ライフサイエンスコーパス: promoter element

1 cco seeds relative to the soybean fad3C gene promoter element.

2 (NF-YA), binds to the CCAAT motif, a common promoter element.

3 x1 for a C base 5' relative to the core TAAT promoter element.

4 leotides at the 3' terminus of the S segment promoter element.

5 e transcription bubble downstream of the -10 promoter element.

6 ransgene driven by a tetracycline-responsive promoter element.

7 of a promoter segment, especially the '-10' promoter element.

8 t for late cell cycle genes containing a CHR promoter element.

9 t-induced genes through binding to the L box promoter element.

10 control via phase variation of an invertible promoter element.

11 n but cannot initiate DNA melting at the -10 promoter element.

12 ch does not contain a discernable downstream promoter element.

13 nd A14G) in the most highly conserved 3'-end promoter element.

14 rylation and Csrp2 gene expression via a CRE promoter element.

15 rol of an interferon gamma-inducible H-2K(b) promoter element.

16 , and fimX) phase variation of an invertible promoter element.

17 on of H4 genes required an acetate-sensitive promoter element.

18 sequence for the human initiator (Inr) core promoter element.

19 acting GLUT4-liver X receptor element (LXRE) promoter element.

20 of BCL2 transcription via the i-motif in the promoter element.

21 ontrol of a tissue-restricted 3.9kbPeriostin promoter element.

22 with promoter spacer between the -10 and -35 promoter elements.

23 tion in essentially the same way as proximal promoter elements.

24 ted transcriptional activation at cooccupied promoter elements.

25 specifically interacts with the -10 and -35 promoter elements.

26 nalyses demonstrate that both are novel core promoter elements.

27 precipitation revealed that LMO4 bound Oprk1 promoter elements.

28 esented DNA motifs and known eukaryotic core promoter elements.

29 tivates CLV3 transcription by binding to its promoter elements.

30 4R), under the control of cell type-specific promoter elements.

31 bp segment in P(shr) that overlaps the core promoter elements.

32 that recruit transcriptional coregulators to promoter elements.

33 significant local overrepresentation of core promoter elements.

34 nding of transcription factors to regulatory promoter elements.

35 e (HSR) and release of HSF1 from its cognate promoter elements.

36 showed direct binding of HNF3beta to 15-PGDH promoter elements.

37 sigma factors and the presence of additional promoter elements.

38 t lacked similarity to the E. coli sigma(70) promoter elements.

39 duced with the loss of RB harbored different promoter elements.

40 der the control of the Tie2, Runx1, or Prox1 promoter elements.

41 of E2F or pocket proteins p107 and p130 with promoter elements.

42 definition of phylogenetically conserved CHR promoter elements.

43 f LDSS-P as a method to delineate functional promoter elements.

44 SS) at variable distances downstream of core promoter elements.

45 ion can occur in the absence of defined core-promoter elements.

46 ay be driven to increased activation through promoter elements.

47 ivates viral genes by binding exclusively at promoter elements.

48 ter fusions were made to identify regulatory promoter elements.

49 nucleotides are strictly conserved and form promoter element 1 (PE1), with adjacent segment-specific

50 ore promoter element, XCPE1 (the X gene core promoter element 1), that drives RNA polymerase II trans

51 tively-regulate gene expression by targeting promoter elements, a phenomenon known as RNA activation

52 d factor (TAF) subunits recognize downstream promoter elements, act as coactivators, and interact wit

53 We show that core promoter elements affect burst size and uncover synergis

54 d that epigenetic signatures at enhancer and promoter elements aligns with transcriptional variation

55 es spatial clustering of MIR335 enhancer and promoter elements along with overexpression of the MIR35

56 We first show here that the '-35' promoter element also can stabilize promoter-proximal pa

57 holoenzyme required for engagement with -10 promoter element, although by a mechanism distinct from

58 pment promotes transcription from the distal promoter element and contributes to the overall transcri

59 randed DNA binding affinity for an essential promoter element and diminished interaction with corepre

60 f-function 0.5-Mb deletion, encompassing the promoter element and exons 1, 2 and 3 of phospholipase C

