ライフサイエンスコーパス: prophase

1 e of retrotransposition in the early meiotic prophase.

2 ions of the horsetail nucleus during meiotic prophase.

3 ter kinetochore sub-complexes during meiotic prophase.

4 three kinases that phosphorylate Rec8 during prophase.

5 rols chromosome structure throughout meiotic prophase.

6 es only after nucleolar disassembly later in prophase.

7 e centromeres and is not incorporated during prophase.

8 no detectable role for chromosomal events of prophase.

9 the leptotene/zygotene transition of meiotic prophase.

10 ase and centrosome separation in the mitotic prophase.

11 ear envelope near centrosomes in late G2 and prophase.

12 he distance centrioles normally reach during prophase.

13 1-activated kinases (Paks) on centrosomes in prophase.

14 a unique role for these proteins in meiotic prophase.

15 t dynein-driven centrosome separation during prophase.

16 ion and activates genes required for meiotic prophase.

17 itment to the PPB occur independently during prophase.

18 for maintaining Xenopus oocytes arrested in prophase.

19 l enzyme in the progression of early meiotic prophase.

20 ated by programmed cell death during meiotic prophase.

21 cannot be sustained as chiasmata until late prophase.

22 ssociate from chromosome arms during mitotic prophase.

23 located from the nucleus to the cytoplasm in prophase.

24 , specifically during meiotic initiation and prophase.

25 lon and its localization to the cytoplasm in prophase.

26 ated density of DSB markers later in meiotic prophase.

27 t reloading of CENP-A during oogenic meiotic prophase.

28 er recombination, which occur during meiotic prophase.

29 sion as a result of accumulation of cells in prophase.

30 tial step for nucleus-centrosome coupling in prophase.

31 otic S phase, followed by entry into meiotic prophase.

32 localize SYCP3 and gammaH2AX during meiotic prophase.

33 into one or two masses during early meiotic prophase.

34 ts are a conserved feature of meiosis I (MI) prophase.

35 expression of SPO11 isoforms in male meiotic prophase.

36 and B compartments are maintained in meiotic prophase.

37 domains, and localized point interactions in prophase.

38 e dynamic methylation of H3K9 during meiotic prophase.

39 d by pairing of their centromeres in meiotic prophase.

40 ex proteins died soon after onset of meiotic prophase.

41 f interphase nuclei is attenuated in meiotic prophase.

42 NDC80 expression is repressed during meiotic prophase.

43 er into meiosis and progress through meiotic prophase [1].

44 roteases of the subtilase family and meiotic prophase aminopeptidase 1 using mass spectrometry-based

45 sister chromatid cohesion during the mitotic prophase-analogous stage of G2/M is repurposed during me

46 ororin is phosphorylated by Cdk1/cyclin B at prophase and acts as a docking protein to bring Plk1 int

47 esin complex released from chromatin in both prophase and anaphase.

48 in removing chromatin-associated RNAs during prophase and demonstrates that Aurora-B-dependent reloca

49 eraging 0.8-1.0 megabase pairs (Mb) in early prophase and extending to 1.5-2.0 Mb in late prophase as

50 partially co-localized with chromatin during prophase and interphase.

51 t pericentromeres and chromosome arms during prophase and is lost upon chromosome alignment.

52 artial loss of centromeric cohesion at early prophase and maintenance of the ability to initiate but

53 During prophase and metaphase activated PSKs are located in the

54 /FLI1 and Aurora B on the chromosomes during prophase and metaphase and, in addition, impairs the loc

55 cell cycle regulated-it is inhibited during prophase and metaphase by cyclin-dependent kinase 1 (CDK

56 centromeric sister-chromatid cohesion during prophase and prevents premature sister-chromatid separat

57 f cohesin is removed from chromosome arms in prophase and prometaphase in a manner that depends on Wa

58 tMAD2 is associated with kinetochores during prophase and prometaphase, but not metaphase, anaphase a

59 os exhibit an anterior shifting of nuclei in prophase and reduced anaphase spindle oscillations.

60 During oogenesis, oocytes are arrested in prophase and resume meiosis by activating the kinase Cdk

61 tected nuclear invagination channels at late prophase and telophase, potentially suggesting roles for

62 sferrin uptake is inhibited after entry into prophase and that it resumes in telophase.

