ライフサイエンスコーパス: prompt us to

1 These considerations prompted us to address the involvement of VE-cadherin cy

2 an regulate liver damage in diverse contexts prompted us to address the role of IL-17RA signaling in

3 ple causative genes underlie the same locus, prompting us to adopt an alternative approach to testing

4 rie-Tooth disease in three related patients, prompted us to analyse the ALS5/SPG11/KIAA1840 gene in a

5 This prompted us to analyse whether A. euteiches can produce

6 The high virulence and mortality rate prompted us to analyze aspects of MERS-CoV pathogenesis,

7 his novel anti-inflammatory CRADD-BCL10 axis prompted us to analyze CRADD expression and its potentia

8 A replication fidelity, and this observation prompted us to analyze genomic cancer data for mutations

9 This prompted us to analyze microarray data from 261 patients

10 This finding prompted us to analyze the formation of the primary cili

11 This prompted us to analyze this scaffold in the context of a

12 These puzzling results prompted us to ask whether neuroligin-3 mutant phenotype

13 parallel loss of N-cadherin expression in OS prompted us to ask whether these observations are direct

14 ence, a pre-requisite for sleep-like states, prompting us to ask whether sleep is present in Cnidaria

15 s of the adiposity-associated microbial OTUs prompted us to assess host genetic-microbe interactions

16 lted in aspartate auxotrophy, a finding that prompted us to assess the role of aspartate in TORC1 act

17 family are involved in oncogenesis and this prompted us to assess whether expression levels of indiv

18 tnership with members of the integrin family prompted us to assume the existence of a direct interact

19 Our recent data in this area prompt us to call for a conceptual shift.

20 ecedes the peak of infected DCs in the lungs prompted us to characterize the role of neutrophils in t

21 xistence of multiple control configurations, prompting us to classify each node in a network based on

22 ral role in the process of memory formation, prompting us to cluster sharp waves (SWs) in the DG [den

23 This discovery prompted us to collect data from nine additional patient

24 hibition of nuclear factor kappaB signaling, prompting us to combine AZD8835 with the Bruton's tyrosi

25 This effect of pre-HCT MRD prompted us to compare outcomes in consecutive patients

26 ells (PBPCs) instead of BM as a graft source prompted us to compare outcomes of PBPC and BM transplan

27 This finding prompted us to compare the gene expression profile of th

28 general intolerability of AAV Rep sequences, prompting us to computationally reengineer the Rep gene

29 he effector-free state should expose the SDS prompted us to conduct solution experiments to delineate

30 rogressive patients was heat stable, thereby prompting us to conduct an unbiased exploratory lipidomi

31 uld help us rule out specific cell types and prompt us to consider other potential mechanisms of dise

32 independently of haematological progenitors prompted us to consider organ-targeted, cell-specific th

33 This finding prompted us to consider that reduced CVR may play a role

34 cal EpoR and rhEpo's effects on cancer cells prompted us to consider the existence of an alternative

35 This variant prompted us to consider this gene as a putative candidat

36 netic factors involved in cellular identity, prompting us to consider how the analyses of 27,578 CpG

37 is important that the development of either prompts us to consider the possibility of the other deve

38 These results prompt us to continue the development of this family of

39 thies ERbeta knockout mice [ERbeta(OS-/-)]), prompted us to create an ERbeta knockout mouse by deleti

40 This prompted us to define the biochemical basis of ATG8 spec

41 chanistic explanation of this transformation prompted us to demonstrate that the acid-labile and solv

42 ombination with microtubule-targeting agents prompted us to design and develop single agents that pos

43 These findings prompted us to determine if SNP genotypes at SH3TC2 are

44 ccharide-induced tumor necrosis factor) gene prompted us to determine its role in modulating cardiac

45 f the disease and intended use in treatment, prompted us to determine the safety of administration of

46 our high-throughput chemical screening assay prompted us to determine whether EGF receptor (EGFR) inh

47 research shifted to network controllability, prompting us to determine proteins that are important fo

48 -reactions associated solely with G729R E1a, prompting us to determine the structure-function effects

49 erapeutic effects in several disease models, prompting us to determine whether DMF is effective as a

50 This finding prompted us to develop a competitive BM chimera model, w

51 sage effects in neurodevelopmental disorders prompted us to develop a computational approach based on

52 This prompted us to develop a high content screening assay (H

53 These observations prompted us to develop a high-throughput screening platf

54 This prompted us to develop a new diagnostic approach.

55 ion in the fruit fly Drosophila melanogaster prompted us to develop a simpler experimental approach w

56 h palladium- and copper-catalyzed processes, prompted us to develop an alternative method.