61 ning a C-repeat/drought-responsive (CRT/DRE) promoter element and metabolic changes that enhance tole

62 luster is controlled by Twist-1 via an E-Box promoter element and supports a role for these miRNAs as

63 the nonoptimal 19-bp spacer between the -10 promoter element and the -35 promoter element in order t

64 and requires two elements: the extended -10 promoter element and the initial transcribed region from

65 n derepressed expression from wild-type (wt) promoter elements and activation of an additional promot

66 42 (afaB-aafCB and aafDA) and identified the promoter elements and AggR-binding sites required for fi

67 Pol II pausing correlates with distinct core promoter elements and associates a TATA-enriched promote

68 rms of subunit composition and architecture, promoter elements and basal transcription factors requir

69 ine its interactions with a panel of natural promoter elements and consensus-derived sequences.

70 ptional complex that binds in IL-10 and ICOS promoter elements and controls gene expression in human

71 transcription initiation by binding to core promoter elements and directing preinitiation complex as

72 rans-acting factors integrating at conserved promoter elements and epigenetic modifications.

73 er, MCSs impose a necessary distance between promoter elements and genes of interest.

74 t many promoters by binding upstream of core promoter elements and interacting with the C-terminal do

75 We show that NSD1 binds near various promoter elements and regulates multiple genes that appe

76 iption with a focus on the identification of promoter elements and regulatory mechanisms.

77 LONGATED HYPOCOTYL5 (HY5) binds to the DEWAX promoter elements and represses its expression to promot

78 TFIIIC stabilizes binding of TFIIIC to core promoter elements and results in enhanced transcriptiona

79 e combinations: increased activation of ISRE promoter elements and simultaneous activation of both IS

80 In addition to the consensus promoter elements and spacer length, the GC content of t

81 e Cbf1-Met4 complex bound to Cbf1-recruiting promoter elements and that Met31/32 are required for for

82 The organization of the different promoter elements and the activator binding site at the

83 e, which causes variable spacing between the promoter elements and the start site; this in turn cause

84 in the undifferentiated M lineage cells via promoter elements and then the CeTwist activates its own

85 rences in the relative strengths of the core promoter elements and to the presence of active binding

86 ional activators act at a distance from core promoter elements and work by recruiting RNA polymerase

87 acts with a conserved beta-globin downstream promoter element, and ablation of this interaction by be

88 exual reproduction and cyst formation, novel promoter elements, and a microRNA system potentially reg

89 a DNA segment that separates the -10 and -35 promoter elements, and facilitates the formation of stab

90 ough a mechanism involving direct binding at promoter elements, and increases the mutation frequency

91 action between transcriptional machinery and promoter elements, and may be the prominent source of th

92 vary according to the sequence of different promoter elements, and our results are important for und

93 All core promoter elements are contacted by subunits of TFIID, wi

94 Alternatively, gene-specific promoter elements are directly fused to the binary facto

95 lds from the cyclin B2 and the canonical UPR promoter elements are upregulated by ELL2 cDNA.

96 ity required functional vitamin D-responsive promoter elements as well as an intact VDR DNA binding d

97 sequences is consistent with the presence of promoter elements associated with MG428-dependent recA i

98 lta binds to DNA immediately upstream of the promoter element at A-rich sequences on the abrB and rrn

99 in vivo gene targeting to insert an enhancer-promoter element at an imprinted chromosome 12 locus in

100 boxes relative to each other and to the core promoter elements at different genes varies dramatically

101 eagues demonstrate the critical role of core promoter elements at p53 target loci, in that they dicta

102 cy can be altered by the nature of different promoter elements at target promoters.

103 interacts with vRNA and cRNA using conserved promoter elements at the 5' and 3' termini.

104 expected, but the model was blind to distal promoter elements between -2871/-750 necessary for gonad

105 oA, IsoC, and IsoD) require Gln3 and UASGATA promoter elements, both requirements typical of NCR-sens

106 nts into close association with the proximal promoter elements bound by CONSTANS (CO).

