ライフサイエンスコーパス: proliferative response

1 longation factor (P-TEFb), instating a large proliferative response.

2 of these factors in WT T cells inhibited the proliferative response.

3 g in Src-dependent activation of STAT3 and a proliferative response.

4 TNF-alpha, and IL-6 in the augmented T cell-proliferative response.

5 tion of CD8 T cells resulting from inhibited proliferative response.

6 the migratory response without affecting the proliferative response.

7 everolimus could inhibit the CD4CD28 T-cell proliferative response.

8 hogen challenge despite their poor secondary proliferative response.

9 naive B cells, which resulted in an abortive proliferative response.

10 beta cells without triggering a generalized proliferative response.

11 ate luminal epithelial cells provokes a mild proliferative response.

12 naling events that mediate the FGF-2-induced proliferative response.

13 , and elicits a robust TLR9-dependent B cell proliferative response.

14 at IGF1 replacement does not rescue the KIKO proliferative response.

15 nd plasminogen activator inhibitor-1-induced proliferative response.

16 rction consistent with resurgence of cardiac proliferative response.

17 s can also induce anti-inflammatory and anti-proliferative responses.

18 ediators, and failed to induce robust T cell proliferative responses.

19 ignificant adaptive CD4(+) and CD8(+) T cell proliferative responses.

20 ency of APCs and boost mitogen-driven T-cell proliferative responses.

21 enes and vaccinia virus, despite weak recall proliferative responses.

22 and programmed death-1 inhibition increased proliferative responses.

23 n, and immunoglobulin secretion, and had low proliferative responses.

24 e sensitive to THPO, activating survival and proliferative responses.

25 sing cholesterol efflux suppressed stem cell proliferative responses.

26 disrupt NF-kappaB-induced cell survival and proliferative responses.

27 uding CD62L and IL-2 expression and enhanced proliferative responses.

28 anied by diminished antigen-specific, T-cell proliferative responses.

29 or ISGs and generation of IFN-inducible anti-proliferative responses.

30 mooth muscle cells thus controlling cellular proliferative responses.

31 tibody binding and induction of human T-cell proliferative responses.

32 faster graft rejection kinetics and greater proliferative responses.

33 line with these findings, the cardiomyocyte proliferative response after cardiac injury was lost in

34 om endothelial cells leads to a delay in the proliferative response after injury.

35 on, and memory phenotype markers and studied proliferative responses after antigen stimulation.

36 paralleled reduced IL-2 secretion and T cell proliferative responses after TCR-CD28 stimulation indic

37 ls from CXCL14-Tg mice exhibited an enhanced proliferative response against collagen II and produced

38 innate immune responses and adaptive T cell proliferative responses, along with only transient antiv

39 sponse represented 16% of the total anti-HIV proliferative response and >70% of the anti-HIV multifun

40 ycoprotein peptide in vitro showed a reduced proliferative response and cytokine (IL-17A and IFN-gamm

41 anti-CTLA-4-Ab DC) showed significantly less proliferative response and enhanced IL-10 and TGF-beta1

42 nuation of alloantigen-specific T-lymphocyte proliferative response and IFN-gamma production, and (c)

43 t on T-cell activation, both in terms of the proliferative response and in the context of activation

44 Recipient splenocytes were analyzed for proliferative response and interferon (IFN)-gamma produc

45 remodeling, we demonstrate a myocardium-wide proliferative response and radial migration of progenito

46 colony survival after irradiation, impaired proliferative response and reduced counts of naive T cel

47 ted a homeostatic-like morphology, decreased proliferative response and reduced expression of neurode

48 Although we found both a high CD4(+) T cell-proliferative response and TH2 cytokines production afte

49 regeneration is associated with a localized proliferative response and the transient expression of e

50 e BE dose greatly affect gene expression and proliferative response and will be crucial determinants

51 lysing CD25(bright) and FoxP3(+) expression, proliferative responses and cytokine production.

