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1 cluster at the top of the seven-bladed beta-propeller.
2 indicate that it is a D3-symmetric molecular propeller.
3 a strongly pitched, C3-symmetric, molecular propeller.
4 BS9 likely results in misfolding of the beta-propeller.
5 -terminal domain reveals a seven-bladed beta-propeller.
6 Rav1, which can be modeled as a double beta-propeller.
7 g site on blades 2-3 of the SEMA domain beta-propeller.
8 ed that Nup37 folds into a seven-bladed beta-propeller.
9 otor and a helical filament, which acts as a propeller.
10 ared by inter-bladed binding grooves of beta-propeller.
11 nto essentially enantiopure, homochiral 9-EP propellers.
12 anded via tandem duplications to form extant propellers.
13 tion to the small family of five-bladed beta-propellers.
14 the hydrophobic core that joins the two beta-propellers.
15 is not shielded from other proteins by beta-propellers.
16 t, modern structural designs such as prisms, propellers, 2-solenoid, super-roll, clam, trefoil and bo
17 ncreasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of re
21 hat the enzyme folds into the catalytic beta-propeller and beta-sandwich domains characteristic of GH
23 eracts through a region near the alphaM beta-propeller and beta2 betaI domain with a region of the C3
26 elch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains, which were associated wit
27 ibrin to multiple sites in the alphaIIb beta-propeller and further indicate that recognition specific
28 er of key structural connections between the propeller and pore domains located close to lipid-bindin
31 of the Fab bound to an alpha4 integrin beta-propeller and thigh domain fragment shows that natalizum
33 he structure consists of a seven-bladed beta-propeller and, unexpectedly, contains two pseudo-equival
34 des, respectively, show structurally diverse propellers and include a novel fold, highlighting the in
35 ear dictates the rotational direction of the propellers and step-wise rotations can be induced by app
36 eling predicts that WDR-23 folds into a beta-propeller, and we identify the top of this structure and
38 main architecture consisting of an open beta-propeller appended to an alpha/beta hydrolase domain.
39 l catalytic domain with five-fold alpha/beta-propeller architecture and a C-terminal immunoglobulin-l
40 t is determined by the interplay between the propeller architecture and the intermolecular van der Wa
42 ingly, numerous contacts with the Nup37 beta-propeller are located on this extension of the 6D-7A ins
43 , the rotation steps of individual molecular propellers are directly visualized, which confirms the u
47 ow that Vps18 indeed has a seven-bladed beta-propeller as its N-terminal domain by revealing its stru
49 nanomachine and comprises a rotating helical propeller attached to a membrane-embedded motor complex.
51 rotrudes from the intracellular side of the "propeller" blade toward the inner vestibule of the chann
53 of C. reinhardtii, that the C-terminal beta-propeller but not the N-terminal domain of CrODA16 is re
54 therefore investigated whether such nascent propellers can fold as homo-oligomers before they have b
58 of a C-terminal coiled-coil segment and beta-propeller combination (Olfm1(coil-Olf)) that reveals a d
61 The catalytic domain was a five-bladed beta-propeller consisting of five radially oriented anti-para
62 17 protruding from one end of the BamB beta-propeller contact the face of the POTRA3 beta-sheet in B
65 ck residues 537-578 or 897-917 from its beta-propeller core diffused faster on the PM and exhibited r
66 d to be the active state and comprise a beta-propeller core domain and intrinsically disordered N- an
68 , or inserting a linker between NLS and beta-propeller, disrupts specificity for importin alpha3, dem
69 sociate mutations in the PF3D7_1343700 kelch propeller domain ('K13-propeller') with artemisinin resi
70 d a direct interaction between the Rrp9 beta-propeller domain and Rrp36, the strength of which was re
72 Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be importan
74 continuous segments within the alphaIIb beta-propeller domain of alphaIIbbeta3 enriched with negative
75 requires an unexpected swiveling of the beta-propeller domain of BBS1, the subunit most frequently im
76 n with the WD40 repeats-based predicted beta-propeller domain of COP1, whereas COP1 activity is regul
77 of Arp2/3 complex, with the N-terminal beta-propeller domain of Coronin positioned near the p35/ARPC
80 Pal is tethered to the OM and binds the beta-propeller domain of periplasmic TolB, which, as recent e
82 etween the MLL1 SET domain and the WD40 beta-propeller domain of RbBP5, and demonstrate the susceptib
84 that recognize a defined epitope on the beta-propeller domain of the platelet integrin alphaIIb subun
85 domains of UVR8 interact with COP1: the beta-propeller domain of UVR8 mediates UV-B-dependent interac
88 rminal domain and a C-terminal 8-bladed beta-propeller domain that are both required for the associat
89 rom Snc1, or deletion of a beta'-COP subunit propeller domain that binds K63-linked polyubiquitin, di