107 roides fragilis sigma(ABfr) consensus -33/-7 promoter elements but lacked similarity to the E. coli s

108 -activated receptor-gamma (PPARG)-responsive promoter elements but not through liver X receptor eleme

109 Further study has shown that distinct promoter elements, but comprising the same E2F-recogniti

110 ognition of the TG motif of the extended -10 promoter element by sigma(70).

111 which is regulated by a proximal cis-acting promoter element called fibroblast transcription site-1

112 M1BP binds a core promoter element called Motif 1.

113 was able to bind to and function via a core promoter element called the Initiator (Inr).

114 stable complex that recognizes an snRNA gene promoter element called the PSEA.

115 The data also indicate that unmelted -10 promoter element can impair RNAP interactions with promo

116 Our results demonstrate that novel promoter elements can be identified on a genome-wide sca

117 ributions to bursting of the individual core promoter elements-CCAAT, TATAA-like, Sp1BS, and Inr-of a

118 ic repeat structure constitutes a novel core promoter element, coincides with human evolution, and co

119 ediction based deletion analysis of both the promoter elements confirmed the necessary cis-acting reg

120 Dorsal gland promoter element-containing effectors are at the front l

121 itu hybridisation and catalogue dorsal gland promoter element-containing effectors from available cys

122 elial growth factor (VEGF) and that the VEGF promoter element contains multiple TTF-1-responsive sequ

123 ising interesting possibilities for how core promoter elements contribute to defining promoters that

124 e-specific transcription factor occupancy of promoter elements contribute to the epigenetic control o

125 y matrix models of gene expression-that each promoter element contributes independently and additivel

126 he piRNA upstream motif is derived from core promoter elements controlling snRNA transcription.

127 rected binding of RNA polymerase to distinct promoter elements controls transcription and promotes ad

128 itiator (Inr) element has been the only core promoter element described in the divergent unicellular

129 We report that core promoter elements determine this promoter specificity; a

130 at are dependent on a TCT or downstream core promoter element (DPE) motif.

131 box or AT-rich region but not the downstream promoter element (DPE) or the motif ten element (MTE).

132 motif ten element (MTE), and downstream core promoter element (DPE) promoter motifs within the TFIID-

133 initiator, TATA box, and the downstream core promoter element (DPE), which confer specific properties

134 the TATA box, initiator, and downstream core promoter element (DPE), which confer specific properties

135 motifs, the TATA box and the downstream core promoter element (DPE).

136 nts such as the TATA box and downstream core promoter element (DPE).

137 TA-box, initiator [Inr], and downstream core promoter element [DPE]) that confer specific properties

138 genome integration, a selectable marker and promoter elements driving a coding gene.

139 e data, we suggest coevolution of epigenetic promoter elements during the establishment of C4 photosy

140 Mutations in this promoter element eliminate the transcription delay and p

141 calization of the uninduced gene depended on promoter elements essential for induction and required t

142 ack the previously identified canonical core promoter elements except for the Inr.

143 Our data reveal how the TATA and BRE promoter elements facilitate recruitment of the essentia

144 spite the remarkably similar arrangements of promoter elements, FadR predominately regulates fabA exp

145 g regulatory elements as well as the minimal promoter element for optimal expression in each case.

146 required to bind to DNA upstream of the -35 promoter element for transcription activation suggests t

147 uences in mammals identified the likely core promoter elements for most genes encoding OXPHOS subunit

148 is work identifies and validates some of the promoter elements for mouse Ogt and Mgea5 genes.

149 Here, we identified promoter elements for several transcriptional factors in

150 tiple class predictor to separate classes of promoter elements from enhancers or nonfunctional DNA.

151 attern of histone modification distinguished promoter elements from potential enhancer elements acros

152 Core promoter elements function beyond initiation, and when o

153 The downstream core promoter element functionally independent of the initiat

154 or the majority of the 5' genomic regulatory promoter elements fused with ETS genes.

155 SGF-2 binds to promoter elements governing posterior silk gland-specifi

156 However, each mutated core promoter element had a distinct effect on expression: CA

157 1 promoter is CpG rich, no discernable basal promoter elements had been identified.

