ライフサイエンスコーパス: prolonged survival

1 aft model leading to disease attenuation and prolonged survival.

2 CR(+) ALL, ibrutinib treatment significantly prolonged survival.

3 d resisted TNF-induced apoptosis, supporting prolonged survival.

4 gosity of Atoh1 reduced tumor occurrence and prolonged survival.

5 T cell abundance, delayed tumour growth, and prolonged survival.

6 ayed a delayed weight loss and significantly prolonged survival.

7 tration of gemcitabine after tumor resection prolonged survival.

8 melanoma exhibit a slower tumour growth and prolonged survival.

9 radicated CD19-negative leukemia, leading to prolonged survival.

10 D2 suppression decreased leukemia burden and prolonged survival.

11 tal day 5 delayed neurological pathology and prolonged survival.

12 t changes in the tumor vasculature but still prolonged survival.

13 drive correlates with improved outcomes and prolonged survival.

14 potent antitumor responses and significantly prolonged survival.

15 IR2DS4*00101 was independently prognostic of prolonged survival.

16 otection from pulmonary embolism, leading to prolonged survival.

17 ng genomic markers of a good-risk group with prolonged survival.

18 ression of MYCN all reduced tumor growth and prolonged survival.

19 Conversion to resection is associated with prolonged survival.

20 )) significantly improved kidney disease and prolonged survival.

21 4, significantly attenuated tumor growth and prolonged survival.

22 1 therapy, resulting in tumor regression and prolonged survival.

23 nefit in cancer patients was mostly noted as prolonged survival.

24 ssion or low POMP expression associates with prolonged survival.

25 f age; however, injection of WT FOXP3+ Tregs prolonged survival.

26 bacterial burden, attenuated pathology, and prolonged survival.

27 genes, and peripheral anti-miR-155 treatment prolonged survival.

28 nce and type I muscle fiber atrophy; it also prolonged survival.

29 ladder carcinoma and B16-melanoma growth and prolonged survival.

30 suppressing tumor recurrence and leading to prolonged survival.

31 markedly reduced leukemia burden in mice and prolonged survival.

32 nd of the study resulting in a significantly prolonged survival.

33 hearts significantly reduced heart mass and prolonged survival.

34 iated all symptoms of murine HLH and allowed prolonged survival.

35 reduced tumor burden, extended latency, and prolonged survival.

36 ll-, NK cell-, and B cell-dependent means of prolonged survival.

37 blocking ASOs suppressed repeat toxicity and prolonged survival.

38 l marrow function, reduced tumor burden, and prolonged survival.

39 ded to dexamethasone and was associated with prolonged survival.

40 vivo, along with decreased tumor burden and prolonged survival.

41 viral loads in peripheral organs and showed prolonged survival.

42 nal Lin28b deletion reduced tumor burden and prolonged survival.

43 , as evidenced by lower peak parasitemia and prolonged survival.

44 ormation, and Wnt7b expression, and markedly prolonged survival.

45 n lymphomas in vivo reduced tumor burden and prolonged survival.

46 with leukemic MCL; both were associated with prolonged survival.

47 SOX2 peptides delayed tumor development and prolonged survival.

48 on, decreased immune-mediated pathology, and prolonged survival.

49 anced accumulation of functional T cells and prolonged survival.

50 d tumors in vivo, abrogated tumor growth and prolonged survival.

51 ein concentrations in spinal cord tissue and prolonged survival.

52 downregulated Mcl-1, activated caspases, and prolonged survival.

53 y, normalization of behavioral deficits, and prolonged survival.

54 resulted in reduced tissue pathology and in prolonged survival.

55 trophy, reduced intracellular aggregates and prolonged survival.

56 lly, that patients with these responses have prolonged survival.

57 ersus tumor responses, tumor regression, and prolonged survival.

58 o phenformin as a single agent, resulting in prolonged survival.

59 omes the differentiation block, and leads to prolonged survival.

60 nt induced tumor reduction and significantly prolonged survival.

61 in tumor growth inhibition and significantly prolonged survival.

62 mmunotherapy group, corresponding with their prolonged survival.

63 ling in LSCs delayed disease progression and prolonged survival.

64 including a reduction in neuronal death and prolonged survival.

