ライフサイエンスコーパス: propriospinal

1 rade tracing demonstrated that the number of propriospinal and brainstem axons reaching 5-6 mm beyond

2 al, intersegmental, and supraspinal input to propriospinal and motor neurons over many spinal cord le

3 The generation of both propriospinal and supraspinal projection neurons began o

4 stsynaptic potentials evoked from segmental, propriospinal, and bulbospinal systems in motor neurons

5 dorsal column sensory, regionally projecting propriospinal, and local motor axons.

6 f SC transplantation in mediating descending propriospinal axonal regeneration as well as optimizing

7 eration of certain subtypes of brainstem and propriospinal axons across the injury site and is follow

8 While short thoracic propriospinal axons are severely damaged after injury, 5

9 t providing additional neurotrophic factors, propriospinal axons can grow into the SC environment whi

10 The amount of damage to propriospinal axons following different severities of SC

11 ation (at least 2.5 cm) of injured ascending propriospinal axons was observed in the rostral spinal c

12 Even though the axons of short thoracic propriospinal cells are damaged, their cell bodies of or

13 MN collaterals are a physiologically tenable propriospinal circuit in the mammalian fusimotor system.

14 ggest that LCNs may also form short and long propriospinal connections.

15 ated by the reorganization of descending and propriospinal connections.

16 Propriospinal detour pathways facilitate motor recovery

17 eticulospinal excitation, and reduced direct propriospinal excitation in EphA4 knock-out mice.

18 terminations or projections consistent with propriospinal functions.

19 oanatomical reorganization of descending and propriospinal input was examined in the companion paper.

20 ts of the hindlimb enlargement received more propriospinal inputs from immediately rostral than immed

21 was on V3 neurons involved in ascending long propriospinal interactions (aLPNs).

22 of a disynaptic excitatory pathway via C3-C4 propriospinal interneurones similar to that in the cat.

23 ously we suggested that commissural and long propriospinal interneurons are the main targets for brai

24 ns between these afferents and the ascending propriospinal interneurons of the reflex.

25 n of ascending axons originating from lumbar propriospinal interneurons that can influence cervical i

26 ized the ON- and OFF-phases of 72 descending propriospinal interneurons with distinct activity bursts

27 it control by targeting commissural and long propriospinal interneurons.

28 e labelling demonstrated a greater number of propriospinal labelled neurons above and below the thora

29 and somatic stimulation might be mediated by propriospinal mechanisms located in upper cervical segme

30 the classical types of spinal interneurons (propriospinal, monosynaptic Ia-excitatory, reciprocal Ia

31 -segmental communication via the intraspinal propriospinal network.

32 ation that AIH induces plasticity within the propriospinal network.SIGNIFICANCE STATEMENT Acute inter

33 fects of IS may be mediated via more ventral propriospinal networks and/or brainstem locomotor areas.

34 luded that diffuse DRPs are mediated through propriospinal networks which may contribute to the gatin

35 tation of motoneurones via a system of C3-C4 propriospinal neurones in the monkey.

36 nt with the presence of collaterals of C3-C4 propriospinal neurones to the LRN, as demonstrated in th

37 Descending propriospinal neurons (DPSN) are known to establish func

38 Long ascending propriospinal neurons (LAPNs) are a subpopulation of spi

39 Here, we show that silencing long ascending propriospinal neurons (LAPNs) that inter-connect the lum

40 conditional silencing of the long ascending propriospinal neurons (LAPNs) that project from the lumb

41 equivalent to the LAPNs, the long descending propriospinal neurons (LDPNs) that have cell bodies at C

42 lumbar spinal circuits are mediated by long propriospinal neurons (LPNs).

43 Propriospinal neurons (PNs) present varied patterns of p

44 rol of mammalian forelimb movement, cervical propriospinal neurons (PNs), has the potential to convey

45 Implicated players in this process are the propriospinal neurons (PPNs) that project their axons ac

46 rt, more retrogradely labeled (P < 0.05) DGC propriospinal neurons (T13-S1) were quantified in injure

47 ume, preserves a higher number of descending propriospinal neurons above the injury and a higher inne

48 plete T4 SCI, we evaluated the plasticity of propriospinal neurons conveying visceral input rostrally

49 Raphespinal axons were apposed to numerous propriospinal neurons in control and transplant animals;

50 re used to assess the projection patterns of propriospinal neurons in order to determine how this sys

51 netic actuators to alter the excitability of propriospinal neurons in the thoracic cord of the adult

52 manipulating either excitatory or inhibitory propriospinal neurons in the thoracic levels leads to di

53 Propriospinal neurons play crucial roles in recovery of

54 Long propriospinal neurons that inter-connect these CPGs are

55 es a foundation for understanding changes in propriospinal neurons that may lead to adaptive (or mala

56 re interconnected by local and long-distance propriospinal neurons thought to carry temporal informat

57 demonstrate a strategy of engaging thoracic propriospinal neurons to improve hindlimb function and p

58 This study reveals the diverse responses of propriospinal neurons to injury and provides a foundatio

59 lasticity of severed bulbospinal systems and propriospinal neurons was investigated following unilate

60 the cervical cord, divergent long descending propriospinal neurons were found in contralateral lamina

61 I as local circuit neurons and the remaining propriospinal neurons were generated.

62 f lamina VII and adjacent lamina VIII, where propriospinal neurons with long-range bilateral axon pro

63 to descending, double-midline crossing C3-C4 propriospinal neurons, which crossed the lesion site in

64 tage and generates excitatory and inhibitory propriospinal neurons, which make synaptic connections w

65 kewed distributions, dominated by descending propriospinal neurons.

66 skewed distributions, dominated by ascending propriospinal neurons.

67 PSA) and vagal afferents on C1-C2 descending propriospinal neurons.

68 thways and specifically supraspinal input to propriospinal neurons.

69 ssion is mediated by the adrenal medullae, a propriospinal pathway between the afferent nociceptive i

70 Next, we show that the spared descending propriospinal pathway, rather than other pathways (inclu

71 Propriospinal pathways, consisting of axons from interne

72 xpiratory motoneurons is solely dependent on propriospinal pathways.

73 ant thoracic segments through short and long propriospinal pathways.

74 characterization of inter-enlargement (long propriospinal) pathways, illustrating a substantial and

75 , and/or autonomic response to AIH, and that propriospinal plasticity may contribute to sustained inc

76 culospinal innervation at lumbar levels, the propriospinal projection network, neuromuscular junction

77 These propriospinal projections around the lesion were signifi

78 bunit (CTB) was used to trace long ascending propriospinal projections from neurons in the lumbosacra

79 These propriospinal projections may be involved in coordinatin

80 upper cervical spinal cord, with descending propriospinal projections to the lumbar spinal cord, the

81 Neurons with short propriospinal projections, i.e., neurons with connection

82 and caudal segments receive distinct sets of propriospinal projections.

83 We show that propriospinal relay connections that bypass one or more

84 Chemogenetic silencing of propriospinal relay neurons compromised recovered steppi

85 ly arborize and form contacts onto a plastic propriospinal relay, thereby bypassing the lesion.

86 rephrenic interneurons, suggesting that some propriospinal relays exist between medullary neurons and

87 The propriospinal system is important in mediating reflex co

88 ng intact excitation transmitted via a C3-C4 propriospinal system, the descending axons of which trav

89 y of primary afferents, motoneurons, and the propriospinal system.

90 amaged after injury, 5-7% of long descending propriospinal tract (LDPT) projections survive following

91 Propriospinal tract has been found to respond to several

92 ared with other CNS axonal pathways, injured propriospinal tracts display the strongest regenerative