ライフサイエンスコーパス: prone

1 lasmic reticulum (ER) is complex and failure-prone.

2 m by hand, which is time-consuming and error-prone.

3 dels, (1) senescence accelerated mouse (SAM)-prone 8 (SAMP8) as spontaneous OA model with SAM-resista

4 olecular test for identifying transformation-prone actinic keratoses (AKs) and aggressive squamous ce

5 Heart function data suggest that obesity-prone ALX deficient mice had impaired myocardium strain.

6 bone resorption and BMD loss at key fracture-prone anatomical sites in treatment-naive PWH for 3 year

7 a differentiating factor between aggregation-prone and aggregation-independent LLPS.

8 As Atad5 heterozygous mice are cancer-prone and as ATAD5 mutations have been identified in bre

9 receptors, followed by a discussion on error-prone and low-fidelity polymerases and their impact on v

10 RECQL4 DNA helicase, deficient in the cancer-prone and premature aging Rothmund-Thomson syndrome, phy

11 iratory distress syndrome (ARDS), the use of prone and supine positioning procedures (PP) has been as

12 This approach is time consuming, error prone and unsuitable for combining datasets from many so

13 es either reduce available data or are error-prone, and thus, scalable methods that do not discard da

14 ta processing is complicated, operator error-prone, and time-consuming.

15 l regions not previously regarded as drought prone, and where the impacts of drought remain poorly un

16 models and the identification of 'addiction-prone' animals.

17 or multiplicity and gene expression in tumor-prone Apc (Min/+) mice on highly variant C57BL/6J (B6) a

18 lar smooth muscle cells in lesions of athero-prone Apoe(-/-) mice.

19 Cholera-prone areas should be prioritized to control the disease

20 Exacerbation-prone asthma subtype has been reported in studies using

21 ic tissues from imiquimod-treated autoimmune-prone B6.Sle1b mice sufficient and deficient for IFN-gam

22 ective deuteration that reinforces oxidation-prone, bis-allylic sites of PUFAs is a novel, nonantioxi

23 ence, apoptosis, and ferroptosis, were tumor prone but failed to develop early-onset tumors.

24 world's most widely distributed and conflict-prone carnivores-to understand the behavioral and demogr

25 d cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures.

26 roposed evolutionary re-interpretation of PD-prone cellular phenotypes and of prototypical clinical s

27 We show that aggregate-prone chimeric DPR (cDPR) species underlie the divergent

28 trol of Pu(IV) coordination under hydrolysis-prone conditions, provides an opportunity to extend tren

29 Identifying aggregation prone conformations of monomeric aSyn and the environmen

30 nderlies the RASopathies, a family of cancer-prone disorders.

31 enes also stimulated HDR, and promoted error-prone distal end-joining.

32 ure also results in the recruitment of error-prone DNA polymerases to the replication fork.

33 permutation (SHM) targeting, including error-prone DNA repair activities that are crucial to Ab diver

34 ns UmuD, an important component of the error-prone DNA repair polymerase (Pol V), at very low levels

35 equences and point mutations caused by error-prone DNA synthesis at DNA structures.

36 ase stalling at DNA structures induces error-prone DNA synthesis, which constrains STR expansion.

37 of its DNA binding specificity remain error prone due to a lack of understanding of how adjacent fin

38 s and constitutes a significant pool in fire-prone ecosystems.

39 forks are preferentially repaired via error-prone end joining as depletion of EXO1 diverts repair aw

40 s to inhabit highly seasonal and disturbance-prone environments across ecosystems.

41 e spindle bipolarization is reportedly error prone, exhibit no detectable kinetochore enrichment of P

42 Here, we describe cancer-prone families with two unique TINF2 mutations that trun

43 Moreover, hBEX3 aggregation-prone features and the specificity in interaction with t

44 In this study, we exposed autoimmune-prone female MRL/lpr mice to a human-relevant dose of EE

45 onian striatum of LID-resistant Lewis or LID-prone Fischer-344 (F344) male rats.

46 We find that these units are either prone for decommissioning or remain constitutively activ

47 tion to afford further functionalized dienes prone for follow-up reactions.

48 the ligands of B1R, the lung environment is prone for local vascular leakage leading to angioedema.