65 in an increased response to chemotherapy and prolonged survival.

66 que therapeutic options and greater hope for prolonged survival.

67 s exchange, renal flow and urine output, and prolonged survival.

68 and STAT5 phosphorylation and significantly prolonged survival.

69 totoxic to regulatory T cells in tumors, and prolonged survival.

70 not only alleviated muscle wasting, but also prolonged survival.

71 umor progression, resulting in significantly prolonged survival.

72 cient mosquitoes present a lower viremia and prolonged survival.

73 xpression of either IL12A or IL12B exhibited prolonged survival.

74 del, resulting in decreased tumor burden and prolonged survival.

75 revented neurodegeneration and significantly prolonged survival.

76 l treatment modality that offers a chance of prolonged survival.

77 tastases now have the potential to achieve a prolonged survival.

78 vels dramatically decreased tumor burden and prolonged survival.

79 dneys long term, one demonstrated a modestly prolonged survival (11 days), and two rejected rapidly (

80 nterestingly, NZB IRF4(+/-) B1 cells exhibit prolonged survival, accelerated self-renewal, and defect

81 We found that RT significantly prolonged survival across the whole BC patient populatio

82 llular recruitment to the lungs but modestly prolonged survival after infection in Rag1(-/-) mice.

83 ontainment of the bacterial growth and their prolonged survival after primary infection, and upon sec

84 ic cancer cell growth and is associated with prolonged survival after surgery.

85 yloid A amyloidosis have expanded leading to prolonged survival albeit frequently with renal failure.

86 f infection suppressed virus replication and prolonged survival, allowing the mice to make adaptive C

87 ession of lysine decarboxylase resulted in a prolonged survival among early-stage breast cancer patie

88 anIN initiation, resulted in smaller tumors, prolonged survival and a reduced tumor-associated macrop

89 fits of immediate initiation of ART, such as prolonged survival and AIDS-free survival and increased

90 (+), ameliorated aspects of MSN dysfunction, prolonged survival and attenuated some motor phenotypes

91 Efficacy studies demonstrated significantly prolonged survival and decreased metastasis burden after

92 bearing neuroblastoma lesions, significantly prolonged survival and decreased the tumor growth rate c

93 phocytes therefore have qualities indicating prolonged survival and effector function favorable to im

94 , enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together

95 cholinesterase inhibitor neostigmine showed prolonged survival and improved outcome.

96 ne tumors with (177)Lu-octreotate results in prolonged survival and improved quality of life for the

97 ransplantation and despite the difficulties, prolonged survival and improved VA can be achieved in pe

98 rejection and recipient death; 3 mg and 5 mg prolonged survival and led to severe or moderate chronic

99 3B1, or EIF1AX mutations are associated with prolonged survival and low metastatic risk, SF3B1-mutate

100 uencing, and concomitant palliative care has prolonged survival and made living with the disease more

101 Blood, Appelmann et al provide evidence for prolonged survival and prevention of resistance in a mou

102 is in allograft recipients, who demonstrated prolonged survival and reduced evidence of rejection com

103 ective agonist before allo-HCT significantly prolonged survival and reduced GvHD severity in a TNFR2-

104 Finally, prophylactic M8 treatment in vivo prolonged survival and reduced lung viral titers of mice

105 deling microbiota with Lactobacillus reuteri prolonged survival and reduced multiorgan inflammation i

106 nINs), depleted of Treg cells, significantly prolonged survival and reduced PanIN progression (median

107 tinib/GlaxoSmithKline 1120212) significantly prolonged survival and reduced proliferation but did not

108 pression revealed immunoreactive tumors with prolonged survival and response to checkpoint blockade.

