1 using monogenetic neuromuscular disorders as
proof of principle.
2 g omega-1 (omega1) of Schistosoma mansoni as
proof of principle.
3 ing any of this missing information provides
proof of principle.
4 tex, thalamus, and the dopamine system, as a
proof of principle.
5 has so far provided only a limited number of
proofs of principle.
6 As a
proof-of-principle,
2D GeQDs-based PTAs were used in flu
7 d with a phthalimide derivative to achieve a
proof-of-principle 3.2 V all-organic RFB.
8 istic 1,000 and 6,000 muatm exposures, and a
proof-of-principle 30,000 muatm exposure.
9 Here, as a
proof of principle,
a novel cell-membrane-derived NVs th
10 As a
proof of principle,
a selected reaction monitoring (SRM)
11 As a
proof-of-principle,
a wide range of probes were designed
12 Here, we perform
proof-of-principle advancement to embryo selection proce
13 Our
proof-of-principle analyses facilitated informative stra
14 This
proof-of-principle analysis is the first study to integr
15 We offer
proof of principle and a versatile framework.
16 , some are established, whereas others are a
proof of principle and have not yet been applied to envi
17 We highlight a
proof-of-principle and describe the working principle fo
18 Collectively, our results provide
proof-of-principle application of a stable, multiplexed
19 We describe two
proof of principle applications that illustrate the util
20 me analysis by nanoLC-MS(2), and demonstrate
proof-of-principle applications of the duplex and triple
21 nt properties of cell-free DNA and provide a
proof-of-principle approach for the screening, early det
22 synthetic biology have led to an arsenal of
proof-of-principle bacterial circuits that can be levera
23 We demonstrated a
proof-of-principle by generating nanobody-based heterodi
24 This
proof of principle case can stimulate future mechanistic
25 Application of 16S Capture to a
proof-of-principle case series demonstrated its ability
26 A few reporters have migrated to
proof-of-principle clinical demonstrations, and recent a
27 ver, despite strong preclinical evidence and
proof-of-principle clinical trials demonstrating that ta
28 As
proof of principle,
cyclophosphamide and diethylstilbest
29 Our
proof-of-principle data are compatible with the concept
30 omized, sham-controlled trials have provided
proof-of-principle data for its blood pressure-lowering
31 We also provide
proof-of-principle data that gene-targeting ASOs can be
32 cages two meters from the optical system; a
proof-of-principle demonstration of a 30 m system was al
33 This process provides a
proof-of-principle demonstration of a heterogeneity-to-h
34 Using this network, we perform a
proof-of-principle demonstration of QDS mediated by MDI-
35 Our work serves as a
proof-of-principle demonstration of the capability of ou
36 This study provides a
proof-of-principle demonstration that mouse models can i
37 A
proof-of-principle demonstration using recent data from
38 As a
proof-of-principle demonstration, we show that this silk
39 nd relevance of such experiments and a first
proof-of-principle demonstration.
40 These results provide two independent
proof-of-principle demonstrations of symptom relief by t
41 As a
proof-of-principle,
deoxynivalenol (DON), an important m
42 In this article, we report our
proof-of-principle design and experimental commissioning
43 small-molecule standards are validated by a
proof-of-principle development of the H(2)BHT-functional
44 Proof-of-principle double and triple EM labeling experim
45 agged oligodeoxyribonucleotides demonstrated
proof-of-principle during unassisted voltage-driven tran
46 itumorigenic action, and provide preclinical
proof-of-principle evidence for targeting EZH2 in patien
47 In addition to attaining
proof-of-principle evidence for the hypothesis that chim
48 These data provide
proof-of-principle evidence for the therapeutic potentia
49 Together, our results provide
proof-of-principle evidence that p53-mediated transcript
50 Finally, we provide several
proof-of-principle examples in which we model the effect
51 m x 1,000 bps) prototype are demonstrated as
proof-of-principle exemplars for the enhanced method of
52 mbined with a microfluidic chip reactor in a
proof-of-principle experiment on the Hantzsch cyclizatio
53 In a
proof-of-principle experiment, treatment of these two su
54 In a
proof-of-principle experiment, we demonstrate high-fidel
55 In a
proof-of-principle experiment, we demonstrated that the
56 As a
proof-of-principle experiment, we selected four pathways
57 A simple
proof of principle experimental implementation of SQUICH
58 We present a
proof-of-principle experimental realization of one such
59 This
proof-of-principle experimental system allowed us to qua
60 e demonstrate the efficacy of our methods in
proof of principle experiments and application to real w
61 Here, we present
proof of principle experiments of an optical gating conc
62 ases of engineered gene drives due to recent
proof of principle experiments with the CRISPR-Cas9 syst
63 HPMs perform promisingly in these
proof of principle experiments.
