ライフサイエンスコーパス: prolonged

1 the effect of acute (perfusion only) versus prolonged (2 weeks pre-treatment plus perfusion) UDCA ad

2 wise, Keap1(f/f) pups were protected against prolonged (96 h) hyperoxia-induced hypoalveolarization.

3 has been challenging, however, to study the prolonged absence of NMDARs in vertebrates, and hence th

4 the role of the DH in cocaine seeking during prolonged abstinence has not been investigated.

5 R67Q(+/-) myocytes (n=5) demonstrated prolonged action potential duration at 90% repolarizatio

6 ompared with nonfailing hMSCs, failing hMSCs prolonged action potential duration by 24% (P<0.001, n=1

7 tory cortical neurons from both patients had prolonged action potential repolarization.

8 ient-days) were all higher in the setting of prolonged acute mechanical ventilation than short-term m

9 Prolonged admissions to an ICU are associated with high

10 luding a subset of patients with evidence of prolonged AID activity during the pre-malignant phase, i

11 the naturally developed competent state was prolonged and persistent during pneumonia-derived sepsis

12 composition of the AM population to provide prolonged antibacterial protection.

13 ions of endemicity, where treatment requires prolonged antibiotic therapy.

14 In mice, hybrid 7 produced significant and prolonged antinociception (up to 8 h), as compared to th

15 Reductive stress, as caused by prolonged antioxidant signaling or mitochondrial inactiv

16 Prolonged ART may restore the richness of the microbiota

17 al therapy was significantly associated with prolonged bacteremia and worse outcomes.

18 t only provided immobilization of BMP-2 with prolonged bioavailability, but also enhanced the attachm

19 Gpr56 (-/-) mice have prolonged bleeding, defective platelet plug formation, a

20 >50% of mature DG granule cells (GCs) or by prolonged brain-specific VEGF overexpression culminating

21 tive during NMP, which could be enhanced and prolonged by URC.

22 re-activated elevations in calcium can cause prolonged calcium changes and consequent pancreatitis.

23 Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreat

24 eprogramming at >1400 sites in neurons after prolonged cannabinoid exposure.

25 STICK-NPs exhibit prolonged circulation time (17-fold higher area under cu

26 herapies, including improved solubilization, prolonged circulation, reduced toxicity, sustained relea

27 owledge to assess the main consequences of a prolonged civil war (1975-2002) in Southwestern Africa o

28 ergetic environmental deteriorations such as prolonged climatic perturbations and oceanic anoxia, rel

29 all-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic an

30 of 39 human kidneys, we have identified that prolonged cold storage of human kidneys induces accumula

31 a mean graft survival of 35.3 days which was prolonged compared with PRCL-02 monotherapy but not comp

32 d in porous structure, which in turn ensured prolonged contact time of contaminated water with the ma

33 ce and shows high photostability, permitting prolonged continuous imaging.

34 This can permit prolonged control of tumors through intermittent dosing.

35 erbations and stepped down after a period of prolonged control.

36 Prolonged CPX tissue persistence, attributed to slower r

37 itive value, initiating high selectivity and prolonged cravings for drug through reward learning.

38 le and potentially preventable predictors of prolonged critical illness and prolonged critical illnes

39 als each had lower- and higher-than-expected prolonged critical illness frequency.

40 perative factors), whereas only one of eight prolonged critical illness mortality predictors was nonm

41 Cardiac ICU prolonged critical illness mortality was 24% in neonates

42 predictors of prolonged critical illness and prolonged critical illness mortality, and understand the

43 Approximately 40% of the prolonged critical illness predictors were nonmodifiable

44 Case-mix-adjusted prolonged critical illness rates were compared across ho

45 We aimed to define prolonged critical illness, delineate between nonmodifia

46 nd understand the interhospital variation in prolonged critical illness.

47 The upregulation of hapR resulted in a prolonged culturable state of V. cholerae in artificial

48 Prolonged culture also revealed that purified subpopulat

49 After prolonged cycling, the TMs displayed different levels of

50 t disease in two patients (10%), and grade 4 prolonged cytopenia in six patients (32%).

51 most resilient plants, and some can survive prolonged desiccation in semiarid regions with seasonal

52 whereas newborn neurons of the vDG showed a prolonged differentiation, migration, and maturation.