52 Drug-specific proliferative responses and cytokine secretion were meas

53 B-cell proliferative responses and differentiation to immunoglo

54 7-CD127(-)CD28(-)CD57(+) phenotype with poor proliferative responses and enhanced staurosporine-induc

55 Both subjects developed antigen-specific proliferative responses and have discontinued immunoglob

56 They display low proliferative responses and impaired antitumor activity

57 ificant levels of OVA-specific CD4(+) T cell proliferative responses and OVA-induced IFN-gamma and IL

58 Ex vivo grass antigen-driven T-cell proliferative responses and the frequency of IL-4(+) CD4

59 cardial beta1-integrin was required for this proliferative response, and ventricular cardiomyocyte-sp

60 gene 3 (LAG3)(+) TR1 cells, antigen-specific proliferative responses, and cytokine production.

61 in SF dampened Borrelia burgdorferi-specific proliferative responses, and in 2 patients with antibiot

62 r, the molecular mechanisms that mediate the proliferative response are poorly understood.

63 en-driven IL-4(+) CD4(+) T cells, and T-cell proliferative responses are detectable in the periphery

64 -15/IL-15R homeostatic pathway, although the proliferative responses are enhanced by the stress agent

65 nt on the surface of donor DCs, donor T cell proliferative responses are generated only in response t

66 her hand, showed a prolonged and a sustained proliferative response as evident by an increased number

67 et recognition and stimulation, and enhanced proliferative responses as a result of both IL-2-depende

68 s in p38delta-null mice involves a defect in proliferative response associated with aberrant signalin

69 tially impaired CD8(+)pp65-specific in vitro proliferative responses at 6 d, with concomitantly lower

70 gatively associated with HBV-specific T-cell proliferative responses at both time points.

71 BM4-pulsed mdDC induced enhanced proliferative responses at earlier time-points in Bet v

72 ation process, which revealed differences in proliferative responses between non-genotoxic and genoto

73 n and were required not only for the ensuing proliferative response, but also for tumor cell growth a

74 e role for uterine epithelial ERalpha in the proliferative response, but ERalpha is required subseque

75 TCPOBOP-dependent genes primarily related to proliferative response, but not to drug metabolism, were

76 ital for host-protective anti-viral and anti-proliferative responses, but signaling via this interact

77 d may also contribute to the CSF-1-regulated proliferative response by activating Src family kinase.

78 we show that ELF4 controls the ERK-mediated proliferative response by maintaining normal levels of d

79 mation prior to the induction of full T cell proliferative responses by concurrent indirect Ag presen

80 in skeletal myoblasts resulted in increased proliferative responses characterized by activation of m

81 The proliferative response coincided with detection of the g

82 B cells, or natural killer cells, or T-cell proliferative response compared with interferon beta alo

83 allogeneic DC, they exhibited much inferior proliferative responses compared with bulk CD4 or CD4CD1

84 thy individuals showed lower gluten-specific proliferative responses compared with those of CD patien

85 /EBPalpha as the molecular regulators of the proliferative response, correlating with the chronic hum

86 However, CMV-specific in vitro proliferative responses could be significantly rescued,

87 rogeny that expressed hair cell markers, but proliferative responses declined postnatally.

88 ned increase in p53 protein, which prevented proliferative responses despite strong signaling through

89 ivation of beta-catenin, and epithelial cell proliferative responses during C. rodentium infection.

90 mination of p53 by TCR signaling that allows proliferative responses, enforcing antigen specificity.

91 turnover but can nevertheless mount a rapid proliferative response following injury.

92 the intestinal epithelium fails to produce a proliferative response following radiation-induced damag

93 Whereas MZ B cells exhibit a robust proliferative response following stimulation with the TL

94 ts suppress telomerase activation during the proliferative response following vascular injury, indica

95 have shown that Gadd45b-/- mice have intact proliferative responses following administration of a si

96 activity primes individual cells for optimal proliferative responses following Ag exposure.

97 severe wheeze had impaired airway epithelial proliferative responses following damage.

98 reas beta-catenin-dependent signals elicit a proliferative response from intestinal cells, thymocytes

99 Furthermore, impaired CMV-specific proliferative responses from relapsers, along with T-bet

100 from PKCgamma(-/-) mice did not result in a proliferative response, further indicating the requireme

101 a toxin, triggers a significant compensatory proliferative response in 1-2-year-old animals.