92 genotyped the P. falciparum K13 (Pfkelch13) propeller domain, mutations in which can mediate artemis
93 onarily conserved amino acid within the beta-propeller domain, which abrogates almost completely the
94 amples carried the C580Y allele in the PfK13 propeller domain, with flanking microsatellite profiles
100 crystal structure of PorZ revealed two beta-propeller domains and a C-terminal beta-sandwich domain,
101 ns predicted to contain four six-bladed beta-propeller domains and both bind the bone-specific Wnt si
102 of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistanc
103 s between the alphaL and alphaX subunit beta-propeller domains concentrate near the binding pocket an
104 brane protein with thioredoxin-like and beta-propeller domains located in the lumen and a haloacid-de
105 h could potentially be useful, including the propeller effect, have therefore not yet been demonstrat
106 s to demonstrate the Baranova and Zel'dovich propeller effect: the separation of a racemic mixture by
107 ed a location for the active site among beta-propeller enzymes cited on the posterior surface of the
109 lecular machine that functions as a cellular propeller, exhibits significant structural variability b
111 rmational flexibility to wedge the RCC1 beta-propeller flanking the NLS against its lateral surface,
112 es (fanciful ball, puzzle pieces, 3D pixels, propellers, fluidic and multicompartments) with mono-, d
113 ts a classical paramyxoviral six-bladed beta-propeller fold and structurally classifies in close prox
114 find that MojV-G displays a six-bladed beta-propeller fold bearing limited similarity to known param
115 recombinant PLL revealed a seven-bladed beta-propeller fold creating seven putative fucose-binding si
116 wed them to enter the protein vestibule, the propeller fold exceeds the size of the latch region, pro
117 based solution, while it formed the parallel propeller fold in water-depleted potassium-based solutio
119 f62A and PaAbf62A reveals a five-bladed beta-propeller fold that confirms their predicted classificat
120 rotein family, bind via their predicted beta-propeller fold the polyphosphoinositides PtdIns3P and Pt
122 trom resolution revealed a seven-bladed beta-propeller fold with an iron cofactor coordinated by four
128 a G-quadruplex with the parallel-stranded ("propeller") fold, consistent with observations that redu
131 dues 70-893), folds into a seven-bladed beta-propeller followed by an alpha-helical domain, which tog
133 1 and Kir6.2 adjacent to the ATP site in the propeller form and is disrupted in the quatrefoil form.
135 se structures, referred to as quatrefoil and propeller forms, were determined by single-particle cryo
136 tivity associated with scaffold protein WD40/Propeller/FYVE (WD40/ProF), which reportedly facilitates
137 ndent FoxO1 phosphorylation occurs on the WD/Propeller/FYVE scaffold in liver and is selectively inhi
138 electron oxidation of dG in chiral hybrid or propeller G-quadruplexes that expose the re or si face t
141 rms of suprastructures, collinear chains and propellers, have been achieved with various chiral HgS N
148 annel impairments, including: misalignments, propeller-induced airflows, power loss, intermodal cross
150 ions of both left and right handed molecular propellers into clockwise and anticlockwise directions r
152 he interaction between RAV1 and the 1st WD40 propeller is conserved with another RAV family member, T
156 l protein that contains BTB and Kelch-repeat propeller (KREP) domains usually found in E3 ubiquitin l
158 subunit of FIPV S protein result in a unique propeller-like conformation, underscoring the importance
166 nbonded P...O interaction, hypervalency, and propeller-like shape of the phosphonium groups in 1a(2+)
172 x folding and identify the single-nucleotide propeller loops as the most fragile part of the quadrupl
177 rotate with the field and act as microscopic propellers; moreover, owing to their opposite handedness
179 h both multiple Pfmdr1 copy number and a K13 propeller mutation were 14 times more likely to fail tre
181 o parasite clearance rates indicate that K13-propeller mutations are important determinants of artemi
182 inated initially but were later overtaken by propeller mutations associated with slower parasite clea
183 recorded P falciparum parasites carrying K13-propeller mutations at high prevalence next to the north
186 alciparum malaria is associated with kelch13 propeller mutations, reduced ring stage parasite killing
190 ur analysis demonstrates that the N-terminal propeller needs to be able to engage the C-terminal tail
191 is work presents a green chiral nanographene propeller (NP), which is built by fusing seven hexabenzo
192 structure identifies blades 4-6 of the beta-propeller of CyRPA as contact sites for Rh5 and Ripr.
193 to bind a similar surface in the third beta-propeller of LRP5/6, sterically interfering with Wnt3/3a
194 th projections clamp to the side of the beta-propeller of Rae1, with the finger also contacting Nup98
195 ions between BCL11A and the side of the beta-propeller of RBBP4 that are not seen with histone H3.
