ライフサイエンスコーパス: promiscuously

1 ronizing the annual mating period and mating promiscuously.

2 deep neural explants cells intercalate more promiscuously.

3 bind divalent cations and accessory proteins promiscuously.

4 the need for most chaperones to bind clients promiscuously.

5 al chemokine receptor endocytoses chemokines promiscuously.

6 nate metabolite N-arachidonyldopamine (NADA) promiscuously activated both CB1 and TRPV1 receptors.

7 biotic receptor pregnane X receptor (PXR) is promiscuously activated by a range of structurally disti

8 40 (SV40) early gene product large T antigen promiscuously activates simple promoters containing a TA

9 alysis of 5'-flanking sequences identified a promiscuously active 172-base pair minimal promoter, whe

10 and DNT1 and DNT2 bind to Toll-6 and Toll-7 promiscuously and are distributed in vivo in domains com

11 yotic or bacterial chromosomes that bind DNA promiscuously and function in diverse DNA reactions.

12 These enzymes act promiscuously and stochastically, causing microheterogen

13 n the same community bind to diverse ligands promiscuously and they are also embedded in diverse doma

14 Cop 1 binds promiscuously and very efficiently to living APCs of var

15 Copolymer 1 binds promiscuously and very efficiently to purified HLA-DR mo

16 The small-molecule dyes bind promiscuously and with high affinity, but their binding

17 GEFs can interact with multiple Rho proteins promiscuously, and overexpression of one dominant negati

18 receptors, often called decoy receptors, act promiscuously as molecular sinks to regulate ligand bioa

19 NC promiscuously associates with cellular RNAs, many of whi

20 rin LFA-1 (CD11a/CD18) of leukocytes and can promiscuously bind and also permeabilize many other cell

21 Here we show that short peptides that promiscuously bind both chemokine classes can be identif

22 Tick evasins promiscuously bind CC and CXC-chemokines, overcoming red

23 despite the ability of each ephrin ligand to promiscuously bind many Eph receptors, the two compounds

24 Indeed, all other Eph receptors, which promiscuously bind many ephrins, have a conserved argini

25 and LidA, which were previously reported to promiscuously bind multiple Rab GTPases in vitro.

26 While the PH domains of intersectin and Dbs promiscuously bind several multiphosphorylated phosphoin

27 y a broad ligand selectivity; i.e., they can promiscuously bind to and may be activated by multiple l

28 ch to the immunosilencing of capsid epitopes promiscuously binding to T cells may be applied to other

29 - particularly heparin, a readily available, promiscuously-binding GAG.

30 the fowlpox virus prosurvival protein FPV039 promiscuously binds to cellular proapoptotic Bcl-2 and e

31 inity and specificity: the N37A mutant binds promiscuously both to cognate (C. thermocellum) as well

32 ata show that PMCA "b" splice forms interact promiscuously but also with specificity with different m

33 Many enzymes can promiscuously catalyse reactions or act on substrates be

34 he V(H) domain of an anti-E2 IgG paired with promiscuously catalytic V(L) domains.

35 onclude that Galphaq, Galpha11, and Galpha14 promiscuously couple several receptors (m3 muscarinic, b

36 activation-induced cytidine deaminase (AID) promiscuously damages oncogenes, leading to chromosomal

37 ADARs deaminate perfectly base-paired dsRNA promiscuously, deamination is limited to a few, selected

38 and undifferentiated phenotype of C8161 was promiscuously dominant.

39 ) that lack this downstream element were not promiscuously edited in McArdle or HepG2 cells.

40 ode new protein isoforms, and dsRNA-induced, promiscuously edited RNAs that encode nonfunctional, mut

41 Phage Mu transposes promiscuously, employing protein MuB for target capture.

42 how the least range in coupling energies and promiscuously encourage heterodimerization.

43 ls from various nonlymphoid tissues migrated promiscuously, except to the intestinal mucosa, supporti

44 how the variable extent to which the domains promiscuously exchange electrons while reducing differen

45 We engineer a selective SMR protein to promiscuously export quaternary ammonium antiseptics, si

46 nt and regulates the alternative splicing of promiscuously expressed genes.

47 lanation as to why these marker genes can be promiscuously expressed in different fibroblast populati

48 ymphocytes, yet they target distinct sets of promiscuously expressed lineage-inappropriate genes to s

49 zeable fraction of the overall repertoire of promiscuously expressed self-antigens.

50 mutants of Taq DNA polymerase that not only promiscuously extended mismatches, but had acquired a ge

51 ified location-specific symbiont types that "promiscuously" form associations with multiple divergent

52 We show here that AID acts promiscuously, generating widespread DNA double-strand b

53 Within a cell, individual glycotransferases promiscuously help to construct dozens of unique glycan

54 ignature broadens the specificity of Aph1 to promiscuously hydrolyze (p)ppGpp in vitro.

55 se 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a broad range of substrates, i

56 One major finding was that all of the promiscuously immunodominant gp120 sequences are located

57 Promiscuously immunodominant helper T-cell epitopes in t

58 Promiscuously immunogenic sequences were associated with

59 f a natural heme transport protein, ChuA, to promiscuously import heme derivatives, we have evolved a

60 ntiquity, the term 'imitation' has been used promiscuously in biology and everyday life.