49 s strongly observed only in less disturbance-prone forests, which contained diverse resource allocati

50 Only half of disturbance-prone forests, which lacked tolerant species, exhibited

51 ptides populate high free energy aggregation-prone ([Formula: see text]) states, which resemble the m

52 but also their purification from aggregation-prone "free-riders".

53 te-keeping step is required to prevent error-prone immature ribosomes from engaging in protein synthe

54 wo types of epithelia are known to be cancer-prone in many organ systems.

55 s for EE-exposure risk for genetically lupus-prone individuals.

56 over future fire risk, while restoring fire prone landscapes to their natural states of succession.

57 a significant reduction in DSBs at structure-prone loci, and that sites of TOP2 cleavage have a great

58 use the AAV-PHP.eB to deliver an instability-prone Mecp2 (iMecp2) transgene cassette which, increasin

59 n circles confirm that DN T cells from lupus-prone mice and patients with SLE undergo clonal prolifer

60 -regulated genes within the kidneys of lupus-prone mice during LN development reflected TLS formation

61 that the gut microbiota community of obesity-prone mice may regulate obesity-associated defects in th

62 IgA -abundance and -nAg reactivity of lupus-prone mice showed a positive correlation with eventual s

63 ion has been shown to modify T1D risk in T1D-prone mice.

64 e cognate T-B lymphocyte interactions in T1D-prone mice.

65 wild type) or once weekly to atherosclerotic prone mice.

66 se or exclude part of their genome as damage-prone micronuclei.

67 results from chromosome damage during error-prone mitoses.

68 NAC region of aSyn are, the more aggregation prone monomeric aSyn conformations become.

69 microbial resistance determinants from error-prone Nanopore sequencing is a substantial bioinformatic

70 n mice, and provides insights into the error-prone nature of human oocytes.

71 The error-prone nature of RNA-dependent RNA polymerases drives the

72 Additionally, due to the error-prone nature of viral RNA synthesis in an individual pat

73 Renal TLS was characterized in lupus-prone New Zealand black x New Zealand white F1 mice anal

74 followed by repair through either the error-prone non-homologous end joining or the homology directe

75 iminate between high-fidelity (HF) and error-prone non-homologous end-joining (NHEJ), as well as betw

76 xpression decreased with age in autoimmunity-prone nonobese diabetic (NOD) mice.

77 per T cell (Tfh)-like subpopulation in lupus-prone NZBxW mice with our binning approach "pattern reco

78 Here, we report on a monogenic form of IR-prone obesity, Alstrom syndrome (ALMS).

79 Furnaces are the most leak-prone of appliances, contributing to 0.14% of total CH(4

80 ions, including face up (supine), face down (prone on a massage pillow), flat on the right side, and

81 The error prone organelle DNA polymerase introduced mutations at m

82 the wild type enzyme in vitro make the error prone organelle DNA polymerase suitable for elevating mu

83 oblem, benchmark it on the set of long error-prone Oxford Nanopore reads generated by the Telomere-to

84 Error-prone PCR mutagenesis reinforced the importance of R225

85 at amino acid 42 was discovered using error-prone PCR to generate additional mutations.

86 However, rupture-prone plaques are often distinguished by their internal

87 polymerase clamp or deleting specific error-prone polymerases abolishes the mutagenic effect of etha

88 plication forks lead to recruitment of error-prone polymerases.

89 ne); cumulative incidences (until day 21) of prone position sessions, extracorporeal membrane oxygena

90 ter receiving noninvasive ventilation in the prone position.

91 ollowed by iNO (13%), corticosteroids (10%), prone positioning (10%), HFOV (9%), and extracorporeal m

92 15 vs 8 cm H2O in controls; p < 0.001), more prone positioning (n = 33, 75% vs n = 6, 27% in controls

93 Prone positioning and HFOV were more common in middle-in

94 le and the inferior and anterior retina than prone positioning even when the gas fill is only 70% of

95 ding lung protective ventilation, paralysis, prone positioning, and inhaled nitric oxide.

96 ementation whose Pao(2) increased >=20% with prone positioning, and their respiratory status after re

97 corticosteroids, inhaled nitric oxide (iNO), prone positioning, high-frequency oscillatory ventilatio

98 y to postinfectious inflammatory neuropathy, prone positioning-related stretch and/or compression inj

99 mmatory areas of the interstitium, while NET-prone primed neutrophils were present in arteriolar micr

100 of these mutations are found in aggregation-prone prion-like domains (PrLDs) within these proteins.