53 onent-shared alterations (trunk-ratio) had a prolonged disease-free survival (DFS), regardless of the

54 Under prolonged drought and reduced photosynthesis, plants con

55 The evidence indicates a prolonged drought in the likely western source region fo

56 group of human organ donors characterized by prolonged duration of stay in an intensive care unit (IC

57 Prolonged emergency department (ED) dwell time before ad

58 Tracheostomy is often performed for prolonged endotracheal intubation in critically ill pati

59 ost assays require high bacterial burdens or prolonged enrichment to achieve acceptable performance.

60 owded cities worldwide could experience more prolonged epidemics.

61 btropic regions during the past decade and a prolonged episode of intermittently bloody diarrhea duri

62 cer pathogenesis, suggesting a mechanism for prolonged epithelioid tumor cell survival.

63 s (depending on the sampler used) because of prolonged equilibration times.

64 Prolonged ER stress has been known to be one of the majo

65 theories of peace of citizens embroiled in a prolonged ethnonational conflict.

66 added to standard LMB chemotherapy markedly prolonged event-free survival and overall survival among

67 t the effectiveness of retreatment for these prolonged events.

68 d minimizes adaptive changes that occur with prolonged ex vivo culture.

69 lti-dimensional NMR experiments that require prolonged experiment times.

70 nselective cation channel; while repeated or prolonged exposure induces formation of a transmembrane

71 rticipated in a randomized clinical trial of prolonged exposure therapy (n = 36) versus treatment wai

72 During prolonged exposure to Ags, such as chronic viral infecti

73 We conclude that prolonged exposure to broad spectrum antibiotics in the

74 to thermoregulate spermatogenetic tissue and prolonged exposure to elevated temperatures are linked t

75 whether thermophilic endospores can survive prolonged exposure to high temperatures, sediments were

76 Prolonged exposure to hyperoxia has deleterious effects

77 and PG production of porcine IVD cells under prolonged exposure to hypoxia with physiological glucose

78 ined a new severity category (level IV) with prolonged exposure to supplemental O2 (>=120 days) that

79 However, prolonged exposure to TF results in the reduction in PTE

80 pounds, this shift occurred spontaneously on prolonged exposure to the Lewis acidic reaction conditio

81 g and implementing the aftereffect following prolonged exposure.

82 a series of half-blinks followed by either a prolonged eye narrow or an eye closure.

83 s essential for the organismal survival upon prolonged fasting and maintaining systemic homeostasis u

84 ung at extremely high rates while undergoing prolonged fasting, making lactation a tremendously energ

85 haracteristic of clinical manifestation of a prolonged fever.

86 resistance to prexasertib monotherapy via a prolonged G2 delay induced by lower CDK1/CyclinB1 activi

87 gene expression of apc/ebp We find that this prolonged gene expression is not dependent on de novo tr

88 isms by which Trial 2 achieves the essential prolonged gene expression of apc/ebp We find that this p

89 ocesses may have been one contributor to the prolonged glaciations if these were near-global.

90 of children with cancer that contributed to prolonged grief for parents; these were different for mo

91 nts are at an increased risk for intense and prolonged grief responses.

92 ariable models for odds to complications and prolonged (>=6 days) length of stay were built.

93 ort (1-2 days), intermediate (3-6 days), and prolonged (>=7 days) and compared for risk factors and o

94 enic clonal groups demonstrate an especially prolonged gut persistence and high rate of bacteriuria w

95 e health care environment, which can lead to prolonged HAI outbreaks.

96 ong-QT syndrome (LQTS) is characterized by a prolonged heart rate-corrected QT interval (QTc).

97 geting of cellular Hsp90, which results in a prolonged heat shock response despite concomitant degrad

98 Although transiently protective, prolonged HIF activity drives distinct pathological resp

99 Prolonged high-temperature extreme events in the ocean,

100 (4.0 +/- 2.0 mg CH(4) m(-2) hr(-1) ) due to prolonged higher WT and more optimal methanogenesis cond

101 nction in humans.(1-9) However, there are no prolonged, highly controlled experimental studies testin

102 rrent smoking (aOR 3.1; 95% CI: 2.2-4.4) and prolonged history of coughing in the source case at enro

103 istent with anal cancer promotion by severe, prolonged HIV-induced immunosuppression.

