ライフサイエンスコーパス: prophylactic

1 4 receptor (5-HT(4)R) agonists could act as prophylactics.

2 for C. difficile infection therapeutics and prophylactics.

3 eting this protein, to generate native human prophylactic Abs to reduce the infection and spread of H

4 ference between therapeutic (n = 766) versus prophylactic AC (n = 1,860) (aHR: 0.86; 95% CI: 0.73 to

5 34.9%), therapeutic AC (n = 900; 20.5%) and prophylactic AC (n = 1,959; 44.6%) were associated with

6 ted on the association of therapeutic versus prophylactic AC initiated <=48 h from admission.

7 Compared with prophylactic AC, therapeutic AC was associated with lowe

8 The practice of prophylactic administration of a macrolide antimicrobial

9 Results show that prophylactic administration of R848 significantly reduce

10 ndicate that men with HIV could benefit from prophylactic administration of the 9v HPV vaccine.

11 ly no countermeasures have been approved for prophylactic administration.

12 induced morbidity and mortality in mice upon prophylactic administration.

13 ously reported that (R,S)-ketamine acts as a prophylactic against stress when administered 1 week bef

14 tamine, 5-HT(4)R agonists are also effective prophylactics against stress, suggesting that the 5-HT(4

15 Moreover, we show that prophylactics against stress-induced depressive-like beh

16 the novel formulation as a safe and feasible prophylactic agent against DS.

17 development as potential therapeutic and/or prophylactic agents against SARS-CoV-2.

18 novel diagnostic technologies, several novel prophylactic agents, and further improvements in preempt

19 Despite graft-versus-host disease (GVHD) prophylactic agents, the success and wider utilization o

20 s suggest a potential role of these drugs as prophylactic agents.

21 intracerebrally prion-infected mice in both prophylactic and delayed dosing paradigms.

22 HTx) recipients treated according to current prophylactic and immunosuppressive regimens.

23 tral conserved domain are protective in both prophylactic and postinfection animal models.

24 lineage), demonstrating their broad-spectrum prophylactic and therapeutic activity against currently

25 human airway epithelial cells in vitro-both prophylactic and therapeutic administration of IFN-lambd

26 In prophylactic and therapeutic animal models of hepatic fi

27 Prophylactic and therapeutic application of CV07-209 pro

28 Potent prophylactic and therapeutic effects against SARS-CoV-2

29 a dose as low as 2 mg/kg and exhibited high prophylactic and therapeutic efficacy in a hamster model

30 IgG1 ab1 also exhibited high prophylactic and therapeutic efficacy in a hamster model

31 These in vivo experiments demonstrated the prophylactic and therapeutic efficacy of the AAV-IFN-alp

32 d-goal - to predict the clinical efficacy of prophylactic and therapeutic interventions in humans.

33 gical process is needed to develop effective prophylactic and therapeutic measures directed at specif

34 d doses may offer an alternative strategy to prophylactic and therapeutic protocols that require mult

35 In mice, both prophylactic and therapeutic RDV improve pulmonary funct

36 Here, we tested the efficacy of prophylactic and therapeutic remdesivir treatment in a n

37 tations (ID8 p53(-/-) brca2(-/-)), both in a prophylactic and therapeutic setting.

38 tect against lethal IBV infection in mice in prophylactic and therapeutic settings.

39 vaccination strategy showed efficacy in both prophylactic and therapeutic settings.

40 ed to protect the eye and will inform future prophylactic and therapeutic strategies.

41 VA vaccination, demonstrated protection as a prophylactic and therapeutic treatment for the respectiv

42 chanisms and identify candidate pathways for prophylactic and therapeutic treatments for IBDs.

43 gs, with the potential to offer a cure-to be prophylactic and transmission blocking in malaria.

44 Both in prophylactic and treatment studies, 22 diminished the ov

45 raftment of AML cells when administered as a prophylactic and when combined with chemotherapy, and er

46 ed with IRIS, which may serve as targets for prophylactic and/or therapeutic interventions in the fut

47 hout CHD, supporting a need for improved RSV prophylactics and treatments that also have efficacy in

48 tification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS-CoV

49 (3.0%) on therapeutic, 33 of 1,959 (1.7%) on prophylactic, and 29 of 1,530 (1.9%) on no AC.

