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1 t through secretion of the signaling protein prosaposin.
2 ve and glioprotective factors prosaptide and prosaposin.
3 equential domain-containing proteins such as prosaposin.
4 rolases that derive from a single precursor, prosaposin.
5 roteolytic processing of a common precursor, prosaposin.
6 e efficient sorting of the lysosomal protein prosaposin.
7 delivery of newly translated progranulin and prosaposin.
8 a putative precursor analogous to vertebrate prosaposins.
9                                              Prosaposin, a cysteine-rich protein that contains STT3A-
10 llular cathepsin D content and impairment of prosaposin activation, a process that is required for me
11 xtracellular cathepsin D to the lysosome for prosaposin activation.
12 ed neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1), we p
13 he neuroprotective and glioprotective ligand prosaposin and communicate with SGCs via the prosaposin
14 ted glycoprotein-1), we purified full-length prosaposin and found that it also stimulated GPR37 and G
15                  These findings suggest that prosaposin and prosaptides bind to a receptor that initi
16                                In C-/- mice, prosaposin and saposins A, B and D proteins were present
17 stically, we identify an interaction between prosaposin and Surf4, a receptor that promotes loading o
18     This partitioning required extracellular prosaposin and was disrupted by lipid raft perturbation
19  flux, altered intracellular localization of prosaposin, and an aggregation of alpha-synuclein in pat
20 derives from the multi-functional precursor, prosaposin, and functions as an activity enhancer for se
21 a show functional association between GPR37, prosaposin, and GM1 in the plasma membrane.
22 cted in the homozygotes (B-/-) mice, whereas prosaposin, and saposins A, C and D were at normal level
23  discover that progranulin interactions with prosaposin, another lysosomal protein, first occur withi
24                                              Prosaposin appears to be a potent neurotrophic factor.
25   Saposins, derived from a common precursor, prosaposin, are small, heat-stable lysosomal glycoprotei
26   After a yeast two-hybrid screen identified prosaposin as a potential interacting protein with the n
27  development of atherosclerosis and identify prosaposin as a potential therapeutic target.
28  Psap, a gene encoding the lysosomal protein prosaposin, as closely related with mTOR signaling.
29 rolases that derive from a single precursor, prosaposin, by proteolytic cleavage.
30 ed a novel role for cathepsin B in mediating prosaposin cleavage to form saposin C, the lysosomal coa
31 d microglia replacement to a mouse model for Prosaposin deficiency, which is characterized by a progr
32 nd sphingolipid-activator-protein-precursor (prosaposin) deficiency.
33 ts and hepatocytes from PS-/- mice and human prosaposin-deficient fibroblasts.
34 laining the deficiency of myelin observed in prosaposin-deficient mice and humans.
35              Although it has been shown that prosaposin-deficient mice fail to positively select inva
36 romoting lipid binding to CD1d, we expressed prosaposin deletion mutants lacking individual saposins
37                                              Prosaposin demonstrates diffuse organ of Corti expressio
38 enes (cystatin C, cathepsin C, lysozyme, and prosaposin) did not require de novo protein synthesis fo
39                              Human and mouse prosaposin displayed similar temporal and spatial regula
40 ins derived from a common precursor protein (prosaposin) encoded by a single gene.
41 eins, metabolic labeling was done with human prosaposin expressed in insect cells, human fibroblasts,
42 ic sequestration of the activation region of prosaposin for protection of the cell from adverse hydro
43  for the efficient export of progranulin and prosaposin from the ER.
44 howed that Sp1 and Sp3 are involved in human prosaposin gene regulation.
45 e 5' region was characterized from the human prosaposin gene.
46                   The neurotrophic region of prosaposin has been localized to a 12-amino acid sequenc
47         Together, these results suggest that prosaposin helps maintain normal innervation patterns to
48 haperone activities and via interaction with prosaposin (i.e., a key regulator of lysosomal sphingoli
49 -/- mice showed an increase of intracellular prosaposin, impaired prosaposin secretion, deficiencies
50 owed large steady state amounts of uncleaved prosaposin in Purkinje cells, cortical neurons, and othe
51 ha10, studies were performed to characterize prosaposin in the normal rodent inner ear.
52                                              Prosaposin is a multifunctional protein encoded at a sin
53                                              Prosaposin is a multifunctional protein that encodes fou
54                                Expression of prosaposin is regulated in a temporal and spatial manner
55                                Expression of prosaposin is required for efficient lipid binding and r
56                                              Prosaposin is the precursor of four activator proteins,
57                                              Prosaposin is the precursor of four low molecular weight
58 n the degradation of glycosphingolipids, and prosaposin itself has neurite outgrowth effects.