57 reviously unidentified MASP-3 G665S mutation prompted us to develop an analytical isoelectric focusin

58 This prompted us to develop and evaluate a new class of radio

59 rous materials with advanced functionalities prompted us to develop dynamic crystalline structures pr

60 This prompted us to develop such a tool, the Angioedema Contr

61 and issue has not been adequately addressed, prompting us to develop StrandScript, a tool that can co

62 This prompted us to directly analyze the transcriptome of dis

63 nature of its N-terminal domain (Ntd), which prompted us to elucidate the solution structure and acti

64 l is much richer than what so far known, and prompts us to establish striking analogies with the feat

65 is 10 times that of large screening trials, prompting us to estimate the prevalence of these symptom

66 ombencephalosynapsis and aqueductal stenosis prompted us to evaluate brain magnetic resonance images

67 These findings prompted us to evaluate enzyme digests as a way to remov

68 ation of oxidation of a carbon at N(6) in EA prompted us to evaluate N(6)-methyladenine (m6A), an imp

69 texture and the absence of meibomian glands prompted us to evaluate other epidermal appendages: skin

70 usly observed in persistent human infections prompted us to evaluate sequence variation in this anima

71 ction of CD4+ T cells against HIV infection, prompted us to evaluate TFV and/or Tenofovir alafenamide

72 progestins compromise ARV anti-HIV activity prompted us to evaluate the effects of progestins on ten

73 These data prompted us to evaluate the induction and functionality

74 This prompted us to evaluate the necessity of this SH2bm for

75 concentration of antigen in the chloroplasts prompted us to evaluate the underlying tolerance mechani

76 to detect mold contamination in two products prompted us to evaluate three test systems (compendial U

77 his transcript was localized in the cytosol, prompting us to evaluate its coding potential.

78 ntion was no longer apparent after 24 hours, prompting us to evaluate the role of CD24 in lung coloni

79 This unexpected result prompted us to examine a much larger set of human mAbs (

80 n of p21 and cell-cycle arrest at G(1)/S and prompted us to examine combinations with the RNR inhibit

81 This interesting observation has prompted us to examine protein lysine succinylation in d

82 ays to the development of many human cancers prompted us to examine the associations between single-n

83 in the contents of theobromine and flavanols prompted us to examine the cocoa varieties to seek corre

84 both disease aggression and in vitro growth prompted us to examine the effects of a small-molecule i

85 This prompted us to examine the effects of rapamycin on rRNA

86 es to l-DOPA in the striatum, these findings prompted us to examine the impact of CK2 ablation on the

87 This prompted us to examine the interaction between the hypox

88 ancreatic cancers, driven by activated Kras, prompted us to examine the involvement of Aldh1b1 in onc

89 This prompted us to examine the localization, topology, and m

90 red/far-red light ratio on the fibre length prompted us to examine the phenotypic effects of RNA int

91 content of the Plasmodium falciparum genome prompted us to examine the possibility that malarial DNA

92 This finding prompted us to examine the relationship between MITF, en

93 iated with the proinflammatory host response prompted us to examine the role of early corticosteroid

94 ta (PC)-associated palmoplantar keratoderma, prompted us to examine the role of Keratin (K) 16 protei

95 normalities in PGC1alpha knock-out (KO) mice prompted us to examine the role of PGC1alpha in CNS myel

96 is inhibited by c-di-AMP and these mutations prompted us to examine the role of TCA cycle enzymes.

97 , resulting in two cases of human infection, prompted us to examine the virulence of this virus (A/Me

98 This prompted us to examine whether NER attenuation might be

99 ecursor spectinomycin with other antibiotics prompted us to examine whether spectinamides sensitize M

100 growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression affects ce

101 appears to be reduced in aging and AMD eyes, prompting us to examine its relationship with AMD.