104 ffers an explanation for previous reports of prolonged hormone retention within fusing vesicles.

105 (odds ratio, 10.4; 95% CI, 5.9-18.1), suffer prolonged hospital stay (odds ratio, 4.4; 95% CI, 3.0-6.

106 To prevent prolonged hospital stay, initiatives should in addition

107 l injuries can lead to high morbidity rates, prolonged hospitalization, and disability.

108 inst systemic Candida albicans infection and prolonged host survival.

109 apamycin with IL-2 for 3 weeks significantly prolonged human islet allograft survival.

110 Simultaneous endo-epi phase mapping of prolonged human persistent AF recordings shows significa

111 cation end-products (AGEs) accumulate during prolonged hyperglycemia, but the mechanistic pathways th

112 e kinase 1), and in a postnatal model due to prolonged hyperoxia.Methods: ETX or sFlt-1 were administ

113 We also provide evidence that prolonged hypoxia down-regulates kindlin-2 expression, l

114 ditional day = 0.55; 95% CI, 0.37-0.80), but prolonged ICU- and hospital stays.

115 Prolonged IFN-alpha and IFN-beta responses can lead to h

116 melanoma cells to investigate the effects of prolonged IFNgamma treatment on mRNA translation.

117 ere disease, apparent diagnostic delays, and prolonged illness, whereas other patients lacked symptom

118 significant clinical consequences, including prolonged immunosuppression, poor vaccine responses and

119 T2(water) was prolonged in leg muscle groups of participants with DPN

120 Cortical silent period was significantly prolonged in writer's cramp.

121 ross all regions, with the greatest and most prolonged increases occurring in the globus pallidus and

122 r GES-harboring isolates, a double inoculum, prolonged incubation, or both was evaluated, with each m

123 Using prolonged incubation, we discovered that wild-type casto

124 astrointestinal infection in humans, however prolonged infection can be seen in cases with underlying

125 Chronic hepatitis B is caused by prolonged infection with the hepatitis B virus (HBV), wh

126 mcitabine plus dacarbazine in LMS; high-dose prolonged-infusion ifosfamide in SS; etoposide plus ifos

127 by gamma-aminobutyric acid (GABA) results in prolonged inhibition of neurotransmission, which is cent

128 del, GSK3008348 engages alphavbeta6, induces prolonged inhibition of TGFbeta signaling and reduces lu

129 n-integration strategy in each and confirmed prolonged integration in all but one subject.

130 Prolonged intermittent theta burst stimulation (piTBS) w

131 als demonstrate limited muscle loss over the prolonged intervals of immobility during winter, which s

132 extran sulfate sodium-induced colitis due to prolonged intestinal inflammation and impaired tissue re

133 ospitalized for serious infections requiring prolonged intravenous antibiotics may face barriers to d

134 ovides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft

135 elter at the age of 17 years had experienced prolonged journeys where they spent months or years livi

136 CI: 1.26-2.82; I2: 96%; p-value < 0.01), and prolonged labor (7,516 FGM/C and 8,060 non-FGM/C partici

137 n to experience dyspareunia, perineal tears, prolonged labor, and episiotomy.

138 nia patients, including higher mortality and prolonged length of hospital stay.

139 h-value hospitals had a higher percentage of prolonged length of stay >14 days (9.3% versus 2.4%, P=0

140 ve adrenomedullin was also associated with a prolonged length of stay (odds ratio, 1.85; 1.49-2.29) a

141 The C-statistics results for prediction of prolonged length of stay were 85 +/- 3% accuracy and AUR

142 ior persistence of T cells and significantly prolonged leukemia control in vivo, confirmed by a secon

143 emonstrated with quick formation of 3 ps but prolonged lifetime of ~0.5 mus.

144 nced power performance, improved durability, prolonged lifetime, and reduced cost for automotive and

145 imary neutrophils cultured in vitro with the prolonged lipopolysaccharides (LPS) stimulation can effe

146 1, and the reduced aggregation following the prolonged LPS challenge as compared to wild type (WT) ne

147 t in suppressing tumor initiation suggesting prolonged mammary exposure may improve efficacy.