59                      Subsequent studies in a prosaposin knock-out (KO) (-/-) mouse showed intact but
60                        Beginning at P12, the prosaposin KO mice showed histologic organ of Corti chan
61 saposin was observed in ugt1(-/-) cells with prosaposin localized to large juxtanuclear aggresome-lik
62 ons into the saposins A and B domains on the prosaposin locus.
63 on of an essential cysteine in exon 7 of the prosaposin locus.
64 GCase activity due to impaired processing of prosaposin may contribute to pathogenesis of FTD resulti
65                                              Prosaposin may function as a myelinotrophic factor in vi
66                        When secreted, intact prosaposin may function as a neuritogenic factor.
67 nscriptase-PCR and immunohistology localizes prosaposin mRNA to DCs and OHCs, and protein predominant
68 mbinant exogenous saposins were added to the prosaposin-negative cells, saposin B was the most effici
69 etion mutants lacking individual saposins in prosaposin-negative, CD1d-positive cells.
70                                  Relative to prosaposin null mice ( approximately 30 days), CD-/- mic
71 observed when compared with tissues from the prosaposin null mice, suggesting a compensation in LacCe
72                    Our findings suggest that prosaposin, or other agents that stimulate p53 activity
73                  These studies indicate that prosaposin processing is highly regulated at a proteolyt
74                                 In addition, prosaposin promotes neurite outgrowth in vitro via seque
75 hich the recently identified natural ligand, prosaposin, promotes plasma membrane association of GPR3
76  In young Gaucher disease mice (V394Lgba+/+//prosaposin[ps]-null//ps-transgene), which demonstrate ne
77 le in alpha-synuclein (SNCA) degradation and prosaposin (PSAP) cleavage; (ii) PSAP, essential for GCa
78                   In this work, we show that prosaposin (pSAP) drives CD8 T cell-mediated tumor immun
79 s with plasma PGRN levels and identified the prosaposin (PSAP) locus as a new locus significantly ass
80                                              Prosaposin (PSAP) modulates glycosphingolipid metabolism
81              Here, we found that variants in prosaposin (PSAP), a rare causative gene of various type
82 es neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides tha
83  4TO7 cells revealed the direct targeting of prosaposin (PSAP), which encodes a secreted protein foun
84 ed a tumor-secreted inhibitor of metastasis, prosaposin (Psap), which functions in a paracrine and en
85 C and D are derived from a common precursor, prosaposin (psap).
86 prosaposin and communicate with SGCs via the prosaposin receptor GPR37L1.
87            Immunoabsorption of extracellular prosaposin reduced GPR37(tGFP) surface density and decre
88                                 Furthermore, prosaposin's overlapping developmental expression patter
89 tabolism and lysosomal storage diseases, and prosaposin's physiological effects.
90 ins were undetectable in AB-/- mice, whereas prosaposin, saposin C and saposin D were expressed near
91                     In both humans and mice, prosaposin/saposin deficiencies lead to severe neurologi
92                            The deficiency of prosaposin/saposins (PS-/-) in humans and mice leads to
93 crease of intracellular prosaposin, impaired prosaposin secretion, deficiencies of saposins C and D a
94             Immunofluorescence studies using prosaposin-specific antisera showed large steady state a
95 pectedly, knockdown of the lysosomal protein prosaposin strongly sensitizes neurons, but not other ce
96  regulated at a proteolytic level to produce prosaposin, tetrasaposins, or mature monosaposins in spe
97 ast, MSC cultured on a stiff matrix secreted prosaposin that promoted proliferation and survival of m
98                                              Prosaposin, the precursor of saposins A, B, C, and D, wa
99                                              Prosaposin, the precursor of saposins A, B, C, and D, wa
100             We report that mice deficient in prosaposin, the precursor to a family of endosomal lipid
101 N mutations on the processing of full-length prosaposin to individual saposins, which are critical re
102   To explore the proteolytic processing from prosaposin to mature activator proteins, metabolic label
103 ufficiency results in impaired processing of prosaposin to saposin C, a critical activator of the lys
104                                       Herein prosaposin was found to increase sulfatide concentration
105                                              Prosaposin was identified as a prominent endogenous UGT1
106      A dramatic decrease in the secretion of prosaposin was observed in ugt1(-/-) cells with prosapos
107                Moreover, both prosaptide and prosaposin were found to protect primary astrocytes agai

 
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