50 ldwide effort to develop effective vaccines, prophylactics, and therapeutics.

51 as been used successfully in therapeutic and prophylactic animal models to treat many different funga

52 There remains an important need for prophylactic anti-Ebola virus vaccine candidates that el

53 are among the most promising therapeutic and prophylactic anti-SARS-CoV-2 agents.

54 Prophylactic anti-TNF therapy reduces both endoscopic an

55 Prophylactic antibiotic regimens and PICU patients demon

56 stresuscitation oxygenation and ventilation, prophylactic antibiotics after resuscitation, postresusc

57 American Dental Society states "in general" prophylactic antibiotics are not recommended to prevent

58 can Dental Society states that "in general," prophylactic antibiotics are not recommended to prevent

59 decrease PPI use and changes in the class of prophylactic antibiotics may impact CDI incidence and wa

60 Routine use of prophylactic antibiotics to prevent infection of sterile

61 ry disease worldwide due to reduced usage of prophylactic antibiotics under consumer preferences and

62 These studies identify promising prophylactic antibodies and define protective epitopes t

63 Ten of the 11 patients received prophylactic anticoagulant therapy; venous thromboemboli

64 In sum, these results suggest that prophylactic anticoagulation might attenuate the inciden

65 Prophylactic anticoagulation was prescribed in 89.4% of

66 nts in the control group who did not receive prophylactic anticoagulation within 7 days after injury,

67 ulmonary arterial vessels despite the use of prophylactic anticoagulation.

68 eep venous thrombosis, despite 40% receiving prophylactic anticoagulation.

69 ill patients receiving different regimens of prophylactic anticoagulation.

70 cally ill) primarily receiving standard-dose prophylactic anticoagulation.

71 receive dexamethasone as a component of the prophylactic antiemetic regimen.

72 on of dexamethasone from guideline-compliant prophylactic antiemetic regimens when CPIs are administe

73 The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently

74 erapy to oral antibiotic therapy) and use of prophylactic antimicrobial regimens in high-risk patient

75 rate a CRISPR-Cas13-based strategy, PAC-MAN (prophylactic antiviral CRISPR in human cells), for viral

76 To develop potentially prophylactic antiviral drugs for combating these acute i

77 We found a trend towards prophylactic aortic root surgery at younger ages but sim

78 Prophylactic aortic root surgery tended to be performed

79 ollow-up (9.1 years), 142 patients underwent prophylactic aortic root surgery, 5 experienced type A a

80 consider visions for AIT development towards prophylactic application.

81 entire growing season due to their frequent, prophylactic application.

82 ould be considered both as a therapeutic and prophylactic approach.

83 Prophylactic approaches, such as maternal immunization,

84 Here we report that prophylactic but not therapeutic administration of obeti

85 trial was to evaluate the risks/benefits of prophylactic central neck dissection (pCND) in patients

86 s at increased risk of ischemic events or on prophylactic CGRP inhibition.

87 Prophylactic cotrimoxazole treatment is recommended in h

88 34; CTX-T) or to not receive (n = 29; CTX-N) prophylactic cotrimoxazole treatment.

89 d to receive (n=34) or to not receive (n=29) prophylactic cotrimoxazole treatment.

90 The drug demonstrated its efficacy both as a prophylactic countermeasure and a mitigator in CD2F1 mic

91 latinum-etoposide every 3 weeks and optional prophylactic cranial irradiation (investigator's discret

92 les of platinum-etoposide every 3 weeks plus prophylactic cranial irradiation (investigator's discret

93 No patients received prophylactic cranial radiation; however, patients with C

94 ly improved skin perfusion in mice receiving prophylactic DFO.

95 n of cells in vitro, and a single intranasal prophylactic dose of decoy protected Syrian hamsters fro

96 (RR 0.02 [95% CrI 0.00-3.86]) and LMWH (low prophylactic dose, 10-14 days) ranked first in the major

97 Low molecular weight heparin (LMWH; standard prophylactic dose, 28-35 days) ranked first in the pulmo

98 iconazole, showed superior effects to single prophylactic dose, suggesting tissue retention and/or ac

99 d in normal monkeys and shows both acute and prophylactic dose-dependent efficacy in hemophilic monke

100 er, there are no clear guidelines concerning prophylactic dose.