158 To date, relatively few clock-associated promoter elements have been identified and characterized

159 romoter elements in metazoans, but analogous promoter elements have not been identified in Saccharomy

160 in planta-specific upregulation and a common promoter element; however, only three subfamily members

161 1-deficient worms requiring the same UPR(mt) promoter element identified in C. elegans.

162 e promoter, identifying for the first time a promoter element important for late promoter function in

163 s later verified E2F1 responsiveness of this promoter element in C(2)C(12) myoblasts and IMR90 fibrob

164 binding of transcription factors to the AP-1 promoter element in macrophages.

165 between the -10 promoter element and the -35 promoter element in order to facilitate productive RNA p

166 ogenous inducer and (2) the leakiness of the promoter element in the absence of the inducer.

167 We show that DDB2 binds to an upstream promoter element in the HIF1Alpha gene and promotes hist

168 a previously unknown liver-specific enhancer-promoter element in the wild-type AAV2 genome that is fo

169 provide evidence that the CHR is the central promoter element in transcriptional regulation of late c

170 immunoprecipitation assays identified an FN promoter element in which EZH2-mediated tri-methylation

171 he effects of mutations in coding regions or promoter elements in a highly parallel fashion.

172 y, and the holoenzyme releases contacts with promoter elements in a non-sequential fashion during esc

173 hows that RBR1 binds in the proximity of E2F promoter elements in CCS52A1 and CSS52A2 genes, central

174 tions between retinoid X receptors and CYP4F promoter elements in epidermal cells.

175 ss genes, recognizes short sequence-specific promoter elements in metazoans, but analogous promoter e

176 When the nonoptimal spacing between promoter elements in P1 or the coagulase promoter was al

177 The role of core promoter elements in regulating transcription initiation

178 ng HO-1 expression by participation with its promoter elements in renal epithelial cells.

179 nteraction promotes SRF binding to essential promoter elements in SM-specific genes.

180 Active LMO2 promoter elements in T-ALL included a previously unrecog

181 Unmarked deletions of these promoter elements in the D39 genome also led to signific

182 Among the most highly enriched promoter elements in the induced gene set were heat-shoc

183 ed promoters have identified overrepresented promoter elements in various biosynthetic pathway genes,

184 ption driven by MYC2 using JAZ6 and JAZ8 DNA promoter elements in yeast one hybrid assays.

185 erminal domain of sigma(54) bound to the -24 promoter element, in which the conserved RpoN box motif

186 8 cooperation to be essential for normal p53-promoter element interactions and gene transactivation-a

187 open reading frames, identification of gene promoter elements, intron/exon splicing sites, and SH RN

188 nd of the cis-regulatory element in the BCL2 promoter element is highly dynamic in nature and can for

189 The TCT core promoter element is present in most ribosomal protein (R

190 A single nucleotide change in a conserved promoter element is responsible for both human-selected

191 Binding of endogenous c-Myc to the distal promoter element is significantly enhanced upon interleu

192 his motif, designated the hypoxia-responsive promoter element, is enriched in promoters of hypoxia-re

193 s with expression of EKLF target genes whose promoter elements it no longer binds.

194 stood, since IE62 efficiently transactivates promoter elements lacking this sequence.

195 polymerase (RNAP) binding to a conserved -10 promoter element located at the upstream edge of the tra

196 ction of two or more features such as active promoter elements, location and connectivity.

197 approaches or the use of highly active viral promoter elements may overwhelm a cell's post-transcript

198 We identify a dorsal gland promoter element motif (termed DOG Box) present upstream

199 Additional, as-yet-unidentified core promoter elements must be present in eukaryotic genomes.

200 ssion, RNA interference underexpression, and promoter element mutation studies.

201 the ferric uptake regulator (Fur); however, promoter elements necessary for regulated expression of

202 Although the key promoter elements necessary to drive transcription in Es

203 es 18 to 22 and 27 to 29), a downstream core promoter element (nucleotides 27 to 29 and 30 to 33), an

204 nding domain in complex with a high affinity promoter element of another MODY gene, HNF1alpha, which

205 clude the binding of sigma(70) R4 to the -35 promoter element of class II promoters.