101 plex and the release of harmful, aggregation-prone products.

102 ator to define +19-enhancer and the leukemic prone promoter IV interaction for TAL1 activation in T-A

103 gy in mediating the clearance of aggregation-prone proteins and damaged organelles are vital for post

104 y changed to the point that many aggregation-prone proteins are now considered bona fide prions.

105 ophagy degrades many of the toxic, aggregate-prone proteins responsible for such diseases, including

106 hanisms targeting the removal of aggregation-prone proteins upon proteasomal impairment.

107 c aggresomes in cells expressing aggregation-prone proteins, and (iii) thermoprotection against heat

108 protein homeostasis of cytosolic aggregation-prone proteins.

109 ategy could be extended to other aggregating-prone proteins.

110 gainst the accumulation of toxic aggregation-prone proteins.

111 tarvation or the accumulation of aggregation-prone proteins.

112 stant" to obesity with those who are obesity prone provides an avenue for unraveling the difficulties

113 ilar to optogenetic activation of PeF, panic-prone rats also exhibited delayed extinction.

114 Next, we demonstrate that panic-prone rats had altered inhibitory and enhanced excitator

115 Treating panic-prone rats with mGluR2 PAM blocked sodium lactate (NaLac

116 urotransmission in the BLA slices from panic-prone rats.

117 aced the challenge of translating long error-prone reads from the nucleotide alphabet into the alphab

118 Moreover, since the mapping of error-prone reads to ETRs remains an open problem, it is not c

119 thm for centromere assembly using long error-prone reads, and apply it to assemble human centromeres

120 alled forks to NPCs and restriction of error-prone recombination between repeated sequences.

121 ereas the coiled-coil domain and aggregation-prone region additively contribute to competent mRNA exp

122 domain and a novel 10-amino acid aggregation-prone region, both of which are necessary for proper Gle

123 ped so far to identify potential aggregation prone regions (APRs) use amino acid residue composition

124 utrophil microvesicles accumulate at disease-prone regions of arteries exposed to disturbed flow patt

125 prediction of fire activity over these fire-prone regions remains a challenge and relies heavily on

126 ave not been as widely used in other drought-prone regions throughout the rest of the world, presenti

127 factors such as the presence of aggregation-prone regions.

128 of microvesicles carrying miR-155 to disease-prone regions.

129 dine deaminase-induced DNA lesions and error-prone repair that underlie SHM are known to exhibit intr

130 key role in translesion synthesis, an error-prone replication mechanism.

131 he Fanconi anaemia pathway, inhibiting error-prone replicative lesion bypass and interstrand crosslin

132 in M. florum, which apparently has an error-prone RNA polymerase.

133 ) and FUS (fused in sarcoma) are aggregation-prone RNA-binding proteins that in ALS can mislocalize t

134 n and gastric carcinogenesis using gastritis-prone SAMP1/YitFc (SAMP) mice.

135 Short aggregation prone sequence motifs can trigger aggregation in peptide

136 om Oxford Nanopore, can generate long, error-prone sequencing reads which pose new challenges for fra

137 le in the repair of DSBs performing an error-prone single strand annealing (SSA).

138 ase miR-155 and enhance NF-kappaB at disease-prone sites of disturbed flow in vivo.

139 ved an enrichment of DNA secondary structure-prone sites overlapping transcription start sites (TSSs)

140 of endothelial activation at atherosclerosis-prone sites remains limited.

141 nt mice reveal that 5hmC is triggered at DSB-prone sites upon PRDM9 binding and histone modification,

142 iments recapitulate aspects of these failure-prone snakes and elucidate how re-encountering previousl

143 othesis that the minor, but more aggregation-prone, sRPT facilitates amyloid formation of lRPT.

144 These data demonstrate that a panic-prone state leads to specific reduction in mGluR2 functi

145 F-actin potentially triggers the aggregation-prone structural transition of a short CPEB3 sequence by

146 in TAL1-expressing T-ALL cells, the leukemia-prone TAL1 promoter-IV specifically interacts with the +

147 ulation engine remains a difficult and error-prone task.