102 SK3alpha and PP2B knockout mice are similar, prompting us to examine the interrelationship between th

103 these mutations lacked nuclear localization, prompting us to examine the role of nuclear PTEN in regu

104 ation in the hydrophobic pocket of Munc18-2, prompting us to examine the role of this region in the c

105 pends upon cellular mRNA processing factors, prompting us to examine whether MMTV utilizes a similar

106 torneurons to establish orderly connections, prompting us to examine whether the intraspinal circuitr

107 and/or superstoichiometric metal salts have prompted us to explore a possible user-friendly method f

108 These findings prompted us to explore a preventive medicine which is or

109 This population diversity prompted us to explore how distinct macrophage subsets l

110 y of boron-containing heteroalkene complexes prompted us to explore the coordination of phosphinobora

111 y in plasma membranes of airway lining cells prompted us to explore the possibility of enriching Clar

112 This unique structure prompted us to explore the possibility of protein bindin

113 he putative bacterial origin of mitochondria prompted us to explore the possible existence of NTR act

114 This prompted us to explore the SAR of the Lactobacillus reut

115 ompounds having multiple phenyl substituents prompted us to explore the use of phenyls as alternative

116 enic mediator of all four of these diseases, prompting us to explore glucocorticoid/TGF-beta signalin

117 nor necessary to control the entire network, prompting us to explore target control: the efficient co

118 dysfunctional fatty acid oxidation and ROS, prompting us to explore the effects of XN on muscle cell

119 he arboviral vector mosquito, Aedes aegypti, prompting us to explore the role of AMTs in reproduction

120 tonsils of humans naturally exposed to GAS, prompting us to explore whether GAS-specific CD4+ T cell

121 of the electrode, which is also inexpensive, prompts us to explore its use in fabrication of solar-dr

122 tive yeast thiamine (vitamin B1) transporter prompted us to express human SLC35F3 in Escherichia coli

123 This prompted us to express the enzyme heterologously.

124 onsuming immunocytochemistry technique which prompted us to extend further investigation using real p

125 These observations prompted us to further characterize XEEL.

126 lastogenesis and rheumatoid arthritis, which prompted us to further investigate the FOXO3 locus.

127 This finding prompted us to generate a series of Mcl-1 deletion mutan

128 These contradictory findings prompted us to genetically explore the role of eIF2alpha

129 ings of pathogenic lung inflammation in mice prompted us to hypothesize a possible role in cancer.

130 These observations prompted us to hypothesize that robust immunotherapy res

131 ved in the regulation of microglia function, prompting us to hypothesize Kv channels may also be invo

132 n A is upregulated in dysplastic epithelium, prompting us to hypothesize that it might be modulated i

133 CUL4B are linked to intellectual disability, prompts us to hypothesize a pathogenic mechanism, in whi

134 This ensemble prompts us to hypothesize that endogenous apoA-II (i) he

135 rs induce high levels of its homologue MDM4, prompt us to identify, through a receptor-based virtual

136 This prompted us to identify a pool of candidate cellular gen

137 icotinic acetylcholine receptors (nAChR) has prompted us to identify and develop a distinct scaffold

138 with numerous cardiovascular manifestations, prompted us to identify cells in adult heart harboring a

139 ive surface epitopes, despite abundant VlsE, prompted us to identify the specificities of the protect

140 vented by using classic upstream modulators, prompting us to identify more effective approaches to ta

141 he cocrystal structures of an initial lead 8 prompted us to incorporate spirocycles followed by its f

142 outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of met

143 IV Nef-mediated CD4 and MHC-I downregulation prompted us to investigate a putative tyrosine motif (Y2

144 protein involved in chloroplast RNA splicing prompted us to investigate a role for APO1 in splicing.

145 high-affinity IL-2R on gammadeltaT-17 cells prompted us to investigate a role for this cytokine.

146 pollen at dosages that cause embryo abortion prompted us to investigate endosperm as a potential sour

147 ylogenetic relationship between RlmN and Cfr prompted us to investigate evolutionary origin of antibi

148 literature concerning c-Fos homodimerization prompted us to investigate Fos homodimerization.