102 aled that they induced a significantly lower proliferative response in allogenic MLR than the B cells

103 (+) cells) showed an enhanced and more rapid proliferative response in an autologous, APC-dependent c

104 udy identifies PKD as a major regulator of a proliferative response in differentiated KCs, probably t

105 s into the mechanism of reinitiation of this proliferative response in differentiated KCs, we examine

106 eeI, SeeL, and SeeM induced a dose-dependent proliferative response in equine CD4 T lymphocytes and s

107 -myc expression fully restored the defective proliferative response in FM B cells.

108 levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MC

109 lthioadenosine (MTA) inhibit mitogen-induced proliferative response in liver and colon cancer cells.

110 from N. lactamica mediate a B cell-dependent proliferative response in mucosal mononuclear cells that

111 FAP filament assembly and inhibition of cell proliferative response in Muller glia.

112 vitro, CTL-expressed Ag induced an abortive proliferative response in specific B lymphocytes, whereb

113 ulting in the lack of a robust cardiomyocyte proliferative response in the adult heart after injury.

114 There was a significant suppression of proliferative response in the GPC3 TG mice, as assessed

115 fails to induce a robust transcriptional and proliferative response in the heart.

116 The prolonged proliferative response in the ILK/liver-/- mice seems to

117 lopmental abnormality in the epithelial cell proliferative response in those mice.

118 Vacc-4x was immunogenic, inducing proliferative responses in both CD4 and CD8 T-cell popul

119 e context of oncogene activation can promote proliferative responses in normal human hematopoietic pr

120 to disrupt AR-dependent transcriptional and proliferative responses in PCa, and can enhance efficacy

121 BAFF neutralization rescues aberrant B cell proliferative responses in such mice.

122 and elicited robust activation and vigorous proliferative responses in the absence of T cells.

123 both CD4(+) T-cell counts and their in vitro proliferative responses in these women.

124 stitute Rag1(-/-) mice and were defective in proliferative responses in vitro and in vivo.

125 olzeta in tolerating DNA damage and enabling proliferative responses in vivo.

126 functions for E2F proteins during a cellular proliferative response including a role for E2F1-3 in th

127 man HSCs did not stimulate allogeneic T-cell proliferative response, indicating that they are not pro

128 ardiomyocyte endowment of P8 hearts, but the proliferative response is confined to cardiomyocytes of

129 The proliferative response is impaired by a reduced fibrobla

130 Despite such disparities in proliferative response, Myc is bound to DNA at open elem

131 ets, inhibition of EGFR or HB-EGF blocks the proliferative response not only to HB-EGF but also to gl

132 r, CL injection, which largely abrogated the proliferative response of adoptively transferred OVA pep

133 liver, results in a 3-fold reduction in the proliferative response of Ag-specific CD8(+) T cells.

134 D27(-) atypical B cells showed the strongest proliferative response of all memory B cell subsets.

135 ukocyte reactions-while dampening the global proliferative response of allostimulated Balb/c T cells-

136 glial cultures resulted in a dose-dependent proliferative response of astrocytes.

137 ed human MDSCs also similarly attenuated the proliferative response of autologous T cells to SEB.

138 elpers in that they not only induce a strong proliferative response of B cells in vitro but also trig

139 We show that the proliferative response of B cells to the latter stimuli

140 fficient avidity to induce a TLR-independent proliferative response of BALB/c AM14 Vkappa8 B cells bo

141 7(kip1) by adenoviral delivery decreases the proliferative response of beta-cells from non-diabetic d

142 pDC GrB levels inversely correlate with the proliferative response of coincubated T cells and that G

143 Thus, targeting Src prevents the proliferative response of dormant cells to external stim

144 y, CPC transplantation triggered a prolonged proliferative response of endogenous cells, resulting in

145 that this increase is primarily because of a proliferative response of endogenous TM cells.

146 e, PPI treatment decreased the IL-13-induced proliferative response of esophageal epithelial cells.

147 ed intrinsic mechanisms for the differential proliferative response of gray and white matter cells.