206 The promoter element of the KRAS gene contains a GC-rich nuc

207 transcription factor that binds to the core promoter element of the rDNA.

208 To define the core promoter elements of bidirectional promoters in human, w

209 rect binding of NF-kappaB p65 subunit to the promoter elements of mir-17-92, mir-125b-1, mir-21, mir-

210 MUC1 occupies the promoter elements of multiple genes directly involved in

211 Further, we show that MP binds to distinct promoter elements of multiple genetically defined PIN ge

212 This study aimed to characterize the basic promoter elements of PRPF31 and TFPT.

213 a transgenic vector expressing mpl from the promoter elements of the 2-kb region of DNA just proxima

214 ne factor 3 complex (ISGF3) does not bind to promoter elements of the affected genes.

215 when juxtaposed with additional far-upstream promoter elements of the gene.

216 inding sites were identified in the putative promoter elements of their corresponding genes.

217 ites by core clock transcription factors and promoter elements of these effector genes provided a fun

218 al transcription factors/coregulators at the promoter elements of various genes.

219 along with STAT3 and c-Maf, are recruited to promoter elements on Entpd1 and Nt5e (encoding CD39 and

220 .2 regulates NeuroD1 through two independent promoter elements, one that is bound and activated direc

221 Expression of Rv0081 initiates from two promoter elements; one promoter located downstream of th

222 irectly by the position of a particular core promoter element or the first nucleosome.

223 induction of the HSR is independent of these promoter elements or E2F/DP and instead requires a disti

224 ne promoters is not due to conventional core promoter elements or splicing signals.

225 We compare the broadly used promoter elements P(tac) and P(BAD) to versions that hav

226 g biosynthesis gene cluster is driven by one promoter element (P(cap) ).

227 en on the basis of identified cis-regulatory promoter elements, presented considerable differences in

228 tween upstream activation sequence (UAS) and promoter elements, promoter and terminator regions, and

229 es, but also this unexpected complexity in a promoter element provides additional justification for t

230 ng site lies immediately upstream of the -35 promoter element recognized by Region 4 of the sigma sub

231 ated that the hdrRM system utilizes the same promoter elements recognized by ComE and thus appears to

232 rrence of a base pair at a given position of promoter elements reflects its contribution to intrinsic

233 The weak P1 promoter elements remain relaxed in the three genetic ba

234 We identify a conserved promoter element required for TamA activation, and show

235 his study was undertaken to identify the MIF promoter elements responsible for regulating gene expres

236 We identify 3 critical promoter elements responsible for transcriptional activa

237 DNA binding domains (DBDs) bound to IFN-beta promoter elements revealed flexibility in the loops (L1-

238 In search of another core promoter element(s), a nonredundant database containing

239 omain mediates Hamp suppression via proximal promoter element(s).

240 2) and sigma(4) matches the distance between promoter elements separated by approximately 17 bp.

241 We identify and experimentally validate a promoter element sequence motif that is enriched upstrea

242 eover, although the host genomic copy of the promoter element showed no CpG methylation, the same seq

243 Unlike previously defined promoter elements shown to affect alternative splicing,

244 e clusters exhibited little gene homology or promoter element similarity, and largely overlapped with

245 ovides a genome-wide background for specific promoter elements, such as transcription-factor binding

246 The sequences of predicted promoter elements suggest that the alternative sigma fac

247 l promoter opening is recognition of the -10 promoter element (T(-12)A(-11)T(-10)A(-9)A(-8)T(-7) cons

248 No promoter element (TATA or CAAT box) was observed for eit

249 We hypothesize that a G-rich promoter element that is a potential G-quadruplex-formin

250 hat the DPR is a functionally important core promoter element that is widely used in human promoters.