101 cs highlights the potential for intermittent prophylactic doses of exogenous IFN-beta to modulate vir

102 Prophylactic dosing of a CSF-1R inhibitor to deplete Mon

103 ysiology was used to determine the effect of prophylactic drug administration on glutamatergic activi

104 that the 5-HT(4)R may be a novel target for prophylactic drug development.

105 for AnxA1 to act both as a therapeutic and a prophylactic drug via its ability to promote endogenous

106 Use of prophylactic eculizumab was independently associated wit

107 ly, topical vaginal estrogen treatment has a prophylactic effect against such infections.

108 The prophylactic effect of NPWT has not been established.

109 duction in viral replication, suggesting the prophylactic effectiveness of IFNs against SARS-CoV-2.

110 ical models, but have not been evaluated for prophylactic effects.

111 tachment, revealing a mechanism behind their prophylactic effects.

112 ited improved pharmacokinetic properties and prophylactic efficacy against organophosphate poisoning,

113 that ovarian hormones are necessary for the prophylactic efficacy of (R,S)-ketamine and (2R,6R)-HNK

114 Here, we investigated the causal prophylactic efficacy of KAF156 in a controlled human ma

115 ohort, the efficacy endpoint was efficacy of prophylactic emicizumab in maintaining adequate bleed pr

116 All of them received either prophylactic entecavir or tenofovir therapy.

117 Our initial in vivo prophylactic evaluation of an oxidation-resistant GRFT (

118 enotypes prior to infection, suggesting that prophylactic expression of defense-associated genes coul

119 of bleeding events and complete cessation of prophylactic factor VIII use in all participants who had

120 ng paradigm have the potential to be used as prophylactics for patients traveling to endemic regions

121 ction have prompted recommendation for total prophylactic gastrectomy for carriers of pathogenic or l

122 Abs) that are critical for the efficacy of a prophylactic HCV vaccine.

123 Prophylactic hemoclip application did not reduce delayed

124 Routine prophylactic hemoclip application during EMR may lead to

125 In polyps sized 6 to 20 mm, prophylactic hemoclip placement did not decrease the ris

126 s study was to evaluate the effectiveness of prophylactic hemoclipping and identify the risk factors

127 The patients with prophylactic hemoclipping for delayed PPB prevention wer

128 The effect of prophylactic hemoclipping on delayed PPB is uncertain.

129 ded in the clipping group, and those without prophylactic hemoclipping were included in the non-clipp

130 anticoagulant use are no need to performing prophylactic hemoclipping.

131 es included lifetime cumulative incidence of prophylactic IA treatment and mortality and SAH deaths p

132 nd thus underpowered randomized trial, early prophylactic ICD implantation demonstrated lower total a

133 well-treated population undergoing dialysis, prophylactic ICD therapy did not reduce the rate of SCD

134 Background Prophylactic image-guided procedures performed by interv

135 s key when considering whether to treat with prophylactic immune suppression.

136 ased clearance rate, makes Lm-RIID ideal for prophylactic immunization against diseases that require

137 r future trials such as anti-inflammatory or prophylactic immunotherapy.

138 y) aimed to evaluate the survival benefit of prophylactic implantable cardioverter defibrillator (ICD

139 veness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU

140 The feasibility and value of prophylactic implantable cardioverter-defibrillator (ICD

141 y low-risk patients who may not benefit from prophylactic implantable cardioverter-defibrillator ther

142 y vulnerable patients who would benefit from prophylactic implantation of ICDs by way of a reduction

143 predict mortality reductions associated with prophylactic implantation of ICDs in contemporarily trea

144 hey met guideline-based criteria for primary prophylactic implantation of ICDs.

145 whether metabolites of (R,S)-ketamine can be prophylactic in both sexes.

146 cts as a surprisingly effective pre-exposure prophylactic in highly lethal murine models of aerosoliz

147 Prophylactic inhibition of sEH significantly improved su

148 lasmodium infection is a critical window for prophylactic intervention.

149 eprosy control through the availability of a prophylactic intervention; therefore, we recommend rolli

150 hem for immunological screening and initiate prophylactic interventions and treatment.