64 Proof-of-principle experiments are provided for the rapa
65 lity of the novel method was demonstrated in
proof-of-principle experiments by analyzing urine from A
66 These
proof-of-principle experiments establish a platform to o
67 Results from
proof-of-principle experiments from distinct morphologic
68 iLeu for quantitative proteomics, we perform
proof-of-principle experiments of mdDiLeu-labeled Saccha
69 Proof-of-principle experiments show that elevating cofil
70 en atoms(9-20) has been demonstrated only in
proof-of-principle experiments with microwave clocks of
71 a Cre-dependent calling cards system and, in
proof-of-principle experiments, show utility in defining
72 In
proof-of-principle experiments, we manipulated apterous,
73 In our first
proof-of-principle experiments, we were able to detect,
74 rms and demonstrate their functionality in 2
proof-of-principle experiments.
75 pulmonary hypertension in both rat models in
proof-of-principle experiments.
76 tter than 25 mum was obtained in these first
proof-of-principle experiments.
77 As a
proof-of-principle,
fluorophores containing a borinate (
78 Here, we provide
proof of principle for a new system enabling multiple ge
79 These results provide
proof of principle for a novel strategy in developing hi
80 This study provides a
proof of principle for a strategy to create protein-leve
81 This study provides the first
proof of principle for an epigenetics-based therapy for
82 lectively, these results provide therapeutic
proof of principle for FEN1 blockade in tamoxifen-resist
83 Our results provide important
proof of principle for Gcn5 functions in formation and p
84 We provide
proof of principle for immunologically targeting AML-ini
85 is of CN in FFPE material using NGS provides
proof of principle for intensive examination of populati
86 This study presents a
proof of principle for intestinal iontophoresis as a nov
87 ully reconstruct the biliary tree, providing
proof of principle for organ regeneration using human pr
88 Together, these results provide the first
proof of principle for the application of DSB-3-based fl
89 This study provides
proof of principle for the application of targeted next-
90 ne duplication mutation and further, provide
proof of principle for the benefits of stem cell transpl
91 Taken together, this work offers a
proof of principle for the design of a gene drive in vir
92 to act against intracellular Mtb, providing
proof of principle for the efficacy of a "release and ki
93 istant lines into distinct groups, providing
proof of principle for the feasibility of generating a p
94 Proof of principle for the potential of scanning LC-FAIM
95 To sum up, our data provide
proof of principle for the therapeutic potential of comb
96 replacement for type 1 diabetes and provide
proof of principle for therapeutic cloning combined with
97 Proof of principle for this therapeutic approach was dem
98 c benefit in this disease model, providing a
proof of principle for treating patients with CMT1X at d
99 y contrast, several studies have established
proof of principle for various innovative AST methods, i
100 This study provides a
proof of principle for viral gene replacement therapy ta
101 This provides the
proof-of-principle for a new metabolic modeling framewor
102 ize-pesticide sensitivity pattern we provide
proof-of-principle for a novel, likely general mechanism
103 This study provides the
proof-of-principle for a translational CRISPR-based appr
104 This study provides
proof-of-principle for an exercise approach that may be
105 These results provide
proof-of-principle for CD117-ADC as a non-genotoxic, hig
106 These results provide
proof-of-principle for continuous vector-mediated l-DOPA
107 cohort studies and the CALERIE trial provide
proof-of-principle for DunedinPoAm as a single-time-poin
108 Their
proof-of-principle for generating human tissue is demons
109 These data provide
proof-of-principle for interspecific blastocyst compleme
110 In this article, we establish a
proof-of-principle for methods to initiate and then moni
111 for insect sex-separation that demonstrates
proof-of-principle for positive sex selection in D. mela
112 These results provide
proof-of-principle for selective forms of ADT that prefe
113 These data provide
proof-of-principle for the clinical development of EP300
114 These results provide
proof-of-principle for the development of immunotherapeu
115 These encouraging findings demonstrate a
proof-of-principle for the proposed approach of high-thr
116 These data provide
proof-of-principle for the view that newly generated ASC
117 These data provide generalizable
proof-of-principle for this approach, and reveal molecul
118 We provide
proof-of-principle for this assertion by demonstrating t
119 Meanwhile, recent discoveries provide
proofs of principle for breakthroughs in a family of res
120 ng mechanism is found for which we propose a
proof-of-principle force generation theory.