149 ation of transcription and pre-mRNA splicing prompted us to investigate how automethylation is regula

150 tion of hRes expression with cellular stress prompted us to investigate hRes as a possible chaperone.

151 This prompted us to investigate in more detail the functional

152 nt HO-1 expression at late hour of infection prompted us to investigate its effect on other host defe

153 of ST18 expression in pancreatic beta-cells prompted us to investigate its regulation and its role i

154 This prompted us to investigate more carefully the effects of

155 at do not fulfill the classical risk factors prompted us to investigate new risk factors of disease.

156 activation of Wnt/beta-catenin pathway that prompted us to investigate possible interaction among FG

157 This unexpected swing in the response prompted us to investigate the ability of different lymp

158 This prompted us to investigate the aggregation propensity of

159 ed a lymphoma in a patient with Q fever that prompted us to investigate the association between the 2

160 o transcribed during latent infection, which prompted us to investigate the contribution of this locu

161 This prompted us to investigate the correlation between semiq

162 This prompted us to investigate the CYP76C subfamily genetic

163 Together, these results prompted us to investigate the downstream consequences o

164 on islands in the Inner Hebrides of Scotland prompted us to investigate the effects of livestock trea

165 sustains B9 plasmacytoma cell proliferation prompted us to investigate the effects of p28/CLF on mou

166 This prompted us to investigate the effects of two antidiabet

167 in vitro sulfonamide resistance in Nocardia prompted us to investigate the findings.

168 This prompted us to investigate the immunological impacts med

169 This has prompted us to investigate the importance of IL-15 in S.

170 The high conservation of the Rb cyclin fold prompted us to investigate the link between conformation

171 anciclovir in the treatment of EBV lymphomas prompted us to investigate the potential of several HDAC

172 as E. coli CPS acts on sn-2 of phospholipids prompted us to investigate the preferred positions of CP

173 ked to the ability of cells to migrate, this prompted us to investigate the role of AnxA6 in cell mig

174 This prompted us to investigate the role of matriptase, a mem

175 This observation prompted us to investigate the role of prohibitin in neu

176 This observation prompted us to investigate the role of RAD51D in cancer

177 OP data than the earlier efforts, but rather prompted us to investigate the statistical limitations o

178 t the role of the heterogeneous catalyst has prompted us to investigate the surface processes occurri

179 ant increase in CD3+ T cell frequency, which prompted us to investigate the T cell receptor beta (TCR

180 majority of HCMV-induced gammadelta T cells prompted us to investigate their cooperation with anti-H

181 the amide-linked hybrids previously reported prompted us to investigate their pain-relieving mechanis

182 heir inevitable seepage into the environment prompted us to investigate their potential toxicity to a

183 ntal stressors induce glucocorticoids, which prompted us to investigate their role in developmental p

184 oton transfer dynamics of the photoacid HPTS prompted us to investigate these systems with two highly

185 This prompted us to investigate whether activation of MASP-2

186 This prompted us to investigate whether adult hippocampal neu

187 These observations prompted us to investigate whether AhR modulates the epi

188 This prompted us to investigate whether CMV infection limits

189 at ERRalpha regulates OPN expression in bone prompted us to investigate whether ERRalpha controls OPN

190 This prompted us to investigate whether IGF signaling is esse

191 This prompted us to investigate whether niclosamide affects t

192 This contradictory finding prompted us to investigate whether the beneficial effect

193 sensory epithelia and their supporting cells prompted us to investigate whether the capacity to activ

194 with ICAP-1, an inhibitor of beta1 integrin, prompted us to investigate whether the CCM complex inter

195 These findings prompted us to investigate whether the expression of onc

196 re dramatically decreased in old mice, which prompted us to investigate whether the Klotho decline ma

197 This action thus prompted us to investigate whether this stage can be a p

198 antigen and an immune response to foreign Ag prompted us to investigate whether VH1-46 B cells may be

199 , AKT, and Wnt/beta-catenin in fibrosis have prompted us to investigate, in a mouse model of ROS-indu

200 s an integral component of cancer metastasis prompting us to investigate a possible role of mda-9/syn

201 MP involved in the synthesis of ATP and GTP, prompting us to investigate ADS lyase in C. neoformans.

202 localization of the cardiac CaValpha2delta1 prompting us to investigate deletions of its hydrophobic