109 m amyloid P (SAP; pentraxin-2) significantly prolonged survival and slowed the development of BM fibr

110 in the brain, did not induce adverse events, prolonged survival, and cured a fraction of glioma-beari

111 xpression have significantly less nephritis, prolonged survival, and decreased infiltrating inflammat

112 d that crizotinib decreased tumor dimension, prolonged survival, and increased blood and tissue conce

113 er tissue human ARC and beta-catenin levels, prolonged survival, and increased sensitivity to chemoth

114 In MMTV-ErbB2 transgenic mice, loss of Pak1 prolonged survival, and mammary tissues of such mice sho

115 of IkappaBalphaSR attenuated leukemogenesis, prolonged survival, and reduced myeloid leukemic stem ce

116 ished tumors with ppp-TGF-beta significantly prolonged survival as compared with ppp-RNA or TGF-beta

117 litinib combined with Navitoclax or BV alone prolonged survival but did not cure HDLM-2 tumor-bearing

118 TMZ, EGFRvIII expression is associated with prolonged survival, but only in patients with O6-methylg

119 Collectively, invasion of RPE by Pg and its prolonged survival by autophagy evasion within these cel

120 Symptomatic therapy has prolonged survival by limiting deaths resulting from res

121 his case-control study seems to confirm that prolonged survival can be achieved in highly selected pa

122 1Delta/Delta mutant strain had significantly prolonged survival compared to that of mice infected wit

123 at "M1" high tumors were not associated with prolonged survival compared with "M1" low tumors, or wit

124 ed vessel density, delayed tumor growth, and prolonged survival compared with B20.

125 d radiation therapy results in substantially prolonged survival compared with historical controls.

126 versus-host disease (GVHD) and significantly prolonged survival compared with MAC-transplanted recipi

127 ipients treated with 20-mg/kg 4SC-101 showed prolonged survival compared with placebo-treated animals

128 ia reduced leukemia burden significantly and prolonged survival compared with results in the single-d

129 macologic treatment delayed tumor growth and prolonged survival compared with subjects receiving sing

130 ted a significant delay in disease onset and prolonged survival compared with their AAV2/9-GFP-inject

131 antly delayed PanIN formation and ultimately prolonged survival compared with vehicle-treated control

132 ce are protected from renal disease and have prolonged survival compared with wild-type littermates;

133 ozygous null mice demonstrated significantly prolonged survival compared with wild-type.

134 tion, along with ameliorated weight loss and prolonged survival, depends on microbiota-enhanced IFNga

135 Kit(W-sh/W-sh) mice showed a prolonged survival during the first few days after media

136 A prolonged survival, even without treatment, is common.

137 gen-challenged wild-type mice are capable of prolonged survival ex vivo, in contrast to eosinophils f

138 warranted because this regimen may allow for prolonged survival following LXT.

139 astases, termed oligometastases, can achieve prolonged survival following metastasis-directed therapi

140 n cancer cases and inversely correlated with prolonged survival for two types of cancer.

141 ng 10% plasticizer and either 60 or 50% PLGA prolonged survival from 27 to 70 days in a GBM xenograft

142 ve Lactobacillus species promotes robust and prolonged survival from an otherwise lethal infection wi

143 Improved therapeutic options and prolonged survival have further increased the need for s

144 oxic impact of therapy, thereby allowing for prolonged survival in a dormant state, with the potentia

145 SI-IPT 1 region inhibited brain invasion and prolonged survival in a glioblastoma multiforme model, p

146 Furthermore, this mutein prolonged survival in a model of graft-versus-host disea

147 ption, correlating with tumor regression and prolonged survival in a mouse model of MYCN-driven neuro

148 tovaquone to mice inhibited tumor growth and prolonged survival in a murine model of multiple myeloma

149 T5 knockdown or PJ-68 treatment dramatically prolonged survival in a murine model of retroviral BCR-A

150 bined with temozolomide) was associated with prolonged survival in a prospective phase I/II trial enr

151 No blood pressure-lowering strategy prolonged survival in adults with diabetes and kidney di

152 The prolonged survival in AID-deficient BXSB mice appears at

153 glia substantially delayed disease onset and prolonged survival in ALS mice, suggesting that ALS-link

154 cell maturation, induced growth arrest, and prolonged survival in an AML mouse model.

155 Gene transfer of murine TMZ-CD40L prolonged survival in an animal model.

156 tantly, an orally bioavailable PKC inhibitor prolonged survival in an experimental cerebral malaria m

157 K27me3, altered chromatin accessibility, and prolonged survival in animal models.

158 ablation of alveolar macrophages results in prolonged survival in association with a reduction in vi

159 kedly reduced tumor growth and significantly prolonged survival in association with Mcl-1 down-regula

160 tosis of human EVI1-positive cell lines, and prolonged survival in both orthotopic xenograft models a

161 , culminating in suppressed tumor growth and prolonged survival in GBM-bearing mice after temozolomid

162 HIV-1) load, higher CD4(+) T-cell count, and prolonged survival in HIV-1 coinfected patients.

163 ro, and GBV-C coinfection is associated with prolonged survival in HIV-infected people.