63 ia to stop mitosis and transition to meiotic prophase and the spermatocyte state.

64 oshin protects the centromeric SC in meiotic prophase and, in anaphase, promotes the proper segregati

65 t dTopors localizes to the nuclear lamina at prophase, and also transiently to intranuclear foci.

66 ure to establish apical cortical polarity at prophase, and lack of cortical Scribble localization thr

67 CCS52B mRNAs are confined to the nucleus at prophase, and the cognate proteins are not translated un

68 ss, regulation and cell signaling, phage and prophases, antibiotic and heavy metal resistance that mi

69 Hsp90), LKB1, or AMPKalpha all show similar prophase apical cortical polarity defects (but no Scribb

70 uclear sequestration of these transcripts at prophase appears to protect cyclins from precocious degr

71 r various animal cell types, growth rates in prophase are commensurate with or higher than interphase

72 gs to synapse along their lengths, provoking prophase arrest and, ultimately, sterility.

73 ovulatory ovarian follicles of mice, meiotic prophase arrest in the oocyte is maintained by cyclic GM

74 In all vertebrates, release from prophase arrest relies on protein kinase A (PKA) downreg

75 ar lamina disassembly in the transition from prophase arrest to meiosis I is also impaired in Rab5a-d

76 kinase regulates resumption of meiosis from prophase arrest, chromosome condensation, and kinetochor

77 to phosphorylate Zip1 4S results in meiotic prophase arrest, specifically in the absence of SGS1.

78 in the ovaries in a unique state of meiotic prophase arrest.

79 nctions into the oocyte, maintaining meiotic prophase arrest.

80 le-strand breaks in meiotically competent G2/prophase-arrested mouse oocytes do not prevent entry int

81 lowing exogenously induced genotoxic stress, prophase-arrested oocytes are highly capable of function

82 Here we show that prophase-arrested oocytes rapidly respond to gamma-irrad

83 ings of high Ccnb2 mRNA translation rates in prophase-arrested oocytes, we re-evaluated the role of t

84 well characterized, the same is not true for prophase-arrested oocytes.

85 els of DNA damage result in the apoptosis of prophase-arrested oocytes.

86 prophase and extending to 1.5-2.0 Mb in late prophase as chromosomes compact and homologs undergo syn

87 matin (MSUC) occurs during the first meiotic prophase, as chromosomes that fail to pair are sequester

88 nesis in the developing ovary: the events of prophase at the onset of meiosis in the fetal ovary and

89 physically definable steps of recombination, prophase axis length and S-phase progression, in budding

90 A subset of the DSBs induced during meiotic prophase become designated to be repaired by a pathway t

91 Its formation begins in early prophase before NEBD when the SAC has not been activated

92 ocate throughout the chromatin region during prophase but during anaphase move to surround segregatin

93 at confers a csm4Delta-like delay in meiotic prophase but promotes high spore viability.

94 associated with chromatin in interphase and prophase but released upon nuclear envelope breakdown (N

95 mately 300 genes coordinately during meiotic prophase, but different mRNAs within the NDT80 regulon a

96 ) is required for the removal of cohesins at prophase, but how Plk1 is recruited to phosphorylate SA2

97 is necessary for arrest of the oocyte at G2-prophase, but it is unclear whether this regulation func

98 osis: Ndc80 degradation is active in meiotic prophase, but not in metaphase I.

99 cells are exceedingly rare in early meiotic prophase, but they are the only cells that progress into

100 sm4 to drive chromosome movements in meiotic prophase by coupling telomeres to the actin cytoskeleton

101 ver between homologs is initiated in meiotic prophase by the formation of DNA double-strand breaks th

102 Crossovers form late in meiosis I prophase, by polo kinase-triggered resolution of Hollida

103 We found that germ cells already in meiotic prophase can nonetheless be sexually transformed from a

104 We show that during prophase, centrosomes and nucleus reorient so that centr

105 The G2-to-M transition (or prophase) checkpoint of the cell cycle is a critical reg

106 Rec8 is a prominent component of the meiotic prophase chromosome axis that mediates sister chromatid

107 f first division (afd1), required for proper prophase chromosome morphology and for meiotic sister-ch

108 Prophase chromosomes exhibit a highly irregular surface

109 Here we show that RNA is evicted from prophase chromosomes through Aurora-B-dependent phosphor

110 Prophase chromosomes, whose organization was previously

111 huge condensed middle chromosome regions on prophase chromosomes.