121 In addition,
proof of principle has been demonstrated for the dynamic
122 This study provides
proof-of-principle immunogenicity toward eliciting bNAbs
123 This study demonstrated
proof of principle in an animal model that virally modif
124 We show two
proofs of principle:
in a nonlinear genetic toggle switc
125 stor bioassay of small-molecule glucose as a
proof-of-principle,
interestingly, we discover a new ele
126 Proof-of-principle is established with the identificatio
127 By testing this strategy on the
proof-of-principle level with a library of 13 fluorinate
128 nd longitudinal signals, we have developed a
proof-of-principle logic device to control the amplitude
129 Proof-of-principle LPA based undulator emission, with st
130 Proof-of-principle measurements utilizing a chopper with
131 We aimed to develop a
proof of principle mechanistic machine learning model th
132 real space and momentum space demonstrates a
proof-of-principle method for revealing topological magn
133 dy, we describe an optimized high-throughput
proof-of-principle method for the expanded generation, e
134 Viewed as a
proof of principle model for therapeutic development, ou
135 Our
proof of principle model successfully predicted the dail
136 nolysis of alpha-pinene has been chosen as a
proof-of-principle model system.
137 gapixel fluorescence lifetime images, with a
proof-of-principle mosaic image shown with 3.6 MP.
138 As
proof-of-principle, "
NAMB" chemistry was utilized for th
139 with chloride as a nucleophile to achieve a
proof-of-principle Ni(II/IV)-catalyzed C(sp(3))-H functi
140 Proof of principle now exists that major photoprotective
141 As a
proof of principle of a future vector saliva-based pan-L
142 Proof of principle of in vivo targeting of human islets
143 As a
proof of principle of its activity, 1 was used as a prec
144 vo In summary, this study provides the first
proof of principle of small-molecule-mediated interferen
145 Proof of principle of the hypothesis was obtained by ana
146 In a
proof-of-principle of our approach, we demonstrate a pro
147 After obtaining
proof-of-principle of RT-specific DNA labeling reported
148 This work provides the
proof-of-principle of the microbubbling assay with a dig
149 We present an experimental
proof-of-principle of this approach, where a TW-class CO
150 Proof-of-principle particle-in-cell simulations reproduc
151 on, gastric inhibitory polypeptide (GIP), as
proof-of-principle peptides to demonstrate the value of
152 This is why we propose our approach as a
proof-of principle,
perhaps not only applicable to the a
153 As a
proof of principle,
PLSR was used to build soil-bacteriu
154 ositive model bacterium Bacillus subtilis as
proof-of-principle precedent.
155 Recent work has demonstrated
proof-of-principle prototype systems; however, very unev
156 In summary, these findings provide a
proof-of-principle,
rational strategy to target the MYB
157 These
proof of principle results open a pathway for directing
158 These
proof-of-principle results establish the feasibility of
159 Based on these
proof-of-principle results in healthy individuals, we pr
160 Our
proof-of-principle results provide experimental evidence
161 These
proof-of-principle results suggest that covariance-based
162 Recent
proof-of-principle studies demonstrate the potential the
163 Proof-of-principle studies have demonstrated the potenti
164 Proof-of-principle studies showing simultaneous measurem
165 Overall, this
proof of principle study demonstrates that metabolomics
166 This
proof of principle study establishes a new engineering t
167 This is a
proof of principle study showing the response of cancer
168 A
proof of principle study using F/R incorporated into lip
169 In a
proof of principle study, we collected data from the Dut
170 This
proof-of principle study provides valuable probes for NT
171 We report here a
proof-of-principle study applying new methods to select
172 This
proof-of-principle study demonstrates that features of n
173 Our
proof-of-principle study demonstrates that the off-line
174 ne therapy using AAV vectors and showed in a
proof-of-principle study how this virus-host interaction
175 This
proof-of-principle study introduces a sensing mechanism
176 This work was a
proof-of-principle study of this in vivo noninvasive bio
177 This
proof-of-principle study provides support for DEP-IF of
178 This
proof-of-principle study serves to present both the outs
179 This
proof-of-principle study shows significant uptake of an
180 A
proof-of-principle study suggested that intravenous zole
181 This
proof-of-principle study suggests that it may be feasibl
182 This is the first
proof-of-principle study to show that high anti-stalk ti
183 A
proof-of-principle study was conducted with primary huma
184 Furthermore, as a
proof-of-principle study, a point mutation can be effici
185 In a
proof-of-principle study, we demonstrate that Cas9 prote
186 In this physiologic
proof-of-principle study, we determined whether transfus
187 In this
proof-of-principle study, we have utilized label-free sp
188 To test this concept, in this-
proof-of-principle study, we screened for modulators of
189 In our
proof-of-principle study, we used comparative flow cytom
190 providing an excellent starting point for a
proof-of-principle study.