151 tance for future efforts toward establishing prophylactic interventions for AD on a general populatio

152 Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus o

153 Randomized controlled trials that evaluated prophylactic interventions for the prevention of postden

154 enefit diagnostics, treatment decisions, and prophylactic interventions.

155 There is no role for the routine use of prophylactic irradiation to chest wall procedure sites i

156 risk of RRD was highest in 33 patients with prophylactic laser (45.5%), lower in 15 patients with no

157 In a multivariable model including prophylactic laser and ARN severity, only zone was predi

158 Retinal interventions included prophylactic laser and surgical retinal repair.

159 ot observe a reduction in the risk of RRD by prophylactic laser in eyes with ARN.

160 Therefore, prophylactic laser may be abandoned.

161 iridotomy is limited; therefore, widespread prophylactic laser peripheral iridotomy for primary angl

162 o immediate threat to vision, the benefit of prophylactic laser peripheral iridotomy is limited; ther

163 30.2%), sectoral laser (41 cases, 6.0%), and prophylactic laser photocoagulation (33 cases, 4.8%).

164 different groups with either no prophylaxis, prophylactic laser, or prophylactic vitrectomy.

165 Addition of prophylactic levofloxacin to active myeloma treatment du

166 In contrast, prophylactic LPV/RTV-IFNb slightly reduces viral loads w

167 Breast cancers detected by imaging and/or prophylactic mastectomy compared with physical findings

168 e further evidence that resilience-enhancing prophylactics may alter AMPAR-mediated glutamatergic tra

169 RISPR-mediated Myd88 repression can act as a prophylactic measure against septicaemia in both Cas9 tr

170 hole-bacteria vaccine, is currently the only prophylactic measure that is protective against C. burne

171 Risk stratification and prophylactic measures have good evidence supporting thei

172 Prophylactic measures were not associated with an increa

173 powered to demonstrate the efficacy of these prophylactic measures, it provides important insight to

174 tion, which suggests the need for additional prophylactic measures.

175 e randomisation was stratified by the use of prophylactic medication (yes or no), and was carried out

176 ysis there was a lower incidence of VIH with prophylactic mesh (11.1%vs21.3%, RR = 0.32; 95%CI = 0.19

177 When adjusted for this bias, prophylactic mesh had a more conservative effect (RR = 0

178 Prophylactic mesh has been proposed as an adjunct to pre

179 .08, 95%CI = 0.82-1.43; P = 0.118), however, prophylactic mesh increased the risk of SSO (14.2%vs8.9%

180 rent RCTs suggest that in mid-term follow-up prophylactic mesh prevents VIH with increased risk for S

181 mized controlled trials (RCTs) that compared prophylactic mesh reinforcement versus conventional sutu

182 Importantly, prophylactic metformin treatment reversed these characte

183 We found prophylactic mtOFF activation increased survival followi

184 of liver-related disease after cessation of prophylactic NA therapy in patients who received rituxim

185 t multivalent adhesin-based ETEC vaccines or prophylactics need more than one active component to rea

186 These findings do not support routine use of prophylactic negative pressure wound therapy in obese wo

187 espite widespread use, it is unclear whether prophylactic negative pressure wound therapy reduces sur

188 ng obese women undergoing cesarean delivery, prophylactic negative pressure wound therapy, compared w

189 nts were randomly assigned to either undergo prophylactic negative pressure wound therapy, with appli

190 Therefore, Bbeta2 may represent a target for prophylactic neuroprotective therapy in populations at h

191 Prophylactic NPWT has shown promise for SSI reduction.

192 Prophylactic NPWT on closed incisions has shown promisin

193 colorectal surgery were assigned to receive prophylactic NPWT or standard gauze dressing.

194 f English language RCTs comparing the use of prophylactic NPWT to standard dressings on primarily clo

195 , omission of drain placement (OR 5.51), and prophylactic octreotide (OR 3.09).

196 The USPSTF recommends prophylactic ocular topical medication for all newborns

197 nt of aortic aneurysms relies exclusively on prophylactic operative repair of larger aneurysms.

198 With no specific therapeutic and prophylactic options available, the virus has infected m

199 Considering the limited prophylactic options that are currently offered to women

200 ingosine is warranted for potential use as a prophylactic or early treatment for coronavirus disease-

201 the characteristics necessary for potential prophylactic or therapeutic approaches.