148 The deletion of FGFR4 has no effect on the proliferative response of hepatocytes after liver injury

149 Here, we demonstrate that the proliferative response of human beta-cells from T2D dono

150 Skp2 overexpression increased similarly the proliferative response of human beta-cells, only Skp2 wa

151 The proliferative response of human peripheral blood mononuc

152 In vitro, FR104 controlled the proliferative response of human preexisting Tfh cells mo

153 monstrate that the 5-HT(2B) receptor-induced proliferative response of ICC is through phospholipase C

154 Here, we measure the signalling and proliferative response of individual primary T-lymphocyt

155 TAZ are necessary for the stimulation of the proliferative response of intestinal epithelial cells to

156 e-specific response which contrasts with the proliferative response of most cell types and underlies

157 hown that RANKL is responsible for the major proliferative response of mouse mammary epithelium to pr

158 y antisense morpholino oligonucleotides, the proliferative response of Muller glia following injury w

159 toma also rely on its ability to disable the proliferative response of Myc, yet in this tumor context

160 Mst1 removes a barrier to the activation and proliferative response of naive T cells.

161 However, the proliferative response of neoblasts to amputation or gro

162 Furthermore, the proliferative response of Olfml3(-/-) pericytes upon PDG

163 lination failure correlated with a truncated proliferative response of oligodendrocyte progenitor cel

164 of the induced subpopulations of MDSC on the proliferative response of OVA-specific CD4(+) T cells.

165 ously unrecognized role of P-selectin in the proliferative response of PASMCs associated with PH.

166 tion of liver injury biomarkers and enhanced proliferative response of peripheral blood mononuclear c

167 Skp2 was also able to double the proliferative response of T2D beta-cells.

168 mplication in liver diseases that triggers a proliferative response of the biliary tree.

169 Indeed, the proliferative response of the epithelium involves expres

170 In vitro, the proliferative response of TNFR2 deficient naive CD4 cell

171 Proliferative responses of allergen-specific T cells fro

172 er approach to demonstrate that two distinct proliferative responses of autologous T cells occur in v

173 bacterial lipoprotein Pam3CSK4, enhanced the proliferative responses of both conventional T cells and

174 We report here that antigen-specific proliferative responses of CD4(+) T cells required downm

175 regulating the oxidative, inflammatory, and proliferative responses of ECs to disturbed flow with OS

176 cell carcinomas and amplifies migratory and proliferative responses of primary epithelial cells to t

177 These cells, defined by their proliferative response on coculture with dendritic cells

178 cells were also capable of mounting a recall proliferative response on HSV reactivation and could do

179 rrelate with the strength of the Ag-specific proliferative response or the secretion of cytokines/cyt

180 guinal lymph nodes, without affecting T cell proliferative responses or levels of anticollagen antibo

181 c signaling perturb hepatocellular metabolic/proliferative responses, paradoxically resulting in mali

182 pment in which LOX-PP may act to inhibit the proliferative response possibly to allow cells to exit f

183 surface phenotype, secretory mediators, and proliferative responses (referred to as an "activated st

184 as protective and actually increased hepatic proliferative responses relative to control mice.

185 y cellular functions within 4 weeks, but the proliferative response remain impaired.

186 reversed in part within 4 weeks, whereas the proliferative response remains impaired.

187 sense systemic insulin demand and initiate a proliferative response remains unknown.

188 valve interstitial cells in vitro induces a proliferative response reminiscent of the fibrosis that

189 Inhibition of proliferative responses required T cell-MDSC contact and

190 To promote a proliferative response, samples were treated with EDTA a

191 nd reconstituted T cells exhibited defective proliferative responses suggesting incomplete recovery o

192 ted with significantly impaired CMV-specific proliferative responses, T-cell effector functions, and

193 tching or wounding, epithelia display a fast proliferative response that allows for re-establishment

194 elped CD8(+) T cells impairs their secondary proliferative response that is reversible by TRAIL block

195 tion of any cell type in the heart induces a proliferative response that lasts at least 1 year.

196 o engraftment potential and triggers a hyper-proliferative response that leads to their exhaustion.

197 deranged processes culminate in an exuberant proliferative response that occludes the pulmonary arter

198 Depletion of Dkk1 induces a strong proliferative response that promotes wound repair after

199 es in limiting chemically induced injury and proliferative responses that lead to tumor development.

200 ear factor 4 alpha expression concomitant to proliferative response; this was not seen in [MET KO + E

201 on, when wild-type hepatocytes mount a rapid proliferative response, those without dyskerin do not di

202 quantitative IHC, we identified a transient proliferative response throughout the gland.

203 itic cell responses (flow cytometry), T-cell proliferative responses (thymidine incorporation), and c

204 dicating the requirement for PKCgamma in the proliferative response to 5-HT(2B) receptor activation.