112 specific organizational features of meiotic-prophase chromosomes.

113 In meiotic prophase, chromosomes are organized into compacted loop

114 During meiotic prophase, chromosomes organise into a series of chromati

115 We propose that prophase cohesin removal is a key step in reprogramming

116 During late meiotic prophase, COSA-1 localizes to foci that correspond to th

117 (or hal-2) mutants exhibit multiple meiotic prophase defects including failure to establish homolog

118 These late-prophase defects then lead to aberrant reconfiguring of

119 sms, homolog pairing and synapsis at meiotic prophase depend on interactions between chromosomes and

120 At late prophase, dependent on topoisomerase II and with concomi

121 mice, BPA induces subtle disturbances in the prophase events that set the stage for chromosome segreg

122 calization of key protein markers of meiotic prophase events, indicating that initiation of meiotic p

123 ed at two steps of DSB repair during meiotic prophase: first by the activity of the MCM-like protein

124 omplexes), facilitates the formation of this prophase form of the CDC20-MAD2 complex but is inactive

125 Our results suggest that Rec8's prophase function, independently of cohesin cleavage, co

126 thousands of other genes, including meiotic prophase genes, factors mediating DNA replication and th

127 he central visible characteristic of meiotic prophase, has been a matter of intense interest for deca

128 Cells in meiotic prophase have already replicated their DNA, but they hav

129 During Schizosaccharomyces pombe meiotic prophase, homologous chromosomes are co-aligned by linea

130 imination of more than two-thirds of meiotic prophase I (MPI) oocytes before birth.

131 -strand DNA breaks (DSBs) throughout meiotic prophase I and a concurrent reduction in male fertility.

132 1 in the resection of DSBs in middle meiotic prophase I and in blocking NHEJ.

133 airing at telomeres persists upon entry into prophase I and is most likely important for initiation o

134 molecular assembly that forms during meiotic prophase I and mediates adhesion of paired homologous ch

135 hromosome 10 from B73 in different stages of prophase I and metaphase I during meiosis.

136 ated P4-induced inhibition of oocyte meiotic prophase I and primordial follicle formation.

137 not commit to finishing meiosis until after prophase I and the realization of such meiosis-specific

138 oocytes (in which the nuclei are intact) at prophase I are stimulated to resume meiosis and mature t

139 hypothesized that gene expression during the prophase I arrest is primarily epigenetically regulated.

140 lear because of the long (months to decades) prophase I arrest.

141 We show that during prophase I ASY1 and its interacting partner, ASY3, are e

142 min localizations, centriole separation, and prophase I chromatin condensation and also cause anaphas

143 mbination machinery is reactivated following prophase I exit to repair any persisting meiotic DNA dou

144 re arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the hi

145 o confirms the importance of early stages of prophase I for the control of recombination in large gen

146 as a gene involved in key events of meiotic prophase I in Caenorhabditis elegans.

147 s failed to be repaired from early to middle prophase I in mre-11(iow1) mutants.

148 versus homoeologous chromosomes during early prophase I in two representative B. napus accessions tha

149 rompt disassembly of the SC during exit from prophase I is a landmark event of meiosis, the underlyin

150 CID assembly in prophase I is also conserved in female meiosis.

151 e interactions during premeiotic S phase and prophase I is essential for establishing the meiosis I c

152 Meanwhile, no replicative PGCs or prophase I meiocytes could be found.

153 splantation, as evidenced by the presence of prophase I meiocytes displaying homologous pairing.