196 urthermore, we demonstrate that the 1st WD40 propeller of TPL can form a complex with RAV1 both in ye
201 nose, and ribose substitutions stabilize the propeller parallel G-quadruplex form over competing conf
202 arallel lines with enhanced reconstruction ( PROPELLER periodically rotated overlapping parallel line
203 on CT images (3.49), while findings with the PROPELLER periodically rotated overlapping parallel line
204 erated volume acquisition , 2.52 [P = .002]; PROPELLER periodically rotated overlapping parallel line
210 one distantly related dual seven-bladed beta-propeller protein from a marine bacterium, highlighted k
211 de novo mutations in WDR45, encoding a beta-propeller protein postulated to play a role in autophagy
212 astic cells) domains(7), and WDR41 is a beta-propeller protein that binds to SMCR8 such that the whol
214 c diseases: EPG5-related Vici syndrome, beta-propeller protein-associated neurodegeneration due to mu
217 he substrate affinity of USP12, the two beta-propeller proteins potentiate the enzyme through differe
218 f these complexes are mLST8 and Raptor, beta-propeller proteins that stabilize the mTOR kinase and re
219 election forces underlying emergence of beta-propeller proteins, a globular and symmetric fold group
223 sis that rs688, which is located in the beta-propeller region of LDLR, has effects on LDLR activity b
224 ymous single nucleotide polymorphisms in the propeller region of the kelch 13 gene among isolates cir
225 sociated with single point mutations in the "propeller" region of the P. falciparum kelch protein gen
228 aV-Fab interface were interactions involving Propeller residues Lys-203 and Gln-145, with the latter
229 n of an unstructured loop in its second beta-propeller, ruling out models of phosphorylation-dependen
230 structural variation in the six-bladed beta-propeller scaffold of the GhV-G receptor-binding domain,
232 ide a conclusive rationale for worldwide K13-propeller sequencing to identify and eliminate artemisin
234 s spanning the sequence of the alphaIIb beta-propeller, several sequences were identified as candidat
236 nt-solubilized complex adopts a three-bladed propeller shape with a curved transmembrane region conta
237 he discovery and optimization of a series of propeller shaped PI3Kdelta inhibitors comprising a novel
238 uted quinolizinone 20 to a novel "four-blade propeller" shaped 1,2,3-trisubstituted quinolizinone 34.
239 systematic transformation of a "three-blade propeller" shaped lead, 2,3-disubstituted quinolizinone
245 es of Cas1 (Cas2/32:Cas14) into a four-lobed propeller-shaped structure, where the two Cas2 domains f
251 lation variation data, we show that the beta-propeller structure of the ubiquitous WD40 domain provid
253 domain, which potentially folds into a beta-propeller structure resembling the alpha-integrin ligand
259 and characterize a multi-component molecular propeller that enables unidirectional rotations on a mat
260 la are ultimately constructed from a helical propeller that is attached to a motor embedded in the in
267 cause a subtle conformational change in the propeller tips, potentially perturbing an interaction si
269 ide-linked dimeric arrangement with the beta-propeller top faces in an outward exposed orientation.
270 al features (i.e., minor groove width, roll, propeller twist and helix twist) for 739 TF datasets fro
273 ts four broad and static DNA shape features, Propeller twist, Helical twist, Minor groove width and R
274 tions (GBshape) provides minor groove width, propeller twist, roll, helix twist and hydroxyl radical
275 Our simulations also indicate that the actin propeller twist-angle and nucleotide cleft-angles are in
278 l strands in their structures by stabilizing propeller type loops, shifting the antiparallel htel-22
282 he d(TTGTGGTGGGTGGGTGGGT) sequence reveals a propeller-type parallel-stranded G-quadruplex containing
284 l variability and structural dynamics of the propeller-type topology, we performed molecular dynamics
289 trad, or located at the top face of the beta-propeller, where 'hotspot' residues affect the binding o
290 for cytochrome c binding to regulatory beta-propellers, which is dependent on shape and charge compl
291 ealing an intimately associated pair of beta-propellers, which we term a TAPE (tandem atypical propel
293 Structurally, PON1 is a six-bladed beta-propeller with a flexible loop (residues 70-81) covering
294 Nup120(1-950) also folds into a seven-bladed propeller with a markedly protruding 6D-7A insert and is
295 N-terminal region and a C-terminal WD40 beta propeller with a preformed KEN-box-binding site at its t
298 e PF3D7_1343700 kelch propeller domain ('K13-propeller') with artemisinin resistance in vitro and in
299 ng blocks derived from two seven-bladed WD40 propellers yielded stable homo-oligomers with six to nin