164 lecules also decreased BTIC propagation, and prolonged survival in mice bearing orthotopic GBM xenogr

165 patient-derived GBM xenografts substantially prolonged survival in mice compared to that of VEGF depl

166 ted that AS101 abrogated drug resistance and prolonged survival in mice receiving chemotherapy.

167 ding to reduced HPV(+) TC-1 tumor growth and prolonged survival in mice.

168 after alloHSCT decreased aGVHD severity and prolonged survival in mice.

169 and alone or in combination with Cytarabine, prolonged survival in mouse model of human leukemia incl

170 endent fashion, causing tumor regression and prolonged survival in mouse models.

171 ransplantation (HDT/ASCT) is a surrogate for prolonged survival in multiple myeloma; however, patient

172 owth and colony formation, and significantly prolonged survival in murine AML xenografts.

173 t, is associated with reduced metastasis and prolonged survival in pancreatic ductal adenocarcinoma (

174 The findings of prolonged survival in patients treated with concomitant

175 b, a monoclonal antibody VEGFR-2 antagonist, prolonged survival in patients with advanced gastric can

176 Salvage surgery was associated with prolonged survival in patients with lung-only and liver-

177 ecreased USP1 expression was associated with prolonged survival in patients with proneural glioblasto

178 ed and associated with durable responses and prolonged survival in patients with refractory metastati

179 wth in a xenograft model and correlates with prolonged survival in patients.

180 Furthermore, HPssCD-HET0016 significantly prolonged survival in PDX GBM811 model.

181 ion of ROR1 reduced metastatic outgrowth and prolonged survival in preclinical models.

182 etastasis of human prostate cancer cells and prolonged survival in recipient mice.

183 Increased DNMT3B expression prolonged survival in retrovirally induced Myc-Bcl2- or

184 ls of Il1beta/18 and splenic cell death, and prolonged survival in septic Sharpin-deficient mice.

185 ation reduced the number of GICs in vivo and prolonged survival in syngeneic and patient-derived orth

186 afts results in slower tumor growth rate and prolonged survival in the ABC-like DLBCL xenografts comp

187 , indicating that bb0449 is not required for prolonged survival in the nutrient-limited environment i

188 s, reduced spontaneous seizure frequency and prolonged survival in the Scn1a (+/-) mice.

189 the parent, the double mutant also exhibited prolonged survival in the stationary phase.

190 s conventional, cisplatin-based chemotherapy prolonged survival in this model compared with chemother

191 Prolonged survival in this subgroup was supported by pos

192 Therapy with Z12-formulated vaccines prolonged survival in three robust tumor models, with th

193 at iron chelation therapy is associated with prolonged survival in transfusion-dependent MDS patients

194 ) polymerase (PARP) inhibitor, olaparib, and prolonged survival in tumor-bearing mice.

195 ecreased tumor growth rate and significantly prolonged survival in vivo.

196 Consequently, we observed prolonged survival in which nearly 90% of the mice survi

197 Only 3 factors independently associated with prolonged survival, including extended duration (>=6 cyc

198 GDNF prolonged survival, induced enteric neurogenesis, and im

199 Prolonged survival is associated with relative overexpre

200 Rather, prolonged survival is dominantly mediated via induced ex

201 ncidence might increase in the future due to prolonged survival observed after pancreaticoduodenectom

202 ve environment was maintained, with markedly prolonged survival of a second identical allograft.

203 ressed MET/CAT-induced tumor development and prolonged survival of animals with MET/CAT-induced HCC.

204 ore infection, transfer of hyperimmune serum prolonged survival of C3aR(-/-) mice.