205 specific Rb deletion resulted in an aberrant proliferative response to AFB1.

206 These cells suppressed the proliferative response to allogeneic stimulation of CD4(

207 th an antibody against CTLA4 increased their proliferative response to antigen and to CD3 stimulation

208 T cells from patients with ALF had a reduced proliferative response to antigen or CD3 stimulation com

209 agonists was greatly reduced, except for the proliferative response to ATF.

210 Here we show in mice that the proliferative response to bacterial infection or chemica

211 entricular cardiac myocytes display a robust proliferative response to beta-catenin-mediated signalin

212 ls of long-term graft recipients generated a proliferative response to donor Ags at a similar magnitu

213 A proliferative response to EDTA was not found.

214 like growth factor (HB-EGF) in the beta-cell proliferative response to glucose, a beta-cell mitogen a

215 only partially reduced the naive CD8 T cell proliferative response to IL-15/IL-15Ralpha complex.

216 regulation is critical for the smooth muscle proliferative response to increased mechanical tension.

217 Mutation order influenced the proliferative response to JAK2 V617F and the capacity of

218 ex, which correlated with a poor homeostatic proliferative response to lymphopenia.

219 which express CCR2, demonstrate an enhanced proliferative response to MCP-1 when compared with WT SM

220 We hypothesized that the proliferative response to mitogens of human beta-cells f

221 FDG-PET is not predictive of proliferative response to mTOR inhibitor therapy in both

222 sociated with a significantly reduced T cell proliferative response to mycobacterial Hsp65, which was

223 reatment with BCR-specific Abs abrogated the proliferative response to N. lactamica outer membrane ve

224 NG2 cells in white matter exhibited greater proliferative response to PDGF AA than those in gray mat

225 white matter NG2 cells showed a more robust proliferative response to PDGF.

226 r NG2 cells in the developing brain in their proliferative response to PDGF.

227 ng cancer model because it lacks an in vitro proliferative response to PDGFRalpha activation.

228 vents and elicitation of a robust hepatocyte proliferative response to PH.

229 d growth factor (PDGF)-beta receptor and the proliferative response to platelet-derived growth factor

230 to therapeutic resistance via an unexpected proliferative response to repopulate residual tumours be

231 po pathway, is required in ISCs to drive the proliferative response to stress.

232 M6P/IGF-2-R knockout cells have a reduced proliferative response to TGF-beta, and don't proliferat

233 sults from EGFR/CD44 coupling and leads to a proliferative response to TGF-beta1.

234 igenic, we demonstrate a maternal splenocyte proliferative response to the CD4(+) T cell restricted e

235 A proliferative response to the citrullinated aggrecan pep

236 IL-7gly at intervals of 4-6 wk maximized the proliferative response to therapy but resulted in only t

237 Loss of RB yielded a unique proliferative response to this agent, which was distinct

238 on immature than on mature MKs, explaining a proliferative response to THPO of immature cells and a d

239 ckout T cells therefore lack the appropriate proliferative response to TL1A.

240 ated with a CB(1)R antagonist have a delayed proliferative response to two-thirds partial hepatectomy

241 l biopsies of adults and children and tested proliferative response to various gluten peptides.

242 on of FLAP-replete myeloid cells rescued the proliferative response to vascular injury.

243 , decreasing cell adhesion and promoting pro-proliferative responses to activin-A and Nodal.

244 The apoptotic and proliferative responses to acute UV radiation exposure a

245 D8(+) T cells from LTx patients showed lower proliferative responses to alloantigen, as well as to po

246 ocompromised, with reduced polyclonal T cell proliferative responses to alloantigen, defined peptide

247 These include BCR down-regulation, impaired proliferative responses to anti-CD40, and diminished cal

248 m cGVHD patients had significantly increased proliferative responses to BCR stimulation along with el

249 Proliferative responses to BM4 and Bet v 1 of peripheral

250 l interfering RNA silencing of Smad1 invoked proliferative responses to BMP4 in male hPASMCs.

251 s mellitus, anti-B cell mAb causes increased proliferative responses to diabetes Ags and attenuated b

252 T cell proliferative responses to diabetes-associated Ags were

253 nt C-peptide preservation at 6 mo (58%), the proliferative responses to diabetes-associated total (p

254 ompare changes in lymphocyte subsets, T cell proliferative responses to disease-associated target Ags

255 t the chimeric T cells had enhanced specific proliferative responses to donor airway alloantigens.