251 Here, we identify a non-canonical promoter element that plays a key role.

252 s a methodology to identify and characterize promoter elements that affect the distribution of stocha

253 Furthermore, several core promoter elements that are absent in the slob57 promoter

254 l transcription factors and for the DNA core promoter elements that are located close to transcriptio

255 s driven from both initiator (Inr) and novel promoter elements that are tightly developmentally regul

256 s were infected with rOka mutants lacking gI promoter elements that bind cellular transactivators, sp

257 Promoter elements that contribute to high light (HL) ind

258 in the ChIP-Seq screen and characterize the promoter elements that facilitate PSPTO_1203-dependent r

259 Furthermore, we identified critical promoter elements that mediate the inductive effects of

260 We investigated the signals and promoter elements that regulate CTSK gene expression in

261 e C terminus of sigma(70) and binds to a DNA promoter element, the MotA box.

262 This complex binds to an essential promoter element, the proximal sequence element, centere

263 amily of sigma factors contact two conserved promoter elements, the -10 and -35 elements, which are s

264 paused Pol II stability correlates with core promoter elements, the contribution of individual sequen

265 artial interactions with the -10, -35 and UP promoter elements; the TG motif of the extended -10 elem

266 ectional promoters utilize a variety of core promoter elements to initiate transcription.

267 The ability of core promoter elements to modulate transcriptional bursting i

268 ncy, but the contribution of individual core promoter elements to transcriptional bursting is not kno

269 ARPE (high-throughput analysis of randomized promoter elements) to create hundreds of thousands of DP

270 ectors, driven by excitatory neuron-specific promoter elements, to manipulate circuit recruitment in

271 hat lower c-MYC to direct targeting of these promoter elements unless this assay, or similar ones, de

272 tory sequence with similarity to an upstream promoter element (UP) was identified upstream of the oxd

273 data demonstrate the significance of the 5' promoter element upstream of the conventional KIR promot

274 We find that a promoter element upstream of the TSS, the "discriminator

275 We found that, while Pfim3 promoter elements upstream of the +1 transcriptional sta

276 majority of locations contain the four core promoter elements- upstream TFIIB recognition element (B

277 the inductive signal is absent, and another promoter element, VPCact, which is required for activati

278 A 3-kb human ROBO4 promoter element was able to drive reporter expression i

279 Moreover, CREB binding to this promoter element was confirmed by chromatin immunoprecip

280 The LMP1-regulated promoter element was mapped to a region containing two E

281 ontaining the bb0729-cdr operon and upstream promoter element was used to complement the cdr mutant.

282 e deletion or mutation of ZmHyPRP regulatory promoter elements we conclude that the promoter expressi

283 ifferent configurations relative to the core promoter elements, we constructed promoter-lacZ fusions

284 Spatially distinct promoter elements were found to be required for post-ger

285 For this purpose, TAPNAC promoter elements were fused to the beta-glucuronidase (

286 their ability to bind and amplify identified promoter elements when present in a genomic DNA context

287 The HLA-E CGI functions as an active promoter element which is dramatically repressed by DNA

288 rase II (Pol II) is dictated in part by core promoter elements, which are DNA sequences flanking the

289 eted regions, and are more enriched for core promoter elements, which largely differ between tissues.

290 usters of co-regulated genes with shared cis promoter elements, whose expression can be controlled po

291 zed that the mutation identified a candidate promoter element with a more widespread role in gene reg

292 NPF6.1(HapB) differs in both the protein and promoter element with natural variations, which are diff

293 ontext of the holoenzyme, recognizes the -10 promoter element with the same efficiency and specificit

294 for all putative enhancers; p = 3e-14), and promoter elements with ancient sequence age were 13.5x e

295 resent Survey of TRanscription Initiation at Promoter Elements with high-throughput sequencing (STRIP

296 c leukaemia, human T-ALL samples largely use promoter elements with little influence from distal enha

297 ically induces trpBA expression from a novel promoter element within an intergenic region flanked by

298 NA sequences of BvgA-binding motifs and core promoter elements would indicate the opposite.

299 tivity in skeletal and cardiac myocytes (MCK Promoter Element X [MPEX]).

300 X gene promoter, here we identify a new core promoter element, XCPE1 (the X gene core promoter elemen