205 Furthermore, compound 1 prolonged survival of Caenorhabditis elegans infected wi

206 mproved immune control by activated NK cells prolonged survival of CD27-trunc-expressing lymphoma-bea

207 Conversely, overexpression of PDKs prolonged survival of cells in suspension.

208 mmune modulating effect, leading to markedly prolonged survival of donor swine skin xenografts that m

209 These findings as well as the prolonged survival of f10(-/-) mutants will enable us to

210 of Antarctic geological deposits points to a prolonged survival of giant-sized pelagornithids within

211 of Stat5 causes excessive granulopoiesis and prolonged survival of granulocytes in circulation.

212 pressing murine interleukin-12 (IL-12; M002) prolonged survival of immunocompetent mice in intracrani

213 y, depletion of CD4(+) T cells abrogated the prolonged survival of infected CD8(-/-) mice, demonstrat

214 nsplantation model, alloTregs but not nTregs prolonged survival of islet allografts without any other

215 gle systemic administration of MDSC markedly prolonged survival of islet allografts without requireme

216 Cotransplantation with WT MDSCs markedly prolonged survival of islet allografts, which was associ

217 bservation that coating with wax facilitates prolonged survival of L. monocytogenes on whole apples i

218 RAF3 from B lymphocytes in mice leads to the prolonged survival of mature B cells and expanded B cell

219 uximab vedotin promoted tumor regression and prolonged survival of mice bearing previously reported U

220 mbination therapy inhibited tumor growth and prolonged survival of mice bearing the WU-BC4 line, but

221 Strikingly, recombinant IL12 prolonged survival of mice challenged with highly aggres

222 oliferating cells in neurofibroma and MPNST, prolonged survival of mice implanted with human MPNST ce

223 and synergistically reduced tumor growth and prolonged survival of mice in 2 of the subcutaneous and

224 In contrast, the CD24-specific T-bodies prolonged survival of mice in which only a subpopulation

225 erapy with compound 7 and gammadelta T cells prolonged survival of mice inoculated with either human

226 Cs in the BM, induced disease remission, and prolonged survival of mice with CML.

227 The sodium channel modulator GS967/Prax330 prolonged survival of mice with global expression of R18

228 injection of T-bodies reduced tumor size and prolonged survival of mice with orthotopically transplan

229 In addition, the HSP90 inhibitor AUY922 prolonged survival of mice xenografted with primary huma

230 eukemia onset, reduced CNS infiltration, and prolonged survival of mice.

231 creased Jo2-induced liver cell apoptosis and prolonged survival of mice.

232 of PSMA-expressing tumors, and significantly prolonged survival of mice.

233 , resulting in reduced tumor progression and prolonged survival of mice.

234 -free (GF) donors and recipients resulted in prolonged survival of minor antigen-mismatched skin graf

235 ction by T cells and upon transfer no longer prolonged survival of MRL.Fas(lpr) mice.

236 ALT-803 treatment also significantly prolonged survival of myeloma-bearing mice and provided

237 Chemotherapy combined with Natalizumab prolonged survival of NOD/SCID recipients of primary ALL

238 lumican and its presence is associated with prolonged survival of patients with localized PDAC.

239 The prolonged survival of patients with stable, compensated

240 mately lead to improved immune therapies and prolonged survival of patients.

241 s PEL cell death, resulting in significantly prolonged survival of PEL-bearing mice.

242 The studies demonstrated prolonged survival of rats subjected to hemorrhagic inju

243 ed studies, SNX27-depleted cell lines showed prolonged survival of SCID mice, suggesting a possible i

244 ransient H57-597 mAb treatment significantly prolonged survival of skin allografts in naive recipient

245 delayed denervation of hindlimb muscles, and prolonged survival of spinal motor neurons.

246 dney grafts from LTT animals showed markedly prolonged survival of the naive renal grafts (day 28, >1

247 d phosphatidylcholine synthesis supports the prolonged survival of Traf3 (-/-) B lymphocytes.

248 nkage, restoration of immune competence, and prolonged survival of TRAMP mice, repeated boosting did

249 d pre-B ALL cells in vitro and significantly prolonged survival of transplant recipient mice in vivo.

250 deficiency (ob/ob) increased lipogenesis and prolonged survival of Trex1(-/-) mice without dampening

251 Myc and Notch ICN-driven leukemia models and prolonged survival of tumor-bearing animals by accelerat

252 LNPs induced gene silencing in MCL cells and prolonged survival of tumor-bearing mice with no observe

253 f memory cells from this combination therapy prolonged survival of tumor-bearing recipients.