203 , we observed site-selectivity in each case, prompting us to investigate potential transition states

204 ala and reduced peptidoglycan cross-linking, prompting us to investigate synergism between beta-lacta

205 disease burden of JAK2-mutated clones(6,7), prompting us to investigate the mechanism underlying dis

206 ll and underlying mechanisms remain elusive, prompting us to investigate the relevance of CXCR4 in va

207 st, beta-Gal only partially depends on PPCA, prompting us to investigate the role that beta-Gal plays

208 medically relevant enzymes remains unclear, prompting us to investigate their origin and evolution.

209 as impaired by interruption of Hh signaling, prompting us to investigate whether the target of Hh ant

210 ality of this enzyme from different origins, prompted us to isolate and evaluate a high-yielding TG s

211 ression of dissatisfaction with tomato aroma prompted us to lead this study on the impact of domestic

212 lation profile is altered in Clock(-/-) mice prompted us to link the acetylome to the circadian metab

213 This prompted us to look for lysosomal proteins that are invo

214 ate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like virus

215 E STATEMENT One of the numerous foibles that prompt us to make poor decisions is known as the "Banker

216 This prompted us to make a detailed comparative study of the

217 The increased prevalence of syphilis in Cuba prompted us to map the circulating Treponema pallidum su

218 of identifying distinct Foxp3 T cell subsets prompted us to more thoroughly characterize Tregs in ope

219 g highly selective for phosphatidylglycerol, prompting us to obtain an X-ray structure in this lipid

220 This prompted us to perform a detailed investigation of murin

221 This low yield prompted us to perform a more quantitative assessment of

222 e lactate as their sole carbon source, which prompted us to perform a shotgun metagenomic analysis in

223 (D1R) stimulation is involved in dyskinesias prompted us to perform electrophysiological recordings o

224 en together, the existing results and models prompt us to postulate a new structural and functional r

225 These observations prompted us to prepare and evaluate ternary nylon-3 copo

226 Those results prompted us to prepare the Sc(3)N@C(80) trianion, which

227 Our findings prompt us to present a revised model of CSS wherein the

228 -C(80), but not dianionic Sc(3)N@I(h)-C(80), prompted us to probe the causes using theoretical calcul

229 of extracellular conversion of NAD(+) to NR prompted us to probe the effects of NAD(+) and NR in pro

230 These data prompt us to propose MG-CA as a new antidandruff drug ta

231 Collectively, these results prompt us to propose these langerin(high) MDLCs as a rel

232 amino acid at the carboxylic terminus, which prompted us to propose a mode of binding based on polar

233 y, we identify that GTP binds to eIF2Bgamma, prompting us to propose a multi-step mechanism for nucle

234 h severe disease lacked a complete response, prompting us to propose early intervention and search fo

235 nodes do not participate in control equally, prompting us to quantify their participations.

236 This prompted us to question the effect of incremental [ADP]

237 This finding prompted us to re-analyze published datasets from a rece

238 This discovery prompted us to re-evaluate the current model for the aut

239 rane proteins, including HIV-1 capsid, which prompted us to re-examine MA-PI(4,5)P2 interactions usin

240 This finding prompted us to re-examine mutants that have been reporte

241 ody Y188 that is highly specific for APP and prompted us to re-examine the expression, localization,

242 h mutant, spondo, whose spine is dysmorphic, prompted us to reconstruct paleontological evidence, hig

243 This prompted us to redefine the natural product structure by

244 sence of two nested feedback circuits, which prompted us to reexamine the behavior of M. xanthus cell

245 rtant role for Tom1 in normal physiology and prompt us to refer to this pathway as ERISQ, for excess

246 n of synapses by neurexin/neuroligin binding prompted us to refer to this approach as "SynView." Our

247 This prompted us to refine this model by investigating the dy

248 sphatase (PGP) from mouse, human, and yeast, prompting us to reinvestigate the biochemical properties

249 ate public health importance of our findings prompted us to report the efficacy data on dihydroartemi

250 This unique study prompted us to review current knowledge about SMM and ad

251 These unprecedented tumor responses have prompted us to review how mesothelin was discovered and

252 ole and the echinocandins are of concern and prompted us to review the experience of two large survei