154 sed Aurora B kinase (AIR-2) signals in early prophase I nuclei, coupled with a parallel decrease in s

155 rate that embryonic exposure to ATZ disrupts prophase I of meiosis and affects normal follicle format

156 affect spindle nucleation or progression of prophase I of meiosis but does inhibit maturation of Ser

157 t encompasses key events taking place during prophase I of meiosis that are required for achieving pr

158 ouble-strand breaks (DSBs) introduced during prophase I precede and are required for efficient homolo

159 d, events: oocyte maturation (release of the prophase I primary arrest) and egg activation (release f

160 through the RAS-ERK pathway to drive meiotic prophase I progression and oogenesis; in the absence of

161 meiotic time course revealed a 12-h delay in prophase I progression to the first labeled tetrads.

162 motes efficient SC destruction at the end of prophase I to ensure faithful inheritance of the genome.

163 Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce th

164 the prophase of the first meiotic division (prophase I).

165 es are deficient in progression through late prophase I, a time point when expression of the X-linked

166 epletion of the germ cell pool at the end of prophase I, as in males.

167 ks (DSBs) by the Spo11 endonuclease early in prophase I, at discrete regions in the genome coined "ho

168 tin transitions between substages of meiotic prophase I, both at sites of genetic recombination and a

169 in accumulates on meiotic chromosomes during prophase I, consistent with MSH2 regulating meiotic reco

170 Upon exit from prophase I, Dbf4, the regulatory subunit of DDK, directl

171 arrested as early as the leptotene stage of prophase I, demonstrating that cohesin plays an essentia

172 t the onset of leptotene, the first stage of prophase I, frequently occurred earlier in fst-1 than in

173 In meiotic prophase I, homologous chromosome pairing is promoted th

174 tants exhibit severe meiotic defects in late prophase I, including improper disassembly of the SC and

175 nd their fetal oocytes are arrested at early prophase I, leading to oocyte depletion at 1 week of age

176 ity or gametogenesis stages prior to meiotic prophase I, mice bearing a deregulated allele (Cdk2(Y15S

177 is highly enriched at the rDNA region during prophase I, released at the prophase I/metaphase I trans

178 normal chromosome remodeling in late meiotic prophase I, resulting in accurate chromosome segregation

179 alizes to spermatocyte nuclei during meiotic prophase I, specifically at sites of asynapsis and the t

180 spermatocytes at the early stages of meiotic prophase I, the limited period when PRDM9 is expressed.

181 spontaneous DSBs ( approximately 10) in late prophase I, the repair of which is inhibited by the pres

182 n is essential for chromosome pairing during prophase I, the resulting crossovers are critical for ma

183 During prophase I, the sex body assembles incorrectly in Ago4(-

184 the dissociation of Rec114 and Mer2 later in prophase I, whereas the timing of replication and the pr

185 defective in chromosome synapsis at meiotic prophase I, which provokes an arrest at the pachytene-li

186 iation of AtRECQ4A with the telomeres during prophase I, which we propose enables dissolution of reco

187 s regulating transcriptional activity in the prophase I-arrested oocyte are still not entirely unders

188 cluding G0-arrested tissue culture cells and prophase I-arrested oocytes.

189 in the context of the important landmarks of prophase I.

190 c chromatin for subsequent functions in late prophase I.

191 formation, suggesting a role during meiotic prophase I.

192 plete absence of CO formation during meiotic prophase I.

193 osomal fragmentation and aggregation in late prophase I.

194 (synapsis) of homologous chromosomes during prophase I.

195 stablishment of sister chromatid cohesion in prophase I.

196 sely associate with the nuclear periphery at prophase I.

197 the accumulation of Rec114 and Mer2 early in prophase I.

198 patterns of H3K9 methylation during meiotic prophase I.

199 NA region during prophase I, released at the prophase I/metaphase I transition, and reassociates with

200 round the late pachytene-diplotene stages of prophase I; surprisingly, without any obvious defect in

201 ation of major satellite transcripts in both prophase-I and metaphase-I chromosomes.

202 Hormonal stimulation breaks this prophase-I arrest and induces re-entry into MI.

203 located at the pericentromere during meiotic prophase II but is restricted to the inner centromere at

204 During meiotic prophase in Drosophila males, transcript for the core ce

205 review the critical events in early meiotic prophase in Drosophila melanogaster oocytes.