148 ncreases the droplet stability, allowing for prolonged mapping and the use of highly evaporative sali

149 ective care practices for patients receiving prolonged mechanical ventilation.Methods: We performed a

150 ression of cleaved caspase-3, and leads to a prolonged median survival of the mice (36.5 vs. 22.5 d,

151 In this review, we detail how prolonged metabolic stress leads to adipose tissue dysfu

152 s undergoing neurogenic divisions results in prolonged mitosis due to extension of early mitotic stag

153 eatment with MRE11A inhibitor PFM39 modestly prolonged mitosis.

154 ng a feedback control of APC/C to SAC during prolonged mitotic arrest.

155 Prolonged monitoring and trials of otoprotective agents

156 p and rebound in ensemble mean FR induced by prolonged monocular deprivation.

157 asticity, and can rescue deficits induced by prolonged monocular deprivation.

158 d in proinflammatory T cell differentiation, prolonged monocyte major histocompatibility complex II u

159 hat mostly occurs after chemotherapy-induced prolonged neutropenia in patients with hematological mal

160 nt mice with Borrelia burgdorferi results in prolonged nonresolving Lyme arthritis.

161 During prolonged nutrient restriction, developing animals redis

162 against cerebrovascular dysfunction despite prolonged obesity.

163 (SCT) injection of Sunb-malate MS provided a prolonged ocular drug retention and did not cause ocular

164 fore viscosity enhancement for increased and prolonged ocular surface contact and drug absorption.

165 l particles have improved stabilities during prolonged operation compared to their monometallic count

166 erferences, along with good stability during prolonged operation in artificial ISF.

167 The overall prevalence of prolonged opioid use after musculoskeletal injury for hi

168 Prolonged optogenetic dFB activation nevertheless achiev

169 cell transplant recipients often results in prolonged or indefinite antifungal treatment.

170 To avoid this, prolonged or intermittent social distancing may be neces

171 Many of these develop progressively with prolonged or repeated drug use and then persist, motivat

172 groups, a proportion of patients had clearly prolonged or shortened CLTs.

173 thway ligands and targets are activated upon prolonged p16(INK4a) expression, and Wnt inhibition supp

174 animal kingdom, particularly in species with prolonged parental care, e.g., [8, 9].

175 Together, our results suggest a prolonged period of basal ganglia iron enrichment that e

176 the controlled release of vitamin B6 over a prolonged period of observation.

177 are highly susceptible to infection, with a prolonged period of oral and nasal viral shedding that i

178 a reopening, but would quickly settle into a prolonged period of time with stable, slightly declining

179 h numerous seeds from multiple sources and a prolonged period of unrecognized community spreading.

180 r, a full lockdown cannot be sustained for a prolonged period.

181 c-dependent, and require repeated courses or prolonged periods of antibiotic therapy.

182 developed and tested the feasibility of more prolonged periods of NMP.

183 warming-up while listening to music; or (5) prolonged periods of training at a specific time of day.

184 rast, repeated aversive stimuli that lead to prolonged periods of vigilance were accompanied by robus

185 in vitro and can be delivered topically for prolonged periods through controlled release by specific

186 reduced before the technique can be used for prolonged periods.

187 atin chemotherapy to gefitinib significantly prolonged PFS and OS but increased toxicity in patients

188 r time-dependent photocurrent generation and prolonged photocurrent decay, originated from charge tra

189 pothesize that it may act to protect against prolonged placental hypoxia seen in preeclampsia.

190 rgic innervation to abDGCs develops during a prolonged post-mitotic period and running scales both SS

191 efects in muscle function, consistent with a prolonged postnatal role for EphA4 in adolescent muscle

192 Prolonged postoperative fasting has been the traditional

193 The prolonged presence of PEGylated rhDNase in lung airspace

194 ratory symptoms, prior antibiotic treatment, prolonged prodromal respiratory symptoms and fever, and

195 The feedback loop further enables prolonged production of BisDC, which ensures expression

196 02684006 ), which demonstrated significantly prolonged progression-free survival (PFS) with first-lin

197 inib in the first-line setting significantly prolonged progression-free survival compared with a fixe

198 m-based chemotherapy as first-line treatment prolonged progression-free survival in patients with met

199 KdD significantly prolonged progression-free survival versus Kd in patient

200 expression late in infection is mediated by prolonged promoter-proximal pausing.