61 sely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple envi

62 cells have the capacity to be activated more promiscuously in response to individual cytokines from i

63 most kinase inhibitors that target this site promiscuously inhibit multiple kinases.

64 These aggregates promiscuously inhibit soluble proteins and are a major s

65 ntified a subset of protease inhibitors that promiscuously inhibited spike cleavage by both transmemb

66 possible, this is preferred over the use of promiscuously integrating vectors, which are sometimes a

67 rotein virus assembly systems, coat proteins promiscuously interact to form heterogeneous aberrant st

68 synthesized polypeptide is misfolded and can promiscuously interact with cytosolic factors.

69 r developing polypharmacological agents that promiscuously interact with multiple proteins yet result

70 Strikingly, the same Nup98 groove promiscuously interacts with Nup82 and Nup96 in a mutual

71 Here we show that Ure2p promiscuously interacts with various compositionally sim

72 tol pyrophosphates and SPX domains bind them promiscuously, it is unclear whether a specific inositol

73 pus T cells also have hypomethylated DNA and promiscuously kill autologous monocytes/macrophages, we

74 , a photoactivatable, lipophilic probe which promiscuously labels both proteins and lipids within pho

75 ar interest in species in which females mate promiscuously, leading to paternity uncertainty.

76 ty for multiple myeloid or lymphoid programs promiscuously may allow flexibility in fate commitments

77 Although interacting with RNA promiscuously, PRC2 binding is enriched at specific loca

78 inked with low viremia showed the ability to promiscuously present a larger breadth of peptides with

79 d biotin ligase (BirA*G3) that biotinylates, promiscuously, proteins in a subcellular compartment of

80 This indicates individual CCT monomers can promiscuously re-assemble into dimers, and lack the info

81 eins, while trans-disulfides are rapidly but promiscuously reactive.

82 lopment of CD8+ cytolytic T lymphocytes that promiscuously recognize MHC class II molecules in associ

83 None of the CTLs promiscuously recognized 16 HLA-B7-binding synthetic pep

84 d repertoire of cytolytic T lymphocytes that promiscuously recognizes major histocompatibility comple

85 that PF1 may act as an architectural factor, promiscuously recognizing a spectrum of AT-containing el

86 The encoded Ga15 protein can promiscuously redirect GPCR signaling toward pathways wi

87 the homologous human proteins ABH2 and ABH3 promiscuously repair DNA and RNA bases damaged by S(N)2

88 s GPCR kinases (GRKs) and beta-arrestins and promiscuously responds to CXCL12, CXCL12 variants, other

89 ic T cells recognizing either selectively or promiscuously restricted epitopes were predominantly T e

90 M3 also employs structural mimicry to promiscuously sequester chemokines, engaging conservativ

91 flexible region containing determinants that promiscuously stimulate ParF polymerization.

92 00 microM), some drugs can aggregate and act promiscuously, suggesting that aggregation may be common

93 We found that Restrictor promiscuously suppresses early elongation by RNAPII, but

94 er, these findings indicate that CtpA rather promiscuously targets polypeptides that lack structurall

95 in cell signaling networks tend to interact promiscuously through low-affinity interactions.

96 network of diverse morphologies that extends promiscuously throughout the cytoplasm(3), forming abund

97 monstrate that VDR/RXR heterodimers can bind promiscuously to a wide range of hormone response elemen

98 be location-specifiers, turn out to respond promiscuously to a wide range of stimuli.

99 FR3c in complex with FGF1, an FGF that binds promiscuously to each of the seven principal FGFRs.

100 echanism requires that cPcdh cis dimers form promiscuously to generate diverse recognition units, and

101 tational prediction of their ability to bind promiscuously to human major histocompatibility complex

102 dies have proposed that small molecules bind promiscuously to IDPs, causing expansion of their confor

103 In contrast to mouse FcRn, which binds promiscuously to IgGs across species, human FcRn does no

104 g portions of ephrin ligands bind weakly and promiscuously to many Eph receptors.

105 ant mechanism that prevents Gag from binding promiscuously to phosphatidylserine-containing membranes

106 As a chaperone, it binds promiscuously to precursors to maintain them in a non-na

107 nterparts, zebrafish B-ephrins can also bind promiscuously to several Eph receptors.

108 has been made, but also within genes and in promiscuously transcribed intergenic regions.

109 exhibits a potent nickase activity that acts promiscuously upon DNA secondary structures.

110 ion is made deterministically, downstream of promiscuously used-and frequently oncogenic-signalling p

111 wo different mmBCFAs and serine was acylated promiscuously with a broad range of fatty acids, includi

112 ed cysteine residue in free E2 from reacting promiscuously with electron deficient chemical moieties

113 l chemokine-binding proteins, which interact promiscuously with multiple chemokines, pUL21.5 selectiv

114 multiple ligands and receptors that interact promiscuously with one another and typically appear in c

115 s used preferentially or if LMP2A associates promiscuously with other Src family kinase (SFK) members

116 The FG Nups interact promiscuously with various nuclear transport receptors (

117 Cop 1 binds promiscuously, with high affinity and in a peptide-speci

118 Mammalian PRC2 binds RNA promiscuously, with thousands of target transcripts in v

119 In addition, PF1 can bind promiscuously, with varying affinity, to other AT-contai