206 s been shown to activate condensin II during prophase in human cells, and facilitate further phosphor

207 During meiotic prophase in males, the sex chromosomes partially synapse

208 mologous chromosomes is initiated in meiotic prophase in most sexually reproducing organisms by the a

209 systems regulate the major events of meiotic prophase in mouse.

210 During meiotic prophase in Saccharomyces cerevisiae, expression of the

211 YCA3;4 protein is promptly broken down after prophase in wild-type plants, it remains present in late

212 During meiotic prophase, in a conserved chromosomal configuration calle

213 tration that oxidative stress during meiotic prophase induces chromosome segregation errors and suppo

214 rmatocytes and prohibits the transition from prophase into metaphase of the first meiotic division, r

215 e and from neuroblast chromosome arms during prophase is blocked by translational fusion of Smc3's C-

216 ciation of telomeres with centrosomes during prophase is crucial for efficient spindle formation.

217 lk1 is recruited to phosphorylate SA2 during prophase is currently not known.

218 al of cohesin/Pol II from chromosome arms in prophase is important for accurate chromosome segregatio

219 vents, indicating that initiation of meiotic prophase is not androgen dependent.

220 Meiotic prophase is predominated by short-range intrachromosomal

221 For mouse lymphoblast cells, growth in prophase is promoted by CDK1 through increased phosphory

222 h regulation of CO position early in meiotic prophase is required for proper designation of chromosom

223 moval of cohesin from chromosome arms during prophase is required for the dissociation of Pol II and

224 is is initiated by retinoic acid and meiotic prophase is the first and most complex stage of meiosis

225 The protracted arrest in meiotic prophase makes oocytes particularly susceptible to the a

226 hosphorylation upon cycling that suggested a prophase/metaphase block; germ cells were almost entirel

227 utant neuroblasts showed a striking delay in prophase/metaphase transition by live imaging and increa

228 onents of the machinery that generates rapid prophase movements are unknown, and the mechanism underl

229 mere-led rapid chromosome movements or rapid prophase movements direct fundamental meiotic processes

230 unknown, and the mechanism underlying rapid prophase movements remains poorly understood.

231 mid undergoes Csm4- and Ndj1-dependent rapid prophase movements with speeds comparable to those of te

232 otein quantification in juvenile mice and in prophase mutants indicates that early spermatocytes synt

233 eakdown (NEBD) and impaired the formation of prophase NE invaginations (PNEIs), similar to microtubul

234 Sa15 forms linear structures in meiotic prophase nuclei to which Zhp3 localizes.

235 , was localized with 5-methylcytosine in the prophase nucleus of a subset of KIT(+) progenitors durin

236 m cell samples, especially in females, where prophase occurs in the embryonic ovary.

237 During the extended prophase of Drosophila gametogenesis, spermatocytes unde

238 Vertebrate immature oocytes are arrested at prophase of meiosis I (MI).

239 tinct cell cycle phases during male meiosis: prophase of meiosis I and after exit from meiosis II, in

240 embryonic gonocytes results in arrest during prophase of meiosis I.

241 rrays of rRNA genes (rDNA), dissolves during prophase of mitosis in metazoans, when rDNA transcriptio

242 on causes reduction of perinuclear dynein in prophase of mitosis.

243 are arrested for long periods of time in the prophase of the first meiotic division (prophase I).

244 differentiation does not proceed beyond the prophase of the first meiotic division due to massive ap

245 During prophase of the first meiotic division, cells deliberate

246 holds together homologous chromosomes during prophase of the first meiotic division.

247 During the entire meiotic prophase of the yeast Saccharomyces cerevisiae, chromoso

248 Upon prophase onset, constraints are relaxed, and PCs initiat

249 Third, from prophase onward, chromosomes are deformed into sequentia

250 tors and RBPs followed the cohesin cycle and prophase pathway of cell cycle-regulated interactions wi

251 ibition of Plk1, a kinase essential for the "prophase pathway" of cohesin release from chromosomes, o

252 horylation accumulates at centrosomes during prophase, peaks at metaphase, and decreases through telo

253 upport a role for SPO11alpha in mid- to late prophase, presumably acting as a topoisomerase, that wou

254 presenting at least 35 genes that affect key prophase processes such as pairing, synapsis, and homolo

255 with a single dramatic exception: the normal prophase program of recombination and synapsis between h

256 These observations imply that the prophase program senses absence of karyogamy and/or abse

257 howed evidence that DSB numbers increased as prophase progressed.