202 il accumulation in target organs, and GM-CSF prophylactic or therapeutic blockade substantially decre

203 llenge stock may prove useful for evaluating prophylactic or therapeutic interventions against clade

204 rgery, it still remains without an effective prophylactic or therapeutic medical treatment.

205 ber of severe infections in children, but no prophylactics or therapeutics are currently available.

206 uences the capacity of an allergen to induce prophylactic oral tolerance.

207 Limited retrospective data suggest prophylactic oral vancomycin may prevent Clostridioides

208 Limited retrospective data suggests prophylactic oral vancomycin may prevent Clostridioides

209 We sought to evaluate whether prophylactic oral vancomycin reduces the incidence of CD

210 l amendment in two of the five sites allowed prophylactic paracetamol to be administered before vacci

211 CoV-19 group and many were reduced by use of prophylactic paracetamol, including pain, feeling feveri

212 t to extend survival and delay symptoms in a prophylactic paradigm.

213 Early prophylactic placement of a vena cava filter after major

214 mized equivalence study to determine whether prophylactic placement of hemoclips affects incidence of

215 In a randomized trial, we found that prophylactic placement of hemoclips after removal of lar

216 The efficacy of prophylactic placement of hemoclips to prevent delayed b

217 These results suggest that a 25 x 109/L prophylactic platelet count threshold can be adopted in

218 ecovery were more likely to bleed if given a prophylactic platelet transfusion (odds ratio 2.34, 95%

219 y showed in a randomized clinical trial that prophylactic platelet transfusion did not reduce clinica

220 reported an unexpected overall benefit of a prophylactic platelet transfusion threshold of 25 x 109/

221 (ARV) drugs can serve as an HIV pre-exposure prophylactic (PrEP) strategy.

222 54 centers and randomly assigned to receive prophylactic radiotherapy (n = 186) or no prophylactic r

223 ve prophylactic radiotherapy (n = 186) or no prophylactic radiotherapy (n = 189).

224 s with MPM were randomly assigned to receive prophylactic radiotherapy (within 42 days of the procedu

225 on radiotherapy-related adverse event in the prophylactic radiotherapy group, with 96 patients (51.6%

226 study, we aimed to determine the efficacy of prophylactic radiotherapy in reducing the incidence of c

227 Choice of prophylactic regimen was not related to presence of deep

228 phylaxis is an effective and acceptable GvHD prophylactic regimen.

229 Doxycycline prophylactic regimens have been shown to significantly r

230 ICU antibiotic regimens were inappropriate; prophylactic regimens were often inappropriate across di

231 ely the level of efficacy of the doxycycline prophylactic regimens, especially for Lyme disease and s

232 Prophylactic remdesivir treatment initiated 24 h prior t

233 We report herein the results of the prophylactic replacement strategy in the pediatrics-insp

234 mination with additional close follow-up and prophylactic retinal laser should be considered.

235 For this illness, an effective prophylactic RSV-specific monoclonal antibody is availab

236 There is limited evidence on prophylactic strategies, other than the use of preoperat

237 menorrheic women to BPS is needed to develop prophylactic strategies.

238 on to enhance p53 activity could be a viable prophylactic strategy for alleviating GI syndrome in pat

239 tization therapies, we used a posttransplant prophylactic strategy.

240 ral transmission and could offer a potential prophylactic target for reducing flavivirus transmission

241 The development of new diagnostic, prophylactic, therapeutic and curative strategies is cri

242 rying, and common disinfectants; and lack of prophylactic therapies.

243 significantly reduced in patients receiving prophylactic therapy (2% vs 17%; P = .04).

244 skim proteins could be potentially used as a prophylactic therapy for diabetes and obesity, respectiv

245 In the mouse prophylactic therapy model, none of the FIX products imp

246 There is no prophylactic therapy that reliably prevents anaphylaxis.

247 anticancer therapy should receive antiviral prophylactic therapy through and for minimum 12 months f

248 minal pain, reported symptom resolution with prophylactic therapy.