253 This paradox prompted us to revisit the "two-way" hypothesis of trans

254 Caspase-3 but not other "upstream" caspases, prompting us to revisit the role of Caspase-3.

255 ated IRAK4 to take on variable conformations prompted us to screen for small-molecule inhibitors that

256 These data prompted us to screen MKS patients for mutations in B9D1

257 This finding prompted us to search for an interaction between neprily

258 These findings prompted us to search for arginine forks within experime

259 Lens degeneration in Fpr1(-/-) mice prompted us to search for functional FPR1 expression dir

260 This unexpected result prompted us to search for the factors controlling these

261 y available radiolabeled peptide analogs has prompted us to seek new stabilization strategies.

262 oncordance of antibody status among siblings prompt us to speculate that both genetics and family env

263 CK5 is important for tumorsphere formation, prompting us to speculate that CK5 has regulatory activi

264 ce of single-agent melphalan in this setting prompted us to study a new high-dose combination of infu

265 weak neutralizing activities of anti-V2 MAbs prompted us to study Fc-mediated activities.

266 ort of their occurrence in early land plants prompted us to study its function and metabolism.

267 K to crystallize in the absence of inositide prompted us to study putative conformational changes upo

268 mited to known Smad2/3-dependent ones, which prompted us to study TGF-beta1-induced signaling in macr

269 This finding prompted us to study the effects of fibrinogen and its g

270 nigrostriatal dopaminergic (DAergic) neurons prompted us to study the impact of neuroinflammation and

271 ryotic cell nucleoplasm and nuclear membrane prompted us to study the putative interaction of chromat

272 n and lung cancer cells in situ This finding prompted us to study the role of HD5 in infection and sp

273 This prompted us to subject 1a to an elaborate structure-acti

274 Overall, these findings prompted us to suggest a new, to our knowledge, model fo

275 This has prompted us to suggest that HIV infection alters the end

276 y of this tethered RCM variant but have also prompted us to suggest that the originally assigned abso

277 These observations prompted us to survey the evolution of ycf1.

278 red the concept of "lethal mutagenesis" that prompted us to synthesize pyrimidine nucleoside analogue

279 normal tissue cells has been reported, which prompted us to take a closer look at this phenomenon.

280 diverse genetic backgrounds of MRSA strains prompted us to test the accuracy of the BD GeneOhm MRSA

281 The latter finding prompted us to test the efficacy of a Shp2 inhibitor tar

282 e in other lymphomas with 9p24.1 alterations prompted us to test the efficacy of the anti-PD1 antibod

283 This observation prompted us to test the hypothesis that a substantial pr

284 This in vitro finding prompted us to test the hypothesis that blockade of EP3

285 This finding prompted us to test the hypothesis that vaccination with

286 tion of infrared signals in the optic tectum prompted us to test the implementation of spatiotopicall

287 ns expressing alpha-synuclein, and therefore prompted us to test the possibility that Nurr1 can be ph

288 mall-vessel vasculitis, and this association prompted us to test whether the peculiar structure of NE

289 e potential to be utilized in other formats, prompting us to test the efficacy of rPIV5-H5, which enc

290 the known lifespan-regulating protein SIRT1, prompting us to test whether a pharmacological activatio

291 thers to regulate endothelial cell invasion, prompting us to test whether calpain acted upstream of M

292 A-type lamins anchor TAN lines, prompting us to test whether emerin, a nuclear membrane

293 shown that Snapin interacts with Dysbindin, prompting us to test whether Snapin might be involved in

294 ization of the starting hit compound NNL (3) prompted us to the discovery of 4-(2-(6-methyl-[1,2,4]tr

295 These difficulties prompted us to undertake a metaanalysis of PET studies o

296 This case prompted us to unravel the role of M. pneumoniae in GBS

297 This challenge prompted us to use a long short-term memory (LSTM) langu

298 This prompted us to use an HSP70 inhibitor as bait in a bioin

299 otic-induced model of autoimmune cholangitis prompted us to use these reagents and the model to addre

300 SI-MS in culture-negative cases of infection prompted us to use this approach over other diagnostic m