258 nt defined subnuclear sites during wild-type prophase progression to regulate distinct cellular event

259 ysis of protein abundance remodeling between prophase, prometaphase and anaphase.

260 sis of heterospecific chromosomes in meiotic prophase provides a recurrently evolving trigger for the

261 sites in which replication was delayed until prophase, regardless of FA pathway activation.

262 unction mutant in chicken cells; it disrupts prophase, results in a dramatic shortening of the mitoti

263 nome-wide survey of histone marks in meiotic prophase, revealing a heretofore unappreciated complexit

264 Here, we explore the prophase roles of Rec8.

265 ning GLFG bodies are disassembled in mitotic prophase, significantly ahead of nuclear pore disassembl

266 ession, disturbs ribosome biogenesis in late-prophase spermatocytes and prohibits the transition from

267 tected in the cytoplasm of spermatogonia and prophase spermatocytes.

268 ribution of crossover-associated proteins in prophase-stage oocytes.

269 lar transcriptomic block in an early meiotic prophase state (leptotene/zygotene) in mutant germ cells

270 e detachment in untreated cells increases at prophase suggesting that it is a regulated cellular proc

271 sociating domains (TADs) are lost in meiotic prophase, suggesting that assembly of the meiotic chromo

272 ted with 9-ING-41 become arrested in mitotic prophase, supporting the notion that GSK3beta is necessa

273 ion signal and localizes to knobs earlier in prophase than KINDR.

274 formed between homologous chromosomes during prophase that promotes DSB formation and biases repair o

275 observations, we propose that during meiotic prophase the presence of occasional fast moving chromoso

276 Instead of continuing through meiotic prophase, the cells attempt an abnormal mitotic-like div

277 romosomes first emerge as discrete units, at prophase, they are organized as co-oriented sister linea

278 al of TOP2A prior to mitosis does not affect prophase timing or the initiation of chromosome condensa

279 primarily localizes to spindle poles during prophase to metaphase but gradually diminishes after ana

280 omatin and chromosome individualization from prophase to metaphase transition.

281 that the successful transition from meiotic prophase to mitosis requires the modulation of Cdk1 acti

282 integrity during the transition from meiotic prophase to mitosis.

283 rane fragments, defining the transition from prophase to prometaphase and resulting in complete mixin

284 analogous to sister individualization at the prophase to prometaphase transition of the eukaryotic ce

285 s stage of G2/M is repurposed during meiosis prophase to promote interactions between homologs.

286 hich transiently associates with Exo1 at the prophase-to-metaphase I transition, enables the formatio

287 Here, we show that activation of Mps1 during prophase triggers Mad1 release from NPCs and that this i

288 ansition, and genes that promote the lengthy prophase unique to meiosis I.

289 permatocyte genome in early and late meiotic prophase using chromosome conformation capture (Hi-C).

290 acin AUC24 was 16.9 mg*h/L in the prednisone prophase versus 29.3 mg*h/L with concomitant chemotherap

291 re removed from sister chromatid arms during prophase via phosphorylation, whereas centromeric cohesi

292 ages of the cell cycle, in particular during prophase when most cohesin dissociates from chromosome a

293 hat maximal phosphorylation of Nuf occurs at prophase, when centrosome-associated Nuf disperses throu

294 We find that Ect2 first becomes active in prophase, when it is exported from the nucleus into the

295 skeletal preprophase band in preprophase and prophase, whereas a number of proteins discovered over t

296 and p150 dynactin on the nuclear envelope at prophase, which results in inefficient dynein-driven cen

297 endent recruitment of POK1 to the PPB during prophase, while POK1 retention at the cortical division

298 in is stripped from chromosome arms by early prophase, while the remaining cohesin at kinetochores is

299 Cdk1 (sum1-ci) blocks meiotic development in prophase with an ndt80Delta-like phenotype.

300 ed at mid to late pachytene stage of meiotic prophase with defective synapsis of the homologous chrom