256 tion into grafts but not with altered T-cell proliferative responses to donor stimulators.

257 ent hyaluronan, coordinates the motility and proliferative responses to ECM stiffening.

258 Furthermore, proliferative responses to endogenous autoantigen and di

259 In summary, unliganded PR-B enhanced proliferative responses to estradiol and IGF1 via scaffo

260 ZV specificity were generated and probed for proliferative responses to every VZV protein and selecte

261 sufficient help to allow optimal CD8 T cell proliferative responses to exosomal protein.

262 talized stomach mesenchymal cells, to assess proliferative responses to gastrin.

263 seful strategy for studying and modifying MC proliferative responses to injury.

264 aliva IgA binding to insulin, or CD4+ T-cell proliferative responses to insulin were observed in 2 of

265 liva IgA binding to insulin, and CD4+ T-cell proliferative responses to insulin.

266 ermine whether KLF5 is involved in mediating proliferative responses to intestinal stressors in vivo,

267 kappaBNS knockout (KO) mice were impaired in proliferative responses to LPS and anti-CD40.

268 ity, improved lymphocyte numbers, and normal proliferative responses to mitogens.

269 from unimmunized controls, were screened for proliferative responses to peptide panels spanning the K

270 anzyme B(+)/IFN-gamma(+), CD4(+), and CD8(+) proliferative responses to peptide pools in most individ

271 oliferation graphs, which deconvolve dynamic proliferative responses to perturbations into the relati

272 The metabolic and hepatocellular proliferative responses to PH are modestly augmented in

273 1 cells that displayed greater longevity and proliferative responses to secondary infection.

274 ferase and alkaline phosphatase activity and proliferative responses to secretin.

275 II-DR15/DQ6 alleles significantly attenuated proliferative responses to Strep-SAgs, whereas their pre

276 lability facilitated the induction of T cell proliferative responses to suboptimal stimuli.

277 latory acclimatization and carotid body cell proliferative responses to sustained hypoxia.

278 s cholesterol efflux to HDL and controls the proliferative responses to thrombopoietin.

279 o had a reduced capacity to stimulate T cell proliferative responses to tubercle bacillus Ag 85.

280 o, the role of this nuclear receptor for the proliferative response underlying neointima formation an

281 vivo Skp2 expression is increased during the proliferative response underlying neointima formation, a

282 cted by inhibition of the Ag-specific T cell proliferative response upon Ag presentation by IFN-beta-

283 The IL-33-dependent proliferative response was mediated by an increase in th

284 despite the central role of HIF2alpha, this proliferative response was not initiated by in vivo Vhl

285 The enhanced proliferative response was observed in the CD62L(-) memo

286 ude and duration of tubular and interstitial proliferative responses was consistently greater in inju

287 bsets of lymphocytes and quantitative T-cell proliferative response were assessed in an exploratory p

288 amma2Vdelta2 cell phenotype, repertoire, and proliferative responses were compared between newborns e

289 M- and anti-CD40 plus anti-Ig-induced B cell proliferative responses were decreased in BXD2-Aicda-DN-

290 rimental hypoxic PH, proinflammatory and pro-proliferative responses were dependent on complement (al

291 HC)-mismatched pairs, that T cell restricted proliferative responses were dictated by donor rather th

292 Overall, cell proliferative responses were influenced by both the tiss

293 Indeed, HSC and multipotent progenitor proliferative responses were most suppressed in IL-1RI(-

294 rthermore, specific CD4(+) and CD8(+) T cell proliferative responses were significantly increased and

295 CSCs exhibit marked chemotactic and proliferative responses when cocultured with MSCs but no

296 nized animals exhibited significantly higher proliferative responses, when stimulated ex vivo with he

297 Abeta1-15:DT conjugate resulted in a strong proliferative response, whereas proliferation was absent

298 ion without affecting the estrogen-dependent proliferative response, which suggests that p23 differen

299 ulted in decreased antidonor and third-party proliferative responses, which were significantly revers

300 ad to dramatic impairment of TCPOBOP-induced proliferative response without altering CAR activation.