human cancer cell t

254 b (SCH727965, MK-7965), exhibits potent anti-proliferative effects on a panel of NB cell lines by blo

255 oliferative effects on Namalwa cells and pro-proliferative effects on CD34+ cells, whereas p21WAF-1 e

256 m cell factor (SCF) is a molecule with known proliferative effects on hematopoietic cells.

257 n gene, R-spondin1, with potent and specific proliferative effects on intestinal crypt cells.

258 rowth factor I (IGF-I) are distinct from its proliferative effects on myoblasts.

259 e indicates that extracellular factors exert proliferative effects on neurogenetic precursors in vivo

260 let-derived growth factor were found to have proliferative effects on Schwann cells, but they had no

261 st cell-derived bFGF might exert fibrogenic, proliferative effects on smooth muscle cell/myofibroblas

262 eviously shown that RSpo proteins can induce proliferative effects on the gastrointestinal epithelium

263 ional inflammatory zone but also more global proliferative effects on the liver.

264 2 and E2F3 mutant backgrounds alleviated Myc proliferative effects on the pregnant mammary gland, red

265 ve hematopoietic cells and its ligand exerts proliferative effects on these cells in vitro in synergy

266 mAbs C225 and 4D5 resulted in additive anti-proliferative effects on these cells, which was accompan

267 it is noteworthy that it had no demonstrable proliferative effects on these cells.

268 Other family members have no proliferative effects on these cells.

269 active form of vitamin D, has selective anti-proliferative effects on tumor-derived endothelial cells

270 ependent protein kinase II inhibitors showed proliferative effects only on cardiomyocytes in early de

271 Individual stimuli cause proliferative effects (PHH3(+) mitotic cells, YAP transl

272 ese data indicate that the ouabain-activated proliferative effect previously observed in canine VSMCs

273 bservations indicate that progastrin induces proliferative effects, primarily in colonic progenitor c

274 nism(s) by which adaphostin elicits its anti-proliferative effect(s).

275 nM, with a concentration of 100 nM achieving proliferative effects similar to those of 1 nM estradiol

276 of exogenous interleukin (IL)-2 also had no proliferative effect, suggesting that the mPEG-modified

277 to PL with hPL did not have significant anti-proliferative effects, suggesting that hPL is not membra

278 BRAF and MEK inhibition may reduce cutaneous proliferative effects that arise on BRAF inhibitor monot

279 constriction but also exerts profibrotic and proliferative effects that change vessel architecture, w

280 To exert its anti-proliferative effects, this factor must ultimately contr

281 stem/progenitor cells TKIs exert potent anti-proliferative effects through a poorly understood mechan

282 mediates its potent anti-thrombotic and anti-proliferative effects through its G protein-coupled rece

283 line) ectopic tal-1 expression induces (i) a proliferative effect under suboptimal culture conditions

284 This proliferative effect was blocked by an ER antagonist, in

285 The proliferative effect was confirmed by a tetrazolium dye-

286 This proliferative effect was down-regulated by the arginase

287 SN5 knockdown signature showed that the anti-proliferative effect was driven by a common subset of mo

288 This proliferative effect was suppressed by dimethylsphingosi

289 FK1012's proliferative effect was sustained and reversible.

290 Notwithstanding this proliferative effect, we have shown that a novel isoform

291 The principal mechanisms for their anti-proliferative effects were also described.

292 Proliferative effects were determined by cell count, tox

293 These proliferative effects were modulated by a phosphoinositi

294 Anti-proliferative effects were observed in all cell lines at

295 east tumour explants, and had increased anti-proliferative effects when coupled with an ERalpha antag

296 human cancers and pro-apoptotic and/or anti-proliferative effects when re-expressed in tumor cell li

297 ression of securin resulted in a significant proliferative effect, whereas high levels of securin exp

298 tant being that FGF19 has both metabolic and proliferative effects, whereas FGF21 has only metabolic

299 ctivation was found to be essential for this proliferative effect, which was further confirmed by in

300 lar activation of p-ERK, p-AKT, and cellular proliferative effects, which were abrogated following Kl