148 longation complexes, and Pol I is more error prone than Pol II.

149 The error-prone third-generation sequencing (TGS) long reads can b

150 pyrimidine dimer lesions in skin of melanoma-prone TN(61R) mice, and this was associated with decreas

151 e closo-C(2)B(10) cluster backbone, which is prone to accept up to two electrons to form the cage-ope

152 Although mitochondrial DNA (mtDNA) is prone to accumulate mutations and lacks conventional DNA

153 Amyloid-beta(1-40) was less prone to adopt the alpha-helix secondary structure.

154 Hyperphosphorylation renders tau prone to aggregate and to impair cell viability.

155 The analogous cyclopent-2-enones were less prone to an intramolecular reaction.

156 vity, with granulation and mixing being most prone to API losses.

157 -7, IL-12, or IL-23 cytokines, and were more prone to apoptosis compared with those of healthy contro

158 uction was reduced in such cells, which were prone to apoptosis.

159 -trackers; STs) or less (goal-trackers; GTs) prone to attribute incentive salience to food reward cue

160 cells favors the development of aberrant MBs prone to avoid plasmacytic differentiation on recall and

161 ction, beyond which long reads are too error-prone to be corrected by these methods.

162 Mild cases of keratoconus were more prone to be explanted because of a loss of the initial i

163 female birds, suggesting that they are more prone to be parasitized with parasitemia levels that are

164 lasma was for longer treatment time and more prone to being contaminated.

165 t observational analyses of these models are prone to bias and confounding.

166 complicated sample workup protocols that are prone to bias.

167 or chemical meaning or constraints, they are prone to biased interpretation.

168 often relies on a few advisors, making them prone to biased perceptions; and 3) in the absence of tr

169 By their nature and function, beta-cells are prone to biosynthetic stress with limited measures for s

170 facing design, the electrode surface is less prone to blockage by any formed gas bubbles.

171 ane of the prospective primitive streak more prone to breaching.

172 Low and high protein dairy powders are prone to caking and sticking and can also be highly inso

173 GC B cells are short lived and are prone to caspase-mediated apoptosis.

174 hat large nonrecombining genomic regions are prone to cause multifarious effects across levels of bio

175 d tumor necrosis factor production, and were prone to cell death.

176 vels, making their trophic interactions more prone to changes as oceans warm.

177 They are highly sensitive and prone to climate change(3,4), yet their importance and v

178 expiratory resistances, and mainly in lungs prone to collapse (at low positive end-expiratory pressu

179 plications in ventilated patients with lungs prone to collapse.

180 part of NBL treatment, but maybe hazardous, prone to complications and its role in high-risk disease

181 hout knowledge of returns to contribution is prone to cooperative failure.

182 This feedback makes the ecosystem more prone to coral collapse under fishing pressure but also

183 PCR is prone to create biased libraries - especially with the e

184 However, MOFs are prone to destruction under external stimuli, considerabl

185 power factors but also make the alloys more prone to detrimental bipolar diffusion.

186 2 levels above the median in serum were more prone to develop ADAs (aHR = 2.329 [1.106-4.90], p = 0.0

187 ollutants might occur, rendering individuals prone to develop chronic inflammation as seen in allergi

188 vation and explain why patients with XLA are prone to develop Crohn's disease.

189 d timing of surgery for lesions in locations prone to development of MRE.

190 found that Opn3-knockout (Opn3-KO) mice were prone to diet-induced obesity and insulin resistance.

191 ement in case of complex DNA templates being prone to diversity degeneration and provides a way to pr

192 Cancer, a disease that is prone to drug resistance, is in principle susceptible to

193 The date palm plantations are prone to Dubas bug (DB; Ommatissus lybicus DeBergevin; H

194 cture proceed through reactive intermediates prone to eliminate a fluorine atom and generate monofluo

195 also find that now dominant IS/NFS cells are prone to entering depolarization block, causing them to

196 We show, for neural systems prone to epileptic seizures, that such a reduction in di

197 tate networks to identify potential networks prone to epileptogenicity.

198 phical user interface (GUI); thus, names are prone to errors or non-standardized representations.