201 tunistic infection requiring indications for prolonged prophylaxis to be defined.

202 re work will evaluate the ability to provide prolonged protection against multiple virus challenges,

203 ptoid modulated the rate of drug release and prolonged protein stability against proteolytic hydrolys

204 on of YAP or TAZ resulted in more severe and prolonged proteinuria in response to injury, as well as

205 e junction length changes that saturate with prolonged pulse durations.

206 as well as to the temporal stability of more prolonged pupil-linked arousal states.

207 We found PR interval shortening and prolonged QRS duration, as well as atrioventricular bund

208 ot result in a significant change in risk of prolonged QTc.

209 Fifteen (14%) patients developed a prolonged-QTc (pQT) after 7 days (mean QTc increase 66+/

210 Furthermore, prolonged RA exposure phenocopies LSD1 inhibition, sugge

211 nists, norbinaltorphimine (norBNI), produces prolonged receptor inactivation by a cJun kinase mechani

212 As cells that show prolonged recruitment to sites of injury or pathology, m

213 1 and antibody responses are associated with prolonged recurrence-free survival.

214 ) into phosphate buffer for 24 h followed by prolonged release for at least another 48 h.

215 o the infection site, as well as the lack of prolonged release.

216 ssible in macaques with MION, despite MION's prolonged response function.

217 In these neurons, prolonged responses were recorded after success or failu

218 rologically favorable survival declines with prolonged resuscitation.

219 muPET/CT imaging showed high uptake and prolonged retention of an 89Zr-labeled surrogate of PEG~

220 ed with placebo (283 RFS events) resulted in prolonged RFS in the overall population (3-year RFS rate

221 vity against FRalpha is also associated with prolonged RFS.

222 Stalled cells exhibited prolonged S-phase, were defective in DNA synthesis and h

223 ize and/or membrane ionic permeability under prolonged salt stress.

224 grams targeting more diverse populations and prolonged sampling times are required.

225 Based on data from prolonged scans, we generated maps that visualized the p

226 ce quality of life in individuals who suffer prolonged seizures.

227 -adrenergic-stimulated cardiomyocytes led to prolonged SERCA activation, presumably because 14-3-3 pr

228 Prolonged sitting time is an emerging risk factor that e

229 ce of B cells at the time of transplantation prolonged skin graft survival.

230 The colder, more humid conditions and prolonged snow-coverage at north exposure likely influen

231 ynurenine/AHR signaling in BMM s to maintain prolonged SOCS1 expression.

232 ful for exploring the health consequences of prolonged spaceflight.

233 M134B axis promotes ER-phagy activation upon prolonged starvation.

234 terest included hospitalization, intubation, prolonged stay, sepsis, and death.

235 +) B cells tended to undergo apoptosis after prolonged stimulation, which may be considered a negativ

236 or supplying vesicles rapidly in the face of prolonged stimulation.

237 mmobilized PALs retain higher activity after prolonged storage and confer reusability for over 100 ru

238 After prolonged storage or during the shipment of raisins, a c

239 nerability to severe stress using the single-prolonged stress (SPS) model in male rats.

240 enable cells to conserve energy, prepare for prolonged stress and accelerate recovery.

241 iated inactivation and are more stable under prolonged stress conditions.

242 Here, we utilized single prolonged stress, a validated rodent model of post-traum

243 Intriguingly, however, under prolonged stress, mutant mice develop larger tumors and

244 Floor bleach cleaning led to prolonged, substantial decreases of up to 71-90% due to

245 FN-alpha) treatment of hepatocytes induced a prolonged suppression of human and duck hepatitis B viru

246 and hematologic response was associated with prolonged survival (P = .0291).

247 CTR was associated with prolonged survival (time-dependent HR 0.23, 95% CI: 0.12

248 yloid A amyloidosis have expanded leading to prolonged survival albeit frequently with renal failure.

249 ozygous null mice demonstrated significantly prolonged survival compared with wild-type.