254 edly protected against I/R, improved LR, and prolonged survival of tumor-laden mice.

255 hatch; however, intrabursal injection of PE prolonged survival of VLR(PE)Tmu(+) bursal and periphera

256 linical factors associated with survival and prolonged survival (of at least 10 years).

257 The pathogenic strain exhibited prolonged survival on stainless steel surfaces compared

258 yte-dependent primary tumor growth delay and prolonged survival only in T-cell-inflamed tumor models

259 rveillance was associated with significantly prolonged survival (OR 1.90, 95% CI 1.67-2.17), which re

260 ol, resulting in tumor growth inhibition and prolonged survival over paclitaxel alone.

261 ulting double knockout mice exhibit slightly prolonged survival over RIP1-deficient animals.

262 t decrease in leukemic burden (P < .001) and prolonged survival (P < .01) was observed compared with

263 T) and AG genotype of rs2279343 (c.785A > G) prolonged survival (p < 0.05).

264 and hematologic response was associated with prolonged survival (P = .0291).

265 ix genes - Immu6Metagene was associated with prolonged survival phenotypes.

266 nt cell transplant or zileuton treatment had prolonged survival, reduced GVHD clinical scores, reduce

267 ve to the wild-type strain, as manifested by prolonged survival, reduced pulmonary fungal burden and

268 s exhibit significant antitumor activity and prolonged survival relative to all other treatment group

269 rological deficits during JEV infection, and prolonged survival, suggesting chymase is a novel therap

270 radiotherapy (SRS and/or WBRT) and TKIs have prolonged survival, suggesting that interventions to con

271 a higher lymph node yield, and resulted in a prolonged survival than THE in pT3, cT3, and node-positi

272 IR prolonged survival; the mean number of life-years per pa

273 growth of Hh-associated medulloblastoma and prolonged survival through inhibition of cell proliferat

274 xenografts to radiotherapy and significantly prolonged survival, thus suggesting the likelihood of tr

275 early times after infection in WT mice and a prolonged survival time in immunocompromised Ifnar1(-/-)

276 xposed to total venom or purified porin, and prolonged survival time in mice following venom injectio

277 apoptosis when cultured in vitro but have a prolonged survival time in vivo, indicating that tissue

278 f tumors in 4 of 5 cases and a significantly prolonged survival time, compared with untreated control

279 CTR was associated with prolonged survival (time-dependent HR 0.23, 95% CI: 0.12

280 of bacteremia at 12 h postinfection and had prolonged survival times compared with the saline-treate

281 STN prolonged survival times of non-human primate kidney all

282 caudal levels of the spinal cord even after prolonged survival times.

283 patient derived xenografts of GBM811, showed prolonged survival to 26 weeks in animals treated with f

284 Importantly, glycOMVs significantly prolonged survival upon subsequent challenge with F. tul

285 or-bearing mice with CCL22 deficiency showed prolonged survival upon vaccination, and further, CCL22-

286 This prolonged survival was associated with increase in numbe

287 Prolonged survival was associated with metastases in few

288 idation with transplantation strategies, and prolonged survival was observed in a proportion of patie

289 Regardless of dose, prolonged survival was observed in patients who achieved

290 Prolonged survival was only achieved in a few patients i

291 ng positive results in terms of response and prolonged survival were determined using receiver operat

292 Synergistic antitumor efficacy and prolonged survival were noted in human orthotopic pancre

293 e VWF D'D3-Fc chimera also exhibits markedly prolonged survival when transfused into FVIII-deficient

294 ted with reduced levels of RAC1 and RAC2 and prolonged survival, whereas elevated expression of RAC1

295 tic and led to complete tumor resolution and prolonged survival, which was dependent on the presence

296 ven their elevated risk for many cancers and prolonged survival with immunosuppression, ART exposure,

297 representative B-ALL xenografts demonstrated prolonged survival with rapamycin treatment compared wit

298 Here, we demonstrate that GBS shows prolonged survival within J774 macrophages and that the

299 -1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) prolonged survival without any apparent toxicities.

300 ial antitumor immune responses, resulting in prolonged survival without toxic effects.