199 s to demonstrate that (i) megabiota are more prone to extinction due to human land use, hunting, and

200 Engineered genetic systems are prone to failure when their genetic parts contain repeti

201 ems is perceived by many to be expensive and prone to failure, in part explaining its low rates of im

202 mptom-based diagnosis, which have been found prone to false negatives and misdiagnoses, respectively.

203 ers identify areas where groundwater is most prone to fecal contamination and prioritize monitoring a

204 e 1) has a genome-wide role in MiDAS at loci prone to form G-quadruplex-associated R-loops, in a proc

205 l flaw in previous membrane models that were prone to generating leucine-rich designs.

206 schemes of multiethnic machine learning are prone to generating significant model performance dispar

207 Furthermore, Vcpip1 knockout mice are prone to genomic instability and premature aging.

208 MPS type I patients are prone to have glaucoma with narrow or closed angles; MPS

209 titis, who were older and pseudophakic, were prone to have more severe vitreous opacities.

210 y have a role in reducing aflatoxin in areas prone to high aflatoxin contamination, and where corn is

211 throughout their exceptionally large ranges, prone to high variations in precipitation.

212 Certain genomic positions can be prone to higher rates of systematic sequencing and align

213 c techniques include the following: they are prone to human error (microscopy) or expensive and time-

214 Some developmental stages will be more prone to hybrid dysfunction due to how molecular evoluti

215 We show that N-trifluoromethyl amines are prone to hydrolysis, whereas N-trifluoromethyl azoles ha

216 However, it is unclear which motifs are prone to impact transcriptional regulation if mutated.

217 nsists of highly repeated sequences that are prone to incurring damage.

218 abolic elimination of xenobiotics, and it is prone to induction by xenobiotics, including phenobarbit

219 Since lupus patients are prone to infections, groups of mice were injected with v

220 However, the reactions are prone to intra-assay spatial variation in hybridization

221 Complexes [L(Ph)(Ni(II)-H)(2)](-) (3) are prone to intramolecular reductive H(2) elimination, and

222 nto pro-inflammatory helper T cells that are prone to invade into tissue and elicit inflammation thro

223 indicating that the nano-ESI source is more prone to ion suppression.

224 proach, but such parameterizations have been prone to issues of instability and climate drift, and th

225 However, Baltic herring is prone to lipid oxidation, which possesses a challenge fo

226 Swimmers were not prone to maintaining the thrust and speed along the tria

227 rect infusion, this technique is known to be prone to matrix effects caused by changes in the ionizat

228 on the surface of the fiber end-face can be prone to mechanical damage or deteriorate due to unwante

229 at gabapentin (GBP), a prescription drug, is prone to misuse, abuse, withdrawal, and dependence.

230 acquired T-cell immunodeficiencies, who are prone to multiple infections.

231 Here, we discuss genomic regions prone to mutation, mechanisms contributing to mutation s

232 conomic region of the midsouth USA, which is prone to natural disasters from extreme climate events a

233 e pulmonary disease (COPD) exacerbations are prone to nonrecovery, but there are no data about the ef

234 Aptamers are often prone to nuclease digestion, which limits their utility

235 However, DNs are prone to nuclease-mediated degradation and are unstable

236 o) vegetarian and vegan optimized diets were prone to nutritional inadequacies.

237 le germination experiments are laborious and prone to observer errors, leading to the necessity for a

238 Unlike SAR1B, SAR1A was prone to oligomerize on a membrane surface.

239 ion monitoring mechanism, which renders them prone to over-elongation, especially during prolonged mi

240 xygenated natural products, one of which was prone to over-oxidation.

241 o analyse short time-series omic data are i) prone to overfitting, ii) do not fully take into account

242 NPY is prone to peptidolysis, generating metabolites with modif

243 Alzheimer's disease, were found to be highly prone to phase separation, suggesting that there might b

244 for many decades, however, is air-sensitive, prone to photodecomposition, and poorly reactive towards

245 gement between light-activated steps, and is prone to photoinactivation and misassembly.

246 ations with low institutional confidence are prone to political instability.

247 Undifferentiated uveitis may be prone to premature discontinuation of ADA due to adverse

248 nesins, is an intrinsically unstable protein prone to proteasomal degradation.

249 to undergo conformational changes and become prone to proteolytic activation.

250 Health Evaluation II at admission (<20) and prone to protracted ICU stay may benefit most from rehab

251 t is a chiral 2-arylbutyrate and potentially prone to racemization.