249 Prophylactic total gastrectomy remains the recommended o

250 BEST PRACTICE ADVICE 10: Prophylactic transcatheter arterial embolization of high

251 CLK3 as a drug target in malaria that offers prophylactic, transmission blocking, and curative potent

252 no approved treatment for HMPV and only one prophylactic treatment against RSV, palivizumab, for hig

253 MW05/LALA blocks infection of SARS-CoV-2 in prophylactic treatment and clears SARS-CoV-2 in three da

254 he frequency of complications and benefit of prophylactic treatment and if eyes treated with anti-vas

255 o direct evidence to support that a migraine prophylactic treatment can reduce future stroke in peopl

256 Prophylactic treatment of CDX-301 resulted in increased

257 he peak fire season would enable methodical, prophylactic treatment strategies of landscapes at high

258 In addition, repeated prophylactic treatment with PC945, but not posaconazole

259 gible screened contacts, 1182 (0.7%) refused prophylactic treatment with SDR.

260 Prophylactic treatment with the LY341495, both systemica

261 tients, resistant bacteria were found during prophylactic treatment.

262 cks in the prior 12 months or were receiving prophylactic treatment.

263 g clone, which would add confidence to their prophylactic/treatment decision making and facilitate ef

264 ng them is of utmost clinical relevance, and prophylactic treatments are perhaps the most efficient s

265 ning at ages 10, 20, and 30 years led to 978 prophylactic treatments for unruptured aneurysms, 19 pro

266 stress-resilient phenotype, indicating that prophylactic treatments reducing mGlu(2) activity may pr

267 ts were followed 4 weeks after completion of prophylactic tuberculosis treatment.

268 We used a prophylactic tumor vaccination model and observed that b

269 sis was more immunogenic than apoptosis in a prophylactic tumor vaccination model.

270 Based on these results, the prophylactic use of mesh to prevent PSH cannot be recomm

271 ults demonstrate that the current widespread prophylactic use of NST in the key soybean-producing are

272 an subjects in order to assess the potential prophylactic use of SiNPs for treating allergic skin con

273 es and open up possibilities for testing the prophylactic use of such an antibody.

274 used the tool to screen antivirals for their prophylactic utility and identify lower bound effective

275 Prophylactic vaccination is a powerful tool for reducing

276 Prophylactic vaccination of pregnant women prior to deli

277 Prophylactic vaccination reduced fentanyl- and sufentani

278 -restricted SIV epitopes in Vif and Nef, and prophylactic vaccination with these epitopes increases t

279 subversion of responses can be prevented by prophylactic vaccination.

280 Thus, it is possible to develop a prophylactic vaccine against LF in humans.

281 ies suggest that it is possible to develop a prophylactic vaccine against LF.

282 Short, 6-month regimens of a mosaic HIV-1 prophylactic vaccine elicited robust HIV-specific immune

283 The development of a prophylactic vaccine for hepatitis C virus (HCV) remains

284 Despite development challenges, a prophylactic vaccine is necessary for global control of

285 Current efficacy studies of a mosaic HIV-1 prophylactic vaccine require four vaccination visits ove

286 mic areas of Africa highlight the need for a prophylactic vaccine that would confer protection agains

287 portant target for the development of a KSHV prophylactic vaccine to prevent initial viral infection.

288 ork needs to be done, but it is clear that a prophylactic vaccine, combined with targeted chemotherap

289 is C virus (HCV) depends on development of a prophylactic vaccine.

290 The HPV prophylactic vaccines Gardasil and Cervarix have been wi

291 AIT differs from prophylactic vaccines that provoke immunity to infectiou

292 al cancer has resulted in the development of prophylactic vaccines to prevent HPV infection and HPV a

293 control and ultimately stop the pandemic are prophylactic vaccines, antiviral therapeutics are import

294 ltogether, flavonoids could have significant prophylactic value for retinal degenerative diseases.

295 Thus, flavonoids could have a prophylactic value for retinal degenerative diseases.

296 eferenced stroma/host cell concentrations to prophylactic values; summary metrics were time from prod

297 laxis (26.7%), and lowest in 7 patients with prophylactic vitrectomy (14.3%).

298 The role of prophylactic vitrectomy is still unclear, but deserves f

299 ither no prophylaxis, prophylactic laser, or prophylactic vitrectomy.

300 (SSRI) fluoxetine (Flx) is ineffective as a prophylactic, we hypothesized that other serotonergic co