191 In this "
proof-of-principle"
study, we explore a strategy of comb
192 of the impaired autophagic flux and provide
proof-of-principle support for increasing bioavailable M
193 These findings provide
proof-of-principle supporting the development of selecti
194 This study provides additional
proof of principle that an apelin receptor agonist may b
195 These studies provide
proof of principle that apigenin has multiple therapeuti
196 These results provide a
proof of principle that can inform prospective vaccine d
197 Our work provides
proof of principle that chemotherapy paired with an "eco
198 Here we provide the
proof of principle that cryopreserved prepubertal testic
199 Thus, our results provide
proof of principle that D/N Vif variants could have ther
200 As
proof of principle that drug discovery in hiPSC-CMs may
201 ogether, these 2 contemporary trials provide
proof of principle that focused cytokine inhibition, not
202 ry analyses of randomized trial data provide
proof of principle that inflammation inhibition, at leas
203 Moreover, these studies provide a
proof of principle that microglia can be targeted as a t
204 Overall, our studies represent a clear
proof of principle that MT-Hec1-interacting compounds ma
205 These results provide a
proof of principle that quantitative, high-resolution im
206 It provides
proof of principle that Skp2 targeting is a promising ap
207 Finally, we provide
proof of principle that stimulating Nrg1TIII signaling,
208 This also provides a
proof of principle that suboptimal CD8 T cell in old org
209 Conclusion: Our data provide a
proof of principle that upfront treatment with the BGJ39
210 CRF-overexpressing (CRF-OE) mice to test the
proof of principle that when CRF is in excess, sex-biase
211 ation and activity of Rab11b, and we provide
proof-of principle that these drugs prevent breast cance
212 These data represent a
proof-of-principle that a therapeutic application of DIP
213 ensory neurons as a model system, we provide
proof-of-principle that aberrant expression of fusogens
214 We determined as a
proof-of-principle that adenoviral delivery of CRISPR/Ca
215 Molecular biology provides an inspiring
proof-of-principle that chemical systems can store and p
216 These model systems serve as
proof-of-principle that facilitating the interaction of
217 We also provide
proof-of-principle that FDA-approved inhibitors with act
218 These findings provide
proof-of-principle that FVH can be caused by single-gene
219 We also provide a
proof-of-principle that HuR expression can be targeted t
220 Notably, we provide
proof-of-principle that inhibiting IP3R3 degradation in
221 We further provide
proof-of-principle that iPSCs, WES, and dynamic clamp ca
222 Here, we provide
proof-of-principle that pharmacological inhibition of KD
223 letely blunted PDAC formation, providing the
proof-of-principle that TGIF1 restrains Kras(G12D) -driv
224 Proof-of-principle that this approach may represent a sh
225 domized pilot trial, we have established the
proof-of-principle that transcatheter bariatric emboloth
226 odels and human material provide preclinical
proof-of-principle that validates uPA as a novel therape
227 These studies provide "
proof of principle"
that targeting CDK6 with PROTACs tha
228 As
proof of principle,
the effects of hydrophobic (e.g., es
229 As a
proof of principle,
the glycoproteomic N-glycan type qua
230 stability of individual nucleosomes and, as
proof of principle,
the nucleosome preference of the chr
231 For
proof-of-principle,
the clinically relevant glucagon-lik
232 Here we present, as
proof-of-principle,
the development of a light-controlle
233 To establish
proof-of-principle therapeutic effects, we tested PEAMOt
234 As a
proof of principle,
this manuscript investigates the com
235 Having demonstrated
proof-of-principle,
this method can be applied to identi
236 Additionally, we assume that our
proof-of-principle through the prediction of protein bin
237 The PLCA is also applied as a
proof of principle to a previously published gut microbi
238 on network and gene regulatory network, as a
proof of principle to identify heterogeneous interactome
239 Our study provides the
proof of principle to support therapeutic applications o
240 In conclusion, we provide
proof-of-principle to propose AD is a PCBDopathy, a dise
241 quired massive amounts of enzyme but enabled
proof-of-principle transfusions without adverse effects
242 We did a
proof-of-principle trial with a novel endovascular baror
243 tis undergoing total knee replacement into a
proof-of-principle trial.