252 utrients, whose fruit quality attributes are prone to rapid deterioration after harvest, especially p

253 HSV-1 infections with strain KOS(M) are more prone to rapid heterochromatinization than those of 17sy

254 Habitat specialists may be especially prone to rapidly changing environmental conditions becau

255 s, the remnant erythrocyte ghost shells were prone to recognition and breakdown by RPMs.

256 ollapse under fishing pressure but also more prone to recovery as fishing is reduced.

257 ificant challenge to DNA replication and are prone to replication stress and telomere fragility.

258 erage frequency and who might, therefore, be prone to reproductive difficulties.

259 nd behavior of their prey species, which are prone to responding to environmental changes, such as va

260 adverse events; however, this association is prone to reverse-causation bias as stopping renin angiot

261 the natural product; all other isomers were prone to ring opening and/or ring expansion.

262 Mutant PTs were slow growing and prone to rupture and morphological irregularities.

263 CD4+ T-cell functions that renders the host prone to secondary infections.

264 ce carrying monoallelic BubR1 mutations were prone to select MVA-related pathologies later in life, w

265 , called low complexity (LC) domains, can be prone to self-assembly into amyloid-like fibrils.

266 the regions within C(H)2 and C(H)2s that are prone to self-association and establishing the differenc

267 Children on anti-TNF-alpha therapy are prone to severe TB disease and significant long-term mor

268 ed with a second toxic molecule that is more prone to slippage, the overall substrate selectivity dra

269 Longlines are prone to snagging DFG, providing an opportunistic, yet r

270 often co-occur, as developed areas are more prone to species invasion.

271 rotic cardiovascular disease (ASCVD) and are prone to statin-related adverse events from drug-drug in

272 ng that highly sexually motivated males were prone to stereotypy but also had high reproductive compe

273 ly non-mitotic tissues such as the brain are prone to stochastic (epi-)genetic alterations that may c

274 te that PcrA is a highly processive helicase prone to stochastic pausing, resulting in average transl

275 f the environment, but that this approach is prone to sub-optimal convergence.

276 found that the treated failing heart is more prone to sustain VF than the normal heart, and is at lea

277 fied which genomic regions were more or less prone to systematic biases, including large homopolymer

278 gative myeloproliferative neoplasm (MPN) are prone to the development of second cancers, but the fact

279 uggest BM-derived myofibroblasts may be more prone to the formation of excessive cellular and extrace

280 studies the Asian population was shown to be prone to these pathologies more than the Caucasian one,

281 ce, indicating a chromatin conformation less prone to transcription in mdx mice.

282 iptionally silent, while euchromatin is more prone to transcription.

283 of immature Lgr5(-)CD44(+) cells, which are prone to transformation in organoid assays, comprise ear

284 Coronaviruses are prone to transmission to new host species, as recently d

285 linking probes to stabilize intermediates is prone to trapping off-pathway artefacts and precludes de

286 colonization, however, neutrophils were less prone to undergo neutrophil extracellular traps cell dea

287 ndings reveal that these proteins are highly prone to undergoing concentration-dependent phase separa

288 individual kinetic traces is cumbersome and prone to user error and bias.

289 provide metadata for each submission that is prone to user error.

290 Field areas prone to water stress are shown to lag as much as 23-33%

291 ng defines a "thriftier" metabolic phenotype prone to weight gain during overfeeding and resistant to

292 ility to acute HFOF can identify individuals prone to weight gain, indicating that an individual's ca

293 We tested the fidelities of error prone tobacco organelle DNA polymerases using a novel po

294 Error-prone translesion synthesis causes the majority of genot

295 ype I and especially the less adverse effect-prone type III IFN are good candidates for the managemen

296 iosis induces SBA deficiency in inflammatory-prone UC patients, which promotes a pro-inflammatory sta

297 polymerase delta (Pol delta), with an error-prone variant allows increased 8-oxodG accumulation into

298 and suppress the establishment of resistance-prone weeds on field borders and ditches in agricultural

299 ed fathers produced sons that were more risk-prone, whereas predator-exposed mothers produced more an

300 ither of two distinct human diseases: Cancer-prone xeroderma pigmentosum (XP-G) or the fatal neurodev