250 ng 10% plasticizer and either 60 or 50% PLGA prolonged survival from 27 to 70 days in a GBM xenograft

251 patient-derived GBM xenografts substantially prolonged survival in mice compared to that of VEGF depl

252 ation reduced the number of GICs in vivo and prolonged survival in syngeneic and patient-derived orth

253 RAF3 from B lymphocytes in mice leads to the prolonged survival of mature B cells and expanded B cell

254 s exhibit significant antitumor activity and prolonged survival relative to all other treatment group

255 ted with reduced levels of RAC1 and RAC2 and prolonged survival, whereas elevated expression of RAC1

256 aft model leading to disease attenuation and prolonged survival.

257 cient mosquitoes present a lower viremia and prolonged survival.

258 d resisted TNF-induced apoptosis, supporting prolonged survival.

259 blocking ASOs suppressed repeat toxicity and prolonged survival.

260 treated with antibiotic therapy still shows prolonged symptoms of fatigue, musculoskeletal pain, and

261 Given that prolonged tentacle retraction reduces foraging opportuni

262 3S and KCNH2-R685P, lumacaftor paradoxically prolonged the APD90 in KCNH2-G604S iPSC-CMs.

263 ty of CREB activity to Ca(2+) elevations and prolonged the duration of CREB activation to more than 2

264 ficantly decreased the R/P rate (P = 0.001), prolonged the R/P-FS time (P = 0.032) and improved the f

265 Brensocatib treatment prolonged the time to the first exacerbation as compared

266 for incompletely resolved COPD exacerbations prolonged the time until the next event.Objectives: To a

267 Mathematical models imply that a prolonged time (decades) elapses from the development of

268 could differentiate in vivo, but required a prolonged time of four to seven months to migrate from t

269 This is explained by the prolonged time to response seen in many patients, probab

270 allowed LEC culture to remain infected for a prolonged time.

271 48%) or antibodies in 6 (29%) controls for a prolonged time.

272 lout), can provide external irradiation over prolonged times.

273 ates on multiple samples of information over prolonged timescales, but only if subjects actually inte

274 stric emptying, slowed colonic motility, and prolonged total gastrointestinal transit.

275 ophil elastase for 3 days, which resulted in prolonged tracheal mucus velocity reduction, mucus hyper

276 Immunotherapy for food allergy requires prolonged treatment protocols and, in most cases, does n

277 targeted therapies could ultimately lead to prolonged treatment responses in cancer patients.

278 d for the treatment of severe pain; however, prolonged treatment with these drugs leads to the develo

279 decreased donor-specific antibodies and, on prolonged treatment, modulated rejection-related gene-ex

280 ination treatment on cognition observed with prolonged treatment.

281 he transcriptional and phenotypic effects of prolonged treatments, indicating durable changes in cell

282 od assays, improved metabolic stability, and prolonged TRT.

283 urgery, compared to 4 patients (3.8%) in the prolonged TTS arm (P = 1.0).

284 Prolonged UDCA administration reduced the incidence of a

285 Neither acute nor prolonged UDCA treatment altered the incidence of reperf

286 and susceptibility testing often results in prolonged use of broad-spectrum antibiotics.

287 eral somatic (epi-)mutations occurred during prolonged vegetative propagation of Gransden, causing re

288 f stay >14 days (9.3% versus 2.4%, P=0.006), prolonged ventilation (17.6% versus 4.8%, P<0.001), and

289 Many ventilated COVID-19 patients require prolonged ventilation.

290 Baboons had prolonged viral RNA shedding and substantially more lung

291 r-triphosphate exhibits a long half-life and prolonged virological effects.

292 f antibody-producing B cells and suffer from prolonged virus infections.

293 need and acquisition of recovery sleep after prolonged wakefulness is an important issue in sleep res

294 signed to reduce and limit the impact of the prolonged warm ischemia inherent to the uDCD process, an

295 bank at depth in peatlands is responsive to prolonged warming.

296 Mice given an antibody against TLR2 had prolonged whole gut transit times; their colonic LMMP ha

297 Participants underwent prolonged wireless reflux monitoring (off PPIs for >=7 d

298 by the study investigator was significantly prolonged with atezolizumab versus control (15.1 vs 10.6

299 DFS was not significantly prolonged with capecitabine versus observation [hazard r

300 depends on accumulation of Naked/NKD during prolonged Wnt stimulation.