244 We introduce the design and
proof-of-principle trials that demonstrate the utility o
245 We offer
proof of principle using simulations based on functional
246 We demonstrate here the
proof-of-principle visual characterization of the reacti
247 The
proof of principle was demonstrated by synthesizing a mu
248 As a
proof of principle we apply this approach to the process
249 As our first
proof-of-principle we employed the bacterial chemotaxis
250 ation pathway is dysregulated in MB and as a
proof-of-principle we show that increased GD3 expression
251 As a
proof of principle,
we acquired 4D (H)COCANH, (H)CACONH,
252 As
proof of principle,
we analyzed presynaptic and postsyna
253 As
proof of principle,
we applied the improved workflow to
254 As a
proof of principle,
we applied this approach to the mala
255 As
proof of principle,
we applied this strategy to mouse em
256 As a
proof of principle,
we apply both methods to control the
257 As
proof of principle,
we apply HiHiMap to measure the leve
258 As
proof of principle,
we apply this approach to interrogat
259 As a
proof of principle,
we apply torsional forces to a coars
260 As
proof of principle,
we assembled genomes of the pigeon (
261 As
proof of principle,
we compared trastuzumab conjugated t
262 As
proof of principle,
we conducted an ovalbumin-induced mo
263 As a
proof of principle,
we demonstrated correlation of the h
264 nting with symptoms of long-QT syndrome as a
proof of principle,
we demonstrated that commercially av
265 As
proof of principle,
we demonstrated that inactivation of
266 As a
proof of principle,
we demonstrated that SimCells can be
267 As a
proof of principle,
we developed a simple model that dis
268 As
proof of principle,
we document over a million new names
269 As a
proof of principle,
we employed (4,6-O-benzylidene)methy
270 Finally, as a
proof of principle,
we have created an allosteric metal
271 As
proof of principle,
we have quantified an endogenous pep
272 Using the Chlorella virus DNA ligase as a
proof of principle,
we recapitulate the ligase's substra
273 As a
proof of principle,
we show that our method can accurate
274 As
proof of principle,
we solved by room temperature SFX th
275 As
proof of principle,
we tagged, isolated, and expanded in
276 As a
proof of principle,
we tested our model in an allogeneic
277 As a
proof of principle,
we use an air-puff stimulus to the e
278 As a
proof of principle,
we use the SH3 domain from human Fyn
279 As a
proof of principle,
we used CRISPR/Cas9-mediated editing
280 As a
proof of principle,
we used this new "nanomapping" metho
281 As
proof of principle,
we validated PKCbeta-a known modifie
282 As
proof of principle,
we verify candidate fSNPs on three w
283 As a
proof of principle,
we were able to simultaneously inact
284 As
proof-of-principle,
we analyzed amino acids using a doub
285 As a
proof-of-principle,
we apply md-LED to IAV NS1 protein.
286 As a
proof-of-principle,
we apply MutSpace to 560 breast canc
287 As an initial
proof-of-principle,
we chose an anchoring molecule compo
288 As
proof-of-principle,
we conducted large-scale cell cycle
289 As a
proof-of-principle,
we demonstrate that chemogenetic man
290 As a
proof-of-principle,
we demonstrate the advantages of thi
291 As a
proof-of-principle,
we demonstrate the use of optics to
292 As a
proof-of-principle,
we have applied CIT-MS to compare th
293 As
proof-of-principle,
we identify and validate specific TF
294 As
proof-of-principle,
we performed a head-to-head comparis
295 As a
proof-of-principle,
we report the rapid and efficient fi
296 As
proof-of-principle,
we show that the septuple phy(-) mut
297 To demonstrate the
proof-of-principle,
we tested the sensors with Escherich
298 As
proof-of-principle,
we used site-specific mutagenesis to
299 To demonstrate
proof-of-principle,
we used the TRBO-sgRNA delivery plat
300 in recent years from theoretical to clinical
proof of principle with the publication of a first-in-ma